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Human Radiation-Induced Eye Diseases: A Scoping Review towards “In-silico” Experimental Studies 人类辐射诱发的眼疾:面向 "微观 "实验研究的范围审查
Pub Date : 2024-02-21 DOI: 10.29011/2689-7407.100159
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引用次数: 0
Chronic Deposits on Implantable Collamer Lens after Surgery 人工晶状体术后慢性沉积
Pub Date : 2023-10-13 DOI: 10.29011/2689-7407.100156
Introduction: we reported a rare case involving chronic ICL V4c deposits after surgery without any other clinical manifestations. The deposits was found one month after surgery, and last about six weeks. After using topical steroid, the deposits were removed gradually. Patient and Clinical Findings: A 24-year-old female presented with granular opacity of implantable collamer lens (ICL) from one month after surgery (OS). There were no other inflammatory responses in the anterior segment of the eye. Diagnosis, Intervention, and Outcomes: The patient was diagnosed as chronic deposits on implantable collamer lens after surgery. After using 1% Prednisolone Acetate Eye Drop, the deposits were removed gradually. Conclusions: After ICL surgery, it is very uncommon for the chronic deposits to form on the ICL surface. Topical steroids was effective to help eliminate the deposits.
我们报告一例罕见的ICL术后慢性V4c沉积,无其他临床表现。这些沉积物是在手术后一个月发现的,持续了大约六周。使用局部类固醇后,沉积物逐渐被清除。患者和临床表现:一位24岁的女性在术后一个月出现了颗粒状的人工晶体混浊(ICL)。眼前段未见其他炎症反应。诊断、干预和结果:患者在手术后被诊断为可植入式晶状体的慢性沉积。使用1%醋酸泼尼松龙滴眼液后,沉积物逐渐清除。结论:ICL手术后,ICL表面形成慢性沉积物的情况并不多见。局部类固醇是有效的,有助于消除沉积物。
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引用次数: 0
Bilateral Retinoblastoma 双边视网膜母细胞瘤
Pub Date : 2023-09-13 DOI: 10.29011/2689-7407.100054
S Crăiţoiu
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引用次数: 0
Bilateral Fixed Dilated Pupils after MicroPulse Transscleral Cyclophotocoagulation: A Case Report and Review of Urrets-Zavalia Syndrome 微脉冲经巩膜光凝治疗双侧固定瞳孔扩大:Urrets-Zavalia综合征1例报告及回顾
Pub Date : 2023-06-30 DOI: 10.33425/2639-9482.1028
Mohammed Bin Maneea, A. Maqbool, A. Alzahrani, Alhanouf Alatawi, Ohoud Owaidhah
MicroPulse transscleral cyclophotocoagulation (MP-TSCPC) is a relatively new procedure for treating refractory advanced glaucoma. It uses repetitive micropulses of diode laser in an "on-off" cyclic manner, delivered with the Cyclo G6 Glaucoma Laser System (IRIDEX Corp., Mountain View, CA). In this unique case, we report the only instance of bilateral Urrets Zavalia Syndrome (UZS) in medical literature following MP-TSCPC in a 33-year-old Asian female with refractory angle-closure glaucoma. The patient developed bilateral fixed dilated pupils (UZS) after the treatment. The treatment settings included 100 seconds of laser application (50 seconds superiorly and 50 seconds inferiorly). Treated areas were the superior and inferior 180 degrees of the eye, excluding the 3 and 9 o'clock positions. On the first postoperative day, vision and intraocular pressure (IOP) were stable. Six weeks postoperatively, the patient presented with fixed mid-dilated pupils bilaterally and a visual acuity (VA) of 20/200 and 20/300, despite discontinuing Atropine 1% for 42 days. The patient was given pilocarpine 2% for ten days without response; however, vision improved to 20/125 and 20/160 with refraction and a +4.50 add for near vision. One and a half years postoperatively, the patient showed spontaneous partial recovery of the fixed dilated pupils in both eyes, with sectoral paralytic iris superiorly. The overall pupils' size was smaller in both eyes compared to previous visits. This case outlines the patient's symptoms, treatment, and outcome while discussing the potential risk of UZS following MP-TSCPC in specific populations. Further research is needed to better understand and mitigate the UZS complication after MP-TSCPC.
微脉冲经巩膜光凝治疗(MP-TSCPC)是治疗难治性晚期青光眼的一种相对较新的方法。它以“开-关”循环方式使用二极管激光器的重复微脉冲,与Cyclo G6青光眼激光系统(IRIDEX公司,Mountain View, CA)一起交付。在这个独特的病例中,我们报告了医学文献中唯一一例MP-TSCPC后的双侧尿路扎瓦利亚综合征(UZS),患者为33岁亚洲女性难治性闭角型青光眼。治疗后患者出现双侧固定瞳孔扩大(UZS)。治疗设置包括100秒激光应用(50秒优势和50秒劣势)。治疗部位为眼上下180度,不包括3、9点钟位置。术后第一天视力和眼压稳定。术后6周,尽管停用1%阿托品42天,患者仍出现双侧固定中瞳孔扩张,视力(VA)分别为20/200和20/300。患者给予2%匹罗卡品10天无反应;但是,屈光视力提高到20/125和20/160,近视视力+4.50。术后1年半,患者双眼瞳孔固定扩大,自发部分恢复,虹膜局部麻痹为主。与之前的检查相比,他们的双眼瞳孔总体变小了。本病例概述了患者的症状、治疗和结果,同时讨论了在特定人群中MP-TSCPC后UZS的潜在风险。需要进一步的研究来更好地了解和减轻MP-TSCPC后的UZS并发症。
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引用次数: 0
Prevalence of Primary Open-Angle Glaucoma in Candidates for a Public Competition 公开竞赛候选人原发性开角型青光眼的患病率
Pub Date : 2023-06-30 DOI: 10.33425/2639-9482.1027
Bilé Pefk, Konan Msmp, Diomandé Gf, Koffi Kfk, Gode Le, Goule Am, Babajeyu Rlo, D. Z, O. Y, Diomandé Ia
Primary open-angle glaucoma is a chronically progressive anterior optic neuropathy characterized by perimetric changes and pathological excavation of the optic disc. It is recognized as a disease that affects quality of life, social and professional life. If seen late or not treated, it can be disabling for all workers by making them medically unfit for their jobs. The prevention of occupational deintegration and job retention are important public health issues today. We report on 350 (700 eyes) glaucoma patients screened during a medical ophthalmological visit in the context of preparation for a public competition, which took place over 24 days in Yamoussoukro. The objective of this study was to determine the prevalence of primary open-angle glaucoma in candidates for a public competition.
原发性开角型青光眼是一种慢性进行性视神经病变,其特征是视盘周围改变和病理性突出。它被认为是一种影响生活质量、社会和职业生活的疾病。如果发现晚了或不及时治疗,它可能会使所有工人失去能力,使他们在医学上不适合他们的工作。预防职业解体和保留工作是当今重要的公共卫生问题。我们报告了在亚穆苏克罗举行的为期24天的公开竞赛准备期间,在眼科医疗访问期间对350名(700只眼睛)青光眼患者进行筛查的情况。本研究的目的是确定公开竞争候选人中原发性开角型青光眼的患病率。
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引用次数: 0
A Comparison of Visual Outcomes Between Patients Treated with Intravitreal Ranibizumab and Bevacizumab for Diabetic Macula Edema in A Real World Setting in Sub-Saharan Africa 在撒哈拉以南非洲的真实世界环境中,玻璃体内注射雷尼单抗和贝伐单抗治疗糖尿病黄斑水肿患者的视力结果比较
Pub Date : 2022-12-31 DOI: 10.33425/2639-9482.1026
Oderinlo Olufemi, Hassan Adekunle, O. Idris, Odubela Tolulope, L. Oshunkoya
Aims and Objectives: To report a comparison of visual outcomes between patients treated with intravitreal ranibizumab and bevacizumab for diabetic macula oedema (DME) in a real-world setting in sub-Saharan Africa. Methods: A retrospective review of cases files of patients who were treated with either intravitreal ranibizumab or bevacizumab for diabetic macular edema in Eye Foundation Hospital Ikeja, Lagos, Nigeria between January 2018, and January 2019. Results: A total of 508 injections were received by 138 eyes of 115 patients within the study year and diabetic macular edema accounted for 36 eyes, (26.1%) of the total eyes that received either intravitreal Ranibizumab or Bevacizumab. There were 18 males (50%) and 18 (50%) females. Overall, the mean baseline pre injection BCVA was 0.32 ± 0.24 (range:0.05-1.0). One hundred and forty-three total injections of either Bevacizumab or Ranibizumab were received by the 36 eyes of DME participants. Fifteen eyes (41.7%) received Bevacizumab while 21 eyes (58.3%) received Ranibizumab injections. At 4 months a larger percentage of eyes (47.6%) that received Ranibizumab had better visual acuities compared to (13.3%) eyes that received Bevacizumab. At 6 months, more of the eyes that received Ranibizumab had better visual acuities (26.7%) compared to 23.8% that received Bevacizumab. At 9 months, more of the eyes that received Ranibizumab had better visual acuities (33.3%) compared to (19%) those that received Bevacizumab. However, these differences were not statistically significant. Compliance to treatment regime was poor, only 7 eyes of the 36 eyes (19.4%) were compliant, 5 eyes (33.3%) form Bevacizumab group and 2 eyes (9.5%) from the Ranibizumab group. Conclusion: Despite poor compliance, improvements in best corrected visual acuities was achieved and maintained with the use of either intravitreal bevacizumab or ranibizumab for diabetic macula edema in a real life setting in sub-Saharan Africa. Neither bevacizumab nor ranibizumab showed statistically significant superiority.
目的和目的:报告在撒哈拉以南非洲的现实环境中,使用玻璃体内雷尼单抗和贝伐单抗治疗糖尿病黄斑水肿(DME)患者的视力结果的比较。方法:回顾性分析2018年1月至2019年1月在尼日利亚拉各斯Ikeja眼科基金会医院接受玻璃体内注射雷尼单抗或贝伐单抗治疗糖尿病黄斑水肿的病例档案。结果:研究年内115例患者138只眼共接受508次注射,糖尿病性黄斑水肿占36只眼,占玻璃体内注射雷尼单抗或贝伐单抗患者总数的26.1%。男性18只(50%),女性18只(50%)。总体而言,平均基线注射前BCVA为0.32±0.24(范围:0.05-1.0)。DME参与者的36只眼睛共接受了143次贝伐单抗或雷尼单抗注射。15只眼(41.7%)接受贝伐单抗注射,21只眼(58.3%)接受雷尼单抗注射。在4个月时,接受雷尼单抗的眼睛视力较好(47.6%),而接受贝伐单抗的眼睛视力较好(13.3%)。6个月时,接受雷尼单抗治疗的患者视力较好(26.7%),而接受贝伐单抗治疗的患者视力较好(23.8%)。在9个月时,接受雷尼单抗的眼睛有更好的视力(33.3%),而接受贝伐单抗的眼睛有更好的视力(19%)。然而,这些差异没有统计学意义。治疗方案的依从性较差,36只眼中只有7只眼(19.4%)符合治疗方案,贝伐单抗组5只眼(33.3%),雷尼单抗组2只眼(9.5%)。结论:尽管依从性较差,但在撒哈拉以南非洲的现实生活中,使用玻璃体内贝伐单抗或雷尼单抗治疗糖尿病黄斑水肿,可实现并维持最佳矫正视力的改善。贝伐单抗和雷尼单抗均未显示统计学上的显著优势。
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引用次数: 0
Artificial Intelligence (AI) in Ophthalmology: An Overview 人工智能(AI)在眼科中的应用综述
Pub Date : 2022-12-31 DOI: 10.33425/2639-9482.1024
Syeed Mehbub Ul Kadir, Rokhsanda Rehnuma, S. Rahman, M. Z. Raihani, Mahar Ali, Muhammad Moniruzzaman
Artificial intelligence (AI) is an emerging continuous equipment-based power that is initiating to spread throughout to all aspects of our lifestyles for digital revolution even in medical diagnosis, management of the disease AI application in ophthalmology can help in screening, diagnosing, staging, and providing best possible management planning of various eye diseases especially for sight-threatening eye conditions. This paper demonstrates a review of the art of AI in the ophthalmic field and focusing on the applications of AI for the diagnosis and treatment of ophthalmic diseases including cataract, glaucoma, diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, and future AI applications with image enhancement in Ophthalmology. Diabetic retinopathy is occurring due to damage of retinal blood. Advanced diabetic retinopathy can cause blindness. So, early detection and management of diabetic retinopathy is crucial to prevent vision loss. AI based technology is playing a role as an auxiliary assistant in screening and diagnostic support for ophthalmologist.
人工智能(AI)是一种新兴的、持续的、基于设备的力量,它正开始渗透到我们生活方式的各个方面,甚至在医疗诊断、疾病管理方面,人工智能在眼科的应用可以帮助筛查、诊断、分期,并为各种眼病提供最佳的管理计划,特别是对视力威胁的眼病。本文综述了人工智能在眼科领域的研究进展,重点介绍了人工智能在白内障、青光眼、糖尿病视网膜病变、年龄相关性黄斑变性、早产儿视网膜病变等眼科疾病的诊断和治疗中的应用,以及未来人工智能在眼科图像增强中的应用。糖尿病视网膜病变是由于视网膜血液的损伤而发生的。晚期糖尿病视网膜病变可导致失明。因此,早期发现和治疗糖尿病视网膜病变对于预防视力丧失至关重要。基于人工智能的技术在眼科医生的筛查和诊断支持中发挥着辅助助手的作用。
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引用次数: 0
Knowledges, Attitudes and Practices Related to Primitive Open Angle Glaucoma in The Adult Population in Northern Benin 贝宁北部成人对原始开角型青光眼的认识、态度和实践
Pub Date : 2021-12-30 DOI: 10.33425/2639-9482.1020
Assavedo Codjo Rodrigue Abel, Amedome Kokou Messan, A. Amadou, Abouki Chakiratou Oladouke, Monteiro Salimatou, Dionadji Memlelem Laeticia, Alamou Soulé, Sounouvou Ignace, O. Lisette, Tchabi Hounnou Sidonie
Introduction: Primary Open Angle Glaucoma (POAG) is a serious condition responsible for irreversible blindness. It is one of the main causes of blindness in developing countries. Purpose: To assess the knowledges, attitudes and practices relating to Primary Open Angle Glaucoma (POAG) in the adult population in northern Benin. Patients and methods: This was a cross-sectional descriptive and analytical study. It concerned all persons aged 18 years old and over. We had done a two-stage sampling. The Chi2 test, at the 5% threshold, had been used to study the associations. Results: Of a total of 560 subjects, 548 (97.85%) participated in the study. The mean age was 33.1 ± 16.5 years. The male sex was more represented (61.13%) with a sex ratio of 1.57. The secondary level was represented with 46.35% (n = 254) and as an occupation, 22.63% (n = 124) were traders. 70.99% (n = 389) of subjects had heard of eye disease, of which only 8.76% (n = 48) had heard of glaucoma. It is called Naradiou in Bariba. But only 1.24% had a good knowledge of the disease. 50% (n = 24) did not known the cause, 4.17% (n = 2) attributed it to the curse and 2.08% (n = 1) to witchcraft. 72.50% (n = 35) knew that glaucoma could progress to blindness and 59.09% (n = 13) thought it was irreversible. 79.17% (n = 38) of subjects knew that there is a treatment, 52.63% (n = 20) said it was medical, 36.84% (n = 14) said it was surgical and 10, 53% (n = 4) thought it is traditional. The attitude was bad in 57.74% of the cases. Education and occupation were significantly associated with glaucoma knowledge and practice, but only gender was statistically related to attitude with a p-value of 0.0052. Conclusion: The level of knowledge of POAG in the adult population in northern Benin is alarming, as is the attitude and the practice which remains to be improved. Communication programs for behavior change must be initiated in order to reduce the rate of blindness linked to this pathology in this population.
原发性开角型青光眼(POAG)是一种导致不可逆失明的严重疾病。它是发展中国家致盲的主要原因之一。目的:了解贝宁北部成年人对原发性开角型青光眼(POAG)的认识、态度和做法。患者和方法:这是一项横断面描述性和分析性研究。它涉及所有年满18岁的人。我们做了两个阶段的抽样。在5%的阈值下,Chi2测试被用来研究这些关联。结果:560名受试者中,548名(97.85%)参与了研究。平均年龄33.1±16.5岁。性别比率为1.57,男性占61.13%。二级水平为46.35% (n = 254),作为职业,22.63% (n = 124)为贸易商。70.99% (n = 389)的被试听说过眼病,其中只有8.76% (n = 48)的被试听说过青光眼。它在巴里巴被称为Naradiou。但仅有1.24%的人对该病有良好的了解。50% (n = 24)不知道原因,4.17% (n = 2)认为是诅咒,2.08% (n = 1)认为是巫术。72.50% (n = 35)的患者认为青光眼会发展为失明,59.09% (n = 13)的患者认为不可逆。79.17% (n = 38)的被试知道有一种治疗方法,52.63% (n = 20)的被试认为是药物治疗,36.84% (n = 14)的被试认为是手术治疗,10.53% (n = 4)的被试认为是传统治疗。态度不良的占57.74%。学历和职业与青光眼知识和行为有显著相关性,而性别与态度有统计学相关性,p值为0.0052。结论:贝宁北部成年人口对POAG的知识水平令人担忧,对POAG的态度和实践有待改进。必须启动行为改变的交流计划,以减少与该疾病相关的失明率。
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引用次数: 0
Management of Angle Closure Glaucoma in a Myopic Pregnant Woman during the COVID-19 Pandemic – A Case Journey COVID-19大流行期间近视孕妇闭角型青光眼的治疗——一个病例之旅
Pub Date : 2021-12-30 DOI: 10.33425/2639-9482.1021
Shivani Sharma, M. Chakrabarti, T. Sharma
Introduction: We present a case of a young Caucasian myopic patient with secondary ACG and the management during her pregnancy amidst the COVID-19 pandemic. Angle closure glaucoma (ACG) is an uncommon condition in younger myopic individuals. Thus, ACG in pregnancy is not well researched and no definitive guidelines exist for its treatment. Case Report: This 27-year-old female patient had been diagnosed with hypertensive uveitis and referred to the glaucoma clinic where peripheral anterior synechiae (PAS) was noticed on gonioscopy. As she had subacute angle closure glaucoma symptoms, she had been started on topical pilocarpine drops. She remained stable and under our regular follow up (dates). At her review in January 2021, she notified us that she was 27 weeks pregnant. She had continued pilocarpine drops once a day. Pilocarpine is a category C drug (with potential foetal risk though lack of human studies). Pilocarpine was advised to be stopped in the clinic as intra-ocular pressure is known to stabilise during pregnancy. She was further reviewed in the third trimester and had an uneventful delivery with a healthy baby. Her last review was post-pregnancy. She remained asymptomatic and her intra-ocular pressures were stable for the entire duration. Conclusion: Our case was an unusual presentation of subacute angle closure secondary to PAS in a young myopic female. Her management of pregnancy in the COVID-19 pandemic when secondary to the social distancing rules was challenging as the clinic reviews are limited. We successfully managed timely reviews without risking the patient or the baby of any potential side effects to pilocarpine or COVID-19.
我们报告了一例年轻的白人近视继发性ACG患者及其在COVID-19大流行期间的处理。闭角型青光眼(ACG)是一种少见的年轻近视患者。因此,妊娠期ACG的研究并不充分,也没有明确的治疗指南。病例报告:这名27岁的女性患者被诊断为高血压性葡萄膜炎,并被转介到青光眼诊所,在角膜镜检查中发现周围前粘连(PAS)。由于她有亚急性闭角型青光眼症状,她已开始局部使用匹罗卡品滴剂。她保持稳定,并在我们的定期随访(日期)。在2021年1月的复查中,她告诉我们她已经怀孕27周了。她每天服用一次匹罗卡品滴剂。匹罗卡品是C类药物(有潜在的胎儿风险,但缺乏人体研究)。临床建议停用匹罗卡品,因为已知眼压在妊娠期间趋于稳定。她在妊娠晚期接受了进一步检查,顺利分娩,生下了一个健康的宝宝。她最后一次检查是在怀孕后。患者无症状,整个过程中眼压稳定。结论:我们的病例是一个罕见的亚急性闭角继发于PAS的年轻女性。在COVID-19大流行期间,她对怀孕的管理是具有挑战性的,因为诊所审查有限。我们成功地及时进行了复查,没有给患者或婴儿带来匹罗卡品或COVID-19的任何潜在副作用的风险。
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引用次数: 0
Knowledges, Attitudes and Practices of Diabetic Patients Face to Diabetic Retinopathy in Parakou in 2019 2019年帕拉口地区糖尿病患者对糖尿病视网膜病变的认识、态度和行为
Pub Date : 2021-12-30 DOI: 10.33425/2639-9482.1016
Assavedo Codjo Rodrigue Abel, Alfa Bio Amadou Issifou, Sina Zabdi, Monteiro Salimatou, Abouki Chakiratou, Alamou Soulé, Tchabi Hounnou Sidonie
Introduction: Diabetic retinopathy is one of the main causes of blindness. Preventive measures and screening will reduce its impact. Objective: Study the knowledges, attitudes and practices of diabetic patients about diabetic retinopathy from 03 hospitals in the District of Parakou in 2019. Methods: The study was carried out in 03 hospitals in northern Benin (University and Regional Health Center of Borgou and Alibori, Army Health Center of Parakou, and the Diabetes Center of Benin. This was a descriptive and analytical cross-sectional prospective study that covered a period of 03 months from 15th May to 20th August, 2019. The sampling method was non-probability. Selection of diabetic patients was exhaustive taking care for the consent of each patient. The aged group was at least 18 years old and above, resident in Parakou and followed up in one of the above heath centers. We enrolled 150 patients after submitted them to some questionnaires. Results: From the total number of 150 patients, 59.33% were male. The mean age was 55.07 ± 11.62 years. The participants were predominantly married (87.33%) and 62% of them were literate. 48% of patients said diabetes mellitus is responsible of eye complications. 52% and 12% of patients reported that balancing blood sugar and normalizing blood pressure, respectively, are preventative factors for diabetic retinopathy. 27.33% of patients reported the need for a regular eye fundus exam. 12.67% of patients have a regular annual eye fundus examination and 56.67% of patients have never had one. Education and gender were associated with level of knowledges; education and low income were associated with level of practices. Conclusion: Reducing the impact of diabetic retinopathy requires better involvement of the diabetic patient, the ophthalmologist, the endocrinologist and the authorities of the Ministry of Health.
导读:糖尿病视网膜病变是致盲的主要原因之一。预防措施和筛查将减少其影响。目的:了解2019年帕拉口区03家医院糖尿病患者对糖尿病视网膜病变的认知、态度和行为。方法:在贝宁北部地区的03家医院(博古和阿里博里地区卫生中心、帕拉库陆军卫生中心和贝宁糖尿病中心)开展研究。这是一项描述性和分析性横断面前瞻性研究,涵盖了2019年5月15日至8月20日的03个月。采用非概率抽样方法。糖尿病患者的选择是详尽的,并得到每位患者的同意。年龄组至少为18岁及以上,居住在Parakou,并在上述卫生中心之一进行随访。我们招募了150名患者,并向他们提交了一些问卷。结果:150例患者中,男性占59.33%。平均年龄55.07±11.62岁。参与者主要是已婚(87.33%),62%的人受过教育。48%的患者认为糖尿病是眼部并发症的原因。52%和12%的患者分别报告,平衡血糖和使血压正常化是糖尿病视网膜病变的预防因素。27.33%的患者报告需要定期进行眼底检查。12.67%的患者每年定期进行眼底检查,56.67%的患者从未进行过眼底检查。教育程度和性别与知识水平相关;教育程度和低收入水平与实践水平有关。结论:减少糖尿病视网膜病变的影响需要糖尿病患者、眼科医生、内分泌科医生和卫生部有关部门更好地参与。
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引用次数: 0
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Ophthalmology research and reports
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