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Predictive and Prognostic Value of Heart Rate Variability Analysis in Early Bedside Diagnosis and Management of COVID-19 Patients 心率变异性分析在COVID-19患者早期床边诊断和管理中的预测和预后价值
Pub Date : 2020-04-17 DOI: 10.33552/asoaj.2020.01.000522
N. Mageed
Viral infection, sepsis and multiple organ dysfunction are the most common causes of death in critically ill patients. Early diagnosis and early management are the key factor in improving outcome in sepsis due to viral infection, so, there is need to develop more rapid, sensitive, and specific diagnostic strategies that allow early intervention to improve patient outcome. Heart rate variability (HRV) has been documented to be both altered in the presence of systemic infection, and correlated with its severity. This aim of this article is to review the HRV analysis and its value in detection early diagnosis of viral infection including COVID-19 patients. The prognostic value of clinical bedside application of HRV in the management and treatment viral infection and sepsis are highlighted in this review. The overall HRV decreased with lower low frequency component has been shown to be consistently correlated with the presence and severity of viral infection. HRV monitoring may enhance the early diagnosis, prognosis and early initiation of treatment of viral infectionCOVID-19. Bedside wearable devices that are based on photoplethysmography such as watch-like devices and mobile phone apps may be used as a useful non-invasive tool for early diagnosis of COVID -19 by analyzing the HRV.
病毒感染、败血症和多器官功能障碍是危重症患者最常见的死亡原因。早期诊断和早期处理是改善病毒感染脓毒症转归的关键因素,因此需要制定更快速、更敏感、更有针对性的诊断策略,使早期干预能够改善患者转归。心率变异性(HRV)在全身性感染时发生改变,并与其严重程度相关。本文旨在综述HRV分析及其在包括COVID-19患者在内的病毒感染的早期诊断中的价值。本文综述了HRV临床床边应用在病毒性感染和脓毒症的管理和治疗中的预后价值。总体HRV降低,低频成分较低,已被证明与病毒感染的存在和严重程度一致相关。HRV监测可提高covid -19病毒感染的早期诊断、预后和早期治疗。基于光电脉搏波描记的床边可穿戴设备,如类似手表的设备和手机应用程序,可以作为一种有用的非侵入性工具,通过分析HRV来早期诊断COVID -19。
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引用次数: 3
A Comparative Study between the Routine Using of Ultrasound Guidance versus Anatomical Guidance in Femoral Artery Access for Endovascular Treatment of Chronic Lower Limb Ischemia 常规超声引导与解剖引导股动脉入路在血管内治疗慢性下肢缺血的比较研究
Pub Date : 2020-04-13 DOI: 10.37532/fmic.2020.12(2).649
Usama Imam, Ayman Refaat Abdelhaseeb, Mohamed Hassan Abd El Mawla, M. Abdelmalak
The goal of this study is comparison between the using of ultrasound guidance versus anatomical guidance in femoral artery access for endovascular treatment of chronic lower limb ischemia, by assessment of first pass success rate, total number of attempts required for access, rate of accidental venipunctures, rate of PFA puncture and time to sheath insertion, and assessment of post procedural puncture site complications defined as bruises or hematoma formation. The study found that US guidance is superior to anatomical guidance in femoral artery access in endovascular treatment of chronic lower limb ischemia in reducing access time, total number of punctures, and number of incidental venipuncture, the incidence of PFA access and incidence of local bruises.
本研究的目的是比较超声引导与解剖引导在股动脉入路治疗慢性下肢缺血的血管内治疗中的应用,通过评估一次通过成功率、入路总次数、意外静脉穿刺率、PFA穿刺率和鞘插入时间,以及评估术后穿刺部位并发症(定义为瘀伤或血肿形成)。研究发现,在血管内治疗慢性下肢缺血时,US引导股动脉通路优于解剖引导,在减少通路时间、总穿刺次数、意外静脉穿刺次数、PFA通路发生率和局部瘀伤发生率等方面均优于解剖引导。
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引用次数: 0
Ventricular Assist Devices Insertion, Overview and Anesthetic Considerations 心室辅助装置的插入,概述和麻醉注意事项
Pub Date : 2020-04-09 DOI: 10.33552/asoaj.2020.01.000520
N. Mageed
Ventricular assist devices (VAD) represent a revolution for the management of severe heart failure. Their insertion requires the use of cardiopulmonary bypass. They are used either permanently for long term treatment of refractory heart failure or temporally as a bridge until cardiac transplantation and until cardiac recovery from reversible cardiomyopathy. Insertion of VAD is a risky surgery with high incidence of complication such as bleeding, cardiac tamponade, renal failure and device failure. Anesthetic management of patients with heart failure undergoing VAD insertion requires full review of the patient critical condition, understanding VAD physiology, extensive hemodynamic monitoring and a harmony between cardiac anesthesia and surgical teams. Marinating and protection the right ventricular function is highly important for the continuation of VAD function. The aim of this review is to put new insights on anesthetic management of VAD insertion and to show their different types and their physiology.
心室辅助装置(VAD)代表了严重心力衰竭管理的一场革命。它们的插入需要使用体外循环。它们要么用于永久性的长期治疗难治性心力衰竭,要么暂时作为心脏移植和心脏从可逆性心肌病恢复的桥梁。VAD的插入是一项高风险的手术,并发症发生率高,如出血、心包填塞、肾功能衰竭和装置失效。心衰患者的麻醉管理需要对患者危重情况进行全面回顾,了解VAD生理,广泛的血流动力学监测以及心脏麻醉和手术团队之间的协调。浸泡和保护右心室功能对VAD功能的延续具有重要意义。本文综述的目的是对VAD插入的麻醉管理提出新的见解,并展示它们的不同类型及其生理学。
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引用次数: 0
Anesthetic Management of Surgical Repair of Descending Thoracic Aortic Aneurysm 胸降主动脉瘤手术修复术的麻醉处理
Pub Date : 2020-04-06 DOI: 10.33552/asoaj.2020.01.000518
N. Mageed
Anesthetic management of surgical repair of descending thoracic aortic aneurysm is a difficult mission for anesthesiologists. The surgical approach is best achieved through left postero-lateral thoracotomy with the use of one lung ventilation. The post-operative outcome is affected by the presence of associated co morbidities such as cardiac and renal diseases, the severe intra-operative hemodynamic fluctuations and the use of mechanical circulatory assisted devices. The severe hemodynamic fluctuations that result from clamping and declamping the descending thoracic aorta require an experienced cardiac anesthesiologist for the proper perioperative management of these patients. The aim of this review is to give new insights on the anesthetic management and the techniques of distal perfusion using partial cardiopulmonary bypass. Anesthetic goals are directed to provide spinal cord and renal protection with controlling the proximal hypertension.
胸降主动脉瘤手术修复的麻醉管理是麻醉医师面临的一项艰巨任务。手术入路最好通过左后外侧开胸并使用单肺通气。术后结果受到相关合并症的影响,如心脏和肾脏疾病、术中严重的血流动力学波动和机械循环辅助装置的使用。由于胸降主动脉夹紧和去钳导致的严重血流动力学波动需要经验丰富的心脏麻醉师对这些患者进行适当的围手术期管理。本文综述的目的是对部分体外循环远端灌注的麻醉管理和技术提供新的见解。麻醉目的是通过控制近端高血压来保护脊髓和肾脏。
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引用次数: 0
Impact of Local Anesthetics on Intrathecal Anesthesia 局麻药对鞘内麻醉的影响
Pub Date : 2020-04-01 DOI: 10.33552/asoaj.2019.01.000517
Carlos de la Paz Estrada
Summary Of all regional techniques, subarachnoid block is the fastest, most predictable, and most reliable. It is a technique that has unique characteristics for use in ambulatory surgery: immediate initiation of anesthesia, predictable response according to the dose administered, and the possibility of adjusting the anesthetic duration by selecting the appropriate agent. Its main advantages are its easy realization, the quick establishment of the lock, its high effectiveness and reliability and its low toxicity. It is a simple technique to perform since anatomical references are usually easy to locate and the procedure is performed in a short time, even in obese patients. The quality of the blockage is especially evident in interventions of the lower extremities performed with tourniquet and in perineal surgery, thanks to its ability to achieve complete sacral anesthesia. It has low toxicity because the small doses of local anesthetic required eliminate the risk of systemic toxicity in case of inadvertent intravascular injection.
在所有区域性技术中,蛛网膜下腔阻滞是最快、最可预测和最可靠的。这是一种用于门诊手术的独特技术:立即开始麻醉,根据给药剂量预测反应,通过选择适当的药物调整麻醉持续时间的可能性。其主要优点是易于实现、快速建立锁、高效可靠、低毒性。这是一项简单的技术,因为解剖参考通常很容易定位,而且手术可以在短时间内完成,即使是肥胖患者。在使用止血带和会阴手术的下肢干预中,阻塞的质量尤其明显,因为它能够实现完全的骶部麻醉。它具有低毒性,因为所需的小剂量局部麻醉剂消除了意外血管内注射时全身毒性的风险。
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引用次数: 0
Perioperative Management of Pulmonary Hypertension in Pediatric Cardiac Surgery 小儿心脏外科肺动脉高压的围手术期处理
Pub Date : 2020-03-17 DOI: 10.33552/asoaj.2020.01.000516
Ibrahim I. Abd El Baser
Pediatric pulmonary hypertension (PH) is associated with many cardiovascular, and pulmonary diseases that result in a high risk of morbidity and mortality. The cause of PH in children is mainly due to congenital heart disease (CHD). The proper preoperative evaluation and the accurate anesthetic management are essential to obtain the best outcome. The perioperative anesthetic goal is directed to avoid pulmonary hypertensive crisis which is associated with poor outcome in children with PH secondary to CHD undergoing cardiopulmonary bypass. The purpose of this review is to discuss the pathophysiology of PH in children with CHD and to show how to avoid and manage the perioperative pulmonary hypertensive crisis.
小儿肺动脉高压(PH)与许多心血管和肺部疾病相关,导致高发病率和死亡率。儿童PH的病因主要是先天性心脏病(CHD)。正确的术前评估和准确的麻醉管理是获得最佳结果的必要条件。围手术期麻醉的目的是为了避免肺动脉高压危象,肺动脉高压危象与行体外循环的继发于冠心病的PH患儿预后不良有关。本文旨在探讨冠心病患儿PH的病理生理学,并探讨如何避免和处理围手术期肺动脉高压危象。
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引用次数: 2
Cardiac Output assessed via Esophageal Doppler Monitoring Fails to Predict Changes in Renal Microvascular Perfusion 通过食管多普勒监测评估心输出量不能预测肾微血管灌注的变化
Pub Date : 2019-10-01 DOI: 10.33552/asoaj.2019.01.000510
D. Read, B. Doleman, John P. Williams
This work is licensed under Creative Commons Attribution 4.0 License ASOAJ.MS.ID.000510. Abstract Background: Vasoactive drugs are routinely used clinically to alter mean arterial blood pressure (MAP) and cardiac output (CO) and to maintain organ perfusion. However, the effect of such drugs on microvascular visceral blood flow (MiBF) is not fully understood. We aimed to track changes in renal MiBF, using the well-validated technique of Contrast Enhanced Ultrasound (CEUS), across a range of MAP and CO generated via the vasoactive drugs, phenylephrine and ephedrine. Methods: Baseline cardiovascular measurements were recorded, with renal MiBF determined via CEUS as renal microvascular transit time (RTT). Phenylephrine was then administered, via a standardized protocol, to increase MAP and CO, with repeat CEUS. Following return to baseline, the above was repeated using ephedrine. CEUS time-intensity curves were constructed and renal MiBF calculated. Results: In 11 male volunteers (median age 32), phenylephrine increased MAP (98.7 vs 110.8 mmHg, p<0.001), but not CO (4211 vs. 4089 ml.min-1, p=0.42), while ephedrine increased CO (4110 vs 6097, p<0.001) and MAP (95.6 vs 100.9, p=0.02). Phenylephrine reduced time to organ perfusion (TTOP) (22.3 vs 18.4 secs, p=0.009), but not RTT (14 vs 13.2 secs, p=0.46). Ephedrine decreased TTOP (21.1 vs 14.7 secs, p=0.003), and RTT (3.5 vs 9.6 secs, p=0.007). Change in CO predicted change in TTOP (r2=0.26, p=0.02), but not RTT (r2=0.04, p=0.43). Change in MAP did not predict change in TTOP (r2=0.02, p=0.58), or RTT (r2<0.001, p=0.89). Conclusion: Changes in MAP and CO fail to predict renal MiBF.
本作品采用知识共享署名4.0许可协议ASOAJ.MS.ID.000510。背景:血管活性药物在临床上常用来改变平均动脉血压(MAP)和心输出量(CO),维持器官灌注。然而,这些药物对微血管内脏血流(MiBF)的影响尚不完全清楚。我们的目的是通过血管活性药物苯肾上腺素和麻黄碱产生的MAP和CO,使用经过验证的对比增强超声(CEUS)技术跟踪肾脏MiBF的变化。方法:记录基线心血管测量,通过超声造影(CEUS)测定肾脏MiBF作为肾脏微血管传递时间(RTT)。然后通过标准化方案给予苯肾上腺素,以增加MAP和CO,并重复超声心动图。回到基线后,使用麻黄碱重复上述试验。构建超声造影时间-强度曲线,计算肾脏MiBF。结果:在11名男性志愿者(中位年龄32岁)中,苯肾上腺素增加了MAP (98.7 vs 110.8 mmHg, p<0.001),但没有增加CO (4211 vs 4089 ml.min-1, p=0.42),而麻黄碱增加了CO (4110 vs 6097, p<0.001)和MAP (95.6 vs 100.9, p=0.02)。苯肾上腺素缩短了器官灌注时间(TTOP) (22.3 vs 18.4秒,p=0.009),但没有缩短RTT (14 vs 13.2秒,p=0.46)。麻黄碱降低TTOP (21.1 vs 14.7秒,p=0.003)和RTT (3.5 vs 9.6秒,p=0.007)。CO的变化可预测TTOP的变化(r2=0.26, p=0.02),但不能预测RTT的变化(r2=0.04, p=0.43)。MAP的变化不能预测TTOP (r2=0.02, p=0.58)或RTT的变化(r2<0.001, p=0.89)。结论:MAP和CO的变化不能预测肾脏MiBF。
{"title":"Cardiac Output assessed via Esophageal Doppler Monitoring Fails to Predict Changes in Renal Microvascular Perfusion","authors":"D. Read, B. Doleman, John P. Williams","doi":"10.33552/asoaj.2019.01.000510","DOIUrl":"https://doi.org/10.33552/asoaj.2019.01.000510","url":null,"abstract":"This work is licensed under Creative Commons Attribution 4.0 License ASOAJ.MS.ID.000510. Abstract Background: Vasoactive drugs are routinely used clinically to alter mean arterial blood pressure (MAP) and cardiac output (CO) and to maintain organ perfusion. However, the effect of such drugs on microvascular visceral blood flow (MiBF) is not fully understood. We aimed to track changes in renal MiBF, using the well-validated technique of Contrast Enhanced Ultrasound (CEUS), across a range of MAP and CO generated via the vasoactive drugs, phenylephrine and ephedrine. Methods: Baseline cardiovascular measurements were recorded, with renal MiBF determined via CEUS as renal microvascular transit time (RTT). Phenylephrine was then administered, via a standardized protocol, to increase MAP and CO, with repeat CEUS. Following return to baseline, the above was repeated using ephedrine. CEUS time-intensity curves were constructed and renal MiBF calculated. Results: In 11 male volunteers (median age 32), phenylephrine increased MAP (98.7 vs 110.8 mmHg, p<0.001), but not CO (4211 vs. 4089 ml.min-1, p=0.42), while ephedrine increased CO (4110 vs 6097, p<0.001) and MAP (95.6 vs 100.9, p=0.02). Phenylephrine reduced time to organ perfusion (TTOP) (22.3 vs 18.4 secs, p=0.009), but not RTT (14 vs 13.2 secs, p=0.46). Ephedrine decreased TTOP (21.1 vs 14.7 secs, p=0.003), and RTT (3.5 vs 9.6 secs, p=0.007). Change in CO predicted change in TTOP (r2=0.26, p=0.02), but not RTT (r2=0.04, p=0.43). Change in MAP did not predict change in TTOP (r2=0.02, p=0.58), or RTT (r2<0.001, p=0.89). Conclusion: Changes in MAP and CO fail to predict renal MiBF.","PeriodicalId":92982,"journal":{"name":"Anaesthesia & surgery open access journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77518558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-Choosing the Right Anesthesia 怀孕——选择正确的麻醉
Pub Date : 2019-09-25 DOI: 10.33552/asoaj.2019.01.000509
RN Dr. Aloma Wallace
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引用次数: 0
Neutrophil Extracellular Traps and Acute Pancreatitis 中性粒细胞胞外陷阱与急性胰腺炎
Pub Date : 2019-09-10 DOI: 10.33552/asoaj.2019.01.000508
Raed Madhi
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引用次数: 0
Real Impact of Varicocele Surgery on Male Fertility 精索静脉曲张手术对男性生育能力的真正影响
Pub Date : 2019-08-01 DOI: 10.33552/asoaj.2019.01.000507
B. Balla
Varicocele is among the most common causes of male infertility. It is also one of the most controversial issues in the field of Andrology, especially regarding why, when and to whom varicocelectomy should be applied. Many experts believe that the surgical repair of varicocele should be applied only in a meticulously selected group of infertile men, although there are no generally accepted criteria. Up to now, the only confirmed prognostic factor for achievement of pregnancy after varicocelectomy is the age of the female partner. We perform a retrospective study that collected 120 patients over 7 years between 2010-2017 in urological department at the Military Hospital Moulay Ismail in Meknes, Morocco, to evaluate the issues currently associated with varicocele treatment in infertile men.
精索静脉曲张是男性不育最常见的原因之一。这也是男科领域最具争议的问题之一,特别是关于为什么,何时以及对谁进行精索静脉曲张切除术。许多专家认为精索静脉曲张的手术修复应该只应用于精心挑选的不育男性,尽管没有普遍接受的标准。到目前为止,唯一确定的影响精索静脉曲张切除术后妊娠的预后因素是女性伴侣的年龄。我们进行了一项回顾性研究,收集了摩洛哥梅克内斯Moulay Ismail军事医院泌尿科2010-2017年7年间的120例患者,以评估目前与不育男性精索静脉曲张治疗相关的问题。
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引用次数: 0
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Anaesthesia & surgery open access journal
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