Pub Date : 2021-09-03DOI: 10.24966/srdt-2060/100077
Marcelo Braga
In this peculiar setting, the infiltrations with BMA proved to be an efficient alternative tool for the treatment of severe thoracic rib trauma and delayed union. The patient returned with no complaints and CT evidence indicated that all of the fractured ribs had complete consolidation. Pain and functional outcome of the chest wall in terms of stability improved with the help of this orthobiologic alternative.
{"title":"Bone Marrow Aspirate for Delayed Union due to Severe Thoracic Rib Trauma","authors":"Marcelo Braga","doi":"10.24966/srdt-2060/100077","DOIUrl":"https://doi.org/10.24966/srdt-2060/100077","url":null,"abstract":"In this peculiar setting, the infiltrations with BMA proved to be an efficient alternative tool for the treatment of severe thoracic rib trauma and delayed union. The patient returned with no complaints and CT evidence indicated that all of the fractured ribs had complete consolidation. Pain and functional outcome of the chest wall in terms of stability improved with the help of this orthobiologic alternative.","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78754927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-21DOI: 10.24966/srdt-2060/100074
M. Valadares, São Paulo Brazil Pluricell Biotech
Recently, Biagi et al., 2021 published results of yet another successful demonstration of how hiPSC-derived cardiomyocytes can engraft in rats' hearts and improve their cardiac function [1]. According to the work, these results are probably due to the segmental improvement in areas where the grafts were found
{"title":"Cell Therapy Moving in the Right Direction","authors":"M. Valadares, São Paulo Brazil Pluricell Biotech","doi":"10.24966/srdt-2060/100074","DOIUrl":"https://doi.org/10.24966/srdt-2060/100074","url":null,"abstract":"Recently, Biagi et al., 2021 published results of yet another successful demonstration of how hiPSC-derived cardiomyocytes can engraft in rats' hearts and improve their cardiac function [1]. According to the work, these results are probably due to the segmental improvement in areas where the grafts were found","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74951200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-09-09DOI: 10.24966/srdt-2060/100076
Candace M Howard, Stephen Bush, Nadim Bou Zgheib, Seth T Lirette, Antonio Cortese, Antonio Mollo, Jagan Valluri, Pier Paolo Claudio
Background: Disease recurrence and progression of ovarian cancer is a common event, which is accompanied by the development of platinum-resistant or refractory disease. The presence of chemo-resistant Cancer Stem Cells (CSCs) contribute to tumor propagation, maintenance, and treatment resistance of this difficult to treat disease. We have developed ChemoID, a cytotoxic synergy assay against CSCs that identifies the most effective chemotherapy treatment from a panel of FDA-approved chemotherapies using fresh cancer biopsies.
Patients and methods: Ascites or interventional radiology biopsies were collected under physician order from 78 consecutive patients affected by 3rd relapsed ovarian cancer. Test results from the assay were used when possible to treat patients with the highest cell kill drugs, taking into consideration their health status and using dose reductions, if needed. A chart analysis and review of CT and PET scans were performed to determine patients' outcomes for tumor response, Progression-Free Survival (PFS), and Overall Survival (OS).
Results: We observed that recurrent ovarian cancer patients treated with high-cell kill chemotherapy agents guided by the CSCs drug response assay had an improvement in their median PFS and OS when compared to historical median PFS and OS and/or when compared to patients who could not receive high cell kill chemotherapies (PFS low cell kill 3.5 months vs. high cell kill 12.0 months; OS low cell kill 6.0 months vs. high cell kill 15.0 months).
Conclusion: This data indicates that the drug cytotoxicity assay aimed at targeting CSCs may be a useful tool for optimizing treatment selection when first-line therapy fails, and when there are multiple clinically-acceptable and -equivalent treatments available.
{"title":"Cancer Stem Cell Assay for the Treatment of Platinum-Resistant Recurrent Ovarian Cancer.","authors":"Candace M Howard, Stephen Bush, Nadim Bou Zgheib, Seth T Lirette, Antonio Cortese, Antonio Mollo, Jagan Valluri, Pier Paolo Claudio","doi":"10.24966/srdt-2060/100076","DOIUrl":"10.24966/srdt-2060/100076","url":null,"abstract":"<p><strong>Background: </strong>Disease recurrence and progression of ovarian cancer is a common event, which is accompanied by the development of platinum-resistant or refractory disease. The presence of chemo-resistant Cancer Stem Cells (CSCs) contribute to tumor propagation, maintenance, and treatment resistance of this difficult to treat disease. We have developed ChemoID, a cytotoxic synergy assay against CSCs that identifies the most effective chemotherapy treatment from a panel of FDA-approved chemotherapies using fresh cancer biopsies.</p><p><strong>Patients and methods: </strong>Ascites or interventional radiology biopsies were collected under physician order from 78 consecutive patients affected by 3<sup>rd</sup> relapsed ovarian cancer. Test results from the assay were used when possible to treat patients with the highest cell kill drugs, taking into consideration their health status and using dose reductions, if needed. A chart analysis and review of CT and PET scans were performed to determine patients' outcomes for tumor response, Progression-Free Survival (PFS), and Overall Survival (OS).</p><p><strong>Results: </strong>We observed that recurrent ovarian cancer patients treated with high-cell kill chemotherapy agents guided by the CSCs drug response assay had an improvement in their median PFS and OS when compared to historical median PFS and OS and/or when compared to patients who could not receive high cell kill chemotherapies (PFS low cell kill 3.5 months vs. high cell kill 12.0 months; OS low cell kill 6.0 months vs. high cell kill 15.0 months).</p><p><strong>Conclusion: </strong>This data indicates that the drug cytotoxicity assay aimed at targeting CSCs may be a useful tool for optimizing treatment selection when first-line therapy fails, and when there are multiple clinically-acceptable and -equivalent treatments available.</p>","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-23DOI: 10.24966/srdt-2060/100055
Jeong Beom Kim
uman Pluripotent Stem Cells (hPSCs) are an essential cell source for regenerative medicine. With the increasing importance of hPSCs for cell-based therapy, the need for hPSCs in basic and clinical research is to develop live-cell imaging systems that monitor hPSCs during reprogramming or differentiation processes
{"title":"Development Of A Human Pluripotency Sensor For Real-Time Cell Imaging And Biomedical Applications","authors":"Jeong Beom Kim","doi":"10.24966/srdt-2060/100055","DOIUrl":"https://doi.org/10.24966/srdt-2060/100055","url":null,"abstract":"uman Pluripotent Stem Cells (hPSCs) are an essential cell source for regenerative medicine. With the increasing importance of hPSCs for cell-based therapy, the need for hPSCs in basic and clinical research is to develop live-cell imaging systems that monitor hPSCs during reprogramming or differentiation processes","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79725214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-23DOI: 10.24966/srdt-2060/100059
M. F. Viña, Argentina Clínica San Nicolás S.A
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone. Sports injuries are considered disorders of the musculoskeletal system or concussions that are generally caused during sportive activities such as football
{"title":"Regenerative Medicine In An Elite Football Athlete: A Case Report","authors":"M. F. Viña, Argentina Clínica San Nicolás S.A","doi":"10.24966/srdt-2060/100059","DOIUrl":"https://doi.org/10.24966/srdt-2060/100059","url":null,"abstract":"Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone. Sports injuries are considered disorders of the musculoskeletal system or concussions that are generally caused during sportive activities such as football","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75823872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-23DOI: 10.24966/srdt-2060/100054
D. Smiler
Combining bone-marrow aspirate with xenograft and allograft particulate material has been demonstrated to produce a significant quantity of new bone growth. However, securing 1 to 4 ccs of adult autogenous stem cells by means of bone-marrow aspiration is invasive, and the aspirated stem cells are typically senescent, as the procedure most often is used in aging patients
{"title":"Enhanced Bone Regeneration With Umbilical Cord Stem Cells: A Case Report And Histomorphometric Analysis","authors":"D. Smiler","doi":"10.24966/srdt-2060/100054","DOIUrl":"https://doi.org/10.24966/srdt-2060/100054","url":null,"abstract":"Combining bone-marrow aspirate with xenograft and allograft particulate material has been demonstrated to produce a significant quantity of new bone growth. However, securing 1 to 4 ccs of adult autogenous stem cells by means of bone-marrow aspiration is invasive, and the aspirated stem cells are typically senescent, as the procedure most often is used in aging patients","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78234748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-23DOI: 10.24966/srdt-2060/100057
Khoa Nguyen
Although highly transmissible due to its highly infectious nature, since a large proportion of cases are asymptomatic or mild, self-awareness which promotes the spread of the disease worldwide. The public health manages against Corona virus should reduce the numbers of people infected with influenza virus to avoid the two viruses infections will be interacted
{"title":"Would The End Of COVID-19 Infection As A Chronic Disease?","authors":"Khoa Nguyen","doi":"10.24966/srdt-2060/100057","DOIUrl":"https://doi.org/10.24966/srdt-2060/100057","url":null,"abstract":"Although highly transmissible due to its highly infectious nature, since a large proportion of cases are asymptomatic or mild, self-awareness which promotes the spread of the disease worldwide. The public health manages against Corona virus should reduce the numbers of people infected with influenza virus to avoid the two viruses infections will be interacted","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82645870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-23DOI: 10.24966/srdt-2060/100058
M. Serafini
One of the most common anatomic limitation which prevents a correct implant placement, is horizontal and vertical bone deficiency. Modern surgical techniques allow predictable rehabilitation of these severe defects, using on one side the great regenerative potential of autologous growth factors, on the other side instruments that allow more bone preservation and less trauma on hard and soft tissues, crucial criteria for successful surgeries
{"title":"Maxillary Split Crest And Sinus Augmentation With Piezosurgery And Growth Factors","authors":"M. Serafini","doi":"10.24966/srdt-2060/100058","DOIUrl":"https://doi.org/10.24966/srdt-2060/100058","url":null,"abstract":"One of the most common anatomic limitation which prevents a correct implant placement, is horizontal and vertical bone deficiency. Modern surgical techniques allow predictable rehabilitation of these severe defects, using on one side the great regenerative potential of autologous growth factors, on the other side instruments that allow more bone preservation and less trauma on hard and soft tissues, crucial criteria for successful surgeries","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86033756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-13DOI: 10.24966/srdt-2060/100053
B. Pontes
The surface of mammalian cells consists of the plasma membrane lined by an underneath cortical actomyosin cytoskeleton. This pair of structures forms the Membrane-Cytoskeleton Complex (MCC), a known regulator of cellular processes, ranging from shape control and cell migration to molecule presentation and signaling [1-3].
{"title":"Exploring Stem Cell Differentiation From A Mechanobiological Perspective: Insights From Neural Precursor Cells And Beyond","authors":"B. Pontes","doi":"10.24966/srdt-2060/100053","DOIUrl":"https://doi.org/10.24966/srdt-2060/100053","url":null,"abstract":"The surface of mammalian cells consists of the plasma membrane lined by an underneath cortical actomyosin cytoskeleton. This pair of structures forms the Membrane-Cytoskeleton Complex (MCC), a known regulator of cellular processes, ranging from shape control and cell migration to molecule presentation and signaling [1-3].","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73153881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-23DOI: 10.24966/srdt-2060/100039
Maria Beatriz Herrera Sanchez
{"title":"Review: Extracellular Vesicles From Human Liver Stem Cells As An Alternative Therapeutic Approach For The Treatment Of Urea Cycle Diseases","authors":"Maria Beatriz Herrera Sanchez","doi":"10.24966/srdt-2060/100039","DOIUrl":"https://doi.org/10.24966/srdt-2060/100039","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78777682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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