The chromatin remodeling factor chromodomain helicase DNA-binding protein 4 (CHD4) is a core component of the nucleosome remodeling and deacetylase (NuRD) complex. Due to its important role in DNA damage repair, CHD4 has been identified as a key determinant in cancer progression, stem cell differentiation, and T cell and B cell development. Accumulating evidence has revealed that CHD4 can function in NuRD dependent and independent manner in response to DNA damage. Mutations of CHD4 have been shown to diminish its functions, which indicates that interpretation of its mutations may provide tangible benefit for patients. The expression of CHD4 play a dual role in sensitizing cancer cells to chemotherapeutic agents, which provides new insights into the contribution of CHD4 to tumor biology and new therapeutic avenues.
{"title":"The Tale of CHD4 in DNA Damage Response and Chemotherapeutic Response.","authors":"Jing Zhang, David J H Shih, Shiaw-Yih Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chromatin remodeling factor chromodomain helicase DNA-binding protein 4 (CHD4) is a core component of the nucleosome remodeling and deacetylase (NuRD) complex. Due to its important role in DNA damage repair, CHD4 has been identified as a key determinant in cancer progression, stem cell differentiation, and T cell and B cell development. Accumulating evidence has revealed that CHD4 can function in NuRD dependent and independent manner in response to DNA damage. Mutations of CHD4 have been shown to diminish its functions, which indicates that interpretation of its mutations may provide tangible benefit for patients. The expression of CHD4 play a dual role in sensitizing cancer cells to chemotherapeutic agents, which provides new insights into the contribution of CHD4 to tumor biology and new therapeutic avenues.</p>","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38078194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, we study Curious Chloride (CmCl3) and Titanic Chloride (TiCl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano molecules incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations.
{"title":"Curious Chloride (Cmcl3) and Titanic Chloride (Ticl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (Eppsi) Nano Molecules for Cancer Treatment and Cellular Therapeutics","authors":"A. Heidari","doi":"10.31579/2640-1053/005","DOIUrl":"https://doi.org/10.31579/2640-1053/005","url":null,"abstract":"In the current study, we study Curious Chloride (CmCl3) and Titanic Chloride (TiCl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano molecules incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45053247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The term “targeted” is being used to describe various new drugs and therapies with an intent to suggest that such drugs exhibit higher specificity with respect to the disease to be treated. The reality, however is that the use of all such recently denoted drugs is associated with large number often very serious undesirable side effects. It is concluded that using the term “targeted” when it relates to the intent of what the drug is to do and ignoring the fact that the drug’s action is generally distributed throughout the body rather than acting on the locus of the disease is misleading
{"title":"The Difference between Targeted Drug Therapies and Targeted-Drug Therapies","authors":"K. Petrak","doi":"10.31579/2640-1053/032","DOIUrl":"https://doi.org/10.31579/2640-1053/032","url":null,"abstract":"The term “targeted” is being used to describe various new drugs and therapies with an intent to suggest that such drugs exhibit higher specificity with respect to the disease to be treated. The reality, however is that the use of all such recently denoted drugs is associated with large number often very serious undesirable side effects. It is concluded that using the term “targeted” when it relates to the intent of what the drug is to do and ignoring the fact that the drug’s action is generally distributed throughout the body rather than acting on the locus of the disease is misleading","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42795586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plants play an important role in cancer prevention and treatment. Satureja khuzistanica, an endemic plant to Iranian flora is widely distributed in the southern and western parts of Iran. It is famous for its medical uses as analgesic and antiseptic in folk medicine. It has been showed that Satureja khuzistanica possess inhibitory effects on the proliferation and reproduction of certain tumorigenic microorganisms and viruses, such as Heliobacter pylori. Transcriptional regulation of some oncogene and carcinogenesis-related gene expression and interaction with both DNA and RNA are also well documented. Besides, Satureja khuzistanica is a spectrum enzyme inhibitor. More importantly, the suppression of tumor growth and metastasis, the beneficial application in combined medication, and the improvement of multidrug resistance both in vivo and in vitro clearly show its potential as an alternative medicine for tumor chemotherapy.
{"title":"The effectiveness of Satureja khuzistanica against cancerous cells","authors":"A. Rustaiyan","doi":"10.31579/2640-1053/004/","DOIUrl":"https://doi.org/10.31579/2640-1053/004/","url":null,"abstract":"Plants play an important role in cancer prevention and treatment. Satureja khuzistanica, an endemic plant to Iranian flora is widely distributed in the southern and western parts of Iran. It is famous for its medical uses as analgesic and antiseptic in folk medicine. It has been showed that Satureja khuzistanica possess inhibitory effects on the proliferation and reproduction of certain tumorigenic microorganisms and viruses, such as Heliobacter pylori. Transcriptional regulation of some oncogene and carcinogenesis-related gene expression and interaction with both DNA and RNA are also well documented. Besides, Satureja khuzistanica is a spectrum enzyme inhibitor. More importantly, the suppression of tumor growth and metastasis, the beneficial application in combined medication, and the improvement of multidrug resistance both in vivo and in vitro clearly show its potential as an alternative medicine for tumor chemotherapy.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44973818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pseudomonas aeruginosa is an opportunistic bacteria which is one of the most important bacterial infection. As incidence of MDR and XDR strains were reported and antibiotic resistant is a global issue we research about new drug. Materials and methods: Data about Iranian herbal medicine were obtained by searching databases. In this research we study about 50 papers of different databases. Result: The result of our study indicated that ZOUSH ointment which is include herbal medicine such as Satureja Khuzestaniea, Zataria Multiflora, Mentha Mozaffariani Jamzad can use for controlling burn wound infections. Conclusion: ZOUSH ointment will been used as a common ointment for healing burn wound infections.
{"title":"The Importance of Using ZOUSH Ointment in Burn Wound infection Treatments","authors":"D. Esmaeili","doi":"10.31579/2640-1053/029","DOIUrl":"https://doi.org/10.31579/2640-1053/029","url":null,"abstract":"Background: Pseudomonas aeruginosa is an opportunistic bacteria which is one of the most important bacterial infection. As incidence of MDR and XDR strains were reported and antibiotic resistant is a global issue we research about new drug. Materials and methods: Data about Iranian herbal medicine were obtained by searching databases. In this research we study about 50 papers of different databases. Result: The result of our study indicated that ZOUSH ointment which is include herbal medicine such as Satureja Khuzestaniea, Zataria Multiflora, Mentha Mozaffariani Jamzad can use for controlling burn wound infections. Conclusion: ZOUSH ointment will been used as a common ointment for healing burn wound infections.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47080814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The clinical value of Stimulated Thyroglobulin/TSH ratio in patients with differentiated thyroid cancer for successful initial ablation after total thyroidectomy","authors":"Zhixiao Wei","doi":"10.31579/2640-1053/030","DOIUrl":"https://doi.org/10.31579/2640-1053/030","url":null,"abstract":"","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46369489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction It is well known that smoking is injurious to health which causes lung cancer. Although not all smokers develop lung cancer, fraction of lifelong non-smokers will die from lung cancer. Lung cancer is a major cause of cancer related death in developed countries with extremely poor overall survival rate. In present study we set out epidemiological pattern with clinical profile of lung cancer patients in northern india population. Aim:We evaluate the effect of smoking with age distribution on histopathology in lung cancer patients. Material & Methods: We enrolled 218 patients after confirmation of histopathology and also collected demographic data. Results: Out of 218 patients of lung cancer, having median age of 56 years, we found 149 (68.3%) were smokers and 69 (31.6%) were nonsmokers. In histopathology 54.1% patients had squamous cell carcinoma, 29.2% adenocarcinoma, 12.4% Mixed cell, 3.7% Small cell. We also found 63.1% smoker to have squamous cell carcinoma and 50.7% non-smoker have adenocarcinoma.In our study middle age group patients were more frequent in smoking group. While higher age group patients has squamous cell and middle group have adenocarcinoma. Therefore patients group with high smoking are found to develop have more risk to develop small cell carcinoma rather than in case of non-smoker higher age groups have sqamous cell carcinoma type. Conclusion: In this study we found middle age group subjects of smoker having more squamous cell and nonsmoker having adenocarcinoma.
{"title":"Global Patterns of Lung Cancer Incidence","authors":"Saritha Garrepalli","doi":"10.31579/2640-1053/027","DOIUrl":"https://doi.org/10.31579/2640-1053/027","url":null,"abstract":"Introduction It is well known that smoking is injurious to health which causes lung cancer. Although not all smokers develop lung cancer, fraction of lifelong non-smokers will die from lung cancer. Lung cancer is a major cause of cancer related death in developed countries with extremely poor overall survival rate. In present study we set out epidemiological pattern with clinical profile of lung cancer patients in northern india population. Aim:We evaluate the effect of smoking with age distribution on histopathology in lung cancer patients. Material & Methods: We enrolled 218 patients after confirmation of histopathology and also collected demographic data. Results: Out of 218 patients of lung cancer, having median age of 56 years, we found 149 (68.3%) were smokers and 69 (31.6%) were nonsmokers. In histopathology 54.1% patients had squamous cell carcinoma, 29.2% adenocarcinoma, 12.4% Mixed cell, 3.7% Small cell. We also found 63.1% smoker to have squamous cell carcinoma and 50.7% non-smoker have adenocarcinoma.In our study middle age group patients were more frequent in smoking group. While higher age group patients has squamous cell and middle group have adenocarcinoma. Therefore patients group with high smoking are found to develop have more risk to develop small cell carcinoma rather than in case of non-smoker higher age groups have sqamous cell carcinoma type. Conclusion: In this study we found middle age group subjects of smoker having more squamous cell and nonsmoker having adenocarcinoma.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46356433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methods and Materials We reviewed records of 108 patients treated with regimen of split course radiotherapy (median 60 Gy in 30 fractions) and concurrent chemotherapy for stage IIIa/IIIb NSCLC. Fisher's Exact Test and Paired Student T Test were performed to identify factors predictive of development of any pulmonary toxicity (pneumonitis or fibrosis of any grade) and severe pulmonary toxicity (grade 3 or higher pneumonitis, grade 2 or higher fibrosis).
{"title":"Treatment of Locally Advanced Non-small Cell Lung Cancer with our Institutional Protocol of Split Course Concurrent Chemo Irradiation","authors":"Eduardo Harendza","doi":"10.31579/2640-1053/026","DOIUrl":"https://doi.org/10.31579/2640-1053/026","url":null,"abstract":"Methods and Materials We reviewed records of 108 patients treated with regimen of split course radiotherapy (median 60 Gy in 30 fractions) and concurrent chemotherapy for stage IIIa/IIIb NSCLC. Fisher's Exact Test and Paired Student T Test were performed to identify factors predictive of development of any pulmonary toxicity (pneumonitis or fibrosis of any grade) and severe pulmonary toxicity (grade 3 or higher pneumonitis, grade 2 or higher fibrosis).","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47344393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the intricate relationship between cancer and humans developed over time, the medical field has been on a constant search to find the cure to this pathology. Several options have been discovered, including surgery, radiotherapy, drugs that elimínate rapidly dividing cells, and even molecular therapies oriented at disrupting intricate signaling pathways. However, the current paradigm of most present therapies involves several adverse effects that hinder the continuation of the drug regimes or pose life threatening conditions to the patient, such as tumor lysis syndrome, fever, neutropenia and susceptibility to opportunistic infections, just to name a few [2].
{"title":"Artemisinin: How an antimalarial drug will alter the future of cancer Treatment","authors":"Enrique Konstat-Korzenny","doi":"10.31579/2640-1053/006/","DOIUrl":"https://doi.org/10.31579/2640-1053/006/","url":null,"abstract":"As the intricate relationship between cancer and humans developed over time, the medical field has been on a constant search to find the cure to this pathology. Several options have been discovered, including surgery, radiotherapy, drugs that elimínate rapidly dividing cells, and even molecular therapies oriented at disrupting intricate signaling pathways. However, the current paradigm of most present therapies involves several adverse effects that hinder the continuation of the drug regimes or pose life threatening conditions to the patient, such as tumor lysis syndrome, fever, neutropenia and susceptibility to opportunistic infections, just to name a few [2].","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45093628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Women with breast cancer are at increased risk for the development of osteoporosis and skeletal fractures, as consequences of aromatase inhibition or chemotherapy-induced ovarian failure. We investigated the effect of adjuvant chemotherapy on biochemical markers of bone formation and resorption as well as on bone mineral density (BMD) of non-metastatic breast cancer (NMBC) postmenopausal Egyptian women. Methods: We followed 100 newly diagnosed women with T1-3 N0-2 M0 breast cancer, who had a mean age (±SD) of 55.06±8.78 year, before and after receiving 6-cycles of CAF chemotherapy treatment protocol. All participant women were subjected to blood biochemical analysis for determining serum levels of: erythrocyte sedimentation rate, calcium, alkaline phosphatase (ALP), bone specific alkaline phosphatase (S.ALP), Osteocalcin, carboxytelopeptide of collagen type I (CTx-I), 25-Hydroxyvitamin D, Parathyroid Hormone (PTH) and tumor marker CA15-3. Segmental and total BMD were also investigated using Dual X-ray Absorptiometry technique. Results: We found ALP, S.ALP, and CTx-I levels were significantly lower (p<0.001), while PTH levels to be significantly higher for all women after chemotherapy as compared to their initial state before chemotherapy. Both segmental and total BMD, and consequently T- and Z-Scores after chemotherapy were significantly (p<0.01) lower than their levels before chemotherapy. We developed prediction mathematical formulae for spine, pelvis and total BMD for all women before and after chemotherapy. Conclusions: Adjuvant chemotherapy is responsible for decreasing both biochemical markers of bone formation and resorption as well as for decreasing segmental and total BMD in NMBC postmenopausal Egyptian women. We believe the mathematical formulae developed on basis of the two individual variables Age and BMI can be useful for assisting the clinician to frequently monitor bone health status of breast cancer patients in similar conditions.
{"title":"Effect of Adjuvant Chemotherapy is Responsible for Decreasing Segmental and Total BMD in BC Postmenopausal Women","authors":"Srileela Movva, Srinivasa Rao Konijeti","doi":"10.31579/2640-1053/021","DOIUrl":"https://doi.org/10.31579/2640-1053/021","url":null,"abstract":"Background: Women with breast cancer are at increased risk for the development of osteoporosis and skeletal fractures, as consequences of aromatase inhibition or chemotherapy-induced ovarian failure. We investigated the effect of adjuvant chemotherapy on biochemical markers of bone formation and resorption as well as on bone mineral density (BMD) of non-metastatic breast cancer (NMBC) postmenopausal Egyptian women. Methods: We followed 100 newly diagnosed women with T1-3 N0-2 M0 breast cancer, who had a mean age (±SD) of 55.06±8.78 year, before and after receiving 6-cycles of CAF chemotherapy treatment protocol. All participant women were subjected to blood biochemical analysis for determining serum levels of: erythrocyte sedimentation rate, calcium, alkaline phosphatase (ALP), bone specific alkaline phosphatase (S.ALP), Osteocalcin, carboxytelopeptide of collagen type I (CTx-I), 25-Hydroxyvitamin D, Parathyroid Hormone (PTH) and tumor marker CA15-3. Segmental and total BMD were also investigated using Dual X-ray Absorptiometry technique. Results: We found ALP, S.ALP, and CTx-I levels were significantly lower (p<0.001), while PTH levels to be significantly higher for all women after chemotherapy as compared to their initial state before chemotherapy. Both segmental and total BMD, and consequently T- and Z-Scores after chemotherapy were significantly (p<0.01) lower than their levels before chemotherapy. We developed prediction mathematical formulae for spine, pelvis and total BMD for all women before and after chemotherapy. Conclusions: Adjuvant chemotherapy is responsible for decreasing both biochemical markers of bone formation and resorption as well as for decreasing segmental and total BMD in NMBC postmenopausal Egyptian women. We believe the mathematical formulae developed on basis of the two individual variables Age and BMI can be useful for assisting the clinician to frequently monitor bone health status of breast cancer patients in similar conditions.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41990165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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