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Commentary on the "Co-Crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-Surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre Phase II Trial". Implications for Cardiovascular Safety 关于“曲马多-塞来昔布在中重度术后急性口腔疼痛患者中的共晶体:一项剂量发现、随机、双盲、安慰剂和主动对照、多中心II期试验”的评论。对心血管安全的影响
Journal of cardiology and cardiovascular sciences
Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2018/1.1163
S. Videla, Neus Gascón, C. Plata-Salamán
Page 1 of 3 Commentary on the “Co-Crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-Surgical Oral Pain: A DoseFinding, Randomised, Double-Blind, Placeboand Active-Controlled, Multicentre Phase II Trial”. Implications for Cardiovascular Safety Sebastián Videla1*, Neus Gascón2, Carlos Plata-Salamán2 1Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/IDIBELL, Barcelona, Spain. 2Medical Sciences Area, ESTEVE Pharmaceuticals S.A., Barcelona, Spain.
第1页，共3页“曲马多-塞来昔布共晶治疗中重度急性术后口腔疼痛患者：剂量发现、随机、双盲、安慰剂和主动对照、多中心II期试验”的评论。对心血管安全的影响Sebastián Videla1*，Neus Gascón2，Carlos Plata Salamán2 1西班牙巴塞罗那Bellvitge大学医院/IDIBELL临床药理学部临床研究支持单位。2西班牙巴塞罗那ESTEVE Pharmaceuticals美国医学科学区。
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引用次数: 2
Human Perivascular Adipose Tissue as a Regulator of the Vascular Microenvironment and Diseases of the Coronary Artery and Aorta. 人类血管周围脂肪组织作为血管微环境和冠状动脉和主动脉疾病的调节剂。
Journal of cardiology and cardiovascular sciences
Pub Date : 2019-01-01 Epub Date: 2019-08-13 DOI: 10.29245/2578-3025/2019/4.1174
Caitlin Stieber, Kimberly Malka, Joshua M Boucher, Lucy Liaw

Perivascular adipose tissue (PVAT) is an adipose depot that surrounds blood vessels in the human body and exerts local paracrine signaling. Under physiologically healthy conditions, PVAT has an anti-contractile effect on vessels, but in obesity this effect is lost. During metabolic disease, adiponectin secretion is dysregulated, influencing nitric oxide bioavailability and macrophage infiltration and inflammation, all of which mediate PVAT signaling. However, based on the location in the body, and the type of adipocyte present, PVAT has different relationships with risk factors for disease. Imaging studies in patients with cardiovascular disease have demonstrated important associations between PVAT structure and pathology, yet insight into molecular pathways regulating human PVAT function are still lacking. This review focuses on our current understanding of human PVAT and its secretory role in the vascular microenvironment. A current area of priority is defining molecular differences in the secretome between PVAT depots, as this could inform the treatment of diseases that occur in anatomically restricted locations. In addition, understanding progressive changes in PVAT structure and function during metabolic disease is required for effective targeted therapies.

血管周围脂肪组织(PVAT)是人体血管周围的脂肪储存库，并发挥局部旁分泌信号。在生理健康条件下，PVAT对血管有抗收缩作用，但在肥胖中这种作用消失了。在代谢性疾病中，脂联素分泌失调，影响一氧化氮的生物利用度和巨噬细胞的浸润和炎症，所有这些都介导PVAT信号。然而，基于在体内的位置和存在的脂肪细胞类型，PVAT与疾病的危险因素有不同的关系。心血管疾病患者的影像学研究已经证明了PVAT结构与病理之间的重要关联，但对调节人类PVAT功能的分子途径的了解仍然缺乏。本文综述了目前对人类PVAT及其在血管微环境中的分泌作用的认识。目前的一个优先领域是确定PVAT库之间分泌组的分子差异，因为这可以为发生在解剖学受限部位的疾病的治疗提供信息。此外，了解代谢性疾病期间PVAT结构和功能的进行性变化是有效靶向治疗的必要条件。
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引用次数: 14
Electron Tomography Contributing to Ultrastructural Research in Vascular Biology and Transfusion Medicine 电子断层扫描对血管生物学和输血医学超微结构研究的贡献
Journal of cardiology and cardiovascular sciences
Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2019/1.1165
J. Neumüller, T. Wagner
Page 4 of 10 Electron Tomography Contributing to Ultrastructural Research in Vascular Biology and Transfusion Medicine Josef Neumüller1,2, Thomas Wagner3* 1Blood Donation Center of the Austrian Red Cross for Vienna, Lower Austria and Burgenland 2Center for Anatomy and Cell Biology, Department for Development Biology, Medical University of Vienna 3Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Austria
电子断层扫描对血管生物学和输血医学超微结构研究的贡献Josef neumeller1,2, Thomas Wagner3* 1奥地利维也纳红十字会献血中心，下奥地利和布尔根兰2维也纳医科大学发育生物学解剖和细胞生物学中心3奥地利格拉茨医科大学血型血液学和输血医学学系
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引用次数: 0
Commentary: Atherosclerosis, Analysis of the eNOS (T786C) Gene Polymorphism 评论:动脉粥样硬化，eNOS (T786C)基因多态性分析
Journal of cardiology and cardiovascular sciences
Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2019/1.1166
K. Silva
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引用次数: 0
Mini Review on: Simple, Practical, and Evidence-Based - an Algorithm for The Diagnosis and Treatment of Iron Deficiency 简单、实用、循证的缺铁诊疗算法综述
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1162
E. Erdmann
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引用次数: 0
Percutaneous Coronary Intervention with Everolimus-Eluting Bioresorbable Vascular Scaffolds in Diffuse Coronary Artery Disease: Current Knowledge and Future Perspectives 依维莫司洗脱生物可吸收血管支架经皮冠状动脉介入治疗弥漫性冠状动脉疾病：当前知识和未来展望
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1148
G. Masiero, L. N. Fovino, Alessandro Schiavo, D. Ueshima, M. Badawy, G. Tarantini
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引用次数: 0
Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion" 一篇文章的评论:“催产素诱导心肌细胞保护模拟缺血-再灌注的分子机制”
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1158
Marek Jankowski
Page 1 of 3 Commentary to an Article: “Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion” Marek Jankowski1,2*, Tom L. Broderick3, Jolanta Gutkowska1,2# 1Cardiovascular Biochemistry Laboratory, CRCHUM (7-134), Tour Viger, 900 St-Denis St, Montreal, Canada H2X 0A9, USA 2Department of Medicine, University of Montreal, Quebec, Canada, USA 3Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, Midwestern University, Glendale, AZ, USA
1 / 3页文章评论:Marek jankowski1,2 *， Tom L. Broderick3, Jolanta Gutkowska1,2# 1 CRCHUM心血管生物化学实验室(7-134)，Tour Viger, 900 St- denis St, Montreal, Montreal, Quebec, Canada H2X 0A9, USA 2加拿大魁北克蒙特利尔大学医学系，USA 3美国中西部大学糖尿病与运动代谢实验室生理学系，Glendale, AZ, USA
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引用次数: 0
Commentary: Evaluation of the Comorbidity Burden in Patients With Ankylosing Spondylitis Using a Large US Administrative Claims Data Set 评论：使用大型美国行政索赔数据集评估强直性脊柱炎患者的合并症负担
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1159
J. Walsh, Xue Song, Gilwan Kim, Yujin Park
Page 17 of 23 Commentary: Evaluation of the Comorbidity Burden in Patients With Ankylosing Spondylitis Using a Large US Administrative Claims Data Set Jessica A. Walsh1, Xue Song2*, Gilwan Kim2, Yujin Park3 1University of Utah School of Medicine and Salt Lake City Veteran Affairs Medical Center, Division of Rheumatology, Salt Lake City, UT, USA 2IBM Watson Health, Cambridge, MA, USA 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
第17页，共23页评论：使用大型美国行政索赔数据集评估强直性脊柱炎患者的共病负担Jessica a.Walsh1，Xue Song2*，Gilwan Kim2，Yujin Park3 1犹他大学医学院和盐湖城退伍军人事务医疗中心，美国犹他州盐湖城风湿病部2BM Watson Health，马萨诸塞州剑桥，美国3Novatis Pharmaceuticals Corporation，East Hanover，NJ，USA
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引用次数: 0
Commentary: Cardiovascular Comorbidities in a United States Patient Population with Hemophilia A: A Comprehensive Chart Review 评论:美国血友病a患者的心血管合并症:综合图表回顾
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1155
T. Humphries
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引用次数: 0
Pathogenesis Of Portal Vein Thrombosis In Liver Cirrhosis: The Role of the ADAMTS13/VWF Unbalance 肝硬化门静脉血栓形成的发病机制：ADAMTS13/VWF失衡的作用
Journal of cardiology and cardiovascular sciences
Pub Date : 2018-09-01 DOI: 10.29245/2578-3025/2018/5.1150
Stefano lancellotti Monica Sacco, M. Basso, R. Cristofaro
Increasing evidence shows a potential role of ADAMTS13 deficiency as a risk factor for the high prevalence of portal vein thrombosis (PVT) in cirrhotic patients. This deficiency, due to myofibroblastic transformation of hepatic stellate cells (HSCs), the source of ADAMTS13, is responsible for the prevalence of ultra large molecular weight multimers of von Willebrand factor (UL-VWF) in the hepatic microcirculation. This phenomenon would favor the prohaemostatic function of VWF, which, together with an elevation of coagulation FVIII, which is associated to VWF, could sustain microcirculatory thrombosis in the liver. These phenomena, triggering an increase of the intra-hepatic pressure, would cause a slowdown of the portal flow, favoring the occurrence of PVT. Although this scenario is justified by retrospective observational clinical studies, it will be mandatory to clarify the ADAMTS13 expression in HSCs associated with the activity of plasma ADAMTS13 in different stage of liver diseases. Hence, a prospective clinical trial (ClinicalTrials.gov Identifier: NCT03322696) is ongoing to unravel the linkage between all the actors involved in the complex phenomenon of PVT occurring in cirrhosis.
越来越多的证据表明，ADAMTS13缺乏可能是肝硬化患者门静脉血栓形成（PVT）高患病率的危险因素。这种缺陷是由于ADAMTS13来源的肝星状细胞（HSC）的肌成纤维细胞转化引起的，是肝微循环中von Willebrand因子（UL-VWF）的超大分子量多聚体普遍存在的原因。这种现象将有利于VWF的止血功能，再加上与VWF相关的凝血FVIII的升高，可以维持肝脏中的微循环血栓形成。这些现象会引发肝内压力的增加，导致门脉流量减慢，有利于PVT的发生。尽管回顾性观察性临床研究证明了这种情况的合理性，但在不同阶段的肝病中，必须澄清与血浆ADAMTS13活性相关的HSC中ADAMTS13的表达。因此，一项前瞻性临床试验（ClinicalTrials.gov标识符：NCT03322696）正在进行中，以揭示肝硬化PVT复杂现象中所有参与者之间的联系。
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引用次数: 0
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Journal of cardiology and cardiovascular sciences
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