Pub Date : 2018-07-01DOI: 10.29245/2578-3025/2018/4.1144
Karim Saleb
Pulmonary embolism remains one of the major causes of morbidity and mortality in the United States. For patients with an intermediate-risk pulmonary embolism, Ultrasound-Assisted Catheter-Directed Thrombolysis (USAT) is a contemporary treatment modality that has emerged as a potential alternative to systemic thrombolysis and surgical embolectomy. Multiple studies have demonstrated the efficacy of USAT in reducing the thrombus burden and reversing right ventricular dysfunction in patients with an intermediate-risk pulmonary embolism. However, literature addressing the potential impact of an early catheter directed revascularization is lacking. A recent retrospective study carried out by Edla et al suggests that, compared to a delayed intervention, early USAT can improve recovery of pulmonary hemodynamics in patients with submassive pulmonary embolism and also reduce the overall in-hospital length of stay. This commentary provides a thorough analysis of the results of this study and revisits the existing information on ultrasoundassisted thrombolysis for acute pulmonary embolism.
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Pub Date : 2018-07-01DOI: 10.29245/2578-3025/2018/4.1141
N. Gdara
Liver ischemia-reperfusion induced hepatocellular damage that contributes to the morbidity and mortality1,2 associated with shock, thermal injury, re-sectional surgery and liver transplantation. One of the earliest events associated with reperfusion of ischemic liver is the release of Reactive Oxygen Species (ROS) causing oxidative stress. The following review focuses on the antioxidant effects of nitric oxide (NO) and Phycocyanin (Pc) after cold ischemia/reperfusion injury (IRI). In this regard, this review investigates in the first part the effect of the addition of NO to the preservation solution at different concentrations (1000, 500 and 50 nM) and in the second part the effect of the addition of phycocyanin to the conservation solution at two doses (0.2 mg / ml / g of liver and 0.1 mg / ml / g of liver) on liver graft quality. In conclusion, phycocyanin and nitric oxide (at a low dose) are effective in preserving the hepatic graft and protecting it against IRI by acting as a potent antioxidant against the products of oxidative stress.
肝缺血再灌注引起的肝细胞损伤可导致与休克、热损伤、切除手术和肝移植相关的发病率和死亡率1,2。与缺血肝脏再灌注相关的最早事件之一是活性氧(ROS)的释放引起氧化应激。本文就一氧化氮(NO)和藻蓝蛋白(Pc)在冷缺血再灌注损伤(IRI)后的抗氧化作用作一综述。为此，本文首先研究了不同浓度(1000、500和50 nM) NO对保存液的影响，第二部分研究了在保存液中以0.2 mg / ml / g肝脏和0.1 mg / ml / g肝脏添加藻蓝蛋白对肝移植质量的影响。综上所述，藻蓝蛋白和一氧化氮(低剂量)作为抗氧化应激产物的有效抗氧化剂，可以有效地保护肝移植物并保护其免受IRI。
{"title":"Protective Effects of Nitric Oxide and Phycocyanin Against Oxidative Stress Induced by Hepatic Ischemia/Reperfusion Injuries","authors":"N. Gdara","doi":"10.29245/2578-3025/2018/4.1141","DOIUrl":"https://doi.org/10.29245/2578-3025/2018/4.1141","url":null,"abstract":"Liver ischemia-reperfusion induced hepatocellular damage that contributes to the morbidity and mortality1,2 associated with shock, thermal injury, re-sectional surgery and liver transplantation. One of the earliest events associated with reperfusion of ischemic liver is the release of Reactive Oxygen Species (ROS) causing oxidative stress. The following review focuses on the antioxidant effects of nitric oxide (NO) and Phycocyanin (Pc) after cold ischemia/reperfusion injury (IRI). In this regard, this review investigates in the first part the effect of the addition of NO to the preservation solution at different concentrations (1000, 500 and 50 nM) and in the second part the effect of the addition of phycocyanin to the conservation solution at two doses (0.2 mg / ml / g of liver and 0.1 mg / ml / g of liver) on liver graft quality. In conclusion, phycocyanin and nitric oxide (at a low dose) are effective in preserving the hepatic graft and protecting it against IRI by acting as a potent antioxidant against the products of oxidative stress.","PeriodicalId":93019,"journal":{"name":"Journal of cardiology and cardiovascular sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41571462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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