Kenneth C. Ugoeze, Nora Amadi, Ngozi A. Okoronkwo, Sunday O. Abali, Kennedy E. Oluigbo, Bruno C. Chinko
{"title":"GC-FID guided Identification and Quantification of detectable Phytochemicals in selected Commercial Chamomile Herbal Tea","authors":"Kenneth C. Ugoeze, Nora Amadi, Ngozi A. Okoronkwo, Sunday O. Abali, Kennedy E. Oluigbo, Bruno C. Chinko","doi":"10.26502/ijabpt.202120","DOIUrl":"https://doi.org/10.26502/ijabpt.202120","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methods for Improving Brain-Computer Interface: Using A Brain-Directed Adjuvant and A Second-Generation Artificial Intelligence System to Enhance Information Streaming and Effectiveness of Stimuli","authors":"Hillel Lehmann, D. Arkadir, Y. Ilan","doi":"10.26502/ijabpt.202124","DOIUrl":"https://doi.org/10.26502/ijabpt.202124","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transformed Time Series Analysis of First Wave COVID-19: Universal Similarities Found in The Group of Twenty (G20) Countries","authors":"Albert S. Kim","doi":"10.26502/ijabpt.202122","DOIUrl":"https://doi.org/10.26502/ijabpt.202122","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Appraisal of Behavioural and Non-Behavioural Factors Influencing the Male Infertility: Narrative Approach","authors":"Sudarshan Nagorao kale, Jibanananda Mishra","doi":"10.26502/ijabpt.202125","DOIUrl":"https://doi.org/10.26502/ijabpt.202125","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Filosa, A. Trusio, G. De Cristofaro, P. Marra, G. Malafronte
{"title":"Intratympanic Gentamicin Injection in Ménière’s Disease: Our Ten Years’ Experience and Outcomes","authors":"B. Filosa, A. Trusio, G. De Cristofaro, P. Marra, G. Malafronte","doi":"10.26502/ijabpt.202121","DOIUrl":"https://doi.org/10.26502/ijabpt.202121","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Constrained Disorder Principle Accounts for The Structure and Function of Water as An Ultimate Biosensor and Bioreactor in Biological Systems","authors":"Y. Ilan","doi":"10.26502/ijabpt.202123","DOIUrl":"https://doi.org/10.26502/ijabpt.202123","url":null,"abstract":"","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. K. Sharma, Nimisha, Apurva, Arun R K Kumar, Asgar Ali, Sundeep Singh Saluja, B. Prasad
Background: The potential involvement of Notch signaling pathway in cell fate decision, tumor heterogeneity and angiogenesis in solid tumors can be explored in colorectal cancer (CRC). This might further help to improve outcomes in CRC. Here, the promoter methylation of Notch receptor gene ( Notch2 and Notch3 ) and their co-expression with its downstream transcription factor Hes1 has been analyzed. Methods: Seventy-two CRC patients were enrolled to study the role of Notch2 , Notch3 and Hes1 genes in colorectal cancer. Promoter methylation and mRNA expression in tumor and adjoining normal tissue were assessed by Methylation Specific PCR and quantitative Real time PCR respectively. Statistical correlation was done by using SPSS. Results: We found that Notch2 and Notch3 were hypomethylated in 52/72 (72.22%) and 54/72 (75%) cases respectively. Hypomethylation of Notch 2 and Notch 3 showed significant association with advanced stage ( p =0.001) and (p=0.003) and nodal metastasis ( p =0.036) and ( p =0.012) respectively. Both Notch 2 and Notch 3 showed increased mRNA expression in 49 (68.05%) and 51(70.84%) patients with a fold change of 3.37 and 5.43 respectively. Positive correlation between hypomethylation and expression was observed for both genes. High expression of Hes1 was found in 53(73.61%) of cases which was highly relatable with over expression of notch receptor genes. Upregulation of Notch 2, Notch 3 and Hes1 showed significant association with high grade tumors, advance stage and presence of LN metastasis, additionally Notch 3 and Hes1 showed significant association with distant metastasis. Conclusion: Hypomethylation of Notch 2 and 3 receptors is playing crucial in regulating the expression of these genes in CRC. Overexpression of Notch 2, Notch 3 and Hes1 are associated with disease progression in CRC.
{"title":"Elevated Expression of Notch 2 & Notch 3 is associated with Disease Progression in Colorectal Cancer","authors":"A. K. Sharma, Nimisha, Apurva, Arun R K Kumar, Asgar Ali, Sundeep Singh Saluja, B. Prasad","doi":"10.26502/ijabpt.202118","DOIUrl":"https://doi.org/10.26502/ijabpt.202118","url":null,"abstract":"Background: The potential involvement of Notch signaling pathway in cell fate decision, tumor heterogeneity and angiogenesis in solid tumors can be explored in colorectal cancer (CRC). This might further help to improve outcomes in CRC. Here, the promoter methylation of Notch receptor gene ( Notch2 and Notch3 ) and their co-expression with its downstream transcription factor Hes1 has been analyzed. Methods: Seventy-two CRC patients were enrolled to study the role of Notch2 , Notch3 and Hes1 genes in colorectal cancer. Promoter methylation and mRNA expression in tumor and adjoining normal tissue were assessed by Methylation Specific PCR and quantitative Real time PCR respectively. Statistical correlation was done by using SPSS. Results: We found that Notch2 and Notch3 were hypomethylated in 52/72 (72.22%) and 54/72 (75%) cases respectively. Hypomethylation of Notch 2 and Notch 3 showed significant association with advanced stage ( p =0.001) and (p=0.003) and nodal metastasis ( p =0.036) and ( p =0.012) respectively. Both Notch 2 and Notch 3 showed increased mRNA expression in 49 (68.05%) and 51(70.84%) patients with a fold change of 3.37 and 5.43 respectively. Positive correlation between hypomethylation and expression was observed for both genes. High expression of Hes1 was found in 53(73.61%) of cases which was highly relatable with over expression of notch receptor genes. Upregulation of Notch 2, Notch 3 and Hes1 showed significant association with high grade tumors, advance stage and presence of LN metastasis, additionally Notch 3 and Hes1 showed significant association with distant metastasis. Conclusion: Hypomethylation of Notch 2 and 3 receptors is playing crucial in regulating the expression of these genes in CRC. Overexpression of Notch 2, Notch 3 and Hes1 are associated with disease progression in CRC.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Jamdade, A. Jamdade, Amrita Agarwal, Nilesh D Pardhe
Etiology of oral submucous fibrosis (OSMF) is not fully understood, henceforth treated unsatisfactorily. Generally surgical treatment aims to reopen mouth. Surgery includes relieving fibrous bands followed by grafting to prevent re-fibrosis. Different surgical techniques are used to improve the condition of the patient. Each technique has its own advantage and disadvantages. Lasers application in OSMF is not much studied. In our case, laser (Diode) fibrotomy had an excellent result with satisfactory mouth opening and no recurrence until the last follow up.
{"title":"Diode Laser in the management of Oral Sub-mucous Fibrosis: A Case Report","authors":"V. Jamdade, A. Jamdade, Amrita Agarwal, Nilesh D Pardhe","doi":"10.26502/ijabpt.202111","DOIUrl":"https://doi.org/10.26502/ijabpt.202111","url":null,"abstract":"Etiology of oral submucous fibrosis (OSMF) is not fully understood, henceforth treated unsatisfactorily. Generally surgical treatment aims to reopen mouth. Surgery includes relieving fibrous bands followed by grafting to prevent re-fibrosis. Different surgical techniques are used to improve the condition of the patient. Each technique has its own advantage and disadvantages. Lasers application in OSMF is not much studied. In our case, laser (Diode) fibrotomy had an excellent result with satisfactory mouth opening and no recurrence until the last follow up.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic nephropathy is related to increased mortality in diabetic patients and may be a major reason for end stage renal disease in most countries. The consequence of the combination of metabolic and hemodynamic pathway tends to be diabetic nephropathy. Glucose dependent pathways are activated with in diabetic kidney. This involves growing oxidative stress, and advanced glycated end-product accumulation. The pathogenesis of diabetic nephropathy also includes elevated systemic and intraglomerular pressure and also activation of multiple vasoactive hormone pathways, such as renin-angiotensin and endothelin. The aim of this review analysis is to gather knowledge of the molecular pathways and the factors involved in the pathogenesis of diabetic nephropathy.
{"title":"Molecular Mechanisms of Pathways in Diabetic Nephropathy Development in Patients with T2DM -A Review","authors":"Medha Srivastava, B. Rai","doi":"10.26502/ijabpt.202107","DOIUrl":"https://doi.org/10.26502/ijabpt.202107","url":null,"abstract":"Diabetic nephropathy is related to increased mortality in diabetic patients and may be a major reason for end stage renal disease in most countries. The consequence of the combination of metabolic and hemodynamic pathway tends to be diabetic nephropathy. Glucose dependent pathways are activated with in diabetic kidney. This involves growing oxidative stress, and advanced glycated end-product accumulation. The pathogenesis of diabetic nephropathy also includes elevated systemic and intraglomerular pressure and also activation of multiple vasoactive hormone pathways, such as renin-angiotensin and endothelin. The aim of this review analysis is to gather knowledge of the molecular pathways and the factors involved in the pathogenesis of diabetic nephropathy.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chondrosarcoma is a malignant tumor of long bones which is characterized by the formation of cartilage. It is the second most common tumor of bones after osteosarcoma and only 3-10% of cases occur in maxillofacial region. Chondrosarcomas mostly occur in individuals older than 50 years with maxilla being the most common site of involvement in maxillofacial skeleton. Involvement of mandible is very rare and mostly anterior portion is involved. A rare case of chondrosarcoma of the left posterior mandible in a 21 year old female patient is presented and review of literature is discussed.
{"title":"Chondrosarcoma of the Posterior Mandible: A Case Report","authors":"Nilesh D Pardhe, A. Jamdade, N. Mathur, P. Vijay","doi":"10.26502/ijabpt.202110","DOIUrl":"https://doi.org/10.26502/ijabpt.202110","url":null,"abstract":"Chondrosarcoma is a malignant tumor of long bones which is characterized by the formation of cartilage. It is the second most common tumor of bones after osteosarcoma and only 3-10% of cases occur in maxillofacial region. Chondrosarcomas mostly occur in individuals older than 50 years with maxilla being the most common site of involvement in maxillofacial skeleton. Involvement of mandible is very rare and mostly anterior portion is involved. A rare case of chondrosarcoma of the left posterior mandible in a 21 year old female patient is presented and review of literature is discussed.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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