Sheng-Fang Huang, Hao-Wen Cheng, J. Tsai, C. Kuo, Chih‐Chieh Chang, Li-Jhen Chen, A. Shiau, Yu‐Jen Wang, Ming‐Hsien Li
{"title":"Failure mode and effects analysis for errors detected during pretreatment physics plan and chart review in external beam radiotherapy","authors":"Sheng-Fang Huang, Hao-Wen Cheng, J. Tsai, C. Kuo, Chih‐Chieh Chang, Li-Jhen Chen, A. Shiau, Yu‐Jen Wang, Ming‐Hsien Li","doi":"10.21037/tro-21-38","DOIUrl":"https://doi.org/10.21037/tro-21-38","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45912729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingyan Qu, Lawrence Liu, A. Giebeler, Chang Chang
{"title":"Dosimetric study of Qfix kVue rails for pencil beam scanning proton beam","authors":"Lingyan Qu, Lawrence Liu, A. Giebeler, Chang Chang","doi":"10.21037/tro-22-9","DOIUrl":"https://doi.org/10.21037/tro-22-9","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49409294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemangiopericytoma in the central nervous system: a case report","authors":"Chia-chun Huang, Tung-hao Chang, J. Lin","doi":"10.21037/tro-22-21","DOIUrl":"https://doi.org/10.21037/tro-22-21","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47242107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Hou, Yen-Wen Wu, Le-Jung Wu, C. Hsieh, Chen-Xiong Hsu, D. Kuo, Yueh-Feng Lu, H. Tien, H. Yeh, P. Shueng, B. Teh
{"title":"Initial experience of the implementation of a cardio-oncology program for breast cancer patients receiving modern radiotherapy in a tertiary institution","authors":"P. Hou, Yen-Wen Wu, Le-Jung Wu, C. Hsieh, Chen-Xiong Hsu, D. Kuo, Yueh-Feng Lu, H. Tien, H. Yeh, P. Shueng, B. Teh","doi":"10.21037/tro-21-20","DOIUrl":"https://doi.org/10.21037/tro-21-20","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47861773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Orbital radiotherapy for proptosis in patients with Graves’ ophthalmopathy","authors":"Bo-Yuan Ding, C. Bai, K. Chi, M. Shih, H. Ko","doi":"10.21037/tro-21-10","DOIUrl":"https://doi.org/10.21037/tro-21-10","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47490016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Carpano, G. S. Cruz, C. Rodríguez, S. Nievas, M. Olivera, M. Perona, E. Boggio, J. Longhino, M. Pisarev, G. Juvenal, M. A. Dagrosa
Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10 B (n, α ) lithium-7 ( 7 Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 10 8 /cm 2 /sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier’s Law of Heat Conduction and the Ohm’s law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature’s ratios, was observed with respect to the degree of tumor control (BNCT I with a R 2 of 0.3527, BNCTII with a R 2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.
{"title":"Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma","authors":"M. Carpano, G. S. Cruz, C. Rodríguez, S. Nievas, M. Olivera, M. Perona, E. Boggio, J. Longhino, M. Pisarev, G. Juvenal, M. A. Dagrosa","doi":"10.21037/TRO-20-61","DOIUrl":"https://doi.org/10.21037/TRO-20-61","url":null,"abstract":"Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10 B (n, α ) lithium-7 ( 7 Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 10 8 /cm 2 /sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier’s Law of Heat Conduction and the Ohm’s law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature’s ratios, was observed with respect to the degree of tumor control (BNCT I with a R 2 of 0.3527, BNCTII with a R 2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43816860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li-Jhen Chen, Ming‐Hsien Li, Hao-Wen Cheng, C. Kuo, Wei-Lun Sun, J. Tsai
Background: To compare non-coplanar and coplanar volumetric-modulated arc therapy (VMAT) for hippocampal avoidance during whole-brain radiotherapy (HA-WBRT) using the Elekta Synergy and Pinnacle treatment planning system (TPS) according to the suggested criteria of the radiation therapy oncology group (RTOG) 0933 trial. Methods: Nine patients who underwent WBRT were selected for this retrospective study. The hippocampus was contoured, and the hippocampal avoidance regions were created using a 5-mm volumetric expansion around the hippocampus for each patient. Non-coplanar and coplanar VMAT plans were generated for each patient. All treatment plans were generated for a prescribed dose (PD) of 30 Gy in 10 fractions. Results: The average volumes of the hippocampus and hippocampal avoidance region were 2.8±0.38 and 27±2.48 cm 3 , respectively. For coplanar and non-coplanar VMAT plans, the average D 100% of the hippocampus was 8.60 Gy (range, 8.30–8.80 Gy) and 8.56 Gy (range, 8.30–8.90 Gy), respectively, and the average D max of the hippocampus was 15.29 Gy (range, 14.35–15.92 Gy) and 14.99 Gy (range, 13.80–15.83 Gy), respectively. The non-coplanar VMAT plans showed a significantly lower average D max of the lens (4.23 Gy) than did the coplanar VMAT plans (4.77 Gy). The average gamma passing rate for non-coplanar and coplanar VMAT quality assurance (QA) with criteria of 3%/3 mm were 95.4%±2.6% and 95.6%±1.6%, indicating good agreement between the calculated plan dose and the measured dose. Conclusions: We showed that the suggested criteria of the RTOG 0933 trial for the hippocampal dose can be achieved in both coplanar and non-planar VMAT plans. We performed VMAT QA for each treatment plan to verify the clinical
背景:根据放射治疗肿瘤组(RTOG) 0933试验的建议标准，比较Elekta Synergy和Pinnacle治疗计划系统(TPS)在全脑放疗(HA-WBRT)期间海马回避的非共面和共面体积调制电弧治疗(VMAT)。方法:选择9例接受WBRT的患者进行回顾性研究。对每个患者的海马进行轮廓化处理，并在海马周围进行5毫米的体积扩张来创建海马回避区。为每位患者生成非共面和共面VMAT计划。所有的治疗方案都是按照30 Gy的处方剂量(PD)分成10份制定的。结果:海马和海马回避区平均体积分别为2.8±0.38 cm 3和27±2.48 cm 3。共面和非共面VMAT方案海马平均D 100%分别为8.60 Gy(范围，8.30-8.80 Gy)和8.56 Gy(范围，8.30-8.90 Gy)，海马平均D max分别为15.29 Gy(范围，14.35-15.92 Gy)和14.99 Gy(范围，13.80-15.83 Gy)。非共面VMAT方案晶状体平均D max (4.23 Gy)明显低于共面VMAT方案(4.77 Gy)。以3%/3 mm为标准的非共面和共面VMAT质量保证(QA)的平均伽马通过率分别为95.4%±2.6%和95.6%±1.6%，表明计算的计划剂量与测量剂量吻合良好。结论:我们发现RTOG 0933试验建议的海马剂量标准在共平面和非平面VMAT计划中都可以达到。我们对每个治疗方案进行VMAT QA以验证临床效果
{"title":"Hippocampus-sparing whole-brain radiotherapy: dosimetric comparison between non-coplanar and coplanar planning","authors":"Li-Jhen Chen, Ming‐Hsien Li, Hao-Wen Cheng, C. Kuo, Wei-Lun Sun, J. Tsai","doi":"10.21037/TRO-20-50","DOIUrl":"https://doi.org/10.21037/TRO-20-50","url":null,"abstract":"Background: To compare non-coplanar and coplanar volumetric-modulated arc therapy (VMAT) for hippocampal avoidance during whole-brain radiotherapy (HA-WBRT) using the Elekta Synergy and Pinnacle treatment planning system (TPS) according to the suggested criteria of the radiation therapy oncology group (RTOG) 0933 trial. Methods: Nine patients who underwent WBRT were selected for this retrospective study. The hippocampus was contoured, and the hippocampal avoidance regions were created using a 5-mm volumetric expansion around the hippocampus for each patient. Non-coplanar and coplanar VMAT plans were generated for each patient. All treatment plans were generated for a prescribed dose (PD) of 30 Gy in 10 fractions. Results: The average volumes of the hippocampus and hippocampal avoidance region were 2.8±0.38 and 27±2.48 cm 3 , respectively. For coplanar and non-coplanar VMAT plans, the average D 100% of the hippocampus was 8.60 Gy (range, 8.30–8.80 Gy) and 8.56 Gy (range, 8.30–8.90 Gy), respectively, and the average D max of the hippocampus was 15.29 Gy (range, 14.35–15.92 Gy) and 14.99 Gy (range, 13.80–15.83 Gy), respectively. The non-coplanar VMAT plans showed a significantly lower average D max of the lens (4.23 Gy) than did the coplanar VMAT plans (4.77 Gy). The average gamma passing rate for non-coplanar and coplanar VMAT quality assurance (QA) with criteria of 3%/3 mm were 95.4%±2.6% and 95.6%±1.6%, indicating good agreement between the calculated plan dose and the measured dose. Conclusions: We showed that the suggested criteria of the RTOG 0933 trial for the hippocampal dose can be achieved in both coplanar and non-planar VMAT plans. We performed VMAT QA for each treatment plan to verify the clinical","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41384149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helen Lo, P. Estoesta, E. C. Mackonis, R. Tse, G. Harris, Louise Marie Van Camp, E. Choong
{"title":"Clinical evaluation of RTOG-atlas based contouring, MRI-atlas auto-contouring, and neuroradiologist contouring of the hippocampi for hippocampal avoidance whole-brain radiotherapy","authors":"Helen Lo, P. Estoesta, E. C. Mackonis, R. Tse, G. Harris, Louise Marie Van Camp, E. Choong","doi":"10.21037/tro-21-15","DOIUrl":"https://doi.org/10.21037/tro-21-15","url":null,"abstract":"","PeriodicalId":93236,"journal":{"name":"Therapeutic radiology and oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44909289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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