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Pharmacological management of psychopathology in people with intellectual disabilities and/or autism spectrum disorder 智力残疾和/或自闭症谱系障碍患者精神病理的药理学管理
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-10-03 DOI: 10.1192/bja.2022.61
S. Deb, M. Roy, B. Limbu
SUMMARY On average, 49–63% of people with intellectual disabilities and/or autism spectrum disorder (ASD) are prescribed psychotropic medications to treat psychopathology, including psychiatric illness, behaviours that challenge and the core symptoms and associated behaviours of these developmental disorders. In many cases, psychotropics, particularly antipsychotics, are used off-label without a proper indication, particularly to manage behaviours that challenge. The RCTs show moderate evidence supporting the efficacy of low-dose risperidone and some preliminary evidence for aripiprazole in treating behaviours that challenge among children with ASD and/or intellectual disabilities. The RCT-based evidence for the other psychotropics is equivocal, so no definitive conclusions can be made on their efficacy. Polypharmacy and the use of high doses of antipsychotics are prevalent in this population, leading to the risk of adverse events and drug–drug interactions. Despite various national and international guidelines, and government initiatives encouraging reduced psychotropic use, there is little evidence of this happening; on the contrary, the use of antidepressants, mood stabilisers and benzodiazepines may be increasing. A concerted multi-agency effort is urgently needed to address this significant public health concern of the overmedication of people with intellectual disabilities and/or ASD.
平均而言,49-63%的智力残疾和/或自闭症谱系障碍(ASD)患者接受精神药物治疗,以治疗精神病理学,包括精神疾病、挑战这些发育障碍的行为以及核心症状和相关行为。在许多情况下,精神药物,特别是抗精神病药物,在没有适当适应症的情况下被用于标签外,特别是用于管理具有挑战性的行为。随机对照试验显示,有中度证据支持低剂量利培酮和一些初步证据支持阿立哌唑治疗ASD和/或智力残疾儿童的行为挑战。其他精神药物基于随机对照试验的证据是模棱两可的,因此无法就其疗效得出明确的结论。在这一人群中,多种用药和高剂量抗精神病药物的使用普遍存在,导致不良事件和药物-药物相互作用的风险。尽管有各种国家和国际指南,以及鼓励减少精神药物使用的政府举措,但几乎没有证据表明这种情况正在发生;相反,抗抑郁药、情绪稳定剂和苯二氮卓类药物的使用可能正在增加。迫切需要多机构共同努力,解决智力残疾和/或自闭症谱系障碍患者用药过量这一重大公共卫生问题。
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引用次数: 8
Risk assessment in clinical practice: a framework for decision-making in real-world complex systems 临床实践中的风险评估:现实世界复杂系统中的决策框架
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-09-29 DOI: 10.1192/bja.2022.67
R. Nathan, S. Bhandari
Risk assessment in clinical practice is often characterised as a process of analysing information so as to make a judgement about the likelihood of harmful behaviour occurring in the future. However, this characterisation is brought into question when the evidence does not support the current use of risk assessment approaches to predict, or provide probability estimates of, future behaviour in a way that is usable in single instances arising in individual cases. This article sets out a broader and more clinically applicable description of risk assessment which takes account of the wider influences on how this clinical activity takes place. In so doing, it provides a framework to guide clinicians, researchers and authors of practice guidance who are interested in improving approaches to risk assessment.
临床实践中的风险评估通常被描述为分析信息的过程,以便对未来发生有害行为的可能性做出判断。然而,当证据不支持目前使用的风险评估方法来预测或提供未来行为的概率估计时,这种特征就会受到质疑,这种方法在个别病例中出现的单个实例中可用。本文列出了一个更广泛和更临床适用的风险评估描述,它考虑了对这种临床活动如何发生的更广泛的影响。在这样做的过程中,它提供了一个框架来指导对改进风险评估方法感兴趣的临床医生、研究人员和实践指南的作者。
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引用次数: 1
Challenging behaviour in children with developmental disabilities: an overview of behavioural assessment and treatment methods 发育障碍儿童的挑战性行为:行为评估和治疗方法概述
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-09-07 DOI: 10.1192/bja.2022.59
Celeste Tevis, J. Matson
SUMMARY Challenging behaviours often co-occur at high rates among those with autism spectrum disorder and intellectual disability. Challenging behaviours, including self-injury, aggression and property destruction, can be associated with social impairment and increased caregiver demands and stress. These behaviours often arise from and are maintained by a combination of biological and environmental risk factors throughout the lifespan. Given the impact of challenging behaviours on development, function-based assessment and intervention approaches are crucial. The prevalence, risk factors, assessment tools and evidence-based treatment options utilised for individuals with developmental disorders are discussed.
具有挑战性的行为通常在自闭症谱系障碍和智力残疾患者中高发。具有挑战性的行为,包括自残、攻击和破坏财产,可能与社会障碍和照料者需求和压力增加有关。这些行为往往由生物和环境风险因素共同引起,并在整个生命周期中得到维持。鉴于具有挑战性的行为对发展的影响,基于功能的评估和干预方法至关重要。患病率,风险因素,评估工具和以证据为基础的治疗方案用于个体发育障碍进行了讨论。
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引用次数: 3
The great safety net: the inherent jurisdiction and vulnerable adults 巨大的安全网:固有的管辖权和脆弱的成年人
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-09-07 DOI: 10.1192/bja.2022.58
N. Brindle, Z. Jawaid, Michael Kennedy
Clinicians should be aware of the inherent jurisdiction of the High Court in providing a ‘safety net’ to protect ‘vulnerable’ adults who are not within the scope of the Mental Capacity Act 2005 (MCA) or the Mental Health Act (MHA) 1983. Many situations in which the inherent jurisdiction has been deployed have been to safeguard vulnerable adults where there is abuse, coercion or undue influence, but the person does not lack decision-making capacity under the MCA. We explain the nature of the inherent jurisdiction, including descriptions of concepts surrounding ‘vulnerability’; as an intervention of last resort, we consider what statutory alternatives may exist, including safeguarding law under the Care Act 2014; we discuss decision-making capacity in relation to contact with others and, using real cases, the types of order that may be made under the court's inherent jurisdiction. It is important to be mindful that although there may be a legal remedy to safeguard this ‘vulnerable but capacitous’ group, there is a delicate and challenging balance between protecting those at risk and respecting their autonomy.
临床医生应该意识到高等法院在提供"安全网"以保护不在《2005年精神能力法》(MCA)或《1983年精神卫生法》(MHA)范围内的"弱势"成年人方面的固有管辖权。在许多使用固有管辖权的情况下,都是为了保护受到虐待、胁迫或不当影响的弱势成年人,但该人并不缺乏《民法》规定的决策能力。我们解释了固有管辖权的性质,包括对“脆弱性”相关概念的描述;作为最后的干预手段,我们考虑可能存在的法定替代方案,包括2014年《护理法案》下的保障法;我们讨论了与他人接触有关的决策能力,并利用实际案例讨论了根据法院固有管辖权可能作出的命令类型。重要的是要注意,尽管可能有法律补救措施来保护这个“脆弱但有能力”的群体,但在保护处于危险中的群体和尊重他们的自主权之间,存在一个微妙而具有挑战性的平衡。
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引用次数: 0
Digital literacy in contemporary mental healthcare: online assessments and mobile health apps 当代精神卫生保健中的数字素养:在线评估和移动健康应用程序
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-09-07 DOI: 10.1192/bja.2022.60
D. Tracy, R. Gadelrab, A. Rahim, Gabrielle Pendlebury, Hashim Reza, R. Bhattacharya, Asif M. Bachlani, K. Worlley, David Rigby, Maria Heath, S. Dave
‘Digital’ is an omnipresent yet often vague, misunderstood or feared topic in health services. There are many current and potential gains for individual patients and local populations, clinicians and organisations through optimisation of digital technologies. We argue that understanding the various aspects of digital psychiatry is an essential contemporary need. This is the first of two articles on the subject, exploring the gains and challenges of virtual/online assessments, including ethical considerations and the use of virtual reality and electronic prescribing.
在卫生服务中,“数字化”是一个无所不在但往往模糊不清、被误解或令人恐惧的话题。通过优化数字技术,对个体患者和当地人群、临床医生和组织有许多当前和潜在的收益。我们认为,理解数字精神病学的各个方面是当代的基本需求。这是关于这个主题的两篇文章中的第一篇,探讨了虚拟/在线评估的收益和挑战,包括道德考虑和虚拟现实和电子处方的使用。
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引用次数: 1
BJA volume 28 issue 5 Cover and Front matter BJA第28卷第5期封面和封面问题
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-08-29 DOI: 10.1192/bja.2022.55
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引用次数: 0
New from CPD eLearning CPD在线学习的新内容
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-08-29 DOI: 10.1192/bja.2022.57
B CPD credits: b 0.5 Other recently published CPD eLearning podcasts (each worth 0.5 CPD credits and freely accessible) include: • Are you ignorant about the pandemic? CPD eLearning (formerly CPD Online) is a resource provided by the Royal College of Psychiatrists for mental health professionals, housed on our new eLearning Hub. For more information, visit CPD eLearning on the eLearning Hub: https://elearninghub.rcpsych.ac.uk I BJPsych Advances i and CPD eLearning work together to produce regular joint commissions to enhance learning for mental health professionals. [Extracted from the article] Copyright of BJPsych Advances is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
其他最近发布的CPD在线学习播客(每个价值0.5 CPD学分,免费获取)包括:•你对疫情一无所知吗?CPD在线学习(以前的CPD在线)是由皇家精神科医生学院为心理健康专业人员提供的资源,位于我们新的在线学习中心。欲了解更多信息,请访问在线学习中心的CPD在线学习:https://elearninghub.rcpsych.ac.uk BJPsych advance I和CPD在线学习共同成立定期联合委员会,以加强精神卫生专业人员的学习。BJPsych Advances版权归剑桥大学出版社所有,未经版权所有人书面许可,不得将其内容复制、通过电子邮件发送到多个网站或在listserv中发布。但是,用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有人。)
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引用次数: 0
BJA volume 28 issue 5 Cover and Back matter BJA第28卷第5期封面和封底
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-08-29 DOI: 10.1192/bja.2022.56
Javier Ortiz-Orendain, S. Covarrubias-Castillo, A. O. Vázquez-Álvarez, Santiago Castiello-de Obeso, Gustavo E. Arias Quiñones, Maya Seegers, L. Colunga-Lozano, Noura Al-Juffali, M. Horowitz, David Taylor, G. Malhi, Erica Bell, Idura N. Hisham, Jacqueline Sin, K. Rouf, Danny Taggart, Giles Townsend, Angela Sweeney, Claire A. Wilson, Shirley McNicholas, Emina Redzic, Maneek Sahota, Vincent Kirchner, Gerrit Glas
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引用次数: 18
Is modafinil an effective adjunct to standard care in the treatment of schizophrenia-spectrum disorders? 莫达非尼是治疗精神分裂症谱系障碍标准治疗的有效辅助药物吗?
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-08-29 DOI: 10.1192/bja.2022.36
M. Oyesanya, N. Al-Juffali
SUMMARY Antipsychotics are the cornerstone of schizophrenia management but they are not adequate in treating the negative and cognitive symptoms of the illness. The Cochrane review discussed in this commentary examines the safety and effectiveness of the wakefulness-promoting agent, modafinil, as an adjunct to standard care in the mitigation of negative and cognitive symptoms of schizophrenia. Add-on modafinil, compared to add-on placebo and standard treatment, did not result in a clear benefit. Due to the heterogenous body of evidence, the quality of which ranged from very low to moderate, the review's conclusions are equivocal.
抗精神病药物是精神分裂症治疗的基石,但它们不足以治疗该疾病的阴性和认知症状。本文讨论的Cochrane综述探讨了清醒促进剂莫达非尼作为缓解精神分裂症阴性症状和认知症状的辅助标准治疗的安全性和有效性。与附加安慰剂和标准治疗相比,附加莫达非尼并没有明显的益处。由于证据的异质性,其质量从极低到中等不等,该综述的结论是模棱两可的。
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引用次数: 0
Treating mental stress in elite footballers using a stigma-free psychological approach: the Power Threat Meaning Framework 用无耻辱感的心理学方法治疗精英足球运动员的精神压力:权力威胁意义框架
IF 1.3 Q3 PSYCHIATRY Pub Date : 2022-08-18 DOI: 10.1192/bja.2022.48
I. James, S. Morris, Allanah Johnston, Danny Glover
There are many pressures on elite footballers. They work in a meritocracy, where only the best are selected and play at the highest levels. From the moment they enter an academy to their retirement there is a fear of deselection and rejection. Elite players need to contend with criticisms from fans and via social media; team and management dynamics can be stressful. Fears of injury are major concerns. In addition, the players are likely to face everyday difficulties experienced by the rest of society, such as relationship, family and financial problems. There is a great deal of stigma associated with mental health problems in footballers, hence approaches are required that are destigmatising. This article presents two frameworks conceptualising stress in footballers: the Power Threat Meaning Framework, which describes stress in non-diagnostic terms; and the Yerkes–Dodson curve, which describes how stress can affect footballers’ mental and physical performances on the pitch. Both frameworks can combine to enable therapists to understand players’ distress and its impact and to guide towards appropriate treatments, as we show in a fictitious case study.
优秀的足球运动员承受着许多压力。他们在精英管理下工作,只有最优秀的人才被选中,并在最高水平上发挥作用。从他们进入学院的那一刻起,直到退休,他们都担心被取消选择和被拒绝。精英球员需要应对来自球迷和社交媒体的批评;团队和管理层的动态变化会带来压力。对受伤的恐惧是主要的担忧。此外,玩家可能会面临社会其他人所经历的日常困难,如关系,家庭和经济问题。足球运动员的心理健康问题给人带来了很多耻辱感,因此需要采取消除耻辱感的方法。本文提出了两个概念化足球运动员压力的框架:权力威胁意义框架,它以非诊断术语描述压力;以及Yerkes-Dodson曲线,该曲线描述了压力如何影响足球运动员在球场上的精神和身体表现。正如我们在一个虚构的案例研究中所展示的那样,这两个框架可以结合起来,使治疗师能够理解玩家的痛苦及其影响,并指导他们采取适当的治疗方法。
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引用次数: 0
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BJPsych Advances
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