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Anorexia Nervosa Anorexia紧张
Pub Date : 2020-09-09 DOI: 10.5772/intechopen.91278
Fatima Elif Ergüney Okumuş
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引用次数: 0
Artificial Sweeteners 人造甜味剂
Pub Date : 2020-09-09 DOI: 10.5772/intechopen.93199
Kanagamani Krishnasamy
Artificial Sweeteners provide the sweetness of natural sugar without the calories and produce a low glycemic response. These sweeteners are used instead of sucrose (table sugar) to sweeten foods and beverages. Consumers and food manufacturers have long been interested in dietary sweeteners to replace sucrose in foods. This article goes into a lot of details about the different types of sweeteners such as saccharin, acesulfame potassium, aspartame, neotame and sucralose, their uses, chemistry and their potential effects on health. These sweeteners form acute and chronic effects on human health.
人造甜味剂提供天然糖的甜味而不含卡路里,并产生低血糖反应。这些甜味剂被用来代替蔗糖(食糖)来增加食物和饮料的甜味。长期以来,消费者和食品制造商一直对用膳食甜味剂代替食品中的蔗糖感兴趣。这篇文章详细介绍了不同类型的甜味剂,如糖精、安赛蜜钾、阿斯巴甜、纽甜和三氯蔗糖,以及它们的用途、化学成分和对健康的潜在影响。这些甜味剂对人体健康产生急性和慢性影响。
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引用次数: 0
Evidence-Based and Novel Psychological Therapies for People with Anorexia Nervosa 神经性厌食症的循证新心理疗法
Pub Date : 2020-05-28 DOI: 10.5772/intechopen.92680
A. Carr, K. Tchanturia, E. Dufour, Mary Cowan, H. Himmerich
Anorexia nervosa (AN) is a serious and often highly persistent psychiatric disorder, whereby sufferers struggle to maintain a healthy weight. Its complexity creates challenges regarding treatment, however psychological therapy is recommended by the National Institute for Heath and Care Excellence (NICE). There are four major evidence-based psychotherapies recommended for treating adults – enhanced cognitive behavioural therapy (CBT-E), the Maudsley model of anorexia nervosa treatment for adults (MANTRA), specialist supportive clinical management (SSCM) and focal psychodynamic therapy (FPT)—and three main psychotherapies recommended for treating adolescents with anorexia-family therapy for anorexia nervosa (FT-AN), enhanced cognitive behavioural therapy (CBT-E) and adolescent focused therapy for anorexia nervosa (AFP-AN). Additionally, several novel adjunct treatments are under examination, two of which—cognitive remediation therapy (CRT) and cognitive remediation and emotion skills training (CREST)—are also discussed in this chapter. Other relevant areas regarding psychological treatment include: combinations of medication or occupational therapy and psychotherapy, treating individuals with comorbidities, the challenges of studying psychological treatment for anorexia and future directions of psychotherapies for anorexia, and are also discussed.
神经性厌食症(AN)是一种严重且经常高度持续的精神疾病,患者努力保持健康的体重。它的复杂性给治疗带来了挑战,然而心理治疗是由国家健康和护理卓越研究所(NICE)推荐的。有四种主要的基于证据的心理疗法被推荐用于治疗成人-强化认知行为疗法(CBT-E),成人神经性厌食症治疗的莫兹利模型(MANTRA),专家支持性临床管理(SSCM)和局灶性心理动力疗法(FPT) -三种主要的心理疗法被推荐用于治疗青少年厌食症-神经性厌食症家庭治疗(FT-AN),强化认知行为疗法(CBT-E)和青少年神经性厌食症(AFP-AN)集中治疗。此外,一些新的辅助治疗方法正在研究中,其中两种-认知修复疗法(CRT)和认知修复和情感技能训练(CREST) -也在本章中进行了讨论。其他有关心理治疗的相关领域包括:药物或职业治疗与心理治疗的结合,治疗合并症的个体,厌食症心理治疗研究的挑战和厌食症心理治疗的未来方向,并进行了讨论。
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引用次数: 2
A Software-Assisted Qualitative Study on the Use of Music in People with Anorexia Nervosa 神经性厌食症患者音乐使用的软件辅助定性研究
Pub Date : 2020-05-14 DOI: 10.5772/intechopen.92589
Briana Applewhite, Aishwarya Krishna Priya, V. Cardi, H. Himmerich
Anorexia nervosa (AN) is an eating disorder associated with a high mortality and an often chronic and disabling course. Thus, novel treatment options should be explored. We performed two focus groups with a total of six people with AN on their use of music and their thoughts about music as an additional therapeutic option. Interviews were transcribed and analyzed in-depth using the NVivo 12 software package. The most prevalent theme throughout the focus groups involved positive expressions, emotions and memories related to music. This theme occurred in ~25% of the data. The importance of music was the second most common theme. Negative feelings and memories associated with music accounted for only ~10% of all references. All six patients expressed that they see benefit in using music therapy as an adjunct to their current treatment. Our analysis shows that people with AN connect music mainly with positive emotions and memories. Therapists might think about applying music more frequently during their sessions with AN patients and consider adding music therapy to their overall treatment concept. However, the results also suggest that music can influence mood not only positively but negatively as well. Quantitative research in bigger patient samples and randomized clinical trials will be necessary to verify these results.
神经性厌食症(AN)是一种与高死亡率和通常是慢性和致残过程相关的饮食失调。因此,应该探索新的治疗方案。我们对六名AN患者进行了两个焦点小组的研究,了解他们对音乐的使用以及他们对音乐作为额外治疗选择的看法。使用NVivo 12软件包对访谈进行转录和深入分析。在整个焦点小组中,最普遍的主题是与音乐有关的积极表达、情感和记忆。这个主题出现在约25%的数据中。音乐的重要性是第二个最常见的主题。与音乐相关的负面情绪和记忆只占所有参考文献的10%左右。所有六名患者都表示,他们认为将音乐疗法作为当前治疗的辅助疗法是有益的。我们的分析表明,患有AN的人主要将音乐与积极的情绪和记忆联系在一起。治疗师可能会考虑在治疗AN患者的过程中更频繁地使用音乐,并考虑将音乐疗法添加到他们的整体治疗理念中。然而,研究结果也表明,音乐不仅可以积极地影响情绪,也可以消极地影响情绪。为了验证这些结果,有必要在更大的患者样本中进行定量研究和随机临床试验。
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引用次数: 3
Weight Management: Inflammation 体重管理:炎症
Pub Date : 2020-05-06 DOI: 10.5772/intechopen.92380
Upasana
Nowadays, obesity is considered as one of the fastest escalating nutritional disorders that reached pandemic throughout the world. Obesity is a condition in which overaccumulation of energy in the form of fat happens in an individual’s subcutaneous and/or abdominal visceral tissue. It is described as an abnormal growth of adipose tissue due to the enlargement of fat cell size (hypertrophic obesity) or fat cell number (hyperplastic obesity) or a condition of both. Earlier, it was reported that the most common type of obesity that affects the general popula-tion is the polygenic form that results from a result of a positive energy balance between energy consumption and its expenditure – or a combination of both. The pandemic of obesity has enforced to analyze the link between the role of inflammation and complications of overweight and obesity. This led to crossroads of the field of nutrition, diet therapy, physiology, immunology, and epidemiology and makes the understanding that they are linked inexplicably. The remodeling of obesity as an inflammatory state has led a wide impression in our conceptualization of obesity-related diseases. In this chapter, we highlight the endocrine aspect of adipose tissue, the effect of dysregulated secretion of adipokines due to inflammation and dietary components that affect obesity related to inflammation.
如今,肥胖被认为是全球范围内发展最快的营养失调疾病之一。肥胖是指能量以脂肪的形式过度积累在个人的皮下和/或腹部内脏组织中。它被描述为由于脂肪细胞大小(肥厚性肥胖)或脂肪细胞数量(增生性肥胖)增加或两者兼而有之而导致的脂肪组织的异常生长。早些时候,有报道称,影响普通人群的最常见的肥胖类型是多基因型,它是由能量消耗和能量消耗之间的正能量平衡造成的,或者两者兼而有之。肥胖的流行迫使人们分析炎症的作用与超重和肥胖并发症之间的联系。这导致了营养学、饮食疗法、生理学、免疫学和流行病学领域的交叉,并使人们认识到它们之间有着不可解释的联系。肥胖作为炎症状态的重塑在我们对肥胖相关疾病的概念化中引起了广泛的印象。在本章中,我们强调脂肪组织的内分泌方面,炎症引起的脂肪因子分泌失调的影响以及与炎症有关的影响肥胖的饮食成分。
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引用次数: 0
Long-Term Weight Loss Maintenance 长期减肥维护
Pub Date : 2020-04-29 DOI: 10.5772/intechopen.92103
M. Fischer, N. Oberänder, A. Weimann
Weight maintenance can be considered a challenge for all patients who are in a reduced obese state. In this chapter, we first provide an overview of the chances for maintaining weight loss, how physiological adaptations and psychological dynamics lead to weight regain in the long-term, and of the factors that have been associated with long-term success. Then we review what is known about the patient perspective on that critical time period following weight loss, focusing on the experience of barriers and facilitators as well as attempted strategies. Finally, we introduce an approach for providing a targeted and individualized support at this stage.
对于所有处于肥胖减轻状态的患者来说,体重维持都是一个挑战。在本章中,我们首先概述了维持体重减轻的机会,生理适应和心理动态如何导致长期体重恢复,以及与长期成功相关的因素。然后,我们回顾了已知的患者对减肥后关键时期的看法,重点关注障碍和促进因素以及尝试策略的经验。最后,我们介绍了在此阶段提供有针对性和个性化支持的方法。
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引用次数: 0
Gut Microbiome in Obesity Management 肠道微生物组在肥胖管理中的作用
Pub Date : 2020-04-16 DOI: 10.5772/intechopen.91974
H. Heshmati
Obesity is a worldwide pandemic causing increased morbidity/mortality and high cost for the society. Management of obesity requires multidisciplinary approaches including diet, food supplement, exercise, behavior change, drug, medical device, gut microbiome manipulation, and surgery. Over the past two decades, there has been a growing awareness of the importance of gut microbiome in human health and disease. Profound changes affecting the diversity and the abundance of gut microbiome are associated with several disorders including obesity. A decrease in microbiome diversity and an increase in the ratio of Firmicutes-to-Bacteroidetes phyla have been reported in obese subjects. The gut microbiome can be manipulated to change the host metabolism and manage obesity. Potential interventions include diet (e.g., low calories, low fat, and high fiber), prebiotics (e.g., inulin, lactulose, and resistant starch), probiotics (e.g., yogurt, cheese, and milk), synbiotics (combination of prebiotics and probiotics), bariatric surgery (e.g., Roux-en-Y gastric bypass), and fecal microbiota transplantation (through colonoscopy, esophagogastroduodenoscopy, orogastric tube, or oral capsule). A better understanding of the interactions between different diets and gut microbiome should help the development of new guidelines for the prevention and management of obesity.
肥胖是一种世界性的流行病,造成发病率/死亡率增加和社会成本高。肥胖的管理需要多学科的方法,包括饮食、食物补充、运动、行为改变、药物、医疗设备、肠道微生物组操作和手术。在过去的二十年里,人们越来越意识到肠道微生物群在人类健康和疾病中的重要性。影响肠道微生物群多样性和丰度的深刻变化与包括肥胖在内的几种疾病有关。据报道,肥胖受试者的微生物群多样性下降,厚壁菌门与拟杆菌门的比例增加。肠道微生物组可以被操纵来改变宿主的新陈代谢和控制肥胖。潜在的干预措施包括饮食(如低热量、低脂肪和高纤维)、益生元(如菊糖、乳果糖和抗性淀粉)、益生菌(如酸奶、奶酪和牛奶)、合成菌(益生元和益生菌的组合)、减肥手术(如Roux-en-Y胃旁路术)和粪便微生物群移植(通过结肠镜检查、食管胃十二指肠镜检查、口胃管或口服胶囊)。更好地了解不同饮食和肠道微生物群之间的相互作用应该有助于制定预防和管理肥胖的新指南。
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引用次数: 1
Effect of Foot Morphology and Anthropometry on Bipedal Postural Balance 足部形态和人体测量对两足姿势平衡的影响
Pub Date : 2020-04-15 DOI: 10.5772/intechopen.92149
C. Hemant
Maintenance of accurate postural balance is imperative to avoid falls and inca-pacities especially in overweight and older population. Normal postural balance is affected by various factors like age, gender, body characteristics like lean muscle mass, soft tissue mass, stature, foot anthropometry, etc. A cross-sectional study was conducted among 1000 young population of north Karnataka in which human stature, weight, body mass index, foot anthropometric parameters, etc. along with postural sway were measured. The correlation of these parameters with human stature, weight and postural sway was studied. Data obtained were tabulated, graphically represented and statistically analyzed. Correlation coefficient was for-mulated for each variable. Foot length and width showed positive significant correlation with height, weight and other variables. Study observations were compared with those obtained from previous studies. The study observations will enable us to understand the influence of foot anthropometry on postural balance and help researchers to formulate weight transfer strategies, thereby facilitating management and rehabilitation of patients with postural instability.
保持准确的姿势平衡是避免跌倒和痴呆的必要条件,尤其是在超重和老年人群中。正常的姿势平衡受到各种因素的影响,如年龄、性别、瘦肌肉量、软组织量、身高、足部人体测量等身体特征。在卡纳塔克邦北部的1000名年轻人中进行了一项横断面研究,测量了他们的身高、体重、身体质量指数、足部人体测量参数等以及姿势摇摆。研究了这些参数与人体身高、体重和体位摇摆的相关性。获得的数据被制成表格,用图形表示并进行统计分析。计算了各变量的相关系数。足长、足宽与身高、体重等变量呈显著正相关。研究结果与以前的研究结果进行了比较。研究结果将使我们了解足部人体测量对体位平衡的影响,帮助研究人员制定体重转移策略,从而促进体位不稳定患者的管理和康复。
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引用次数: 0
Orexin and Psychoneurobiology: A Hidden Treasure 食欲素和心理神经生物学:一个隐藏的宝藏
Pub Date : 2020-04-13 DOI: 10.5772/intechopen.91852
H. Al-kuraishy, Ali I. Al-Gareeb, Naseer A. Al-harchan
Orexin is a neuropeptide secreted from the lateral hypothalamus and prefrontal cortex concerned in wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin. A diversity of search strategies was adopted and assumed which included electronic database searches of Medline and PubMed using MeSH terms, keywords, and title words. Orexin plays a vital role in activation of learning, memory acquisition, and consolidation through activation of the monoaminergic system, which affects cognitive flexibility and cognitive function. Orexin stimulates adrenocorticotrophin (ACTH) and corticosteroid secretions via activation of the central corticotropin-releasing hormone (CRH). Cerebrospinal (CSF) and serum orexin serum levels are reduced in depression, schizophrenia, and narcolepsy. However, high orexin serum levels are revealed in drug addictions. Regarding neurodegenerative brain diseases, CSF and serum orexin levels are reduced in Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Orexin antagonist leads to significant reduction of sympathetic overactivity during withdrawal syndrome. Also, orexin antagonist improves sleep pattern. The orexinergic system is involved in different psychiatric and neurological disorders; therefore targeting of this system could be a possible novel pathway in the management of these disorders. In addition measurement of CSF and serum orexin levels might predict the relapse and withdrawal of addict patients.
食欲素是一种由外侧下丘脑和前额叶皮层分泌的神经肽,与清醒和兴奋有关。本研究旨在综述食欲素可能的神经生物学作用。采用并假设了多种搜索策略,包括使用MeSH术语、关键词和标题词对Medline和PubMed进行电子数据库搜索。食欲素通过激活单胺能系统,在学习、记忆获取和巩固中起着至关重要的作用,影响认知灵活性和认知功能。食欲素通过激活中枢促肾上腺皮质激素释放激素(CRH)刺激促肾上腺皮质激素(ACTH)和皮质类固醇的分泌。脑脊髓(CSF)和血清促食欲素水平在抑郁症、精神分裂症和嗜睡症中降低。然而,高促食欲素的血清水平显示在药物成瘾。关于神经退行性脑疾病,脑脊液和血清促食欲素水平在帕金森病(PD)、阿尔茨海默病(AD)、亨廷顿病(HD)、肌萎缩侧索硬化症(ALS)和多发性硬化症(MS)中降低。食欲素拮抗剂导致戒断综合征期间交感神经过度活动的显著减少。此外,食欲素拮抗剂改善睡眠模式。食欲能系统与不同的精神和神经疾病有关;因此,靶向该系统可能是治疗这些疾病的一种可能的新途径。此外,脑脊液和血清促食欲素水平的测定可以预测成瘾患者的复发和戒断。
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引用次数: 0
Anti-Obesity Medical Devices 抗肥胖医疗设备
Pub Date : 2020-03-19 DOI: 10.5772/intechopen.91697
H. Heshmati
Obesity is a major health problem worldwide responsible for increased mor-bidity/mortality and high cost for the society. Management of obesity requires multidisciplinary approaches including diet, food supplement, exercise, behavior change, drug, medical device, gut microbiome manipulation, and surgery. Antiobesity medical devices are an option for subjects who have not responded to more conservative medical treatments but want an alternative to surgery. Compared to bariatric surgery, they have the advantage of being less invasive, easier to perform, and reversible. In the United States of America (USA), based on the expected weight loss, the Center for Devices and Radiological Health (CDRH) of the Food and Drug Administration (FDA) categorizes anti-obesity medical devices as weight-loss devices or weight-management devices. The weight-loss devices include gastric band devices, gastric space-occupying devices, and gastric emptying devices. The weight-management devices include oral removable palatal space-occupying devices and ingested transient gastric space-occupying devices. The effectiveness, safety, and cost of anti-obesity medical devices vary considerably by the type of medical device. Their use should always be combined with lifestyle changes. Considering the large market size of obesity treatment, anti-obesity medical devices can play a major role in the management of obesity.
肥胖是世界范围内的一个主要健康问题,造成了发病率/死亡率的增加和社会成本的高昂。肥胖的管理需要多学科的方法,包括饮食、食物补充、运动、行为改变、药物、医疗设备、肠道微生物组操作和手术。对于那些对更保守的药物治疗没有反应但想要替代手术的受试者来说,抗肥胖医疗设备是一个选择。与减肥手术相比,它们的优点是侵入性较小,更容易实施,并且可逆。在美利坚合众国(USA),根据预期的体重减轻,食品和药物管理局(FDA)的器械和放射健康中心(CDRH)将抗肥胖医疗器械分类为减肥器械或体重管理器械。所述减肥装置包括胃带装置、胃占位装置和胃排空装置。体重管理装置包括口腔可移动腭占位装置和摄入的瞬时胃占位装置。抗肥胖医疗设备的有效性、安全性和成本因医疗设备的类型而有很大差异。它们的使用应该与生活方式的改变相结合。考虑到肥胖治疗的巨大市场规模,抗肥胖医疗设备可以在肥胖的管理中发挥重要作用。
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引用次数: 2
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Obesity and weight management
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