Pub Date : 2022-11-17DOI: 10.46610/rapls.2022.v04i02.005
Twinkle Gautam, Rashi Rai, Abhinav K. Srivastava
One of the main macromolecules found in the human body is lipids, along with proteins, nucleic acids, and carbs. Lipids, however, are not polymers because they are not made up of monomers, in contrast to the other macro biomolecules. Because hydrocarbon chains (-CH2-CH2-CH2-CH2-) predominate in their structures, they are hydrophobic by nature. Lipids participate in a range of signalling pathways; serve as structural components of cell membranes, and store energy, among other functions, in many crucial biological processes. Robert Boyle noticed a milky look in the animal blood that was collected after their feed in 1665. Later, in 1774, Henson discovered that the milky liquid contained fat. The period of intensive research on these compounds is from the 18th to the 19th century. The idea that fat is a necessary ingredient for both humans and animals first gained traction in 1827, along with carbohydrates and protein. The overall structure, characteristics, classification, and functions of lipids in various organisms are presented in this article.
{"title":"Role of Lipids in Biological System","authors":"Twinkle Gautam, Rashi Rai, Abhinav K. Srivastava","doi":"10.46610/rapls.2022.v04i02.005","DOIUrl":"https://doi.org/10.46610/rapls.2022.v04i02.005","url":null,"abstract":"One of the main macromolecules found in the human body is lipids, along with proteins, nucleic acids, and carbs. Lipids, however, are not polymers because they are not made up of monomers, in contrast to the other macro biomolecules. Because hydrocarbon chains (-CH2-CH2-CH2-CH2-) predominate in their structures, they are hydrophobic by nature. Lipids participate in a range of signalling pathways; serve as structural components of cell membranes, and store energy, among other functions, in many crucial biological processes. Robert Boyle noticed a milky look in the animal blood that was collected after their feed in 1665. Later, in 1774, Henson discovered that the milky liquid contained fat. The period of intensive research on these compounds is from the 18th to the 19th century. The idea that fat is a necessary ingredient for both humans and animals first gained traction in 1827, along with carbohydrates and protein. The overall structure, characteristics, classification, and functions of lipids in various organisms are presented in this article.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79287662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-02DOI: 10.46610/rapls.2022.v04i02.002
Sunitha N., P. Paul, M. a, Sravya D., S. P., Jaswanth V., L. Y., M. S
The project was considered to validate and develop an accurate, simple and precise, UV-Visible spectrophotometric, Thin Layer Chromatography (TLC) and Fourier transform Infrared Spectroscopy (FTIR) method for the estimation of Metformin present in extract of Bougainvillea California Gold flowers by using distilled water as solvent at a wavelength of 232 nm. The linearity of the metformin is 10-50 μg/ml with y = 0.0011x - 0.0006 as the regression equation r2 value was 0.9977. Recovery values for Metformin present in Bougainvillea California Gold flowers extract powder is found to 98.45% - 99.16%. The RSD % of intraday precision and intraday precision is 16.67 % and 61.53% respectively. LOQ and LOD values are 0.26 μg/ml and 0.0.08μg/mL respectively. The robustness %RSD values method was 64.38 – 64.66. Rf value of the extract was found to be 0.586 with 60:40 (methanol and water) in TLC. IR interpretation of both bougainvillea California gold flowers extract and Meformin were found to be similar. So the method was simple, precise, exact and economical. This method could be applicable for quantitative determination of the metformin in Bougainvillea California gold flowers extract.
{"title":"Validation and Development of Metformin obtained from the Extraction of Bougainvillea California Gold Flowers by UV Spectrophotometry, TLC and FTIR","authors":"Sunitha N., P. Paul, M. a, Sravya D., S. P., Jaswanth V., L. Y., M. S","doi":"10.46610/rapls.2022.v04i02.002","DOIUrl":"https://doi.org/10.46610/rapls.2022.v04i02.002","url":null,"abstract":"The project was considered to validate and develop an accurate, simple and precise, UV-Visible spectrophotometric, Thin Layer Chromatography (TLC) and Fourier transform Infrared Spectroscopy (FTIR) method for the estimation of Metformin present in extract of Bougainvillea California Gold flowers by using distilled water as solvent at a wavelength of 232 nm. The linearity of the metformin is 10-50 μg/ml with y = 0.0011x - 0.0006 as the regression equation r2 value was 0.9977. Recovery values for Metformin present in Bougainvillea California Gold flowers extract powder is found to 98.45% - 99.16%. The RSD % of intraday precision and intraday precision is 16.67 % and 61.53% respectively. LOQ and LOD values are 0.26 μg/ml and 0.0.08μg/mL respectively. The robustness %RSD values method was 64.38 – 64.66. Rf value of the extract was found to be 0.586 with 60:40 (methanol and water) in TLC. IR interpretation of both bougainvillea California gold flowers extract and Meformin were found to be similar. So the method was simple, precise, exact and economical. This method could be applicable for quantitative determination of the metformin in Bougainvillea California gold flowers extract.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80937570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.46610/rapls.2022.v04i01.001
U. P. Singh, Anubha Gupta, Rajeev Kumar, Abhinav K. Srivastava
Ring chromosomes are formed due to rejoining or breaking in either one or both the chromosome arms. Any chromosome can form such structure and thus a specific ring chromosome will have an altogether distinct size and inherited content. Of intrigue are ring chromosomes 14 and X that have a remarkable relationship with epilepsy and seizure beginning in early years of life. Phenotypic characteristics associated with ring chromosomes are very much disparate and this may be due to any deletion caused by ring arrangement. Other reason may be the imbalances occurred due to ring instability. Extreme deficiency of development without major deformity is a very usual observation in the carrier of the ring chromosomes. Such phenotypic expressions are termed as "ring disorder" and they are strictly related with mitotic instability and ring behavior and does not dependent on the chromosome engaged. In case of ring chromosomes, it is not possible to exactly correlate genotype-phenotype because all the determining factors mostly variegate depending on the magnitude of deletion during ring development. Also, ring instability and the level of mosaicism add extra degree of pleomorphism. In spite of the fact that ring chromosomes generally emerge as de-novo events, filial transmission of rings from carrier to progeny is portrayed and pre-birth diagnosis for any pregnancies should be appraised.
{"title":"Ring Chromosomes and Associated Disorders: A Review","authors":"U. P. Singh, Anubha Gupta, Rajeev Kumar, Abhinav K. Srivastava","doi":"10.46610/rapls.2022.v04i01.001","DOIUrl":"https://doi.org/10.46610/rapls.2022.v04i01.001","url":null,"abstract":"Ring chromosomes are formed due to rejoining or breaking in either one or both the chromosome arms. Any chromosome can form such structure and thus a specific ring chromosome will have an altogether distinct size and inherited content. Of intrigue are ring chromosomes 14 and X that have a remarkable relationship with epilepsy and seizure beginning in early years of life. Phenotypic characteristics associated with ring chromosomes are very much disparate and this may be due to any deletion caused by ring arrangement. Other reason may be the imbalances occurred due to ring instability. Extreme deficiency of development without major deformity is a very usual observation in the carrier of the ring chromosomes. Such phenotypic expressions are termed as \"ring disorder\" and they are strictly related with mitotic instability and ring behavior and does not dependent on the chromosome engaged. In case of ring chromosomes, it is not possible to exactly correlate genotype-phenotype because all the determining factors mostly variegate depending on the magnitude of deletion during ring development. Also, ring instability and the level of mosaicism add extra degree of pleomorphism. In spite of the fact that ring chromosomes generally emerge as de-novo events, filial transmission of rings from carrier to progeny is portrayed and pre-birth diagnosis for any pregnancies should be appraised.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83805660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.46610/rapls.2021.v03i02.001
Septiani Mangiwa
The Itchy leaf [Laportea decumana (Roxb.) Wedd] is a plant that is widely used as traditional medicine by Papuans as a pain reliever. The purpose of this study was to determine the total level of alkaloids in itchy leaf extract and to test the cytotoxic activity using the BSLT method. The research series began with the extraction stage with the maceration method using 96% ethanol, which tested the alkaloid level. The test was carried out using the gravimetric method and the cytotoxic test using the alkaloid level test results using the BSLT method on shrimp larvae (Artemia salina L). The results showed that itchy leaf extract contained a total alkaloid level of 6.46%. Cytotoxic testing using the BSLT method showed an LC50 of 54.33 ppm and was found to be toxic.
{"title":"Alkaloid Cytotoxic Test on Ethanol Extract from Itchy Leaves (Laportea decumana (Roxb.) Wedd.)","authors":"Septiani Mangiwa","doi":"10.46610/rapls.2021.v03i02.001","DOIUrl":"https://doi.org/10.46610/rapls.2021.v03i02.001","url":null,"abstract":"The Itchy leaf [Laportea decumana (Roxb.) Wedd] is a plant that is widely used as traditional medicine by Papuans as a pain reliever. The purpose of this study was to determine the total level of alkaloids in itchy leaf extract and to test the cytotoxic activity using the BSLT method. The research series began with the extraction stage with the maceration method using 96% ethanol, which tested the alkaloid level. The test was carried out using the gravimetric method and the cytotoxic test using the alkaloid level test results using the BSLT method on shrimp larvae (Artemia salina L). The results showed that itchy leaf extract contained a total alkaloid level of 6.46%. Cytotoxic testing using the BSLT method showed an LC50 of 54.33 ppm and was found to be toxic.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90612301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-15DOI: 10.46610/RAPLS.2021.V03I01.003
R. Sethi, G. F. Avetisyan, Sanobar Shariff, Burhan Kantawala
{"title":"The Sojourn Drain Effects on Tissue Healing in Postoperative Patients in Abdominal Surgeries: A Correlation of Prophylactic Antibiotic Administration and Complications","authors":"R. Sethi, G. F. Avetisyan, Sanobar Shariff, Burhan Kantawala","doi":"10.46610/RAPLS.2021.V03I01.003","DOIUrl":"https://doi.org/10.46610/RAPLS.2021.V03I01.003","url":null,"abstract":"","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"721 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76915321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Establishing a positive work environment is critical for successful outcomes and optimized performance. In a high-stakes arena such as healthcare, having all individuals engaged and ready to be part of the team is crucial. In this paper, we highlight a novel strategy for establishing effective communication and breaking down barriers. Through the implementation of a positive culture committee the neurosurgical department will improve relationships and performance. Goals and different strategies are addressed in the discussion. As implementation is underway, we plan to measure improved performance metrics in the coming years.
{"title":"An Approach to Improving Clinical Morale: Targeting a Positive Culture.","authors":"Jonathan Willman, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Establishing a positive work environment is critical for successful outcomes and optimized performance. In a high-stakes arena such as healthcare, having all individuals engaged and ready to be part of the team is crucial. In this paper, we highlight a novel strategy for establishing effective communication and breaking down barriers. Through the implementation of a positive culture committee the neurosurgical department will improve relationships and performance. Goals and different strategies are addressed in the discussion. As implementation is underway, we plan to measure improved performance metrics in the coming years.</p>","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":"3 2","pages":"36-39"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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