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Neuropsychiatric manifestations of sarcoidosis. 结节病的神经精神表现。
Pub Date : 2025-12-01 Epub Date: 2024-12-26 DOI: 10.1080/07853890.2024.2445191
Claudio Tana, Nicol Bernardinello, Bianca Raffaelli, David Garcia-Azorin, Marta Waliszewska-Prosół, Marco Tana, Giulio Albano, Francesco Cipollone, Maria Adele Giamberardino, Paolo Spagnolo

Background: There has been significant progress in understanding neurosarcoidosis (NS) as a distinct disorder, which encompasses a heterogeneous group of clinical and radiological alterations which can affect patients with systemic sarcoidosis or manifest isolated.

Rationale and aim of the study: The healthcare challenges posed by NS and sarcoidosis in general extend beyond their physical symptoms and can include a variety of psychosocial factors, therefore the recognition of main neuropsychiatric symptoms can be useful to approach patients with NS. Methods: For this purpose, databases such as Pubmed, Medline and Pubmed Central (PMC) have been searched.

Results: A correct diagnosis of NS is established by the combination of clinical picture, imaging features and the histopathological finding of non-caseating and non-necrotizing granulomas. After analyzing the current literature, there is a need for specific, case-control, cohort and clinical trials on the psychiatric manifestations of sarcoidosis, because the evaluation of psychological distress (in terms of emotional suffering e.g. anxiety or depression) is often underestimated.

Discussion and conclusion: Exploring the neuropsychiatric manifestations of sarcoidosis is useful to raise awareness of this condition among clinicians and to establish a holistic management, which includes both physical and psychological aspects.

背景:对神经结节病(NS)作为一种独特疾病的认识已经取得了重大进展,它包括一组异质性的临床和影像学改变,这些改变可以影响全身性结节病患者或表现为孤立的。研究的基本原理和目的:NS和结节病带来的医疗挑战通常超出了身体症状,可能包括各种社会心理因素,因此识别主要的神经精神症状对NS患者的治疗是有用的。方法:为此,检索Pubmed、Medline和Pubmed Central (PMC)等数据库。结果:结合非干酪化和非坏死性肉芽肿的临床表现、影像学特征和组织病理学表现,建立NS的正确诊断。在对现有文献进行分析后,由于对结节病的心理困扰(如焦虑或抑郁等情绪痛苦)的评估往往被低估,因此需要对结节病的精神表现进行特异性、病例对照、队列和临床试验。讨论与结论:探讨结节病的神经精神表现有助于提高临床医生对该病的认识,并建立包括生理和心理方面的整体治疗方法。
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引用次数: 0
Occurrence and associated factors of self-reported medical errors among Chinese physicians and nurses: a cross-sectional survey. 中国医师和护士自我报告医疗差错的发生及相关因素:一项横断面调查。
Pub Date : 2025-12-01 Epub Date: 2024-12-26 DOI: 10.1080/07853890.2024.2445187
Zejun Li, Liyan Liu, Xiaoyu Zhang, Kewen Yan, Xin Wang, Min Wu, Huixue Xu, Yueheng Liu, Qianjin Wang, Manyun Li, Yuzhu Hao, Li He, Yunfei Wang, Qijian Deng, Tieqiao Liu, Pu Peng, Qiuxia Wu

Background: Medical errors (MEs) significantly threaten patient safety globally. This study aimed to explore multidimensional factors associated with self-reported MEs among Chinese physicians and nurses.

Methods: A cross-sectional online survey using snowball sampling collected 7197 valid responses from Chinese physicians and nurses between October 2020 and April 2022. A self-reported question assessed MEs within the past three months. Sociodemographic characteristics, work-related factors, and mental distress were collected. Data were analyzed using stepwise logistic regression.

Results: 1285 (17.9%) physicians and nurses self-reported MEs during the previous 3 months. Factors associated with higher odds of self-reported MEs included male sex (OR: 1.44, 95% CI: 1.23-1.69), physician status (OR: 1.48, 95% CI: 1.26-1.73), history of mental illness (OR: 1.49, 95% CI: 1.16-1.91), longer weekly working hours (OR: 1.20-1.23, 95% CI: 1.03-1.47), workplace violence experience (OR: 1.54-1.75, 95% CI: 1.30-2.17), and dissatisfaction with the medical practice environment (OR: 1.20, 95% CI: 1.05-1.37). Conversely, being married (OR: 0.74, 95% CI: 0.62-0.89), holding a bachelor's degree or higher (OR: 0.82, 95% CI: 0.70-0.97), and having more years of professional practice (OR: 0.96, 95% CI: 0.95-0.97) were associated with lower odds of self-reported MEs. Self-reported MEs were significantly and positively correlated with burnout (OR: 1.40, 95% CI: 1.20-1.62), depressive symptoms (OR: 1.38-1.45, 95% CI: 1.04-1.84), perceived stress (OR: 1.28-1.62, 95% CI: 1.06-2.02), and excessive daytime sleepiness (OR: 1.27-1.46, 95% CI: 1.10-1.79).

Conclusions: Self-reported MEs are relatively common among Chinese physicians and nurses, and are associated with various factors. Poor workplace conditions and mental distress are linked to an increased risk of MEs. Implementing effective interventions to improve workplace conditions and mental health is crucial for reducing MEs.

背景:医疗差错严重威胁着全球患者的安全。本研究旨在探讨中国医师和护士自我报告MEs的相关多维因素。方法:采用滚雪球抽样的横断面在线调查方法,在2020年10月至2022年4月期间收集了7197名中国医生和护士的有效回复。一个自我报告的问题评估了中小企业在过去三个月内的表现。收集社会人口学特征、工作相关因素和精神困扰。数据分析采用逐步逻辑回归。结果:1285名(17.9%)医生和护士在过去3个月内自我报告了MEs。与自我报告的MEs较高几率相关的因素包括男性(OR: 1.44, 95% CI: 1.23-1.69)、医生身份(OR: 1.48, 95% CI: 1.26-1.73)、精神病史(OR: 1.49, 95% CI: 1.16-1.91)、较长的每周工作时间(OR: 1.20-1.23, 95% CI: 1.03-1.47)、工作场所暴力经历(OR: 1.54-1.75, 95% CI: 1.30-2.17)和对医疗实践环境的不满(OR: 1.20, 95% CI: 1.05-1.37)。相反,已婚(OR: 0.74, 95% CI: 0.62-0.89)、拥有学士学位或更高学位(OR: 0.82, 95% CI: 0.70-0.97)和拥有更多年的专业实践(OR: 0.96, 95% CI: 0.95-0.97)与自我报告的MEs的几率较低相关。自我报告的MEs与倦怠(OR: 1.40, 95% CI: 1.20-1.62)、抑郁症状(OR: 1.38-1.45, 95% CI: 1.04-1.84)、感知压力(OR: 1.28-1.62, 95% CI: 1.06-2.02)和白天过度嗜睡(OR: 1.27-1.46, 95% CI: 1.10-1.79)显著正相关。结论:自我报告的MEs在我国医护人员中较为普遍,且与多种因素有关。恶劣的工作环境和精神困扰与MEs的风险增加有关。实施有效干预措施,改善工作场所条件和精神健康,对于减少MEs至关重要。
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引用次数: 0
Health system responsiveness: comparison of different levels of medical institutions in Kunshan City, China. 卫生系统响应:昆山市不同层次医疗机构比较
Pub Date : 2025-12-01 Epub Date: 2025-01-04 DOI: 10.1080/07853890.2024.2446693
Zhuang Hong, Jing Lu, Gang Chen, Qi Tang, Heqi Sun, Ting Wei, Sitang Zhao, Jun Lu

Background: Evaluation of health system responsiveness (HSR) can improve patient satisfaction, promote health equity and enhance the quality of health services.

Objectives: To explore the differences in HSR among medical institutions at different levels and in various domains.

Methods: A multi-stage stratified sampling method was used to select 820 participants aged 18 years and older from Kunshan City, China. Analysis of variance was used for univariate analysis. Linear regression and ordinal logistics were applied to explore the relationship between different hospital levels and HSR. Forest plots were used to illustrate the relationship between each domain and the hospital level.

Results: The relationship between hospital level and HSR remained significant (p < 0.05). Compared with primary healthcare institutions, secondary hospitals had lower HSR scores (β = -1.47, 95%CI = [-2.15, -0.79], p < 0.001). Similarly, tertiary hospitals had lower HSR scores compared with primary healthcare institutions (β = -1.54, 95%CI = [-2.39, -0.70], p < 0.001). The study found that attention, communication, basic amenities, social support, and the choice of healthcare providers were lower in secondary hospitals compared to primary healthcare institutions (OR < 1; p < 0.05). In tertiary hospitals, attention, communication, autonomy, basic amenities, social support, and the choice of healthcare provider were lower compared to primary healthcare institutions (OR < 1; p < 0.05).

Conclusions: By comparing the HSR of hospitals at different levels, the study identified areas for improvement. Particularly, urgent improvements are needed in prompt attention, communication, basic amenities, social support and the choice of healthcare providers.

背景:卫生系统响应性评价(HSR)可以提高患者满意度,促进卫生公平,提高卫生服务质量。目的:探讨不同层次、不同领域医疗机构HSR的差异。方法:采用多阶段分层抽样的方法,在昆山市抽取18岁及以上年龄人群820名。单因素分析采用方差分析。采用线性回归和有序logistic方法探讨不同医院级别与高铁的关系。使用森林图来说明每个域与医院层之间的关系。结果:医院级别与高铁率之间存在显著关系(p p p p p p)。结论:通过对不同级别医院高铁率的比较,研究发现了需要改进的地方。特别是,迫切需要在及时关注、沟通、基本便利设施、社会支持和选择医疗保健提供者方面进行改进。
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引用次数: 0
Bleeding risk and prediction model to predict bleeding risk of tissue biopsy for definitive diagnosis in patients with suspected amyloidosis. 预测疑似淀粉样变性患者组织活检确诊出血风险的出血风险和预测模型。
Pub Date : 2025-12-01 Epub Date: 2025-01-12 DOI: 10.1080/07853890.2025.2453088
Watsamon Uraiwan, Pirun Saelue

Introduction: Bleeding from the affected organs is a common manifestation of amyloidosis. The risk for perioperative bleeding in patients with amyloidosis remains controversial. In this study, we aimed to compare the bleeding risk of tissue biopsies for a definitive diagnosis between patients with and without amyloidosis, identify risk factors, and generate a prediction model for bleeding risk in these patients.

Methods: We enrolled patients aged >15 years who had amyloidosis as part of their differential diagnosis before tissue biopsy. After obtaining histopathological reports, we randomly selected patients with and without amyloidosis at a ratio of 4:1.

Results: A total of 360 patients were enrolled before tissue biopsy. Bleeding complications were observed in 5.6% and 4.2% of patients with and without amyloidosis, respectively. Amyloidosis was not associated with an increased perioperative bleeding risk (adjusted odds ratio 1.19; 95% confidence interval 0.17-8.41, p = 0.859). Kidney biopsy was a significant risk factor for perioperative bleeding in tissue biopsies. A KiHPL model was generated to predict the bleeding risk. The area under the curve was 0.87, with a good calibration plot for this model.

Conclusions: Amyloidosis is not associated with an increased risk of bleeding in tissue biopsies. The KiHPL model can predict the bleeding risk of tissue biopsies for a definitive diagnosis in patients with suspected amyloidosis.

导读:受影响器官的出血是淀粉样变性的常见表现:受影响器官的出血是淀粉样变性的常见表现。淀粉样变性患者围手术期出血的风险仍存在争议。在这项研究中,我们旨在比较淀粉样变性患者和非淀粉样变性患者为明确诊断而进行组织活检的出血风险,确定风险因素,并生成一个预测这些患者出血风险的模型:我们招募了年龄大于15岁、在组织活检前将淀粉样变性作为鉴别诊断一部分的患者。在获得组织病理学报告后,我们以 4:1 的比例随机选择了患有和未患有淀粉样变性的患者:结果:共有 360 名患者在组织活检前接受了检查。淀粉样变性患者和非淀粉样变性患者中分别有 5.6% 和 4.2% 出现出血并发症。淀粉样变性与围手术期出血风险增加无关(调整后的几率比1.19;95%置信区间0.17-8.41,P = 0.859)。肾活检是组织活检围手术期出血的重要风险因素。我们建立了一个 KiHPL 模型来预测出血风险。该模型的曲线下面积为0.87,校准图良好:结论:淀粉样变性与组织活检出血风险增加无关。KiHPL模型可以预测组织活检的出血风险,从而对疑似淀粉样变性患者做出明确诊断。
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引用次数: 0
Comparative genetic analysis of blood and semen samples in sperm donors from Hunan, China. 中国湖南捐精者血液和精液样本的比较遗传分析。
Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1080/07853890.2024.2447421
Chuan Huang, Li-Ming Chu, Bo Liang, Hui-Lan Wu, Bai-Shun Li, Shuai Ren, Mei-Ling Hou, Hong-Chuan Nie, Ling-Yin Kong, Li-Qing Fan, Juan Du, Wen-Bing Zhu

Objectives: At present, most genetic tests or carrier screening are performed with blood samples, and the known carrier rate of disease-causing variants is also derived from blood. For semen donors, what is really passed on to offspring is the pathogenic variant in their sperm. This study aimed to determine whether pathogenic variants identified in the sperm of young semen donors are also present in their blood, and whether matching results for blood are consistent with results for sperm.

Methods: We included 40 paired sperm and blood samples from 40 qualified semen donors at the Hunan Province Human Sperm Bank of China. All samples underwent exome sequencing (ES) analysis, and the pathogenicity was assessed according to the American College of Medical Genetics (ACMG) guidelines. Scoring for sperm donation matching, which was based on gene scoring and variant scoring, was also used to assess the consistency of sperm and blood genetic test results.

Results: A total of 108 pathogenic (P)/likely pathogenic (LP) variants in 82 genes were identified. The highest carrier had 7 variants, and there was also one donor did not carry any P/LP variant. On average, each donor carried 2.7 P/LP variants. Among all the P/LP variants, missense mutation was the dominant type and most of them were located in exonic regions. Chromosome 1 harboured the largest number of variants and no pathogenic copy number variants (CNV) was identified in semen donors. The P/LP variant of all the 40 semen donors was consistent by comparing sperm and blood. Except for one case that was slightly different, the rest simulated matching results for blood were all consistent with results for sperm.

Conclusions: It is reasonable to choose either blood or sperm for genetic screening in semen donors.

目的:目前,大多数基因检测或携带者筛查都是通过血液样本进行的,已知致病变异的携带者率也来源于血液。对于捐精者来说,真正传递给后代的是他们精子中的致病变异。这项研究的目的是确定在年轻捐精者精子中发现的致病变异是否也存在于他们的血液中,以及血液的匹配结果是否与精子的结果一致。方法:我们从中国湖南省人类精子库的40名合格的捐精者中收集了40对精子和血液样本。所有样本进行外显子组测序(ES)分析,并根据美国医学遗传学学院(ACMG)指南评估致病性。基于基因评分和变异评分的精子捐赠匹配评分也用于评估精子和血液基因检测结果的一致性。结果:共鉴定出82个基因的108个致病性(P)/可能致病性(LP)变异。最高的携带者有7个变异,也有一个供体没有携带任何P/LP变异。平均每个供者携带2.7个P/LP变异。在所有P/LP变异中,错义突变是显性突变类型,多数位于外显子区。1号染色体的变异数量最多,在精液供者中未发现致病性拷贝数变异(CNV)。通过比较精子和血液,所有40名捐精者的P/LP变异是一致的。除了一个案例略有不同,其余的血液模拟匹配结果都与精子的结果一致。结论:对捐精者进行血液或精子遗传筛查是合理的。
{"title":"Comparative genetic analysis of blood and semen samples in sperm donors from Hunan, China.","authors":"Chuan Huang, Li-Ming Chu, Bo Liang, Hui-Lan Wu, Bai-Shun Li, Shuai Ren, Mei-Ling Hou, Hong-Chuan Nie, Ling-Yin Kong, Li-Qing Fan, Juan Du, Wen-Bing Zhu","doi":"10.1080/07853890.2024.2447421","DOIUrl":"10.1080/07853890.2024.2447421","url":null,"abstract":"<p><strong>Objectives: </strong>At present, most genetic tests or carrier screening are performed with blood samples, and the known carrier rate of disease-causing variants is also derived from blood. For semen donors, what is really passed on to offspring is the pathogenic variant in their sperm. This study aimed to determine whether pathogenic variants identified in the sperm of young semen donors are also present in their blood, and whether matching results for blood are consistent with results for sperm.</p><p><strong>Methods: </strong>We included 40 paired sperm and blood samples from 40 qualified semen donors at the Hunan Province Human Sperm Bank of China. All samples underwent exome sequencing (ES) analysis, and the pathogenicity was assessed according to the American College of Medical Genetics (ACMG) guidelines. Scoring for sperm donation matching, which was based on gene scoring and variant scoring, was also used to assess the consistency of sperm and blood genetic test results.</p><p><strong>Results: </strong>A total of 108 pathogenic (P)/likely pathogenic (LP) variants in 82 genes were identified. The highest carrier had 7 variants, and there was also one donor did not carry any P/LP variant. On average, each donor carried 2.7 P/LP variants. Among all the P/LP variants, missense mutation was the dominant type and most of them were located in exonic regions. Chromosome 1 harboured the largest number of variants and no pathogenic copy number variants (CNV) was identified in semen donors. The P/LP variant of all the 40 semen donors was consistent by comparing sperm and blood. Except for one case that was slightly different, the rest simulated matching results for blood were all consistent with results for sperm.</p><p><strong>Conclusions: </strong>It is reasonable to choose either blood or sperm for genetic screening in semen donors.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2447421"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa. 化疗免疫治疗在鼻咽癌IVa期同步放化疗中的诱导作用。
Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/07853890.2025.2453091
Kun-Peng Wu, Qing-Qing Li, Xu-Qiang Luo, Xiao-Xi Wang, Yan-Zhen Lai, Dan Tian, Hong-Cheng Yang, Xue-Ling Wei, Lan-Ying Wang, Qiu-Ming Li, Dao Zhu, Si-Jie Chen, Yang-Si Li

Background: Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC. However, it remains unclear whether combining immunotherapy with standard induction chemotherapy enhances its efficacy. This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC.

Methods: This study analyzed 50 patients with stage IVa NPC between January 2020 and December 2023 in our hospital. Among them, 23 received induction chemoimmunotherapy, and 27 received induction chemotherapy. All patients underwent standard platinum-based concurrent intensity-modulated radiation therapy. We compared tumor response and toxicity during induction treatment and concurrent chemoradiotherapy (CCRT) between the two groups.

Results: The objective and complete response rates were significantly higher in the induction chemoimmunotherapy group compared to the induction chemotherapy group (95.7% vs 77.8%, and 39.1% vs 22.2%, respectively). All patients completed radical CCRT. Median follow-up was 24 months. Patients who received induction chemoimmunotherapy had longer event-free survival (EFS) compared to those who received induction chemotherapy (p = 0.029, Hazard Ratio and 95%confidence interval [CI]: 0.24 [0.07-0.85]). The 24-month EFS was higher in the induction chemoimmunotherapy group compared with the chemotherapy group (24-month EFS rates and 95%CI: 88.9% [95%CI: 68.3%-100%] vs 62.6% [95%CI: 43.1%-82.1%]). No significant differences in adverse events were observed between the two groups during induction treatment and CCRT.

Conclusions: Adding immunotherapy to induction chemotherapy may be an effective and safe choice for treating patients with stage IVa NPC.

背景:化疗免疫治疗是复发或转移性鼻咽癌(NPC)患者的一线治疗方案,也是目前局部区域晚期鼻咽癌患者的主要诱导治疗方案。然而,免疫治疗联合标准诱导化疗是否能提高其疗效尚不清楚。本研究旨在评估局部区域晚期鼻咽癌患者诱导化学免疫治疗的疗效、毒性和生存结果。方法:对2020年1月至2023年12月在我院收治的50例IVa期鼻咽癌患者进行分析。其中23例接受诱导化疗免疫治疗,27例接受诱导化疗。所有患者均接受了标准的以铂为基础的同步调强放疗。我们比较了两组在诱导治疗和同步放化疗(CCRT)期间的肿瘤反应和毒性。结果:诱导化疗免疫治疗组的客观有效率和完全有效率均显著高于诱导化疗组(95.7% vs 77.8%, 39.1% vs 22.2%)。所有患者均完成根治性CCRT。中位随访时间为24个月。与接受诱导化疗的患者相比,接受诱导化疗的患者无事件生存期(EFS)更长(p = 0.029,风险比和95%可信区间[CI]: 0.24[0.07-0.85])。诱导化学免疫治疗组24个月的EFS高于化疗组(24个月的EFS率和95%CI: 88.9% [95%CI: 68.3%-100%] vs 62.6% [95%CI: 43.1%-82.1%])。诱导治疗和CCRT期间两组不良事件发生率无显著差异。结论:在诱导化疗的基础上加用免疫治疗可能是治疗IVa期鼻咽癌患者安全有效的选择。
{"title":"Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa.","authors":"Kun-Peng Wu, Qing-Qing Li, Xu-Qiang Luo, Xiao-Xi Wang, Yan-Zhen Lai, Dan Tian, Hong-Cheng Yang, Xue-Ling Wei, Lan-Ying Wang, Qiu-Ming Li, Dao Zhu, Si-Jie Chen, Yang-Si Li","doi":"10.1080/07853890.2025.2453091","DOIUrl":"10.1080/07853890.2025.2453091","url":null,"abstract":"<p><strong>Background: </strong>Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC. However, it remains unclear whether combining immunotherapy with standard induction chemotherapy enhances its efficacy. This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC.</p><p><strong>Methods: </strong>This study analyzed 50 patients with stage IVa NPC between January 2020 and December 2023 in our hospital. Among them, 23 received induction chemoimmunotherapy, and 27 received induction chemotherapy. All patients underwent standard platinum-based concurrent intensity-modulated radiation therapy. We compared tumor response and toxicity during induction treatment and concurrent chemoradiotherapy (CCRT) between the two groups.</p><p><strong>Results: </strong>The objective and complete response rates were significantly higher in the induction chemoimmunotherapy group compared to the induction chemotherapy group (95.7% vs 77.8%, and 39.1% vs 22.2%, respectively). All patients completed radical CCRT. Median follow-up was 24 months. Patients who received induction chemoimmunotherapy had longer event-free survival (EFS) compared to those who received induction chemotherapy (<i>p</i> = 0.029, Hazard Ratio and 95%confidence interval [CI]: 0.24 [0.07-0.85]). The 24-month EFS was higher in the induction chemoimmunotherapy group compared with the chemotherapy group (24-month EFS rates and 95%CI: 88.9% [95%CI: 68.3%-100%] vs 62.6% [95%CI: 43.1%-82.1%]). No significant differences in adverse events were observed between the two groups during induction treatment and CCRT.</p><p><strong>Conclusions: </strong>Adding immunotherapy to induction chemotherapy may be an effective and safe choice for treating patients with stage IVa NPC.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2453091"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis. 缺血性卒中取栓后恶性脑水肿的神经影像学预测因素:系统回顾和荟萃分析。
Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/07853890.2025.2453635
Linrui Huang, Xindi Song, Jingjing Li, Yanan Wang, Xing Hua, Meng Liu, Ming Liu, Simiao Wu

Background: We systematically reviewed neuroimaging predictors for malignant brain oedema (MBE) after thrombectomy in patients with ischemic stroke.

Methods: We searched MEDLINE and EMBASE in November 2023 for studies of patients with ischemic stroke. We included studies investigating neuroimaging predictors or prediction models for MBE after thrombectomy. We estimated effect size for the association between predictors and MBE by odds ratios (ORs) or standardized mean differences (SMDs), and pooled results using random-effects modelling.

Results: We included 19 studies (n = 6007) with 17 neuroimaging factors and 5 models. Lower Alberta Stroke Program Early CT scores (ASPECTS, n = 3052, SMD -1.84, 95% CI -2.52 - -1.16; df = 9) and longer extent of arterial occlusion at baseline were associated with higher risk of MBE. Post-thrombectomy ASPECTS was associated with MBE in general stroke patients (n = 453, SMD -2.91, -4.02 - -1.79; df = 1), but not in successfully reperfused patients (n = 110, SMD 0.24, -0.16 - 0.65). Successful reperfusion reduced risk of MBE (n = 4851, OR 0.39, 0.30-0.51; df = 13). Contrast enhancement on CT after thrombectomy was associated with higher risk of MBE (n = 998, OR 4.82, 2.53-9.20; df = 4). More reserved brain volume capacity (baseline: n = 683, OR 0.83, 0.77-0.91, p < .001; post-thrombectomy: n = 329, OR 0.53, 0.37-0.77, p < .001) and good collaterals (baseline: n = 2301, OR 0.14, 0.10-0.20, df = 3; post-thrombectomy: n = 1006, OR 0.28, 0.15-0.51; df = 2) were associated with lower risk of MBE.

Conclusion: Lower ASPECTS and longer arterial occlusion at baseline, and post-thrombectomy CT contrast enhancement increased risk of MBE. Reperfusion after thrombectomy, more reserved brain volume and good collaterals at baseline and post-thrombectomy reduced its risk.

背景:我们系统地回顾了缺血性卒中患者取栓后恶性脑水肿(MBE)的神经影像学预测因素。方法:我们于2023年11月检索MEDLINE和EMBASE中缺血性脑卒中患者的研究。我们纳入了有关取栓后MBE的神经影像学预测或预测模型的研究。我们通过比值比(or)或标准化平均差异(SMDs)估计预测因子与MBE之间关联的效应大小,并使用随机效应模型汇总结果。结果:我们纳入了19项研究(n = 6007), 17个神经影像学因素和5个模型。早期CT评分(ASPECTS, n = 3052, SMD -1.84, 95% CI -2.52 -1.16;df = 9)和基线时较长的动脉闭塞程度与MBE的高风险相关。一般脑卒中患者取栓后ASPECTS与MBE相关(n = 453, SMD -2.91, -4.02 - -1.79;df = 1),但在再灌注成功的患者中没有(n = 110, SMD = 0.24, -0.16 - 0.65)。再灌注成功降低MBE风险(n = 4851, OR 0.39, 0.30-0.51;df = 13)。取栓后CT增强与MBE的高风险相关(n = 998, OR 4.82, 2.53-9.20;df = 4)。预留脑容量增加(基线:n = 683, OR 0.83, 0.77-0.91, p < 0.001;取栓后:n = 329, OR 0.53, 0.37-0.77, p < 0.001)和良好的侧支(基线:n = 2301, OR 0.14, 0.10-0.20, df = 3;取栓后:n = 1006, OR 0.28, 0.15-0.51;df = 2)与较低的MBE风险相关。结论:基线时较低侧面和较长的动脉闭塞以及取栓后CT增强可增加MBE的风险。取栓后再灌注、基线和取栓后更大的预留脑容量和良好的侧支可降低其风险。
{"title":"Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis.","authors":"Linrui Huang, Xindi Song, Jingjing Li, Yanan Wang, Xing Hua, Meng Liu, Ming Liu, Simiao Wu","doi":"10.1080/07853890.2025.2453635","DOIUrl":"10.1080/07853890.2025.2453635","url":null,"abstract":"<p><strong>Background: </strong>We systematically reviewed neuroimaging predictors for malignant brain oedema (MBE) after thrombectomy in patients with ischemic stroke.</p><p><strong>Methods: </strong>We searched MEDLINE and EMBASE in November 2023 for studies of patients with ischemic stroke. We included studies investigating neuroimaging predictors or prediction models for MBE after thrombectomy. We estimated effect size for the association between predictors and MBE by odds ratios (ORs) or standardized mean differences (SMDs), and pooled results using random-effects modelling.</p><p><strong>Results: </strong>We included 19 studies (<i>n</i> = 6007) with 17 neuroimaging factors and 5 models. Lower Alberta Stroke Program Early CT scores (ASPECTS, <i>n</i> = 3052, SMD -1.84, 95% CI -2.52 - -1.16; <i>df</i> = 9) and longer extent of arterial occlusion at baseline were associated with higher risk of MBE. Post-thrombectomy ASPECTS was associated with MBE in general stroke patients (<i>n</i> = 453, SMD -2.91, -4.02 - -1.79; <i>df</i> = 1), but not in successfully reperfused patients (<i>n</i> = 110, SMD 0.24, -0.16 - 0.65). Successful reperfusion reduced risk of MBE (<i>n</i> = 4851, OR 0.39, 0.30-0.51; <i>df</i> = 13). Contrast enhancement on CT after thrombectomy was associated with higher risk of MBE (<i>n</i> = 998, OR 4.82, 2.53-9.20; <i>df</i> = 4). More reserved brain volume capacity (baseline: <i>n</i> = 683, OR 0.83, 0.77-0.91, <i>p</i> < .001; post-thrombectomy: <i>n</i> = 329, OR 0.53, 0.37-0.77, <i>p</i> < .001) and good collaterals (baseline: <i>n</i> = 2301, OR 0.14, 0.10-0.20, <i>df</i> = 3; post-thrombectomy: <i>n</i> = 1006, OR 0.28, 0.15-0.51; <i>df</i> = 2) were associated with lower risk of MBE.</p><p><strong>Conclusion: </strong>Lower ASPECTS and longer arterial occlusion at baseline, and post-thrombectomy CT contrast enhancement increased risk of MBE. Reperfusion after thrombectomy, more reserved brain volume and good collaterals at baseline and post-thrombectomy reduced its risk.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2453635"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural or functional abnormality of sphincter of Oddi: an important factor for the recurrence of choledocholithiasis after endoscopic treatment. Oddi括约肌结构或功能异常:内镜治疗后胆总管结石复发的重要因素。
Pub Date : 2025-12-01 Epub Date: 2024-12-13 DOI: 10.1080/07853890.2024.2440119
Ye Yang, Zeying Zhao, Shuodong Wu, Dianbo Yao

A high recurrence rate is undesirable after treatment of common bile duct (CBD) stones. A major risk factor identified for recurrence is that invasive techniques, including surgical or endoscopic treatments, will impair the biliary tract system either by direct incision of the CBD or by cutting or dilating the ampulla of Vater. During endoscopic treatment, two main assisted methods for lithotomy, sphincterotomy and papillary balloon dilation, can result in different degrees of damage to the structure and function of the sphincter of Oddi (SO), contributing to slowing of biliary excretion, cholestasis, biliary bacterial infection, and promotion of bile duct stone recurrence. In this review, the relationship between endoscopic lithotomy and structural impairment or functional abnormality of the SO will be summarized, and their relationship with the recurrence of CBD stones will also be analyzed. Further improvement of these endoscopic methods or exploration of some novel methods, such as endoscopic endoclip papilloplasty, temporary insertion of a self-expandable metal stent, and combined application of peroral cholangioscopy, may aid in providing more appropriate treatment for patients with choledocholithiasis, repair or protect the function and structure of SO, reduce or prevent the recurrence of bile duct stones, and improve patient outcomes.

总胆管(CBD)结石治疗后复发率高是不可取的。复发的一个主要风险因素是侵入性技术,包括外科手术或内窥镜治疗,会通过直接切开胆总管或切开或扩张瓦特氏瓿而损伤胆道系统。在内镜治疗过程中,括约肌切开术和乳头球囊扩张术这两种主要的辅助碎石方法会对奥奇氏括约肌(SO)的结构和功能造成不同程度的损伤,导致胆汁排泄减慢、胆汁淤积、胆道细菌感染和促进胆管结石复发。在这篇综述中,将总结内镜碎石术与奥狄氏括约肌结构损伤或功能异常之间的关系,并分析它们与胆总管结石复发的关系。进一步改进这些内镜方法或探索一些新的方法,如内镜下内夹乳头成形术、临时插入可自行扩张的金属支架、联合应用口周胆道镜等,可能有助于为胆总管结石患者提供更合适的治疗,修复或保护SO的功能和结构,减少或预防胆总管结石的复发,改善患者的预后。
{"title":"Structural or functional abnormality of sphincter of Oddi: an important factor for the recurrence of choledocholithiasis after endoscopic treatment.","authors":"Ye Yang, Zeying Zhao, Shuodong Wu, Dianbo Yao","doi":"10.1080/07853890.2024.2440119","DOIUrl":"10.1080/07853890.2024.2440119","url":null,"abstract":"<p><p>A high recurrence rate is undesirable after treatment of common bile duct (CBD) stones. A major risk factor identified for recurrence is that invasive techniques, including surgical or endoscopic treatments, will impair the biliary tract system either by direct incision of the CBD or by cutting or dilating the ampulla of Vater. During endoscopic treatment, two main assisted methods for lithotomy, sphincterotomy and papillary balloon dilation, can result in different degrees of damage to the structure and function of the sphincter of Oddi (SO), contributing to slowing of biliary excretion, cholestasis, biliary bacterial infection, and promotion of bile duct stone recurrence. In this review, the relationship between endoscopic lithotomy and structural impairment or functional abnormality of the SO will be summarized, and their relationship with the recurrence of CBD stones will also be analyzed. Further improvement of these endoscopic methods or exploration of some novel methods, such as endoscopic endoclip papilloplasty, temporary insertion of a self-expandable metal stent, and combined application of peroral cholangioscopy, may aid in providing more appropriate treatment for patients with choledocholithiasis, repair or protect the function and structure of SO, reduce or prevent the recurrence of bile duct stones, and improve patient outcomes.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2440119"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study. 中国接受抗病毒治疗的hiv阳性患者的年龄特异性糖代谢异常:一项多中心病例对照研究
Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI: 10.1080/07853890.2024.2427910
Lijun Xu, Mengsha Chen, Chunhui Yan, Xiaofeng Li, Xiaoli Ni, Minghang Zhou, Weiwei Xu, Junfang Xu, Shigui Yang

Background: Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Methods: A multicenter case-control study was conducted in Zhejiang province, China. After matching, the study included 1030 people living with HIV (PLWH) and 1030 people living without HIV (PLWTH). The age-specific incidence of AGM was compared between the two groups. Poisson regression models were used to calculate the relative risk (RR) and its 95% confidence interval (CI) to assess the associations.

Results: Compared to PLWTH, PLWH had a higher rate of IR, IFG and DM, and a higher risk of developing IR (RR: 1.83; 95% CI: 1.60-2.10), IFG (RR: 3.87; 95% CI: 2.55-6.07), and DM (RR: 1.52; 95% CI: 1.09-2.12). In the 30-44 age group, the risk of IR, IFG, and DM was the highest, with RRs of 2.04 (95%CI: 1.69-2.48), 7.46 (95%CI: 2.91-25.27), and 1.88 (95%CI: 0.90-4.10). HIV acquisition and cART usage >5 years were associated with increased risks of DM.

Conclusion: HIV infection is associated with early onset and high prevalence of IR and IFG. Longer duration of HIV infection and cART usage increased the occurrence of DM. These findings contribute to a better understanding of age-specific AGM and the modified glucose monitor strategies in PLWH.

背景:最新消息,HIV感染与异常糖代谢(AGM)之间的联系尚不清楚。本研究旨在探讨HIV感染对AGM的影响,包括胰岛素抵抗(IR)、空腹血糖受损(IFG)和糖尿病(DM)。方法:在浙江省开展多中心病例对照研究。匹配后,研究纳入了1030名HIV感染者(PLWH)和1030名非HIV感染者(PLWTH)。比较两组间AGM的年龄特异性发病率。使用泊松回归模型计算相对危险度(RR)及其95%置信区间(CI)来评估相关性。结果:与PLWTH相比,PLWH的IR、IFG和DM发生率较高,发生IR的风险较高(RR: 1.83;95% ci: 1.60-2.10), ifg (rr: 3.87;95% CI: 2.55-6.07), DM (RR: 1.52;95% ci: 1.09-2.12)。在30-44岁年龄组中,IR、IFG和DM的风险最高,相对危险度分别为2.04 (95%CI: 1.69-2.48)、7.46 (95%CI: 2.91-25.27)和1.88 (95%CI: 0.90-4.10)。结论:HIV感染与IR和IFG的早发性和高发性相关。较长的HIV感染时间和cART的使用增加了糖尿病的发生。这些发现有助于更好地理解年龄特异性AGM和改良的PLWH血糖监测策略。
{"title":"Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study.","authors":"Lijun Xu, Mengsha Chen, Chunhui Yan, Xiaofeng Li, Xiaoli Ni, Minghang Zhou, Weiwei Xu, Junfang Xu, Shigui Yang","doi":"10.1080/07853890.2024.2427910","DOIUrl":"10.1080/07853890.2024.2427910","url":null,"abstract":"<p><strong>Background: </strong>Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).</p><p><strong>Methods: </strong>A multicenter case-control study was conducted in Zhejiang province, China. After matching, the study included 1030 people living with HIV (PLWH) and 1030 people living without HIV (PLWTH). The age-specific incidence of AGM was compared between the two groups. Poisson regression models were used to calculate the relative risk (RR) and its 95% confidence interval (CI) to assess the associations.</p><p><strong>Results: </strong>Compared to PLWTH, PLWH had a higher rate of IR, IFG and DM, and a higher risk of developing IR (RR: 1.83; 95% CI: 1.60-2.10), IFG (RR: 3.87; 95% CI: 2.55-6.07), and DM (RR: 1.52; 95% CI: 1.09-2.12). In the 30-44 age group, the risk of IR, IFG, and DM was the highest, with RRs of 2.04 (95%CI: 1.69-2.48), 7.46 (95%CI: 2.91-25.27), and 1.88 (95%CI: 0.90-4.10). HIV acquisition and cART usage >5 years were associated with increased risks of DM.</p><p><strong>Conclusion: </strong>HIV infection is associated with early onset and high prevalence of IR and IFG. Longer duration of HIV infection and cART usage increased the occurrence of DM. These findings contribute to a better understanding of age-specific AGM and the modified glucose monitor strategies in PLWH.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2427910"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer. 鉴定基于嘧啶代谢的分子亚型和预后特征以预测前列腺癌的免疫景观和指导临床治疗。
Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/07853890.2025.2449584
Yu-Zhong Yu, Xiao Xie, Mao-Ping Cai, Ya-Ying Hong, Yang-Zi Ren, Xi Kang, Hai-Chen Yan, Yang Xiong, Hong Chen, Xing-Cheng Wu, Dao-Sheng Luo, Shan-Chao Zhao

Background: We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, and found significant differences in pyrimidine metabolites. The PMGs is associated with the clinical prognosis of several cancers, but its biological role in PCa is still unclear.

Methods: This study extracted 98 reliable PMGs, and analyzed their somatic mutations, expression levels, and prognostic significance. Unsupervised clustering was applied to classify patients with PCa into clusters based on six PMGs that were related to the prognosis of PCa. The TME, gene mutations, and immune escape ability were compared among the clusters. A scoring algorithm based on prognostic PMGs, referred to as the PMGscore, was developed. TK1 was identified and the biological functions of TK1 were determined using loss-of-function experiments. RNA sequencing was subsequently performed to determine the molecules associated with the underlying mechanisms of TK1 function.

Results: In total, six out of 98 PMGs simultaneously exhibited differential expression in PCa and were correlated with BCR. Patients were clustered into two clusters according to the expression levels of these six PMGs, which reflected distinct clinical outcomes and immune cell infiltration characteristics. Clinical features, tumor prognosis, and functional annotation were analyzed. Subsequently, we constructed a prognostic signature using these six PMGs. In combination with other clinical traits, we found that the six PMGs' prognostic signature was an independent prognostic factor for patients with PCa. Finally, we found that the expression of TK1 was higher in CRPC tissues than in PCa tissues in three GEO datasets. The results indicated that TK1 promotes the growth and metastasis of PCa cells.

Conclusions: We provide evidence for a PMG signature for PCa patients to accurately predict clinical prognosis. TK1 plays crucial roles in the progression of PCa cells and can be used as a potential therapeutic target for CRPC.

背景:我们之前描述了血浆外泌体代谢物在CRPC、PCa和TFC队列中的富集,并发现嘧啶代谢物的显著差异。pmg与几种癌症的临床预后相关,但其在前列腺癌中的生物学作用尚不清楚。方法:本研究提取98个可靠的pmg,分析其体细胞突变、表达水平及预后意义。基于与PCa预后相关的6个pmg,采用无监督聚类方法对PCa患者进行分类。比较各组间的TME、基因突变和免疫逃逸能力。开发了一种基于预测pmg的评分算法,称为pmg评分。鉴定了TK1,并通过功能丧失实验确定了TK1的生物学功能。随后进行RNA测序以确定与TK1功能的潜在机制相关的分子。结果:98个pmg中有6个同时在PCa中表现出差异表达,并与BCR相关。根据这6种pmg的表达水平将患者分为两类,反映了不同的临床结局和免疫细胞浸润特征。分析临床特征、肿瘤预后及功能注释。随后,我们使用这六个pmg构建了一个预后特征。结合其他临床特征,我们发现6种pmg的预后特征是PCa患者的独立预后因素。最后,我们发现在三个GEO数据集中,TK1在CRPC组织中的表达高于PCa组织。结果表明,TK1促进了PCa细胞的生长和转移。结论:我们为PCa患者的PMG特征提供了准确预测临床预后的证据。TK1在PCa细胞的进展中起着至关重要的作用,可以作为CRPC的潜在治疗靶点。
{"title":"Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer.","authors":"Yu-Zhong Yu, Xiao Xie, Mao-Ping Cai, Ya-Ying Hong, Yang-Zi Ren, Xi Kang, Hai-Chen Yan, Yang Xiong, Hong Chen, Xing-Cheng Wu, Dao-Sheng Luo, Shan-Chao Zhao","doi":"10.1080/07853890.2025.2449584","DOIUrl":"10.1080/07853890.2025.2449584","url":null,"abstract":"<p><strong>Background: </strong>We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, and found significant differences in pyrimidine metabolites. The PMGs is associated with the clinical prognosis of several cancers, but its biological role in PCa is still unclear.</p><p><strong>Methods: </strong>This study extracted 98 reliable PMGs, and analyzed their somatic mutations, expression levels, and prognostic significance. Unsupervised clustering was applied to classify patients with PCa into clusters based on six PMGs that were related to the prognosis of PCa. The TME, gene mutations, and immune escape ability were compared among the clusters. A scoring algorithm based on prognostic PMGs, referred to as the PMGscore, was developed. TK1 was identified and the biological functions of TK1 were determined using loss-of-function experiments. RNA sequencing was subsequently performed to determine the molecules associated with the underlying mechanisms of TK1 function.</p><p><strong>Results: </strong>In total, six out of 98 PMGs simultaneously exhibited differential expression in PCa and were correlated with BCR. Patients were clustered into two clusters according to the expression levels of these six PMGs, which reflected distinct clinical outcomes and immune cell infiltration characteristics. Clinical features, tumor prognosis, and functional annotation were analyzed. Subsequently, we constructed a prognostic signature using these six PMGs. In combination with other clinical traits, we found that the six PMGs' prognostic signature was an independent prognostic factor for patients with PCa. Finally, we found that the expression of TK1 was higher in CRPC tissues than in PCa tissues in three GEO datasets. The results indicated that TK1 promotes the growth and metastasis of PCa cells.</p><p><strong>Conclusions: </strong>We provide evidence for a PMG signature for PCa patients to accurately predict clinical prognosis. TK1 plays crucial roles in the progression of PCa cells and can be used as a potential therapeutic target for CRPC.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2449584"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of medicine
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