Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.226
E. Cohen, M. Tsoukas, L. Legault, J. Yale, J. Von Oettingen, N. Garfield, N. Gouchie-Provencher, M. Odabassian, A. Jafar, M. Ghanbari, J. Rutkowski, E. Palisaitis, A. Haidar
{"title":"ALLEVIATION OF CARBOHYDRATE COUNTING IN TYPE 1 DIABETES WITH AUTOMATED FASTER ASPART AND PRAMLINTIDE CLOSED-LOOP DELIVERY (ARTIFICIAL PANCREAS): A RANDOMIZED CONTROLLED TRIAL","authors":"E. Cohen, M. Tsoukas, L. Legault, J. Yale, J. Von Oettingen, N. Garfield, N. Gouchie-Provencher, M. Odabassian, A. Jafar, M. Ghanbari, J. Rutkowski, E. Palisaitis, A. Haidar","doi":"10.1016/j.jcjd.2023.10.226","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.226","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"224 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.171
S. Salazar, M. Huising, L. Delgadillo Silva, G. Rutter, A. Provencher-Girard
{"title":"KNOCK-IN OF MCARDINAL AT THE MOUSE GCK LOCUS AS A TOOL TO EXPLORE PANCREATIC BETA CELL HETEROGENEITY","authors":"S. Salazar, M. Huising, L. Delgadillo Silva, G. Rutter, A. Provencher-Girard","doi":"10.1016/j.jcjd.2023.10.171","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.171","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.336
L. Camargo, S. Mary, S. Lilla, S. Zanivan, R. Hartley, C. Delles, W. Fuller, Y. Wang, F. Rios, A. Montezano, R. Touyz
{"title":"NOX5 LINKS OXIDATIVE STRESS AND ENDOPLASMIC RETICULUM STRESS TO ENABLE VASCULAR SMOOTH MUSCLE CELL PHENOTYPIC SWITCHING IN HYPERTENSION","authors":"L. Camargo, S. Mary, S. Lilla, S. Zanivan, R. Hartley, C. Delles, W. Fuller, Y. Wang, F. Rios, A. Montezano, R. Touyz","doi":"10.1016/j.jcjd.2023.10.336","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.336","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.319
Y. Shah, R. Turgeon
{"title":"IMPACT OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON QUALITY OF LIFE IN HEART FAILURE ACROSS THE EJECTION FRACTION SPECTRUM: SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Y. Shah, R. Turgeon","doi":"10.1016/j.jcjd.2023.10.319","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.319","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.241
M. Bolduc, K. Potter, M. Olmos, A. Bonhoure, A. Coriati, F. Tremblay, A. Lavoie, M. Carricart, P. Senior, V. Boudreau, R. Rabasa-Lhoret
{"title":"CYSTIC FIBROSIS-RELATED DIABETES DEVELOPS FROM A COMBINATION OF INSULIN SECRETORY DEFECTS AND INSULIN RESISTANCE","authors":"M. Bolduc, K. Potter, M. Olmos, A. Bonhoure, A. Coriati, F. Tremblay, A. Lavoie, M. Carricart, P. Senior, V. Boudreau, R. Rabasa-Lhoret","doi":"10.1016/j.jcjd.2023.10.241","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.241","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.346
O. Perry, M. Doschak, N. Daneshtalab
{"title":"QUANTIFICATION OF NEUROVASCULATURE CHANGES IN A POST-HEMORRHAGIC STROKE ANIMAL-MODEL","authors":"O. Perry, M. Doschak, N. Daneshtalab","doi":"10.1016/j.jcjd.2023.10.346","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.346","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"323 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.176
L. Reininger, N. Cinque, C. Tremblay, M. Ethier, J. Ghislain, M. Huising, V. Poitout
{"title":"THE LONG-CHAIN FATTY-ACID RECEPTOR FFA4 STIMULATES INSULIN SECRETION VIA INHIBITION OF SOMATOSTATIN RELEASE FROM DELTA CELL","authors":"L. Reininger, N. Cinque, C. Tremblay, M. Ethier, J. Ghislain, M. Huising, V. Poitout","doi":"10.1016/j.jcjd.2023.10.176","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.176","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"389 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.219
L. Lovblom, K. Everett, G. Booth, G. Tomlinson, A. Weisman
{"title":"STABILITY OF A1C VALUES OVER TIME AMONG ADULTS WITH TYPE 1 DIABETES: A MULTISTATE MODEL FROM A RETROSPECTIVE POPULATION-BASED COHORT STUDY","authors":"L. Lovblom, K. Everett, G. Booth, G. Tomlinson, A. Weisman","doi":"10.1016/j.jcjd.2023.10.219","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.219","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.224
V. Dionne, J. Iglesies-Grau, E. Latour, F. Besnier, D. Maxime, C. Gagnon, M. Gayda, M. Juneau, A. Nigam, P. L'Allier, F. Simard, L. Bherer, V. Pelletier
{"title":"TYPE 2 DIABETES REMISSION WITH AN INTENSIVE MULTIDISCIPLINARY INTERVENTION: THE DIABEPIC 2 PILOT STUDY","authors":"V. Dionne, J. Iglesies-Grau, E. Latour, F. Besnier, D. Maxime, C. Gagnon, M. Gayda, M. Juneau, A. Nigam, P. L'Allier, F. Simard, L. Bherer, V. Pelletier","doi":"10.1016/j.jcjd.2023.10.224","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.224","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1016/j.jcjd.2023.10.169
R. Melhem, L. Delgadillo Silva, G. Rutter
Mitofusins are membrane-bound GTPases responsible for the fusion of mitochondria in mammalian cells and, thus, the maintenance of an interconnected mitochondrial network. Correspondingly, mutations in human MFN2 are associated with lipodystrophies and increased diabetes risk. Our group has recently reported that deleting the mouse homologues Mfn1 and Mfn2 selectively in the beta cell results in mitochondrial fragmentation, severely impaired insulin secretion, and hyperglycemia (Georgiadou et al, Diabetes, 2022). The latter is partly reversed by treatment with glucagon-like peptide-1 receptor (GLP1R) agonists, such as exednin-4 (Ex4). Whether these findings also apply to human beta cells has been unclear up to now.
有丝分裂酶是一种膜结合的gtp酶，负责哺乳动物细胞中线粒体的融合，从而维持相互连接的线粒体网络。相应地，人类MFN2突变与脂肪营养不良和糖尿病风险增加有关。我们小组最近报道，在β细胞中选择性地删除小鼠同源物Mfn1和Mfn2会导致线粒体断裂、胰岛素分泌严重受损和高血糖(Georgiadou et al .， Diabetes, 2022)。后者可通过胰高血糖素样肽-1受体(GLP1R)激动剂治疗部分逆转，如exedinin -4 (Ex4)。到目前为止，这些发现是否也适用于人类β细胞还不清楚。
{"title":"IMPACT OF MFN2 DELETION ON INSULIN SECRETION AND TRANSIENT MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING IN HUMAN ENDOCBH3 BETA CELLS","authors":"R. Melhem, L. Delgadillo Silva, G. Rutter","doi":"10.1016/j.jcjd.2023.10.169","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.169","url":null,"abstract":"Mitofusins are membrane-bound GTPases responsible for the fusion of mitochondria in mammalian cells and, thus, the maintenance of an interconnected mitochondrial network. Correspondingly, mutations in human MFN2 are associated with lipodystrophies and increased diabetes risk. Our group has recently reported that deleting the mouse homologues Mfn1 and Mfn2 selectively in the beta cell results in mitochondrial fragmentation, severely impaired insulin secretion, and hyperglycemia (Georgiadou et al, Diabetes, 2022). The latter is partly reversed by treatment with glucagon-like peptide-1 receptor (GLP1R) agonists, such as exednin-4 (Ex4). Whether these findings also apply to human beta cells has been unclear up to now.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"145 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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