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Association between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction. 保留左心室射血分数的非卧床患者左心室几何形状、收缩期射血时间与 eGFR 之间的关系
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-01 DOI: 10.1159/000541725
Lee A Goeddel, Sergio Navarrete, Natalie Waldron, Anjali D'Amiano, Nauder Faraday, Joao A C Lima, Chirag R Parikh, Karen Bandeen-Roche, Allison G Hays, Charles Brown Iv
<p><strong>Introduction: </strong>Cardiac function is important to quantify for risk stratification. Although left ventricular ejection fraction (LVEF) is commonly used, and identifies patients with poor systolic function, other easily acquired measures of cardiac function are needed, particularly to stratify patients with relatively preserved LVEF. LV relative wall thickness (RWT) has been associated with adverse clinical outcomes in patients with preserved LVEF, but the clinical relevance of this observation is not known. The purpose of this study was to assess whether increased RWT is a marker of subclinical cardiac dysfunction as measured by a surrogate of LV dysfunction and left ventricular ejection time (LVET) and if increased RWT is independently associated with chronic kidney disease (CKD), an important clinical outcome and cardiovascular disease risk equivalent.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled ambulatory patients 18 years and older undergoing routine transthoracic echocardiography (TTE) at Johns Hopkins Hospital from January 2017 to January 2018. Patients with LVEF <50%, severe valvular disease, or liver failure were excluded. Multivariable regression evaluated the relationship between RWT, LVET, and CKD adjusted for demographics, comorbidities, and vital signs.</p><p><strong>Results: </strong>We analyzed data from 375 patients with mean age (±SD) 52.2 ± 15.3 years of whom 58% were female. Mean ± SD of RWT was 0.45 ± 0.10, while mean ± SD of LVET was 270 ms ± 33. In multivariable linear regression adjusted for demographics, comorbidities, vital signs, and left ventricular mass, each 0.1 increase in RWT was associated with a decrease of 4.6 ms in LVET, indicating worse cardiac function (β, ± 95% CI) (-4.60, -7.37 to -1.48, p = 0.004). Of those with serum creatinine available 1 month before or after TTE, 20% (50/247) had stage 3 or greater CKD. In logistic regression (adjusted for sex, comorbidities, and medications), each 0.1 unit increase in RWT was associated with an 61% increased odds of CKD (aOR = 1.61, 1.03-2.53, p = 0.037). In multivariable ordinal regression adjusted for the same covariates, each 0.1 unit increase in RWT was associated with a 44% increased odds of higher CKD stage (aOR = 1.44, 1.03-2.02, p = 0.035). There was a trend but no statistically significant relationship between RWT and change in estimated glomerular filtration rate at 1 year.</p><p><strong>Conclusion: </strong>In an outpatient cohort undergoing TTE, increased RWT was independently associated with a surrogate of subclinical systolic dysfunction (LVET) and CKD. This suggests that RWT, an easily derived measure of LV geometry on TTE, may identify clinically relevant subclinical systolic dysfunction and patients with worse kidney function. Additional investigation to further clarify the relationships between RWT, systolic function, and kidney dysfunction over time and how this information may guide clinical intervent
导言量化心脏功能对于风险分层非常重要。虽然左心室射血分数(LVEF)常用于识别收缩功能较差的患者,但还需要其他容易获得的心功能测量指标,尤其是对 LVEF 相对保留的患者进行分层。左心室相对壁厚度(RWT)与左心室容积保留患者的不良临床预后有关,但这一观察结果的临床意义尚不清楚。本研究的目的是评估 RWT 的增加是否是亚临床心功能不全的标志,这是由左心室功能不全的代用指标左心室射血时间(LVET)来衡量的,以及 RWT 的增加是否与慢性肾病(CKD)(一种重要的临床结果和心血管疾病风险等价物)独立相关:这项回顾性队列研究招募了2017年1月至2018年1月在约翰霍普金斯医院接受常规经胸超声心动图(TTE)检查的18岁及以上非住院患者。排除了LVEF<50%、严重瓣膜病或肝功能衰竭的患者。经人口统计学、合并症和生命体征调整后,多变量回归评估了RWT、LVET和CKD之间的关系:我们分析了 375 名患者的数据,他们的平均年龄(± SD)为 52.2 ± 15.3 岁,其中 58% 为女性。RWT 的平均(±SD)值为 0.45 ± 0.10,而 LVET 的平均(±SD)值为 270 ms ± 33。在对人口统计学、合并症、生命体征和左心室质量进行调整后的多变量线性回归中,RWT 每增加 0.1,LVET 就会减少 4.6 毫秒,表明心功能更差(Beta,± 95%CI)(-4.60,-7.37 至-1.48,p=.004)。在 TTE 前后 1 个月能获得血清肌酐的患者中,20%(50/247)为 3 期或更严重的慢性肾功能衰竭。在逻辑回归中(根据性别、合并症和药物进行调整),RWT 每增加 0.1 个单位,患 CKD 的几率就会增加 61%(aOR=1.61,1.03 至 2.53,p=.037)。在对相同协变量进行调整后的多变量序数回归中,RWT 每增加 0.1 个单位与较高的 CKD 分期几率增加 44% 相关(aOR=1.44,1.03 至 2.02,p=.035)。RWT与1年后eGFR变化之间存在趋势,但无统计学意义:结论:在接受 TTE 检查的门诊病人队列中,RWT 的增加与亚临床收缩功能障碍(LVET)和慢性肾脏病的代用指标独立相关。这表明,RWT 是 TTE 上测量左心室几何形状的一种简便方法,可识别与临床相关的亚临床收缩功能障碍和肾功能较差的患者。有必要进行进一步研究,以进一步明确 RWT、收缩功能和肾功能不全之间随时间变化的关系,以及这些信息如何指导临床干预。
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引用次数: 0
Potential Use of Systolic Pulmonary Artery Pressure/Pulmonary Artery Acceleration Time Ratio in Severe Functional Tricuspid Regurgitation with Pulmonary Hypertension. sPAP /PAAT 比值在严重功能性三尖瓣反流合并肺动脉高压中的潜在应用。
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-30 DOI: 10.1159/000541529
Walter Serra, Andrea Botti, Luigi Vignali, Alfredo Chetta

Introduction: To date, there is no specific evidence or criteria for the selection of patients with PH and severe tricuspid insufficiency that can be initiated into correction of tricuspid valvulopathy. Tricuspid regurgitation is a risk marker independent of mortality in patients with pulmonary hypertension. The critical factor for the procedure's success is to find the parameters to select patients so that they do not become just a futile act.

Method: From the initial group of 271 patients, a final group of 123 patients were selected, all diagnosed with precapillary PH confirmed by catheterization and with tricuspid regurgitation by echocardiography. Patients were in groups 1 and 2 according to the 2022 Pulmonary Hypertension Guidelines. Patients with right to left shunt were not excluded.

Results: In patients with severe precapillary PH, the sPAP/PAAT ratio was close to 1 (0.89 ± 0.43), while in patients with mild precapillary PH or in the postcapillary group, the sPAP/PAAT ratio was considerably lower (0.47 ± 0.20, p < 0.001). The average sPAP/PAAT of deceased patients was 0.76. Among the 68 deceased patients, 42 (61.70%) had severe tricuspid regurgitation.

Conclusion: In our study, the average sPAP/PAAT ratio of the deceased patients with severe FTR was 0.76 mm Hg/ms; nevertheless, this knowledge could have a potential use but is not sufficient for full-informed qualification or disqualification for valve intervention, which requires specific TTVR-related data.

导言:迄今为止,还没有具体的证据或标准来选择肺动脉高压和严重三尖瓣关闭不全的患者,以启动三尖瓣瓣膜病变的矫正治疗。三尖瓣反流是与肺动脉高压患者死亡率无关的风险标志。手术成功的关键因素无疑是找到选择患者的参数,从而避免徒劳无功。方法:从最初的 271 名患者中筛选出最后的 123 名患者,这些患者均经导管检查确诊为毛细血管前 PH,并经超声心动图检查确诊为三尖瓣反流。根据《2022 年肺动脉高压指南》,患者被分为 1 组和 2 组。不排除右向左分流的患者。结果 在重度毛细血管前 PH 患者中,sPAP/PAAT 比值接近 1(0.89± 0.43),而在轻度毛细血管前 PH 患者或毛细血管后组患者中,sPAP/PAAT 比值要低很多(0.47±0.20)p<0.001。死亡患者的 sPAP/PAAT 平均值为 0.76。61.70%的死亡患者(68 例中的 42 例)有严重的三尖瓣反流。结论 在我们的研究中,严重三尖瓣反流死亡患者的平均 sPAP/PAAT 比值为 0.76 mmHg/ms,尽管如此,这一知识仍有潜在用途,但不足以在充分知情的情况下确定是否有资格进行瓣膜介入治疗,这需要具体的三尖瓣反流相关数据。
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引用次数: 0
Evaluation of Cardiac Function Recovery in Patients with Paroxysmal Atrial Fibrillation after Catheter Radiofrequency Ablation Using Two-Dimensional Speckle Tracking Imaging and Real-Time Three-Dimensional Echocardiography. 利用二维斑点追踪成像和实时三维超声心动图评估阵发性心房颤动患者导管射频消融术后的心功能恢复情况
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-27 DOI: 10.1159/000541247
Rui Han, Ying-Chen Mei, Hai-Wei Li, Rong-Juan Li, Yi-Hua He, Ze-Feng Wang, Yong-Quan Wu

Introduction: The aim of this study was to evaluate the utility of 2D-STI and real-time three-dimensional echocardiography (RT-3DE) in assessing changes in left atrial (LA) structure and function in patients with paroxysmal atrial fibrillation (PAF) post-radiofrequency catheter ablation (RFCA).

Methods: A retrospective analysis was conducted on 44 PAF patients who underwent RFCA at BA Hospital from March 2022 to March 2023. An age- and gender-matched control group of 32 healthy individuals was also included. Comprehensive echocardiographic parameters including LA dimensions (LAAPD, LALRD), volumes (LAVmin, LAVmax), ejection fraction (LAEF), and tissue velocities (a', Ar) were compared between groups. Post-RFCA changes in these parameters were also assessed at 1, 3, and 6 months.

Results: Pre-RFCA, PAF patients demonstrated larger LA dimensions and volumes with reduced LAEF and tissue velocities compared to controls. Post-RFCA, there was a significant improvement in LAEF and left ventricular ejection fraction at 1, 3, and 6 months, with the most pronounced changes observed at 6 months. LA dimensions increased initially but then decreased from 1 to 6 months post-RFCA. Notably, strain rate (SRS, SRE, SRA) measurements in various LA segments improved progressively, with the most significant enhancements at 6 months, suggesting improved atrial mechanics.

Conclusion: The application of 2D-STI and RT-3DE provides a quantitative means to evaluate the structural and functional changes in the LA of PAF patients following RFCA. The progressive improvements in LA dimensions, volumes, and strain measurements up to 6-month post-RFCA indicate the potential of these techniques in monitoring treatment efficacy and patient recovery.

简介本研究旨在评估二维超声心动图(2D-STI)和实时三维超声心动图(RT-3DE)在评估射频导管消融术(RFCA)后阵发性心房颤动(PAF)患者左心房(LA)结构和功能变化方面的实用性:对2022年3月至2023年3月期间在广医三院接受射频导管消融术的44名PAF患者进行了回顾性分析。方法:对 2022 年 3 月至 2023 年 3 月期间在广医三院接受 RFCA 的 44 例 PAF 患者进行回顾性分析,同时纳入年龄和性别匹配的 32 例健康对照组。比较了各组之间的综合超声心动图参数,包括 LA 尺寸(LAAPD、LALRD)、容积(LAVmin、LAVmax)、射血分数(LAEF)和组织速度(a'、Ar)。RFCA后1个月、3个月和6个月时也对这些参数的变化进行了评估:与对照组相比,RFCA 术前 PAF 患者的 LA 尺寸和容积增大,LAEF 和组织速度降低。RFCA术后,LAEF和左心室射血分数在1、3和6个月时均有显著改善,其中6个月时的变化最为明显。LA 尺寸最初有所增加,但在 RFCA 术后 1 至 6 个月内又有所减少。值得注意的是,LA各节段的应变率(SRS、SRE、SRA)测量结果逐渐改善,6个月时改善最明显,表明心房力学得到改善:结论:2D-STI 和 RT-3DE 的应用为评估 RFCA 后 PAF 患者 LA 的结构和功能变化提供了定量方法。RFCA术后6个月内LA尺寸、容积和应变测量的逐步改善表明,这些技术在监测治疗效果和患者恢复方面具有潜力。
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引用次数: 0
Improved Outcomes following a Conservative Approach to Hemodynamically Significant Patent Ductus Arteriosus: A Comparison across Two Periods. 采用保守方法治疗血流动力学意义重大的 PDA 后疗效更佳:两个时期的比较。
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-24 DOI: 10.1159/000541477
Yu-Mi Seo, Sae Yun Kim, Young-Ah Youn

Introduction: Patent ductus arteriosus (PDA) is a commonly encountered morbidity that occurs inversely with gestational age. In response to the growing trend of avoiding PDA ligation and prophylactic interventions, our center adopted a conservative approach starting in September 2020. This approach involves more precise fluid restriction for hemodynamically significant (hs) PDA. This study aimed to evaluate whether a conservative approach to hsPDA has led to a reduction in adverse clinical outcomes for very low birth weight infants (VLBWIs) during the period of conservative treatment.

Methods: Since more conservative approach to hsPDA was adopted since September 2020, the two periods were divided into period 1 (January 2015 to August 2020) and period 2 (September 2020 to June 2023). Fluid therapy was carefully monitored and advanced from day 1 in all VLBWI, and a more conservative approach as fluid restriction was attempted in hsPDA during period 2.

Results: Of the 540 VLBWI with hsPDA, 348 infants were born and diagnosed with hsPDA. Period 2 demonstrated a significantly higher rate of medical treatment (79.17% vs. 19.51%) and lower PDA ligation (54.17% vs. 78.05%). Period 2 showed a greater adherence to conservative fluid restriction compared to period 1. Bronchopulmonary dysplasia (BPD) and BPD ≥ moderate, sepsis, necrotizing enterocolitis (≥ grade 2), IVH (grade ≥3) were notably lower in period 2 with lower mortality. In regard to PDA-related treatment, primary PDA ligation was significantly higher in period 1. The secondary PDA ligation after medical failure and more conservative fluid restriction were significantly higher in period 2. At corrected age of 18-24 months, cognitive score was significantly lower in VLBWI born in period 1 compared to those born in period 2.

Conclusion: Our study demonstrated that a conservative approach to hsPDA led to better clinical outcomes and improved cognitive scores at a corrected age of 18-24 months compared to the period of active PDA ligation. This conservative strategy, involving more precise fluid restriction and the judicious use of appropriate diuretics, has shown to improve clinical outcomes with minimal intervention.

导言:动脉导管未闭(PDA)是一种常见病,发病率与胎龄成反比。为了顺应避免结扎 PDA 和预防性干预的趋势,本中心从 2020 年 9 月开始采用保守方法。本研究旨在评估在采取保守治疗方法期间,对有血流动力学显著性(hs)的 PDA 采取保守治疗方法是否减少了极低出生体重儿(VLBWI)的不良临床结局:由于自 2020 年 9 月起对有血流动力学意义(hs)的 PDA 采用了更为保守的方法,因此将两个时期分为第一时期(2015 年 1 月至 2020 年 8 月)和第二时期(2020 年 9 月至 2023 年 6 月)。从第 1 天起,对所有 VLBWI 进行仔细监测并推进液体疗法,而在第 2 阶段,对 hs PDA 尝试了更为保守的液体限制方法:结果:在 540 名患有 hs PDA 的 VLBWI 中,有 348 名婴儿出生后被诊断为患有 hs PDA。第二阶段的医疗治疗率明显较高(79.17% 对 19.51%),PDA 结扎率较低(54.17% 对 78.05%)。与第一阶段相比,第二阶段更坚持保守的液体限制。第二阶段的 BPD 和 BPD ≥ 中度、败血症、NEC(≥ 2 级)、IVH(≥ 3 级)明显较低,死亡率也较低。在与 PDA 相关的治疗方面,第 1 期的初次 PDA 结扎率明显较高,而第 2 期的医疗失败后二次 PDA 结扎率和更保守的液体限制率明显较高。在 18-24 个月校正年龄时,第一阶段出生的 VLBWI 的认知评分明显低于第二阶段出生的 VLBWI:我们的研究表明,与主动结扎 PDA 的时期相比,对 hs PDA 采取保守治疗可获得更好的临床效果,并在 18-24 个月大时提高认知评分。这种保守策略包括更精确的液体限制和合理使用适当的利尿剂,已证明能以最少的干预改善临床效果。
{"title":"Improved Outcomes following a Conservative Approach to Hemodynamically Significant Patent Ductus Arteriosus: A Comparison across Two Periods.","authors":"Yu-Mi Seo, Sae Yun Kim, Young-Ah Youn","doi":"10.1159/000541477","DOIUrl":"10.1159/000541477","url":null,"abstract":"<p><strong>Introduction: </strong>Patent ductus arteriosus (PDA) is a commonly encountered morbidity that occurs inversely with gestational age. In response to the growing trend of avoiding PDA ligation and prophylactic interventions, our center adopted a conservative approach starting in September 2020. This approach involves more precise fluid restriction for hemodynamically significant (hs) PDA. This study aimed to evaluate whether a conservative approach to hsPDA has led to a reduction in adverse clinical outcomes for very low birth weight infants (VLBWIs) during the period of conservative treatment.</p><p><strong>Methods: </strong>Since more conservative approach to hsPDA was adopted since September 2020, the two periods were divided into period 1 (January 2015 to August 2020) and period 2 (September 2020 to June 2023). Fluid therapy was carefully monitored and advanced from day 1 in all VLBWI, and a more conservative approach as fluid restriction was attempted in hsPDA during period 2.</p><p><strong>Results: </strong>Of the 540 VLBWI with hsPDA, 348 infants were born and diagnosed with hsPDA. Period 2 demonstrated a significantly higher rate of medical treatment (79.17% vs. 19.51%) and lower PDA ligation (54.17% vs. 78.05%). Period 2 showed a greater adherence to conservative fluid restriction compared to period 1. Bronchopulmonary dysplasia (BPD) and BPD ≥ moderate, sepsis, necrotizing enterocolitis (≥ grade 2), IVH (grade ≥3) were notably lower in period 2 with lower mortality. In regard to PDA-related treatment, primary PDA ligation was significantly higher in period 1. The secondary PDA ligation after medical failure and more conservative fluid restriction were significantly higher in period 2. At corrected age of 18-24 months, cognitive score was significantly lower in VLBWI born in period 1 compared to those born in period 2.</p><p><strong>Conclusion: </strong>Our study demonstrated that a conservative approach to hsPDA led to better clinical outcomes and improved cognitive scores at a corrected age of 18-24 months compared to the period of active PDA ligation. This conservative strategy, involving more precise fluid restriction and the judicious use of appropriate diuretics, has shown to improve clinical outcomes with minimal intervention.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of obstructive sleep apnea on heart failure and its risk factors: A two-step Mendelian randomization study. 阻塞性睡眠呼吸暂停与心力衰竭及其风险因素的关系:孟德尔随机两步法研究
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-17 DOI: 10.1159/000541360
Jianhui Liu,Zhikui Chen,Dihui Cai
BACKGROUNDRecent studies have indicated that obstructive sleep apnea (OSA) is linked to a higher likelihood of heart failure (HF). However, the causal connection between the two conditions is uncertain. We aimed to investigate the causal association of OSA with HF and its risk factors.METHODSThe OSA summary statistics are derived from the FinnGen database, including 38,998 cases and 336,659 controls. and HF summary statistics come from HERMES, the UK biobank, and the FinnGen database. A two-sample Mendelian randomization (MR) analysis was conducted to examine the causality of OSA on HF risk. Furthermore, the mediator effect of potential risk factors was assessed by a two-step MR.RESULTSThe results of MR analysis demonstrated that genetically determined OSA is causal associated with the higher likelihood of HF (HERME: odds ratio [OR] = 1.222; 95% confidence interval [CI] [1.091, 1.369]; p = 5.19 × 10-4) (FinnGen: OR = 1.233; 95% CI [1.129, 1.346]; p = 3.32 × 10-6) (UK Biobank: OR = 1.002; 95% CI [1.000, 1.003]; p = 0.014). Two-step MR analysis indicated that obesity, blood glucose, depression, and other CVDs have significant mediating effects on the causal effect between OSA and HF.CONCLUSIONThis MR study emphasizes the causal effect of OSA on HF risk. Adiposity traits play a major role in the process of OSA leading to HF. Considering the detrimental impact of OSA on HF, it becomes imperative to prioritize the prevention and management of HF in individuals afflicted with OSA. The foremost intervention strategy should revolve around effective obesity management.
背景最近的研究表明,阻塞性睡眠呼吸暂停(OSA)与较高的心力衰竭(HF)可能性有关。然而,这两种情况之间的因果关系尚不确定。我们的目的是研究 OSA 与 HF 及其风险因素之间的因果关系。方法:OSA 的简要统计数据来自芬兰基因数据库,其中包括 38,998 例病例和 336,659 例对照,HF 的简要统计数据来自 HERMES、英国生物库和芬兰基因数据库。我们进行了双样本孟德尔随机化(MR)分析,以检验 OSA 与高血压风险的因果关系。结果MR分析的结果表明,由基因决定的OSA与较高的HF可能性有因果关系(HERME:比值比 [OR] = 1.222; 95% confidence interval [CI] [1.091, 1.369]; p = 5.19 × 10-4)(FinnGen:OR = 1.233; 95% CI [1.129, 1.346]; p = 3.32 × 10-6)(UK Biobank:OR = 1.002; 95% CI [1.000, 1.003]; p = 0.014)。两步磁共振分析表明,肥胖、血糖、抑郁和其他心血管疾病对 OSA 和 HF 之间的因果效应有显著的中介作用。肥胖特征在 OSA 导致高血压的过程中发挥了重要作用。考虑到 OSA 对高血压的不利影响,当务之急是优先预防和管理 OSA 患者的高血压。首要的干预策略应围绕有效控制肥胖展开。
{"title":"Association of obstructive sleep apnea on heart failure and its risk factors: A two-step Mendelian randomization study.","authors":"Jianhui Liu,Zhikui Chen,Dihui Cai","doi":"10.1159/000541360","DOIUrl":"https://doi.org/10.1159/000541360","url":null,"abstract":"BACKGROUNDRecent studies have indicated that obstructive sleep apnea (OSA) is linked to a higher likelihood of heart failure (HF). However, the causal connection between the two conditions is uncertain. We aimed to investigate the causal association of OSA with HF and its risk factors.METHODSThe OSA summary statistics are derived from the FinnGen database, including 38,998 cases and 336,659 controls. and HF summary statistics come from HERMES, the UK biobank, and the FinnGen database. A two-sample Mendelian randomization (MR) analysis was conducted to examine the causality of OSA on HF risk. Furthermore, the mediator effect of potential risk factors was assessed by a two-step MR.RESULTSThe results of MR analysis demonstrated that genetically determined OSA is causal associated with the higher likelihood of HF (HERME: odds ratio [OR] = 1.222; 95% confidence interval [CI] [1.091, 1.369]; p = 5.19 × 10-4) (FinnGen: OR = 1.233; 95% CI [1.129, 1.346]; p = 3.32 × 10-6) (UK Biobank: OR = 1.002; 95% CI [1.000, 1.003]; p = 0.014). Two-step MR analysis indicated that obesity, blood glucose, depression, and other CVDs have significant mediating effects on the causal effect between OSA and HF.CONCLUSIONThis MR study emphasizes the causal effect of OSA on HF risk. Adiposity traits play a major role in the process of OSA leading to HF. Considering the detrimental impact of OSA on HF, it becomes imperative to prioritize the prevention and management of HF in individuals afflicted with OSA. The foremost intervention strategy should revolve around effective obesity management.","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":"55 1","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose-Dependent Relationship between Iron Metabolism and Perioperative Myocardial Injury in Cardiac Surgery with Cardiopulmonary Bypass: A Retrospective Analysis. 心肺旁路心脏手术中铁代谢与围手术期心肌损伤之间的剂量依赖关系:回顾性分析
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-16 DOI: 10.1159/000541213
Qian Li, Hong Lv, Yuye Chen, Jingjia Shen, Jia Shi, Chenghui Zhou

Introduction: We sought to comprehensively explore the potential linear and nonlinear relationship between preoperative iron metabolism and perioperative myocardial injury (PMI) following cardiac surgery with cardiopulmonary bypass (CPB).

Methods: Patients who underwent cardiac surgery with CPB between December 2018 and April 2021 were retrospectively collected. The measurements of iron metabolism included serum iron (SI), serum ferritin (SF), transferrin (TRF), transferrin saturation (TS), and total iron-binding capacity (TIBC). Logistic regression and restricted cubic spline (RCS) models were used for linear and nonlinear analysis. The primary outcome was PMI with a 100× upper reference limit.

Results: Of 2,420 patients screened, 744 eligible patients were enrolled for the final analysis. The incidence of PMI was 25.7%. No significant linear relationship was observed. In the RCS models adjusted with age (median: 56), female, and history of diabetes, a statistically significant difference was detected between TRF (p for nonlinear 0.0152) or TIBC (p for nonlinear 0.0477) and PMI. The gentle U-shaped relationship observed between TRF, TIBC, and PMI suggests that when TRF and TIBC increase, the risk decreases, reaching its lowest point when TRF = 2.4 and TIBC = 54. Nevertheless, as TRF and TIBC continue to increase, the risk starts to rise again. Subgroup analyses yielded consistent findings, with a notable emphasis on older patients who were more susceptible to variations in iron metabolism.

Conclusion: Iron metabolism, including TRF, and TIBC, exhibited a nonlinear relationship with PMI by the RCS model adjusted by age, gender, and history of diabetes.

简介:我们试图全面探讨心肺旁路(CPB)心脏手术后术前铁代谢与围手术期心肌损伤(PMI)之间潜在的线性和非线性关系:回顾性收集2018年12月至2021年4月期间接受CPB心脏手术的患者。铁代谢测量包括血清铁(SI)、血清铁蛋白(SF)、转铁蛋白(TRF)、转铁蛋白饱和度(TS)和总铁结合能力(TIBC)。线性和非线性分析采用了逻辑回归和限制性三次样条(RCS)模型。主要结果是参考上限(URL)为 100 倍的 PMI:在接受筛查的 2420 名患者中,有 744 名符合条件的患者被纳入最终分析。PMI 发生率为 25.7%。未观察到明显的线性关系。在根据年龄(中位数:56)、女性和糖尿病史进行调整的 RCS 模型中,发现 TRF(非线性 p 为 0.0152)或 TIBC(非线性 p 为 0.0477)与 PMI 之间存在统计学意义上的显著差异。在 TRF、TIBC 和 PMI 之间观察到的平缓 U 型关系表明,当 TRF 和 TIBC 增加时,风险降低,当 TRF=2.4 和 TIBC=54 时达到最低点。然而,随着 TRF 和 TIBC 的继续增加,风险又开始上升。亚组分析得出了一致的结果,尤其是老年患者更容易受到铁代谢变化的影响:铁代谢(包括 TRF 和 TIBC)与 PMI 呈非线性关系,RCS 模型根据年龄、性别和糖尿病史进行了调整。
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引用次数: 0
Gender Differences in Cardiovascular Disease: Perspectives on Disparities in Women's Treatment and Outcomes. 心血管疾病的性别差异:心血管疾病的性别差异:女性治疗和结果差异的视角》(Perspectives on Disparities in Women's Treatment and Outcomes.
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-06 DOI: 10.1159/000541302
Takahiro Okumura, Toyoaki Murohara
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引用次数: 0
Meta-Analysis of the Efficacy and Safety of Radiofrequency Catheter Ablation for Pediatric Paroxysmal Supraventricular Tachycardia. 射频导管消融治疗小儿阵发性室上性心动过速的有效性和安全性的 Meta 分析。
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-05 DOI: 10.1159/000541178
Xue Zhang, Yue Yuan

Introduction: This meta-analysis was to evaluate the efficacy and safety of radiofrequency catheter ablation (RFCA) in treating children with paroxysmal supraventricular tachycardia (PSVT).

Methods: From inception to December 16, 2023, PubMed, Embase, Cochrane Library, Web of Science, CNKI (China National Knowledge Infrastructure), VIP (Chinese Science and Technology Periodical Database), and WanFang were searched for this meta-analysis. Children under the age of 18 diagnosed with atrioventricular reentrant tachycardia (AVRT) and atrioventricular nodal reentrant tachycardia (AVNRT) were enrolled. The outcomes included the success rate of RFCA, the recurrence rate of PSVT following RFCA treatment, and any complications associated with the procedure. Newcastle-Ottawa Scale (NOS) was used to assess the quality of studies. The outcome data were represented as rates (RATE) and corresponding 95% confidence intervals (CIs). Subgroup analyses were conducted based on regions and follow-ups.

Results: Fourteen articles encompassing 6,032 children were included in the study. RFCA demonstrated remarkable efficacy in children patients, achieving success rates of 98% (RATE: 0.98, 95% CI: 0.96-0.99) for AVRT and 99% (RATE: 0.99, 95% CI: 0.98-1.00) for AVNRT. The analysis also reveals that post-RFCA, the recurrence rates for AVRT were 5% (RATE: 0.05, 95% CI: 0.03-0.07), while for AVNRT, they were slightly lower at 4% (RATE: 0.04, 95% CI: 0.02-0.08). In the subset of Asian children patients, these recurrence rates were observed to be 5% for AVRT and 3% for AVNRT. Monitoring for a duration of up to 12 months of post-RFCA indicated recurrence rates of 4% for AVRT and 3% for AVNRT. However, for follow-up periods extending beyond 1 year, there was a slight increase in these rates to 4% for AVRT and 6% for AVNRT. Additionally, the complication rates associated with RFCA in the children population were relatively minimal, recorded at 2% (RATE: 0.02, 95% CI: -0.01-0.06) for AVRT and 1% (RATE: 0.01, 95% CI: 0.00-0.02) for AVNRT.

Conclusion: RFCA appears to be a highly effective and safe treatment option for AVRT and AVNRT in children, with high success rates and relatively low recurrence and complication rates. However, long-term follow-up may be necessary to monitor for potential recurrences. These findings are valuable for clinicians and patients in making informed decisions about the treatment of these cardiac arrhythmias in pediatric patients.

导言:本荟萃分析旨在评估射频导管消融术(RFCA)治疗儿童阵发性室上性心动过速(PSVT)的有效性和安全性:方法:从开始到2023年12月16日,检索了PubMed、Embase、Cochrane Library、Web of Science、CNKI(中国国家知识基础设施)、VIP(中国科技期刊数据库)和万方数据库,以进行本荟萃分析。研究对象为18岁以下确诊为房室返流性心动过速(AVRT)和房室结返流性心动过速(AVNRT)的儿童。研究结果包括 RFCA 的成功率、RFCA 治疗后 PSVT 的复发率以及与手术相关的并发症。纽卡斯尔-渥太华量表(NOS)用于评估研究质量。结果数据以率(RATE)和相应的 95% 置信区间(CI)表示。根据地区和随访情况进行了分组分析:研究共纳入 14 篇文章,涉及 6032 名儿童。RFCA对儿童患者的疗效显著,AVRT的成功率为98%(RATE:0.98,95% CI:0.96至0.99),AVNRT的成功率为99%(RATE:0.99,95% CI:0.98至1.00)。分析还显示,RFCA 后 AVRT 的复发率为 5%(RATE:0.05,95% CI:0.03 至 0.07),而 AVNRT 的复发率略低,为 4%(RATE:0.04,95% CI:0.02 至 0.08)。据观察,在亚裔儿童患者中,AVRT 的复发率为 5%,AVNRT 为 3%。对 RFCA 术后长达 12 个月的监测显示,AVRT 的复发率为 4%,AVNRT 为 3%。然而,随访期超过一年后,复发率略有上升,其中 AVRT 为 4%,AVNRT 为 6%。此外,RFCA在儿童人群中的并发症发生率相对较低,AVRT为2%(RATE:0.02,95% CI:-0.01至0.06),AVNRT为1%(RATE:0.01,95% CI:0.00至0.02):RFCA似乎是治疗儿童AVRT和AVNRT的一种高效、安全的方法,成功率高,复发率和并发症发生率相对较低。不过,可能需要长期随访以监测潜在的复发。这些研究结果对临床医生和患者在治疗小儿心律失常时做出明智决定很有价值。
{"title":"Meta-Analysis of the Efficacy and Safety of Radiofrequency Catheter Ablation for Pediatric Paroxysmal Supraventricular Tachycardia.","authors":"Xue Zhang, Yue Yuan","doi":"10.1159/000541178","DOIUrl":"10.1159/000541178","url":null,"abstract":"<p><strong>Introduction: </strong>This meta-analysis was to evaluate the efficacy and safety of radiofrequency catheter ablation (RFCA) in treating children with paroxysmal supraventricular tachycardia (PSVT).</p><p><strong>Methods: </strong>From inception to December 16, 2023, PubMed, Embase, Cochrane Library, Web of Science, CNKI (China National Knowledge Infrastructure), VIP (Chinese Science and Technology Periodical Database), and WanFang were searched for this meta-analysis. Children under the age of 18 diagnosed with atrioventricular reentrant tachycardia (AVRT) and atrioventricular nodal reentrant tachycardia (AVNRT) were enrolled. The outcomes included the success rate of RFCA, the recurrence rate of PSVT following RFCA treatment, and any complications associated with the procedure. Newcastle-Ottawa Scale (NOS) was used to assess the quality of studies. The outcome data were represented as rates (RATE) and corresponding 95% confidence intervals (CIs). Subgroup analyses were conducted based on regions and follow-ups.</p><p><strong>Results: </strong>Fourteen articles encompassing 6,032 children were included in the study. RFCA demonstrated remarkable efficacy in children patients, achieving success rates of 98% (RATE: 0.98, 95% CI: 0.96-0.99) for AVRT and 99% (RATE: 0.99, 95% CI: 0.98-1.00) for AVNRT. The analysis also reveals that post-RFCA, the recurrence rates for AVRT were 5% (RATE: 0.05, 95% CI: 0.03-0.07), while for AVNRT, they were slightly lower at 4% (RATE: 0.04, 95% CI: 0.02-0.08). In the subset of Asian children patients, these recurrence rates were observed to be 5% for AVRT and 3% for AVNRT. Monitoring for a duration of up to 12 months of post-RFCA indicated recurrence rates of 4% for AVRT and 3% for AVNRT. However, for follow-up periods extending beyond 1 year, there was a slight increase in these rates to 4% for AVRT and 6% for AVNRT. Additionally, the complication rates associated with RFCA in the children population were relatively minimal, recorded at 2% (RATE: 0.02, 95% CI: -0.01-0.06) for AVRT and 1% (RATE: 0.01, 95% CI: 0.00-0.02) for AVNRT.</p><p><strong>Conclusion: </strong>RFCA appears to be a highly effective and safe treatment option for AVRT and AVNRT in children, with high success rates and relatively low recurrence and complication rates. However, long-term follow-up may be necessary to monitor for potential recurrences. These findings are valuable for clinicians and patients in making informed decisions about the treatment of these cardiac arrhythmias in pediatric patients.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-19"},"PeriodicalIF":1.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Floppy Mitral Valve/Mitral Valve Prolapse and Manifestations Not Related to Mitral Regurgitation: Time to Search the Dark Side of the Moon. 松弛的二尖瓣/二尖瓣脱垂和与二尖瓣反流无关的表现:是时候寻找月球的黑暗面了。
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-03 DOI: 10.1159/000541179
Konstantinos Dean Boudoulas, Antonios Pitsis, Cezar Iliescu, Konstantinos Marmagkiolis, Filippos Triposkiadis, Harisios Boudoulas

Background: Floppy mitral valve/mitral valve prolapse (FMV/MVP) is a complex entity in which several clinical manifestations are not directly related to the severity of mitral regurgitation (MR).

Summary: Patients with FMV/MVP and trivial to mild MR may have exercise intolerance, orthostatic phenomena, syncope/presyncope, chest pain, and ventricular arrhythmias, among others. Several anatomical and pathophysiologic consequences related to the abnormal mitral valve apparatus and to prolapse of the mitral leaflets into the left atrium provide some explanation for these symptoms. Further, it should be emphasized that MVP is a non-specific finding, while FMV (redundant mitral leaflets, elongated/rupture chordae tendineae, annular dilatation) is the central issue in the MVP story.

Key message: The purpose of this review was to highlight the clinical manifestations of FMV/MVP not directly related to the severity of MR and to discuss the pathophysiologic mechanisms contributing to these manifestations.

背景:摘要:患有软化二尖瓣/二尖瓣脱垂(FMV/MVP)和轻微二尖瓣反流(MR)的患者可能会出现运动不耐受、正心现象、晕厥/心前区不适、胸痛和室性心律失常等症状。与二尖瓣器异常和二尖瓣叶脱垂至左心房有关的一些解剖学和病理生理学后果为这些症状提供了一些解释。此外,需要强调的是,MVP 是一种非特异性发现,而 FMV(二尖瓣瓣叶冗长、腱索拉长/断裂、瓣环扩张)才是 MVP 的核心问题:本综述旨在强调与 MR 严重程度无直接关系的 FMV/MVP 临床表现,并讨论导致这些表现的病理生理机制。
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引用次数: 0
Impact of an Exercise-Based Cardiac Rehabilitation Program on Cardiopulmonary Test Parameters. 以运动为基础的心脏康复计划对心肺测试参数的影响。
IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-08-27 DOI: 10.1159/000541011
Fabiana Duarte, Inês Ricardo, Clarissa Faria, Pedro Alves da Silva, Nelson Cunha, Sandra Miguel, Rita Pinto, Fausto Pinto, Ana Abreu

Introduction: Exercise-based cardiac rehabilitation programs (CRPs) represent a multidisciplinary therapeutic approach tailored to improve cardiorespiratory fitness and overall health-related quality of life, while reducing cardiovascular hospitalizations and mortality. Our aim was to determine changes in exercise capacity and cardiac events according to the left ventricular ejection fraction (LVEF) following a CRP.

Methods: This single-center cohort study included 131 patients who completed a center-based CRP from 2015 to 2022. Cardiopulmonary exercise testing (CPET), transthoracic echocardiography, and laboratory analysis were performed before and after program completion.

Results: Of 232 enrolled patients, 131 were included in our cohort analysis, with 36.6% having a reduced LVEF. These patients exhibited higher rates of atrial fibrillation (p = 0.019) and NT-proBNP values (p < 0.001). Patients with reduced LVEF had lower peak VO2 (pVO2) (p = 0.046), percentage of predicted oxygen consumption (ppVO2) (p < 0.001), and VO2 at anaerobic threshold (p = 0.015) during baseline CPET. Completion of the CRP led to comparable improvements in exercise performance between groups, assessed through Δ pVO2 (p = 0.990), Δ ppVO2 (p = 0.610), and Δ VE/VCO2 slope (p = 0.200). In the study population, male gender and hypertension independently predicted variation in VE/VCO2 slope (p = 0.017) and oxygen uptake efficiency slope (p = 0.048), respectively, post-CRP. During follow-up, 9.2% of all patients had hospital admissions for cardiac events, and 3.8% died, with no significant differences between groups.

Conclusion: Patients with reduced LVEF admitted to our CRP showed lower functional status based on specific CPET parameters. After CRP, both reduced and preserved LVEF groups experienced similar functional improvements. Therefore, strategies to increase participation of patients with reduced LVEF in such programs are warranted.

介绍:以运动为基础的心脏康复计划(CRP)是一种多学科治疗方法,旨在改善心肺功能和与健康相关的整体生活质量,同时降低心血管疾病的住院率和死亡率。我们的目的是根据左心室射血分数(LVEF)来确定心肺康复治疗后运动能力和心脏事件的变化:这项单中心队列研究对 2015 年至 2022 年期间完成中心 CRP 的 131 名患者进行了研究。在项目完成前后进行了心肺运动测试(CPET)、经胸超声心动图和实验室分析:在 232 名注册患者中,131 人被纳入队列分析,其中 36.6% 的患者 LVEF 降低。这些患者的心房颤动率(p=0.019)和NT-proBNP值(p<0.001)均较高。在基线 CPET 中,LVEF 降低的患者的峰值 VO2(p=0.046)、ppVO2(p<0.001)和无氧阈值 VO2(p=0.015)均较低。通过Δ pVO2(p=0.990)、Δ ppVO2(p=0.610)和Δ VE/VCO2 斜率(p=0.200)评估,完成 CRP 后,各组之间的运动表现改善程度相当。在研究人群中,男性性别和高血压分别独立预测了CRP后VE/VCO2斜率(p=0.017)和摄氧效率斜率(p=0.048)的变化。在随访期间,9.2%的患者因心脏事件入院,3.8%的患者死亡,没有组间差异:结论:根据特定的 CPET 参数,接受 CRP 治疗的 LVEF 降低的患者功能状态较差。经过 CRP 治疗后,LVEF 降低组和 LVEF 保持组的功能改善情况相似。因此,有必要制定策略,让更多 LVEF 降低的患者参与此类项目。
{"title":"Impact of an Exercise-Based Cardiac Rehabilitation Program on Cardiopulmonary Test Parameters.","authors":"Fabiana Duarte, Inês Ricardo, Clarissa Faria, Pedro Alves da Silva, Nelson Cunha, Sandra Miguel, Rita Pinto, Fausto Pinto, Ana Abreu","doi":"10.1159/000541011","DOIUrl":"10.1159/000541011","url":null,"abstract":"<p><strong>Introduction: </strong>Exercise-based cardiac rehabilitation programs (CRPs) represent a multidisciplinary therapeutic approach tailored to improve cardiorespiratory fitness and overall health-related quality of life, while reducing cardiovascular hospitalizations and mortality. Our aim was to determine changes in exercise capacity and cardiac events according to the left ventricular ejection fraction (LVEF) following a CRP.</p><p><strong>Methods: </strong>This single-center cohort study included 131 patients who completed a center-based CRP from 2015 to 2022. Cardiopulmonary exercise testing (CPET), transthoracic echocardiography, and laboratory analysis were performed before and after program completion.</p><p><strong>Results: </strong>Of 232 enrolled patients, 131 were included in our cohort analysis, with 36.6% having a reduced LVEF. These patients exhibited higher rates of atrial fibrillation (p = 0.019) and NT-proBNP values (p &lt; 0.001). Patients with reduced LVEF had lower peak VO2 (pVO2) (p = 0.046), percentage of predicted oxygen consumption (ppVO2) (p &lt; 0.001), and VO2 at anaerobic threshold (p = 0.015) during baseline CPET. Completion of the CRP led to comparable improvements in exercise performance between groups, assessed through Δ pVO2 (p = 0.990), Δ ppVO2 (p = 0.610), and Δ VE/VCO2 slope (p = 0.200). In the study population, male gender and hypertension independently predicted variation in VE/VCO2 slope (p = 0.017) and oxygen uptake efficiency slope (p = 0.048), respectively, post-CRP. During follow-up, 9.2% of all patients had hospital admissions for cardiac events, and 3.8% died, with no significant differences between groups.</p><p><strong>Conclusion: </strong>Patients with reduced LVEF admitted to our CRP showed lower functional status based on specific CPET parameters. After CRP, both reduced and preserved LVEF groups experienced similar functional improvements. Therefore, strategies to increase participation of patients with reduced LVEF in such programs are warranted.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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