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Outcomes of Complex Wound Reconstruction in High-Risk Patients Using Decellularized Extracellular Matrix from Porcine Urinary Bladder. 利用猪膀胱脱细胞细胞外基质重建高危患者复杂伤口的效果。
Pub Date : 2025-04-29 eCollection Date: 2025-01-01
Gracie R Baum, Cameron T Cox, Ian L Valerio, Brendan J MacKay

Background: The treatment of complex wounds remains a challenging aspect of reconstructive surgery, given their diverse nature and the frequent need for high-level surgical procedures. Standard treatment with flap coverage can achieve many goals; however, it is not without difficulties, including technical complexity, extended recovery times, donor site morbidity, and vascular complications, particularly in non-optimized patients. Acellular extracellular matrices, such as porcine urinary bladder matrices, have emerged as an alternative approach to support wound healing without the risks of high-level reconstruction. Urinary bladder matrix provides an extracellular matrix scaffold that supports intrinsic tissue regeneration mechanisms, allowing for stable, well-vascularized wound bed formation.

Methods: This retrospective case series examines the outcomes of urinary bladder matrix for the treatment of complex wounds in 21 patients deemed high-risk or unfavorable candidates for surgical management with local or free flap techniques. The patients were treated by 2 surgeons at 2 separate level 1 trauma centers from October 2019 through June 2022. Urinary bladder matrix was the primary wound management modality with serial wound debridement, matrix reapplication, and subsequent wound care tailored to each patient until definitive, stable coverage.

Results: In all cases, urinary bladder matrix facilitated soft tissue remodeling, permitting complete wound re-epithelization or preparation for skin grafting and/or flap coverage. Four patients' wounds re-epithelized on their own, while 17 patients received subsequent skin graft. In 2 of these cases, the initial split-thickness skin graft failed, requiring a second skin graft and or/flap coverage.

Conclusions: Our results demonstrate that urinary bladder matrix facilitates definitive soft tissue reconstruction and can be a valuable adjunct to wound repair, providing a simpler, less morbid treatment option for patients with various comorbidities and injury mechanisms.

背景:复杂伤口的治疗仍然是重建手术的一个具有挑战性的方面,因为它们的多样性和高水平的外科手术的频繁需求。皮瓣覆盖标准治疗可达到多种目的;然而,并非没有困难,包括技术复杂性、恢复时间延长、供体部位发病率和血管并发症,特别是在未优化的患者中。脱细胞细胞外基质,如猪膀胱基质,已经成为一种支持伤口愈合的替代方法,而没有高水平重建的风险。膀胱基质提供了一种细胞外基质支架,支持内在的组织再生机制,允许稳定,血管化良好的伤口床形成。方法:回顾性分析了21例膀胱基质治疗复杂伤口的结果,这些患者被认为是高风险或不适合局部或自由皮瓣手术治疗的患者。这些患者从2019年10月到2022年6月在两个不同的一级创伤中心由两名外科医生治疗。膀胱基质是主要的伤口处理方式,通过连续的伤口清创,基质的重新应用,以及针对每个患者的后续伤口护理,直到确定,稳定的覆盖范围。结果:在所有病例中,膀胱基质促进软组织重塑,允许完整的伤口再上皮或为皮肤移植和/或皮瓣覆盖做准备。4例患者创面自行再生上皮,17例患者随后接受皮肤移植。其中2例,最初的裂厚皮肤移植失败,需要第二次皮肤移植和/ /皮瓣覆盖。结论:我们的研究结果表明,膀胱基质有助于软组织重建,是一种有价值的伤口修复辅助手段,为各种合并症和损伤机制的患者提供了一种更简单、更少病态的治疗选择。
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引用次数: 0
Effectiveness of Using Autologous Saphenous Vein as Arteriovenous Graft for Patients With Chronic Wounds Undergoing Hemodialysis. 自体隐静脉作为动静脉移植治疗慢性伤口血液透析的疗效观察。
Pub Date : 2025-04-22 eCollection Date: 2025-01-01
Masahiro Kuwabara, Hiroto Hosoyamada, Kana Tokuno, Takahiro Hirayama, Eri Ichijo, Naoto Yamamoto

Although the first choice of vascular access for hemodialysis is still the creation of an arteriovenous fistula, the increasing number of vascular access creations in Japan, as well as the inability of percutaneous transluminal angioplasty to effectively restore patency in stenotic and obstructed native vascular accesses, has resulted in an increase in the rate of arteriovenous grafting for hemodialysis. However, for patients with infected wounds, using a prosthetic graft is generally contraindicated because of the risk of the spread of infection. In such cases, options tend to be limited to less frequently used or novel methods of vascular hemodialysis access, such as basilic vein transposition and autologous vein transplantation. Herein, we report 3 successful cases of arteriovenous grafting using an autologous saphenous vein. Careful preoperative evaluation of the vascular anatomy is necessary to effectively determine the best option for vascular access in such patients.

虽然血液透析血管通路的首选仍然是建立动静脉瘘,但在日本,血管通路的建立越来越多,以及经皮腔内血管成形术无法有效恢复狭窄和阻塞的天然血管通路的通畅,导致血液透析中动静脉移植的比例增加。然而,对于伤口感染的患者,由于感染扩散的风险,使用假体移植物通常是禁忌的。在这种情况下,选择往往限于较少使用或新颖的血管血液透析途径,如basilic静脉转置和自体静脉移植。在此,我们报告3例成功的自体隐静脉动静脉移植术。术前仔细的血管解剖评估是必要的,以有效地确定这类患者血管通路的最佳选择。
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引用次数: 0
Facial Aesthetics in Artificial Intelligence: First Investigation Comparing Results in a Generative AI Study. 人工智能中的面部美学:第一次对生成式人工智能研究结果的调查比较。
Pub Date : 2025-04-21 eCollection Date: 2025-01-01
Arsany Yassa, Arya Akhavan, Solina Ayad, Olivia Ayad, Anthony Colon, Ashley Ignatiuk

Background: Patients undergoing facial plastic surgery are increasingly using artificial intelligence (AI) to visualize expected postoperative results. However, AI training models' variations and lack of proper surgical photography in training sets may result in inaccurate simulations and unrealistic patient expectations. This study aimed to determine if AI-generated images can deliver realistic expectations and be useful in a surgical context.

Methods: The authors used AI platforms Midjourney (Midjourney, Inc), Leonardo (Canva), and Stable Diffusion (Stability AI) to generate otoplasty, genioplasty, rhinoplasty, and platysmaplasty images. Board-certified plastic surgeons and residents assessed these images based on 11 metrics that were grouped into 2 criteria: realism and clinical value. Analysis of variance and Tukey Honestly Significant Difference post-hoc analysis tests were used for data analysis.

Results: Performance for each metric was reported as mean ± SD. Midjourney outperformed Stable Diffusion significantly in realism (3.57 ± 0.58 vs 2.90 ± 0.65; P < .01), while no significant differences in clinical value were observed between the AI models (P = .38). Leonardo outperformed Stable Diffusion significantly in size and volume accuracy (3.83 ± 0.24 vs 3.00 ± 0.36; P = .02). Stable Diffusion underperformed significantly in anatomical correctness, age simulation, and texture mapping (most P values were less than .01). All 3 AI models consistently underperformed in healing and scarring prediction. The uncanny valley effect was also observed by the evaluators.

Conclusions: Certain AI models outperformed others in generating the images, with evaluator opinions varying on their realism and clinical value. Some images reasonably depicted the target area and the expected outcome; however, many images displayed inappropriate postsurgical outcomes or provoked the uncanny valley effect with their lack of realism. The authors stress the need for AI improvement to produce better pre- and postoperative images, and plan for further research comparing AI-generated visuals with actual surgical results.

背景:接受面部整形手术的患者越来越多地使用人工智能(AI)来可视化预期的术后结果。然而,人工智能训练模型的变化和训练集中缺乏适当的手术摄影可能导致不准确的模拟和不切实际的患者期望。这项研究旨在确定人工智能生成的图像是否能达到现实的预期,并在手术环境中有用。方法:作者使用人工智能平台Midjourney (Midjourney, Inc)、Leonardo (Canva)和Stable Diffusion (Stability AI)生成耳成形术、颏成形术、鼻成形术和平台成形术图像。委员会认证的整形外科医生和住院医师根据11项指标评估这些图像,这些指标分为两个标准:真实性和临床价值。数据分析采用方差分析和Tukey honest显著性差异事后分析检验。结果:每个指标的表现以mean±SD报告。中程在真实感方面明显优于稳定扩散(3.57±0.58 vs 2.90±0.65;P < 0.01),而AI模型之间的临床价值无显著差异(P = .38)。Leonardo在尺寸和体积精度上明显优于Stable Diffusion(3.83±0.24 vs 3.00±0.36;P = .02)。Stable Diffusion在解剖正确性、年龄模拟和纹理映射方面表现不佳(大多数P值小于0.01)。这三种人工智能模型在愈合和疤痕预测方面一直表现不佳。评估者也观察到恐怖谷效应。结论:某些人工智能模型在生成图像方面优于其他模型,评估者对其真实感和临床价值的看法不一。一些图像合理地描绘了目标区域和预期结果;然而,许多图像显示不合适的术后结果或引发恐怖谷效应,因为它们缺乏真实性。作者强调需要改进人工智能以产生更好的术前和术后图像,并计划进一步研究将人工智能生成的视觉效果与实际手术结果进行比较。
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引用次数: 0
Mitigating Hair Loss Among Scalp Laceration Repair Techniques: Review of the Literature. 缓解头皮撕裂伤修复技术中的脱发:文献综述。
Pub Date : 2025-03-17 eCollection Date: 2025-01-01
Virginia Bailey, Kenan Kherallah, Jamie Warner, Sarah Moffit, Meredith Moore, D'Arcy Wainwright, Michael Harrington

Scalp lacerations represent a significant portion of traumatic wounds treated in emergency settings, presenting unique challenges due to the scalp's high vascularity and tension on closure. This study explores primary closure techniques for scalp defects, focusing on sutures, staples, and the hair apposition technique (HAT). Given the cosmetic and psychological implications of hair loss associated with scalp laceration repairs, effective closure methods are paramount. This systematic review evaluates the efficacy of sutures, staples, and HAT in minimizing hair loss and enhancing cosmetic outcomes. Out of an initial 21530 literature sources, 7 studies were included in this analysis, selected through a comprehensive screening process. Findings suggest that while traditional methods like sutures and staples are widely used, HAT shows promise in reducing complications and preserving hair. The study underscores the importance of selecting appropriate closure techniques to optimize patient satisfaction and overall care quality.

头皮撕裂伤在紧急情况下治疗的创伤性伤口中占很大一部分,由于头皮的高血管性和闭合时的张力,它提出了独特的挑战。本研究探讨了头皮缺损的主要闭合技术,重点是缝合线、订书钉和头发贴置技术(HAT)。考虑到与头皮撕裂伤修复相关的脱发的美容和心理影响,有效的闭合方法是至关重要的。本系统综述评估了缝合线、订书钉和HAT在减少脱发和提高美容效果方面的功效。从最初的21530个文献来源中,通过综合筛选过程选择了7项研究纳入本分析。研究结果表明,虽然缝合和钉针等传统方法被广泛使用,但HAT在减少并发症和保护头发方面表现出了希望。该研究强调了选择合适的闭合技术以优化患者满意度和整体护理质量的重要性。
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引用次数: 0
UAD Flap: A Contemporary Alternative to the Conventional Sural Flap for Distal Leg Wound Reconstruction. UAD皮瓣:传统腓肠皮瓣用于小腿远端伤口重建的当代替代方案。
Pub Date : 2025-03-17 eCollection Date: 2025-01-01
Muhammad Usman Amiruddin, Ali Hassan, Hafiz Saqib Sikandar, Tanzeela Razzaq, Muhammad Siyyam

Background: The reconstruction of soft tissue near the heel area is challenging, especially after wheel-spoke injuries. Different varieties of the reverse sural artery flap technique are routinely used in complex locoregional areas for reconstructive surgery.

Methods: This study proposes an innovative surgical method involving the use of a rotation-advancement fasciocutaneous flap based on peroneal artery perforators. In this study, 30 patients with soft-tissue defects in the lower third of the leg, including defects in the ankle and heel areas, were treated with this flap.

Results: The study included 19 women and 11 men. The mean age of the patients was 27.60 years. The most common cause of the defect was wheel-spoke injury due to a road traffic accident. In the authors' experience, the flap survival rate was approximately 100%. Four patients had only marginal necrosis of the distal tip, and 2 patients had minor wound infections; these patients were managed cautiously until their healing was complete.

Conclusions: For distal leg reconstruction, the authors recommend the UAD flap over the traditional sural flap because of its lower donor-site morbidity and better aesthetic appearance.

背景:近跟区软组织的重建是具有挑战性的,特别是轮辐损伤后。不同种类的腓肠反动脉瓣技术通常用于复杂的局部区域重建手术。方法:本研究提出了一种创新的手术方法,包括使用基于腓动脉穿支的旋转推进筋膜皮瓣。在本研究中,30例小腿下三分之一的软组织缺损患者,包括脚踝和脚跟区域的缺损,采用该皮瓣治疗。结果:该研究包括19名女性和11名男性。患者平均年龄27.60岁。这种缺陷最常见的原因是道路交通事故造成的轮辐损伤。根据作者的经验,皮瓣存活率约为100%。4例患者仅有远端边缘坏死,2例患者有轻微创面感染;这些病人被小心地管理直到他们完全愈合。结论:对于小腿远端重建,作者推荐UAD皮瓣优于传统腓肠皮瓣,因为其供区发病率低且美观。
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引用次数: 0
Piscine-Derived Acellular Dermal Matrix in Upper Extremity Reconstruction. 鱼源脱细胞真皮基质在上肢重建中的应用。
Pub Date : 2025-03-13 eCollection Date: 2025-01-01
Shawhin Shahriari, Cees Whisonant, Joseph Kuhn, Tyler Chavez, Joshua Harrison, Casey McDonald, Adam Schwartz, Jolee Suddock, Elizabeth Mikola, Gregory Borah

Background: Wound reconstruction involving exposed critical structures, especially in medically complex patients and in those who are at high risk of loss to follow-up, presents a unique challenge to surgeons. The use of acellular dermal matrix (ADM) has augmented our ability to address these wounds safely and with minimal morbidity. A piscine ADM, the Kerecis Omega3 Wound, has shown promise in the treatment of chronic wounds and burns. In this study, we describe the use of the Omega3 Wound in reconstruction of upper extremity wounds, including those with exposed critical structures.

Methods: From 2019 to 2021, 11 consecutive patients with upper extremity wounds, including 9 with exposed critical structures, were queried. Clinical data was tabulated to evaluate outcomes.

Results: Etiology of the wounds included burns, trauma, infection, and oncologic resection. Wound surface area was 150 ± 42 cm2. Time to incorporation of the Omega3 Wound was 2 weeks, and the vital structures of previously critical wounds were covered with granulation tissue. Clinically and histologically, the ADM became granulation tissue once incorporated. The average time from application to discharge was 6 days, with 3 patients discharged on the day of application. Skin grafting was subsequently performed at an outpatient surgical center, with 3 weeks as the average time to skin grafting.

Conclusions: The Omega3 Wound allows for complete biologic integration and vascularized wound coverage that accepts a skin graft. Patients can be discharged after application and managed at outpatient facilities. This ADM is safe and well tolerated by patients (including those who are diabetic and immunocompromised) for coverage of upper extremity wounds with exposed critical structures.

背景:涉及暴露的关键结构的伤口重建,特别是在医疗复杂的患者和那些在随访中丢失高风险的患者,对外科医生提出了独特的挑战。脱细胞真皮基质(ADM)的使用增强了我们安全处理这些伤口的能力,并且发病率最低。一种名为Kerecis Omega3 Wound的鱼类ADM在治疗慢性伤口和烧伤方面显示出了希望。在本研究中,我们描述了Omega3 Wound在上肢创伤重建中的应用,包括那些关键结构暴露的上肢创伤。方法:对2019年至2021年连续11例上肢创面患者,包括9例关键结构外露患者进行问卷调查。将临床数据制成表格以评估结果。结果:创伤的病因包括烧伤、外伤、感染和肿瘤切除。创面面积150±42 cm2。Omega3创面的植入时间为2周,先前严重创面的重要结构被肉芽组织覆盖。临床和组织学上,ADM一旦合并就变成肉芽组织。申请至出院平均时间为6天,申请当日出院3例。随后在门诊外科中心进行植皮,平均植皮时间为3周。结论:Omega3创面允许完全的生物整合和血管化创面覆盖,接受皮肤移植。患者可申请出院,并在门诊机构管理。对于暴露出关键结构的上肢伤口,这种ADM是安全且耐受性良好的(包括糖尿病患者和免疫功能低下的患者)。
{"title":"Piscine-Derived Acellular Dermal Matrix in Upper Extremity Reconstruction.","authors":"Shawhin Shahriari, Cees Whisonant, Joseph Kuhn, Tyler Chavez, Joshua Harrison, Casey McDonald, Adam Schwartz, Jolee Suddock, Elizabeth Mikola, Gregory Borah","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Wound reconstruction involving exposed critical structures, especially in medically complex patients and in those who are at high risk of loss to follow-up, presents a unique challenge to surgeons. The use of acellular dermal matrix (ADM) has augmented our ability to address these wounds safely and with minimal morbidity. A piscine ADM, the Kerecis Omega3 Wound, has shown promise in the treatment of chronic wounds and burns. In this study, we describe the use of the Omega3 Wound in reconstruction of upper extremity wounds, including those with exposed critical structures.</p><p><strong>Methods: </strong>From 2019 to 2021, 11 consecutive patients with upper extremity wounds, including 9 with exposed critical structures, were queried. Clinical data was tabulated to evaluate outcomes.</p><p><strong>Results: </strong>Etiology of the wounds included burns, trauma, infection, and oncologic resection. Wound surface area was 150 ± 42 cm<sup>2</sup>. Time to incorporation of the Omega3 Wound was 2 weeks, and the vital structures of previously critical wounds were covered with granulation tissue. Clinically and histologically, the ADM became granulation tissue once incorporated. The average time from application to discharge was 6 days, with 3 patients discharged on the day of application. Skin grafting was subsequently performed at an outpatient surgical center, with 3 weeks as the average time to skin grafting.</p><p><strong>Conclusions: </strong>The Omega3 Wound allows for complete biologic integration and vascularized wound coverage that accepts a skin graft. Patients can be discharged after application and managed at outpatient facilities. This ADM is safe and well tolerated by patients (including those who are diabetic and immunocompromised) for coverage of upper extremity wounds with exposed critical structures.</p>","PeriodicalId":93993,"journal":{"name":"Eplasty","volume":"25 ","pages":"e10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle Hernia Repair at Fascia Lata Autograft Donor Site. 自体阔筋膜供体肌疝修复。
Pub Date : 2025-03-07 eCollection Date: 2025-01-01
Tamara Alcala Dominguez, Stephen Viviano, Duane Wang

Background: The fascia lata autograft is a versatile material utilized in a wide variety of soft tissue reconstructive procedures. Our case highlights an instance in which harvesting fascia lata resulted in a symptomatic vastus lateralis muscle herniation at the donor site that required 2 surgical revisions.

Methods: In this case, a patient developed a thigh muscle hernia at a fascia lata graft donor site. The hernia required a secondary surgical reconstruction utilizing a mesh underlay for the fascial defect repair.

Results: There has been no recurrence of the hernia 1 year after reconstruction, and the patient is able to ambulate normally and with minimal pain.

Conclusions: Use of a fascia lata autograft can result in debilitating donor-site morbidity in certain patients. Prompt reconstruction of residual fascial defects at the time of graft harvest is ideal. However, in this patient, reconstruction with a prosthetic mesh reinforcement several years after symptomatic herniation led to significant improvement in quality of life. Cases of lateral thigh pain with associated bulge also benefit from early magnetic resonance imaging or ultrasound imaging to diagnose fascia defects or distinguish other etiologies.

背景:自体阔筋膜是一种用途广泛的材料,广泛应用于各种软组织重建手术。我们的病例突出了一例阔筋膜切除导致供体部位有症状的股外侧肌突出,需要2次手术修复。方法:在本病例中,患者在阔筋膜移植供体部位发生大腿肌肉疝。疝气需要二次手术重建,利用网状垫修复筋膜缺损。结果:术后1年无疝复发,患者能正常行走,疼痛最小。结论:在某些患者中,自体阔筋膜移植可导致供体部位发病率下降。在移植时及时重建残余筋膜缺损是理想的。然而,在该患者中,在症状性疝出数年后使用假体补片进行重建,显著改善了生活质量。大腿外侧疼痛伴隆起的病例也可通过早期磁共振成像或超声成像诊断筋膜缺损或区分其他病因。
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引用次数: 0
Incidental Breast Carcinoma in Reduction Mammoplasty: A Systematic Review. 缩乳术中偶发乳腺癌:系统回顾。
Pub Date : 2025-02-20 eCollection Date: 2025-01-01
Jung Ho Gong, Ronald K Akiki, Rachel Sullivan

Background: Breast reduction is one of the most common plastic surgeries, with more than 40000 procedures performed in the United States annually. As breast reductions remove a portion of the breast and distort the anatomy, plastic surgeons need to be mindful of the possibility of breast cancer. In this study, we sought to review the available literature on breast cancer workup for patients undergoing reduction mammoplasties.

Methods: We queried the PubMed (National Institutes of Health) and Embase (Elsevier) databases to identify studies discussing breast cancer workup before breast reduction via preoperative imaging and/or at the time of surgery via histopathologic evaluation of breast specimens. Two individual reviewers screened the titles and abstracts for relevance. We extracted data on the outcomes of preoperative imaging and histopathologic evaluation of breast reduction specimens.

Results: Twenty-three articles published between 1996 and 2022 met the inclusion/exclusion criteria. Two studies evaluated only the role of preoperative imaging and reported a biopsy rate of 3.7% to 5.1% based on imaging findings. Three studies discussed only the role of histopathologic evaluation without mentioning the preoperative imaging requirements from the patients. For the remaining 18 studies, the rate of incidental breast cancer from breast reduction specimens was 0.0% to 2.0%. All studies recommended universal histopathologic evaluation of breast specimens.

Conclusions: In this review, we found unanimous recommendations for performing histopathologic evaluation of breast reduction samples, consistent with the 2022 American Society of Plastic Surgeons clinical practice guideline. Further research is still required to determine the optimal preoperative imaging approach for breast reduction.

背景:缩胸是最常见的整形手术之一,在美国每年有超过40000例手术。由于缩胸手术切除了部分乳房,使解剖结构发生扭曲,因此整形外科医生需要警惕患乳腺癌的可能性。在这项研究中,我们试图回顾现有的文献乳腺癌检查的患者接受缩小乳房成形术。方法:我们查询了PubMed(美国国立卫生研究院)和Embase(爱思唯尔)数据库,以确定通过术前成像和/或手术时通过乳房标本的组织病理学评估讨论乳房缩小前乳腺癌检查的研究。两位独立的审稿人筛选了标题和摘要的相关性。我们提取了缩乳标本术前影像学和组织病理学评估结果的数据。结果:1996 - 2022年间发表的23篇文章符合纳入/排除标准。两项研究仅评估了术前影像学的作用,并报告了基于影像学结果的活检率为3.7%至5.1%。三项研究仅讨论了组织病理学评估的作用,而未提及患者的术前影像学要求。在剩下的18项研究中,乳房缩小标本的偶发性乳腺癌发生率为0.0%至2.0%。所有的研究都建议对乳腺标本进行普遍的组织病理学评估。结论:在这篇综述中,我们发现了对缩乳样本进行组织病理学评估的一致建议,与2022年美国整形外科学会临床实践指南一致。需要进一步的研究来确定最佳的术前乳房缩小成像方法。
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引用次数: 0
Intensive Care Unit Admission Following Cleft Palate Repair in Patients With Pierre Robin Sequence Corrected With Mandibular Distraction. 下颌骨牵张矫正Pierre Robin序列腭裂修复后患者入住重症监护病房的情况。
Pub Date : 2025-02-19 eCollection Date: 2025-01-01
Shelby D Goza, Katherine E Baker, Madyson I Brown, Samuel J Hopper, John Phillips, Matthew C Sink, Katherine C Benedict, Kathryn W Brown, Colton J Fernstrum, Michael T Friel, Laura S Humphries, Ian C Hoppe

Background: Patients with Pierre Robin Sequence (PRS) treated with mandibular distraction (MD) frequently suffer from a cleft palate (CP). There are no standard practices surrounding the need for admission to a pediatric intensive care unit (PICU) following CP repair in these patients. This study will investigate the frequency of airway events following CP repair in this subset of patients.

Methods: A retrospective chart review of all patients with PRS treated with MD that also required CP repair surgery at the authors' institution from 2012 to 2022 was performed. Intraoperative and postoperative analgesic usage, preoperative and postoperative respiratory status, presence of a concomitant operation, comorbid anomalies, as well as age and weight at CP repair were recorded. Our primary outcomes included length of stay following CP repair, presence of airway events perioperatively/postoperatively, and admission status following CP repair.

Results: Twenty-nine patients underwent MD during this period, of which 13 patients also underwent repair of a CP. The average length of stay following CP repair was 2.3 days. Only 2 airway events were noted, and only 3 patients were admitted to the PICU following repair. Presence of comorbid musculoskeletal and neurologic abnormalities was associated with postoperative PICU admission.Remaining intubated following CP repair was associated with increased analgesic usage intraoperatively. A longer duration of intubation following MD was associated with PICU admission and remaining intubated following CP repair.

Conclusions: Overall, it appears that admission to the floor following CP repair in PRS patients with a history of MD is generally safe.

背景:采用下颌骨牵张术(MD)治疗的Pierre Robin Sequence (PRS)患者常并发腭裂(CP)。这些患者在CP修复后是否需要入住儿科重症监护病房(PICU)尚无标准做法。本研究将调查这部分患者CP修复后气道事件的频率。方法:对2012年至2022年在作者所在机构进行的所有PRS合并MD并需要CP修复手术的患者进行回顾性分析。记录术中和术后镇痛药的使用情况、术前和术后呼吸状况、是否伴有手术、合并症异常以及CP修复时的年龄和体重。我们的主要结果包括CP修复后的住院时间、术中/术后气道事件的存在以及CP修复后的入院情况。结果:29例患者在此期间接受了MD,其中13例患者也接受了CP修复。CP修复后的平均住院时间为2.3天。只有2例气道事件被记录,只有3例患者在修复后住进PICU。并发肌肉骨骼和神经异常与术后PICU住院有关。CP修复后继续插管与术中镇痛药的使用增加有关。MD后插管时间较长与PICU入院和CP修复后继续插管有关。结论:总的来说,有MD病史的PRS患者在CP修复后入院通常是安全的。
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引用次数: 0
Good Outcomes After a Severity Triad: Systemic Complications, Bacterial and Fungal Infections in 3 Patients With Major Burns. 重度烧伤3例系统性并发症、细菌和真菌感染后的良好预后
Pub Date : 2025-02-19 eCollection Date: 2025-01-01
Eliza-Maria Bordeanu-Diaconescu, Andreea Grosu-Bularda, Adrian Frunza, Sabina Grama, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga

Burn injuries resulting from domestic explosions involving liquefied petroleum gas present complex challenges in clinical management. We present 3 cases of patients with severe burn injuries, highlighting diverse presentations and complications encountered during their treatment. Despite significant morbidity, all patients demonstrated favorable outcomes, emphasizing the importance of comprehensive management strategies. Challenges included inhalation injury, microbial infections, thromboembolic complications, and acute kidney injury. Aggressive treatment modalities, including bronchoscopy-guided therapy, targeted antimicrobial therapy, and vigilant infection control, effectively addressed these complications. Multidisciplinary collaboration and adherence to evidence-based guidelines optimized outcomes. Continued research and innovation are needed to further enhance care and improve long-term outcomes for patients with severe burns.

涉及液化石油气的家庭爆炸造成的烧伤在临床管理中提出了复杂的挑战。我们报告了3例严重烧伤患者,强调了他们在治疗过程中遇到的不同表现和并发症。尽管发病率很高,但所有患者均表现出良好的预后,强调了综合管理策略的重要性。挑战包括吸入性损伤、微生物感染、血栓栓塞并发症和急性肾损伤。积极的治疗方式,包括支气管镜引导治疗、靶向抗菌治疗和警惕感染控制,有效地解决了这些并发症。多学科合作和遵守循证指南优化了结果。需要持续的研究和创新来进一步加强严重烧伤患者的护理和改善长期预后。
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引用次数: 0
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