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Robot-assisted Laparoscopic W-shaped Ileocystoplasty in Children. 机器人辅助腹腔镜下儿童w型回肠成形术。
IF 25.2 Pub Date : 2025-12-17 DOI: 10.1016/j.eururo.2025.11.023
Amane-Allah Lachkar, Alexis Arnaud, Camille Duchesne, Matthieu Peycelon, Florence Julien-Marsollier, Annabel Paye, Alaa El-Ghoneimi

Background and objective: Robot-assisted bladder augmentation in children is rarely utilized across Europe. Performing this procedure robotically with an ileal loop "W" configuration is innovative. We analyzed the preliminary results of our experience in robotic-assisted laparoscopic W-shaped ileocystoplasty (RALAWI) in children.

Methods and surgical procedure: A prospective bicentric study included all patients who had RALAWI (2020-2024). The procedures were performed using the DaVinci Xi robot. The statistical analysis was descriptive (median [range]) and comparative. Thirteen patients were included (age 9.5 [5-16] yr, weight 31 [19-99] kg), and followed up for 15.5 (12-50) mo. Etiologies included the following: neuropathic bladder (nine cases), bladder exstrophy (two cases), rhabdomyosarcoma (one case), and bilateral ectopic ureters (one case).

Key findings and limitations: All procedures were performed intra-abdominally without conversion. The median operative time and length of stay were 670 (450-930) min and 12 (6-30) d, respectively. The associated procedures were extraserosal appendicovesicostomy (APV; eight cases), bladder neck reconstruction (six cases), bladder neck closure (one case), and bilateral ureteral reimplantation (two cases). Six patients had multiple abdominal surgeries previously. Four patients had complications at <30 d: urinary anastomotic leakage (N = 2, IIIB according to Clavien-Dindo), abscess (N = 1, IIIA), and ventriculoperitoneal shunt dysfunction (N = 1, IIIB). Five patients had nine complications at >30 d: stoma leakage (three cases, IIIB), bladder stone (one case, IIIB), difficult catheterization (two cases, IIIB), and ileocystoplasty perforation (one case, IIIB, and one case, IVA). None had APV stenosis. Postoperative bladder capacity was significantly higher (170 vs 350 ml; p < 0.01). All patients achieved continence.

Conclusions and clinical implications: To our knowledge, this is the first report of robot-assisted ileocystoplasty in children with a W-shape reconfiguration. It is feasible even after multiple surgeries, offering potential benefits for patients with fragile abdominal wall. The technique requires further refinements to reduce operative time and early postoperative complications.

背景和目的:机器人辅助膀胱增强术在欧洲很少用于儿童。采用回肠环“W”型结构的机器人执行这一过程是一种创新。我们分析了机器人辅助腹腔镜下儿童w型回肠成形术(RALAWI)的初步结果。方法和手术:一项前瞻性双中心研究纳入了所有患有RALAWI的患者(2020-2024)。这些程序是用达芬奇Xi机器人完成的。统计分析采用描述性(中位数[范围])和比较性。纳入13例患者(年龄9.5[5-16]岁,体重31 [19-99]kg),随访15.5(12-50)个月。病因包括:膀胱神经性病变(9例)、膀胱外翻(2例)、横纹肌肉瘤(1例)、双侧输尿管异位(1例)。主要发现和局限性:所有手术均在腹腔内进行,没有转换。中位手术时间670 (450 ~ 930)min,住院时间12 (6 ~ 30)d。相关手术为:膜外阑尾膀胱造口术(APV, 8例)、膀胱颈重建术(6例)、膀胱颈闭合术(1例)、双侧输尿管再植术(2例)。6名患者之前进行过多次腹部手术。4例患者在30 d出现并发症:造瘘瘘3例,IIIB;膀胱结石1例,IIIB;置管困难2例,IIIB;回肠成形术穿孔1例,IIIB, IVA。无APV狭窄。结论和临床意义:据我们所知,这是机器人辅助回肠成形术治疗w型重构儿童的第一篇报道。即使在多次手术后也是可行的,为腹壁脆弱的患者提供了潜在的好处。该技术需要进一步改进以减少手术时间和早期术后并发症。
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引用次数: 0
Re: Microbial Cancer Immunotherapy Reprograms Hematopoiesis To Enhance Myeloid-driven Anti-tumor Immunity. 微生物癌症免疫疗法重编程造血以增强髓细胞驱动的抗肿瘤免疫。
IF 25.2 Pub Date : 2025-12-17 DOI: 10.1016/j.eururo.2025.12.013
Cyrill A Rentsch, Richard L Cathomas
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引用次数: 0
Re: ctDNA-guided Adjuvant Atezolizumab in Muscle-invasive Bladder Cancer. 研究:ctdna引导的Atezolizumab治疗肌肉浸润性膀胱癌。
IF 25.2 Pub Date : 2025-12-17 DOI: 10.1016/j.eururo.2025.12.006
Savio Domenico Pandolfo, Laura Bukavina, Riccardo Autorino
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引用次数: 0
Re: Tumor Transcriptome-wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers. 肿瘤转录组表达分类器预测晚期前列腺癌的治疗敏感性。
IF 25.2 Pub Date : 2025-12-16 DOI: 10.1016/j.eururo.2025.12.012
Andrew J Armstrong
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引用次数: 0
Re: European Study of Prostate Cancer Screening - 23-Year Follow-up. 回复:欧洲前列腺癌筛查研究- 23年随访。
IF 25.2 Pub Date : 2025-12-16 DOI: 10.1016/j.eururo.2025.12.009
David-Dan Nguyen, Girish S Kulkarni, Gordon H Guyatt
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引用次数: 0
Re: Niraparib and Abiraterone Acetate plus Prednisone for HRR-deficient Metastatic Castration-sensitive Prostate Cancer: A Randomized Phase 3 Trial. 尼拉帕尼和醋酸阿比特龙加强的松治疗hrr缺乏的转移性阉割敏感前列腺癌:一项随机3期试验。
IF 25.2 Pub Date : 2025-12-16 DOI: 10.1016/j.eururo.2025.12.008
Jane McKenzie, Arun A Azad
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引用次数: 0
Re: Daniel S. Roberson, Vidit Sharma, Stephen A. Boorjian, et al. Consolidative Surgery for Advanced Urothelial Carcinoma Following Induction Enfortumab Vedotin and/or Immune Checkpoint Inhibitor Therapy: A Multicenter Analysis. Eur Urol 2025;88:212-4. 回复:Daniel S. Roberson, Vidit Sharma, Stephen A. Boorjian,等。诱导维多汀和/或免疫检查点抑制剂治疗后晚期尿路上皮癌的巩固手术:一项多中心分析欧洲地理学报(英文版);2015;88:212-4。
IF 25.2 Pub Date : 2025-12-15 DOI: 10.1016/j.eururo.2025.11.022
Jorge Esteban-Villarrubia, Guillermo de Velasco
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引用次数: 0
Beyond Menopause: Ending the Inequality-Why Men with Prostate Cancer Still Lack Therapies for Hot Flushes. 超越更年期:结束不平等——为什么前列腺癌患者仍然缺乏治疗潮热的方法。
IF 25.2 Pub Date : 2025-12-13 DOI: 10.1016/j.eururo.2025.12.004
Martino Pedrani, Silke Gillessen, Erik Briers, Pierre Blanchard, Anthony M Joshua, Bertrand Tombal

Androgen deprivation therapy (ADT) causes hot flushes that can disrupt an individual's quality of life. NK3R antagonists provide rapid, sustained, and nonhormonal relief of hot flushes in women, but an approved treatment is lacking for men. Pragmatic trials are needed to generate evidence to support approval of these agents for the ADT setting.

雄激素剥夺疗法(ADT)会导致潮热,从而影响个人的生活质量。NK3R拮抗剂对女性潮热提供快速、持续和非激素缓解,但对男性缺乏批准的治疗方法。需要实际的试验来产生证据来支持这些药物用于ADT的批准。
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引用次数: 0
Re: Single-nucleus RNA Sequencing Reveals Cellular and Molecular Signatures in the Prefrontal Cortex of a Hypoactive Sexual Desire Disorder Rat Model. Re:单核RNA测序揭示了性欲减退大鼠模型前额皮质的细胞和分子特征。
IF 25.2 Pub Date : 2025-12-03 DOI: 10.1016/j.eururo.2025.11.016
Guanjian Li, Rongqiu Zhang, Yunxia Cao
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引用次数: 0
Reply to Mattia Longoni, Giorgio Gandaglia, and Francesco Montorsi's Letter to the Editor re: Nicolas Demogeot, Paul Sargos, Julia Salleron, et al. Short-term Androgen Deprivation Therapy and High-dose Radiotherapy in Intermediate- and High-risk Localized Prostate Cancer: Results from the GETUG 14 Randomized Phase 3 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.07.019. 回复Mattia Longoni, Giorgio Gandaglia和Francesco Montorsi给编辑的信:Nicolas Demogeot, Paul Sargos, Julia saleron等人。短期雄激素剥夺疗法和高剂量放疗治疗中高风险局限性前列腺癌:来自GETUG 14随机3期试验的结果Urol欧元。在出版社。https://doi.org/10.1016/j.eururo.2025.07.019。
IF 25.2 Pub Date : 2025-10-23 DOI: 10.1016/j.eururo.2025.09.4176
Nicolas Demogeot, Stéphane Supiot, Paul Sargos
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引用次数: 0
期刊
European urology
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