Pub Date : 2026-01-20DOI: 10.1016/j.medine.2025.502346
Raquel Varona Sáez de Ibarra, Pedro Jiménez Cabrera, Lourdes Fisac Cuadrado
{"title":"Portal pneumatosis and aortic endoleak in a patient with recent aortic valve surgery.","authors":"Raquel Varona Sáez de Ibarra, Pedro Jiménez Cabrera, Lourdes Fisac Cuadrado","doi":"10.1016/j.medine.2025.502346","DOIUrl":"https://doi.org/10.1016/j.medine.2025.502346","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502346"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.medine.2025.502343
José Manuel Añón, María Paz Escuela, Javier Oliva-Navarro, Arís Pérez-Lucendo, Fernando Suarez-Sipmann
{"title":"Authors' response to: Anesthetic gases in the sedation of critically ill patients.","authors":"José Manuel Añón, María Paz Escuela, Javier Oliva-Navarro, Arís Pérez-Lucendo, Fernando Suarez-Sipmann","doi":"10.1016/j.medine.2025.502343","DOIUrl":"https://doi.org/10.1016/j.medine.2025.502343","url":null,"abstract":"","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502343"},"PeriodicalIF":0.0,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.medine.2025.502345
Alba Cebrián-Cortés, Isabel Sánchez-Gaona, José Miguel Pérez-Villares, Antonio Cárdenas-Cruz
EVALI is a rapidly developing toxic inhalation syndrome that has been linked to electronic cigarettes. It is characterized by a wide variety of radiological and histological patterns, with diffuse alveolar damage and acute respiratory distress syndrome being the most severe forms. This condition mainly affects young people and typically has a nonspecific clinical presentation. The diagnosis is one of exclusion, making it essential to thoroughly investigate into the medical history in order to perform a broad differential diagnosis that allows other causes to be ruled out. Treatment is based on supportive measures. Corticosteroids may be beneficial, although there is no standardized protocol and their use is highly heterogeneous. The lack of evidence on the long-term effects of vaping highlights the need for longitudinal studies and preventive strategies aimed at reducing its consumption.
{"title":"Lung injury associated with electronic cigarette use or vaping: A narrative review.","authors":"Alba Cebrián-Cortés, Isabel Sánchez-Gaona, José Miguel Pérez-Villares, Antonio Cárdenas-Cruz","doi":"10.1016/j.medine.2025.502345","DOIUrl":"https://doi.org/10.1016/j.medine.2025.502345","url":null,"abstract":"<p><p>EVALI is a rapidly developing toxic inhalation syndrome that has been linked to electronic cigarettes. It is characterized by a wide variety of radiological and histological patterns, with diffuse alveolar damage and acute respiratory distress syndrome being the most severe forms. This condition mainly affects young people and typically has a nonspecific clinical presentation. The diagnosis is one of exclusion, making it essential to thoroughly investigate into the medical history in order to perform a broad differential diagnosis that allows other causes to be ruled out. Treatment is based on supportive measures. Corticosteroids may be beneficial, although there is no standardized protocol and their use is highly heterogeneous. The lack of evidence on the long-term effects of vaping highlights the need for longitudinal studies and preventive strategies aimed at reducing its consumption.</p>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":" ","pages":"502345"},"PeriodicalIF":0.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.medine.2025.502258
Yukang Dong , Guiyun Li , Jiangquan Fu , Rui Huang , Huan Yao , Jingni Wang , Ying Wang , Feng Shen
Objective
This study aims to evaluate the association of time‑weighted average mechanical power normalized to compliance (TWA-MPCRS) with all-cause mortality to determine its value as a prognostic tool in intensive care patients.
Design
Retrospective observational study.
Setting
Intensive care unit (ICU).
Patients or participants
4387 first-time ICU-admitted patients in the Medical Information Mart for Intensive Care (MIMIC) IV.
Interventions
None.
Main variables of interest
TWA-MPCRS, ICU mortality and in-hospital mortality.
Results
Participants' mean age was 61.4 ± 16.9 years and the median [IQR] baseline TWA-MPCRS was 0.3 (0.2, 0.6) J/min/mL/cmH2O. When TWA-MPCRS was divided into quintiles (with quintile 1 representing the lowest values), after adjusting for covariates, the odds ratios [95% confidence intervals (CIs)] for ICU mortality were 1.49 (95% CI: 1.15–1.94), 1.67 (95% CI: 1.29–2.16), 1.79 (95% CI: 1.37–2.33), and 3.96 (95% CI: 3.01–5.21) for quintiles 2, 3, 4, and 5 respectively, with quintile 1 as reference. Similar results were found for hospital mortality.
Conclusion
Higher TWA-MPCRS is associated with poor clinical outcomes in critically ill patients. Higher TWA-MPCRS can lead to a higher mortality among ICU and in-hospital patients.
{"title":"Association between time weighted average mechanical power normalized to compliance and prognosis of critically ill patients: A retrospective cohort study based on the MIMIC-IV database","authors":"Yukang Dong , Guiyun Li , Jiangquan Fu , Rui Huang , Huan Yao , Jingni Wang , Ying Wang , Feng Shen","doi":"10.1016/j.medine.2025.502258","DOIUrl":"10.1016/j.medine.2025.502258","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the association of time‑weighted average mechanical power normalized to compliance (TWA-MP<sub>CRS</sub>) with all-cause mortality to determine its value as a prognostic tool in intensive care patients.</div></div><div><h3>Design</h3><div>Retrospective observational study.</div></div><div><h3>Setting</h3><div>Intensive care unit (ICU).</div></div><div><h3>Patients or participants</h3><div>4387 first-time ICU-admitted patients in the Medical Information Mart for Intensive Care (MIMIC) IV.</div></div><div><h3>Interventions</h3><div>None.</div></div><div><h3>Main variables of interest</h3><div>TWA-MP<sub>CRS</sub>, ICU mortality and in-hospital mortality.</div></div><div><h3>Results</h3><div>Participants' mean age was 61.4 ± 16.9 years and the median [IQR] baseline TWA-MP<sub>CRS</sub> was 0.3 (0.2, 0.6) J/min/mL/cmH<sub>2</sub>O. When TWA-MP<sub>CRS</sub> was divided into quintiles (with quintile 1 representing the lowest values), after adjusting for covariates, the odds ratios [95% confidence intervals (CIs)] for ICU mortality were 1.49 (95% CI: 1.15–1.94), 1.67 (95% CI: 1.29–2.16), 1.79 (95% CI: 1.37–2.33), and 3.96 (95% CI: 3.01–5.21) for quintiles 2, 3, 4, and 5 respectively, with quintile 1 as reference. Similar results were found for hospital mortality.</div></div><div><h3>Conclusion</h3><div>Higher TWA-MP<sub>CRS</sub> is associated with poor clinical outcomes in critically ill patients. Higher TWA-MP<sub>CRS</sub> can lead to a higher mortality among ICU and in-hospital patients.</div></div>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"50 1","pages":"Article 502258"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.medine.2025.502254
Eric Mayor-Vázquez , Elena Cuenca Fito , Pilar Marcos-Neira , Cándido Díaz-Lagares , Carme Gomila-Sintes , Noelia Albalá , Alejandra García-Roche , Pedro Castro
In recent years, there has been an increase in the number of patients affected by oncohematologic diseases in developed countries due to the improved survival rates and quality of life. This increase has generated a greater need for care in intensive care units (ICU), mainly due to complications related to immunosuppression, treatment toxicity or complications derived from cancer itself. Immunotherapy has transformed cancer treatment, but it can cause serious side effects such as cytokine release syndrome and hemophagocytic syndrome, which often require ICU admission. This review seeks to expand knowledge and management strategies for these complications in the ICU.
{"title":"Cytokine release syndrome and hemophagocytic syndrome associated with immunotherapy: A narrative review","authors":"Eric Mayor-Vázquez , Elena Cuenca Fito , Pilar Marcos-Neira , Cándido Díaz-Lagares , Carme Gomila-Sintes , Noelia Albalá , Alejandra García-Roche , Pedro Castro","doi":"10.1016/j.medine.2025.502254","DOIUrl":"10.1016/j.medine.2025.502254","url":null,"abstract":"<div><div>In recent years, there has been an increase in the number of patients affected by oncohematologic diseases in developed countries due to the improved survival rates and quality of life. This increase has generated a greater need for care in intensive care units (ICU), mainly due to complications related to immunosuppression, treatment toxicity or complications derived from cancer itself. Immunotherapy has transformed cancer treatment, but it can cause serious side effects such as cytokine release syndrome and hemophagocytic syndrome, which often require ICU admission. This review seeks to expand knowledge and management strategies for these complications in the ICU.</div></div>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"50 1","pages":"Article 502254"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.medine.2025.502294
Rafael González Cortés , Martí Pons Òdena , Mirella Gaboli , María Angeles García-Teresa
Prolonged mechanical ventilation (PMV) in paediatric intensive care (PICU) is increasing due to health advances and ethical criteria favouring the survival of chronically ill children. These patients require resources, generate high family demand and present a high risk of complications and mortality. Among the most frequent underlying pathologies are chronic respiratory diseases, neuromuscular diseases, prematurity, bronchopulmonary dysplasia and heart disease, with oncological pathology emerging in recent years.
In PICU, PMV is mainly performed by invasive MV with an endotracheal or tracheostomy tube (TC), with non-invasive ventilation (NIV) being less frequent. Successful weaning from MV requires strategies aimed at identifying and correcting factors that alter the balance between respiratory system load and respiratory work capacity. Both TC and NIV can facilitate ventilatory weaning or be solutions for long-term ventilation. There is no defined optimal time to perform TC in children; this decision should be individualised on a risk-benefit basis. TC tends to be delayed in children much longer than in adults. One-piece cannulae are used in paediatrics; in addition, if there is clinical stability and the possibility of connection to a home ventilator, uncuffed cannulae should be prioritised because of their better tolerance and safety. Home ventilation allows for a return to the home environment, improving quality of life and favouring neurodevelopment. However, institutional support can be insufficient to cope with the high responsibility and burden assumed by families.
{"title":"Prolonged mechanical ventilation and tracheostomised Paediatric","authors":"Rafael González Cortés , Martí Pons Òdena , Mirella Gaboli , María Angeles García-Teresa","doi":"10.1016/j.medine.2025.502294","DOIUrl":"10.1016/j.medine.2025.502294","url":null,"abstract":"<div><div>Prolonged mechanical ventilation (PMV) in paediatric intensive care (PICU) is increasing due to health advances and ethical criteria favouring the survival of chronically ill children. These patients require resources, generate high family demand and present a high risk of complications and mortality. Among the most frequent underlying pathologies are chronic respiratory diseases, neuromuscular diseases, prematurity, bronchopulmonary dysplasia and heart disease, with oncological pathology emerging in recent years.</div><div>In PICU, PMV is mainly performed by invasive MV with an endotracheal or tracheostomy tube (TC), with non-invasive ventilation (NIV) being less frequent. Successful weaning from MV requires strategies aimed at identifying and correcting factors that alter the balance between respiratory system load and respiratory work capacity. Both TC and NIV can facilitate ventilatory weaning or be solutions for long-term ventilation. There is no defined optimal time to perform TC in children; this decision should be individualised on a risk-benefit basis. TC tends to be delayed in children much longer than in adults. One-piece cannulae are used in paediatrics; in addition, if there is clinical stability and the possibility of connection to a home ventilator, uncuffed cannulae should be prioritised because of their better tolerance and safety. Home ventilation allows for a return to the home environment, improving quality of life and favouring neurodevelopment. However, institutional support can be insufficient to cope with the high responsibility and burden assumed by families.</div></div>","PeriodicalId":94139,"journal":{"name":"Medicina intensiva","volume":"50 1","pages":"Article 502294"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号