Pub Date : 2026-02-09DOI: 10.1186/s42466-026-00468-6
Omar Keritam, Julia Bettina Kräutler, Diana Gharib, Elnayer Ahmed Jabir, Rosa Weng, Fiona Jäger, Martin Krenn, Anna Paul, Walter Rinner, Hakan Cetin, Fritz Zimprich, Gudrun Zulehner, Jakob Rath
{"title":"Diagnostic performance and safety of the edrophonium test in myasthenia gravis: a retrospective case-control study.","authors":"Omar Keritam, Julia Bettina Kräutler, Diana Gharib, Elnayer Ahmed Jabir, Rosa Weng, Fiona Jäger, Martin Krenn, Anna Paul, Walter Rinner, Hakan Cetin, Fritz Zimprich, Gudrun Zulehner, Jakob Rath","doi":"10.1186/s42466-026-00468-6","DOIUrl":"10.1186/s42466-026-00468-6","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"11"},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1186/s42466-026-00469-5
Sinda Zarrouk, Josef Finsterer
{"title":"Consider autoimmune encephalitis in cases of headache, dizziness, and mild pleocytosis following SARS-CoV-2 infection.","authors":"Sinda Zarrouk, Josef Finsterer","doi":"10.1186/s42466-026-00469-5","DOIUrl":"10.1186/s42466-026-00469-5","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"10"},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1186/s42466-026-00470-y
Audai H Abudayeh, Iakiv Fishchenko
{"title":"Defining early surgery in traumatic spinal cord injury: admission-based versus injury-based timing.","authors":"Audai H Abudayeh, Iakiv Fishchenko","doi":"10.1186/s42466-026-00470-y","DOIUrl":"10.1186/s42466-026-00470-y","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"9"},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00457-9
Luise Endler, Miar Ouaret, Janos Sebestyen Gellén, Johannes A R Pfaff
{"title":"AI-assisted hemorrhage detection following endovascular stroke treatment: a retrospective diagnostic accuracy study.","authors":"Luise Endler, Miar Ouaret, Janos Sebestyen Gellén, Johannes A R Pfaff","doi":"10.1186/s42466-026-00457-9","DOIUrl":"10.1186/s42466-026-00457-9","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"5"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00461-z
Josef Finsterer
{"title":"Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis.","authors":"Josef Finsterer","doi":"10.1186/s42466-026-00461-z","DOIUrl":"10.1186/s42466-026-00461-z","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00464-w
V Mafael, T Buck, H Stengl, S Hellwig, M G Klammer, M Endres, M Reinthaler, F Barbieri, H J Audebert, D M Leistner, U Landmesser, W Doehner, C Skurk, J F Scheitz
{"title":"Collaborative neurocardiology board meetings for decision-making in stroke care: a real-world experience.","authors":"V Mafael, T Buck, H Stengl, S Hellwig, M G Klammer, M Endres, M Reinthaler, F Barbieri, H J Audebert, D M Leistner, U Landmesser, W Doehner, C Skurk, J F Scheitz","doi":"10.1186/s42466-026-00464-w","DOIUrl":"10.1186/s42466-026-00464-w","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"4"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00463-x
Matija Zupan, Pawel Kermer, Senta Frol
{"title":"Letter to the editor regarding \"Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center\" by Pommeranz et al.","authors":"Matija Zupan, Pawel Kermer, Senta Frol","doi":"10.1186/s42466-026-00463-x","DOIUrl":"10.1186/s42466-026-00463-x","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"2"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00456-w
Stefanie Balk, Teresa Siller, Maximilian I Sprügel, David Haupenthal, Kathrin Kölbl, Stefan Hock, Daniel Heinze, Tobias Engelhorn, Bernd Kallmünzer, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu, Jochen A Sembill
{"title":"Functional outcome, five-year survival and burden of disease after size- and location-matched hemorrhagic versus ischemic stroke.","authors":"Stefanie Balk, Teresa Siller, Maximilian I Sprügel, David Haupenthal, Kathrin Kölbl, Stefan Hock, Daniel Heinze, Tobias Engelhorn, Bernd Kallmünzer, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu, Jochen A Sembill","doi":"10.1186/s42466-026-00456-w","DOIUrl":"10.1186/s42466-026-00456-w","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"6"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s42466-026-00460-0
Vincent Umathum, Carolin König, Heidrun H Krämer, Jens Allendörfer, Anne Schänzer
{"title":"Author response to the letter to the editor regarding \"Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis\".","authors":"Vincent Umathum, Carolin König, Heidrun H Krämer, Jens Allendörfer, Anne Schänzer","doi":"10.1186/s42466-026-00460-0","DOIUrl":"10.1186/s42466-026-00460-0","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"3"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1186/s42466-025-00440-w
Momoko Choudhury, Malte Lenders, Pauline Laufer, Max Masthoff, Sima Canaan-Kühl, Christine Kurschat, Nicole Muschol, Julia B Hennermann, Markus Cybulla, Jessica Kaufeld, Eva Brand, Antje Bischof
Background: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to an increased risk for white matter lesion (WML), stroke and cerebral microbleeds. Utilizing MRI data from the prospective observational FAMOUS study we assessed MRI characteristics of FD and treatment effects of migalastat.
Methods: 19 patients with pathogenic (PV) and 14 patients with likely benign genetic variants (LBV: p.A143T, p.D313Y, and p.S126G) underwent MRI at baseline and 24 month-follow up under migalastat treatment. WML load, using Fazekas and Scheltens scores, basilar artery diameter (BAD), and the occurrence of strokes and cerebral microbleeds were assessed. Patients were compared by variant type (PV/LBV) and presence of arterial hypertension.
Results: WML load was low to moderate and remained stable. Four PV patients showed progress by visual examination. WML load was similar between PV and LBV groups. Patients with arterial hypertension had a higher Scheltens score. PV patients had higher BAD. No patient showed cerebral microbleeds. One PV patient with coincident multiple sclerosis demonstrated a positive central vein sign.
Conclusion: Our data suggest that microangiopathic lesion load remains relatively stable under migalastat. Antihypertensive therapy may be important to reduce WML in FD. Further studies are needed to assess the cerebral effect of migalastat therapy.
{"title":"Impact of migalastat on cerebral outcomes in fabry disease - results from the prospective observational FAMOUS trial.","authors":"Momoko Choudhury, Malte Lenders, Pauline Laufer, Max Masthoff, Sima Canaan-Kühl, Christine Kurschat, Nicole Muschol, Julia B Hennermann, Markus Cybulla, Jessica Kaufeld, Eva Brand, Antje Bischof","doi":"10.1186/s42466-025-00440-w","DOIUrl":"10.1186/s42466-025-00440-w","url":null,"abstract":"<p><strong>Background: </strong>Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to an increased risk for white matter lesion (WML), stroke and cerebral microbleeds. Utilizing MRI data from the prospective observational FAMOUS study we assessed MRI characteristics of FD and treatment effects of migalastat.</p><p><strong>Methods: </strong>19 patients with pathogenic (PV) and 14 patients with likely benign genetic variants (LBV: p.A143T, p.D313Y, and p.S126G) underwent MRI at baseline and 24 month-follow up under migalastat treatment. WML load, using Fazekas and Scheltens scores, basilar artery diameter (BAD), and the occurrence of strokes and cerebral microbleeds were assessed. Patients were compared by variant type (PV/LBV) and presence of arterial hypertension.</p><p><strong>Results: </strong>WML load was low to moderate and remained stable. Four PV patients showed progress by visual examination. WML load was similar between PV and LBV groups. Patients with arterial hypertension had a higher Scheltens score. PV patients had higher BAD. No patient showed cerebral microbleeds. One PV patient with coincident multiple sclerosis demonstrated a positive central vein sign.</p><p><strong>Conclusion: </strong>Our data suggest that microangiopathic lesion load remains relatively stable under migalastat. Antihypertensive therapy may be important to reduce WML in FD. Further studies are needed to assess the cerebral effect of migalastat therapy.</p>","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"7 1","pages":"98"},"PeriodicalIF":3.2,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12706964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145770357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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