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Diagnostic performance and safety of the edrophonium test in myasthenia gravis: a retrospective case-control study. 重症肌无力的诊断性能和安全性:一项回顾性病例对照研究。
IF 3.2 Q2 Medicine Pub Date : 2026-02-09 DOI: 10.1186/s42466-026-00468-6
Omar Keritam, Julia Bettina Kräutler, Diana Gharib, Elnayer Ahmed Jabir, Rosa Weng, Fiona Jäger, Martin Krenn, Anna Paul, Walter Rinner, Hakan Cetin, Fritz Zimprich, Gudrun Zulehner, Jakob Rath
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引用次数: 0
Consider autoimmune encephalitis in cases of headache, dizziness, and mild pleocytosis following SARS-CoV-2 infection. 考虑在SARS-CoV-2感染后出现头痛、头晕和轻度多细胞症的自身免疫性脑炎。
IF 3.2 Q2 Medicine Pub Date : 2026-02-09 DOI: 10.1186/s42466-026-00469-5
Sinda Zarrouk, Josef Finsterer
{"title":"Consider autoimmune encephalitis in cases of headache, dizziness, and mild pleocytosis following SARS-CoV-2 infection.","authors":"Sinda Zarrouk, Josef Finsterer","doi":"10.1186/s42466-026-00469-5","DOIUrl":"10.1186/s42466-026-00469-5","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"10"},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining early surgery in traumatic spinal cord injury: admission-based versus injury-based timing. 确定外伤性脊髓损伤的早期手术:基于住院与基于损伤的时机。
IF 3.2 Q2 Medicine Pub Date : 2026-02-09 DOI: 10.1186/s42466-026-00470-y
Audai H Abudayeh, Iakiv Fishchenko
{"title":"Defining early surgery in traumatic spinal cord injury: admission-based versus injury-based timing.","authors":"Audai H Abudayeh, Iakiv Fishchenko","doi":"10.1186/s42466-026-00470-y","DOIUrl":"10.1186/s42466-026-00470-y","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"9"},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-assisted hemorrhage detection following endovascular stroke treatment: a retrospective diagnostic accuracy study. 脑卒中治疗后ai辅助出血检测:一项回顾性诊断准确性研究。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00457-9
Luise Endler, Miar Ouaret, Janos Sebestyen Gellén, Johannes A R Pfaff
{"title":"AI-assisted hemorrhage detection following endovascular stroke treatment: a retrospective diagnostic accuracy study.","authors":"Luise Endler, Miar Ouaret, Janos Sebestyen Gellén, Johannes A R Pfaff","doi":"10.1186/s42466-026-00457-9","DOIUrl":"10.1186/s42466-026-00457-9","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"5"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis. 新冠肺炎后的头痛和淋巴细胞增多症需要排除脑炎。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00461-z
Josef Finsterer
{"title":"Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis.","authors":"Josef Finsterer","doi":"10.1186/s42466-026-00461-z","DOIUrl":"10.1186/s42466-026-00461-z","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaborative neurocardiology board meetings for decision-making in stroke care: a real-world experience. 协作神经心脏病学董事会会议在中风护理决策:现实世界的经验。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00464-w
V Mafael, T Buck, H Stengl, S Hellwig, M G Klammer, M Endres, M Reinthaler, F Barbieri, H J Audebert, D M Leistner, U Landmesser, W Doehner, C Skurk, J F Scheitz
{"title":"Collaborative neurocardiology board meetings for decision-making in stroke care: a real-world experience.","authors":"V Mafael, T Buck, H Stengl, S Hellwig, M G Klammer, M Endres, M Reinthaler, F Barbieri, H J Audebert, D M Leistner, U Landmesser, W Doehner, C Skurk, J F Scheitz","doi":"10.1186/s42466-026-00464-w","DOIUrl":"10.1186/s42466-026-00464-w","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"4"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor regarding "Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center" by Pommeranz et al. 关于“近期直接口服抗凝剂和急性缺血性中风的摄入:来自综合中风中心的真实世界数据”,由Pommeranz等人致编辑的信。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00463-x
Matija Zupan, Pawel Kermer, Senta Frol
{"title":"Letter to the editor regarding \"Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center\" by Pommeranz et al.","authors":"Matija Zupan, Pawel Kermer, Senta Frol","doi":"10.1186/s42466-026-00463-x","DOIUrl":"10.1186/s42466-026-00463-x","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"2"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional outcome, five-year survival and burden of disease after size- and location-matched hemorrhagic versus ischemic stroke. 功能结局,大小和位置匹配的出血性卒中与缺血性卒中后的5年生存率和疾病负担。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00456-w
Stefanie Balk, Teresa Siller, Maximilian I Sprügel, David Haupenthal, Kathrin Kölbl, Stefan Hock, Daniel Heinze, Tobias Engelhorn, Bernd Kallmünzer, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu, Jochen A Sembill
{"title":"Functional outcome, five-year survival and burden of disease after size- and location-matched hemorrhagic versus ischemic stroke.","authors":"Stefanie Balk, Teresa Siller, Maximilian I Sprügel, David Haupenthal, Kathrin Kölbl, Stefan Hock, Daniel Heinze, Tobias Engelhorn, Bernd Kallmünzer, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu, Jochen A Sembill","doi":"10.1186/s42466-026-00456-w","DOIUrl":"10.1186/s42466-026-00456-w","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"6"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author response to the letter to the editor regarding "Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis". 作者回复关于“COVID-19后头痛和淋巴细胞增多症需要排除脑炎”的致编辑信。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00460-0
Vincent Umathum, Carolin König, Heidrun H Krämer, Jens Allendörfer, Anne Schänzer
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引用次数: 0
Impact of migalastat on cerebral outcomes in fabry disease - results from the prospective observational FAMOUS trial. 米加拉司他对fabry病脑预后的影响——来自前瞻性观察性FAMOUS试验的结果
IF 3.2 Q2 Medicine Pub Date : 2025-12-16 DOI: 10.1186/s42466-025-00440-w
Momoko Choudhury, Malte Lenders, Pauline Laufer, Max Masthoff, Sima Canaan-Kühl, Christine Kurschat, Nicole Muschol, Julia B Hennermann, Markus Cybulla, Jessica Kaufeld, Eva Brand, Antje Bischof

Background: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to an increased risk for white matter lesion (WML), stroke and cerebral microbleeds. Utilizing MRI data from the prospective observational FAMOUS study we assessed MRI characteristics of FD and treatment effects of migalastat.

Methods: 19 patients with pathogenic (PV) and 14 patients with likely benign genetic variants (LBV: p.A143T, p.D313Y, and p.S126G) underwent MRI at baseline and 24 month-follow up under migalastat treatment. WML load, using Fazekas and Scheltens scores, basilar artery diameter (BAD), and the occurrence of strokes and cerebral microbleeds were assessed. Patients were compared by variant type (PV/LBV) and presence of arterial hypertension.

Results: WML load was low to moderate and remained stable. Four PV patients showed progress by visual examination. WML load was similar between PV and LBV groups. Patients with arterial hypertension had a higher Scheltens score. PV patients had higher BAD. No patient showed cerebral microbleeds. One PV patient with coincident multiple sclerosis demonstrated a positive central vein sign.

Conclusion: Our data suggest that microangiopathic lesion load remains relatively stable under migalastat. Antihypertensive therapy may be important to reduce WML in FD. Further studies are needed to assess the cerebral effect of migalastat therapy.

背景:法布里病(FD)是一种由α-半乳糖苷酶A (GLA)基因突变引起的x连锁溶酶体贮积性疾病,可导致白质病变(WML)、中风和脑微出血的风险增加。利用前瞻性观察性FAMOUS研究的MRI数据,我们评估了FD的MRI特征和米加拉司他的治疗效果。方法:19例致病性(PV)患者和14例可能存在良性遗传变异的患者(LBV: p.A143T, p.D313Y和p.S126G)在基线时接受MRI检查,并在咪加司他治疗下随访24个月。采用Fazekas和Scheltens评分评估WML负荷、基底动脉直径(BAD)、卒中和脑微出血的发生情况。比较患者的不同类型(PV/LBV)和是否存在动脉高血压。结果:WML负荷低至中等,保持稳定。4例PV患者视觉检查显示进展。PV组和LBV组的WML负荷相似。动脉高血压患者的Scheltens评分较高。PV患者有较高的BAD。无患者出现脑微出血。一名合并多发性硬化症的PV患者表现出阳性的中央静脉征象。结论:我们的数据表明,微血管病变负荷在咪加拉司他的作用下保持相对稳定。抗高血压治疗可能是减少FD患者WML的重要手段。需要进一步的研究来评估米伽司他治疗对大脑的影响。
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引用次数: 0
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Neurological research and practice
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