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Defining early surgery in traumatic spinal cord injury: admission-based versus injury-based timing. 确定外伤性脊髓损伤的早期手术:基于住院与基于损伤的时机。
IF 3.2 Q2 Medicine Pub Date : 2026-02-09 DOI: 10.1186/s42466-026-00470-y
Audai H Abudayeh, Iakiv Fishchenko
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引用次数: 0
AI-assisted hemorrhage detection following endovascular stroke treatment: a retrospective diagnostic accuracy study. 脑卒中治疗后ai辅助出血检测:一项回顾性诊断准确性研究。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00457-9
Luise Endler, Miar Ouaret, Janos Sebestyen Gellén, Johannes A R Pfaff
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引用次数: 0
Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis. 新冠肺炎后的头痛和淋巴细胞增多症需要排除脑炎。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00461-z
Josef Finsterer
{"title":"Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis.","authors":"Josef Finsterer","doi":"10.1186/s42466-026-00461-z","DOIUrl":"10.1186/s42466-026-00461-z","url":null,"abstract":"","PeriodicalId":94156,"journal":{"name":"Neurological research and practice","volume":"8 1","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaborative neurocardiology board meetings for decision-making in stroke care: a real-world experience. 协作神经心脏病学董事会会议在中风护理决策:现实世界的经验。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00464-w
V Mafael, T Buck, H Stengl, S Hellwig, M G Klammer, M Endres, M Reinthaler, F Barbieri, H J Audebert, D M Leistner, U Landmesser, W Doehner, C Skurk, J F Scheitz
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引用次数: 0
Letter to the editor regarding "Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center" by Pommeranz et al. 关于“近期直接口服抗凝剂和急性缺血性中风的摄入:来自综合中风中心的真实世界数据”,由Pommeranz等人致编辑的信。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00463-x
Matija Zupan, Pawel Kermer, Senta Frol
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引用次数: 0
Functional outcome, five-year survival and burden of disease after size- and location-matched hemorrhagic versus ischemic stroke. 功能结局,大小和位置匹配的出血性卒中与缺血性卒中后的5年生存率和疾病负担。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00456-w
Stefanie Balk, Teresa Siller, Maximilian I Sprügel, David Haupenthal, Kathrin Kölbl, Stefan Hock, Daniel Heinze, Tobias Engelhorn, Bernd Kallmünzer, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu, Jochen A Sembill
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引用次数: 0
Author response to the letter to the editor regarding "Headaches and lymphocytic pleocytosis after COVID-19 require the exclusion of encephalitis". 作者回复关于“COVID-19后头痛和淋巴细胞增多症需要排除脑炎”的致编辑信。
IF 3.2 Q2 Medicine Pub Date : 2026-02-03 DOI: 10.1186/s42466-026-00460-0
Vincent Umathum, Carolin König, Heidrun H Krämer, Jens Allendörfer, Anne Schänzer
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引用次数: 0
Impact of migalastat on cerebral outcomes in fabry disease - results from the prospective observational FAMOUS trial. 米加拉司他对fabry病脑预后的影响——来自前瞻性观察性FAMOUS试验的结果
IF 3.2 Q2 Medicine Pub Date : 2025-12-16 DOI: 10.1186/s42466-025-00440-w
Momoko Choudhury, Malte Lenders, Pauline Laufer, Max Masthoff, Sima Canaan-Kühl, Christine Kurschat, Nicole Muschol, Julia B Hennermann, Markus Cybulla, Jessica Kaufeld, Eva Brand, Antje Bischof

Background: Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to an increased risk for white matter lesion (WML), stroke and cerebral microbleeds. Utilizing MRI data from the prospective observational FAMOUS study we assessed MRI characteristics of FD and treatment effects of migalastat.

Methods: 19 patients with pathogenic (PV) and 14 patients with likely benign genetic variants (LBV: p.A143T, p.D313Y, and p.S126G) underwent MRI at baseline and 24 month-follow up under migalastat treatment. WML load, using Fazekas and Scheltens scores, basilar artery diameter (BAD), and the occurrence of strokes and cerebral microbleeds were assessed. Patients were compared by variant type (PV/LBV) and presence of arterial hypertension.

Results: WML load was low to moderate and remained stable. Four PV patients showed progress by visual examination. WML load was similar between PV and LBV groups. Patients with arterial hypertension had a higher Scheltens score. PV patients had higher BAD. No patient showed cerebral microbleeds. One PV patient with coincident multiple sclerosis demonstrated a positive central vein sign.

Conclusion: Our data suggest that microangiopathic lesion load remains relatively stable under migalastat. Antihypertensive therapy may be important to reduce WML in FD. Further studies are needed to assess the cerebral effect of migalastat therapy.

背景:法布里病(FD)是一种由α-半乳糖苷酶A (GLA)基因突变引起的x连锁溶酶体贮积性疾病,可导致白质病变(WML)、中风和脑微出血的风险增加。利用前瞻性观察性FAMOUS研究的MRI数据,我们评估了FD的MRI特征和米加拉司他的治疗效果。方法:19例致病性(PV)患者和14例可能存在良性遗传变异的患者(LBV: p.A143T, p.D313Y和p.S126G)在基线时接受MRI检查,并在咪加司他治疗下随访24个月。采用Fazekas和Scheltens评分评估WML负荷、基底动脉直径(BAD)、卒中和脑微出血的发生情况。比较患者的不同类型(PV/LBV)和是否存在动脉高血压。结果:WML负荷低至中等,保持稳定。4例PV患者视觉检查显示进展。PV组和LBV组的WML负荷相似。动脉高血压患者的Scheltens评分较高。PV患者有较高的BAD。无患者出现脑微出血。一名合并多发性硬化症的PV患者表现出阳性的中央静脉征象。结论:我们的数据表明,微血管病变负荷在咪加拉司他的作用下保持相对稳定。抗高血压治疗可能是减少FD患者WML的重要手段。需要进一步的研究来评估米伽司他治疗对大脑的影响。
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引用次数: 0
Publisher Correction: State of the art: glioma-associated epilepsy-bridging tumor biology and epileptogenesis. 出版者更正:最新进展:胶质瘤相关的癫痫桥接肿瘤生物学和癫痫发生。
IF 3.2 Q2 Medicine Pub Date : 2025-12-15 DOI: 10.1186/s42466-025-00455-3
Iris Divé, Anna-Luisa Luger, Dorothea Muench, Katharina J Weber, Joachim P Steinbach, Felix Rosenow, Frank Winkler, Pia S Zeiner
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引用次数: 0
Acute care of spontaneous intracerebral hemorrhage. 自发性脑出血的急性护理。
IF 3.2 Q2 Medicine Pub Date : 2025-12-15 DOI: 10.1186/s42466-025-00454-4
Vishank Arun Shah, Bhagyashri Bhende, Shubham Biyani, Rohan Mathur, Sung-Min Cho, Julian Bösel

Background: Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening neurological emergency that afflicts more than 3 million people worldwide each year and has the highest mortality and morbidity of all stroke types. Acute care of ICH patients is targeted towards reducing secondary brain injury by preventing hematoma expansion and alleviating elevated intracranial pressure (ICP) from hydrocephalus, midline shift, brain compression and perihematomal edema.

Aim: To provide a practical standard operating procedure (SOP) for the initial evaluation and management of acute spontaneous ICH patients.

Method: This SOP was developed using the latest clinical guidelines and relevant studies on the management of ICH patients along with the authors' own experience and judgment.

Results: Emergent care of ICH patients begins with stabilizing vital functions, rapid systolic blood pressure lowering and simultaneous reversal of any coagulopathy. Code ICH is a novel proposal to incorporate time-based bundled care to ensure timely institution of these therapies within 60 min of presentation. Clinical signs of elevated ICP and herniation should warrant prompt hyperosmolar therapy and emergent ventricular drainage for hydrocephalus. Emergent craniotomy or decompressive craniectomy for mass effect can be a lifesaving measure but may not improve functional outcomes. Early minimally invasive surgical interventions to promote clearance of intraventricular and parenchymal hemorrhage hold promise in not only improving survival but also promoting long-term functional improvement. Most importantly, early therapeutic nihilism must be avoided, and prognostication should be delayed for the first few days to allow time for recovery.

Conclusion: Avoiding early pessimism and promoting emergent aggressive bundled care for ICH patients can promote favorable outcomes. Minimally invasive surgical interventions to promote prompt blood clearance should be considered to improve long-term recovery.

背景:急性自发性脑出血(Acute spontaneous intraccerebral hemorrhage, ICH)是一种危及生命的神经系统急症,每年全世界有300多万人受到此病的折磨,是所有脑卒中类型中死亡率和发病率最高的。脑出血患者的急性护理旨在通过防止血肿扩张和减轻脑积水、中线移位、脑压迫和血肿周围水肿引起的颅内压升高来减少继发性脑损伤。目的:为急性自发性脑出血患者的初步评估和管理提供实用的标准操作程序。方法:根据最新的临床指南和脑出血患者管理的相关研究,结合笔者的经验和判断,制定本SOP。结果:脑出血患者的急诊护理应从稳定生命功能、迅速降低收缩压和同时逆转凝血功能障碍开始。ICH代码是一项新颖的建议,旨在纳入基于时间的捆绑治疗,以确保在就诊后60分钟内及时提供这些疗法。临床症状升高的颅内压和突出应保证及时高渗治疗和脑积水紧急脑室引流。紧急开颅术或减压开颅术治疗肿块效应可以挽救生命,但可能不能改善功能预后。早期微创手术干预以促进脑室内和脑实质出血的清除,不仅有望提高生存率,而且还能促进长期功能改善。最重要的是,必须避免早期治疗的虚无主义,并且应该在最初几天延迟预测,以便有时间恢复。结论:对脑出血患者避免早期悲观,提倡紧急积极的捆绑治疗可促进良好的预后。应考虑微创手术干预,促进血液迅速清除,以改善长期恢复。
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引用次数: 0
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Neurological research and practice
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