Neurological research and practice最新文献

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Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis. 抗血小板还是抗凝血剂？颈动脉夹层的二级预防：一项最新荟萃分析

Q2 Medicine

Neurological research and practice

Pub Date : 2022-06-13 DOI: 10.1186/s42466-022-00188-7

Ei Zune The, Ne Naing Lin, Ching Jocelyn Chan, Jason Cher Wei Loon, Benjamin Yong-Qiang Tan, Chee Seong Raymond Seet, Hock Luen Teoh, Joy Vijayan, Leong Litt Leonard Yeo

Background: Extracranial artery dissection involving either internal carotid artery or vertebral artery is a major cause of stroke in adults under 50 years of age. There is no conclusive evidence whether antiplatelets or anticoagulants are better suited in the treatment of extracranial artery dissection.

Objectives: To determine whether antiplatelets or anticoagulants have advantage over the other in the treatment of extracranial artery dissection for secondary prevention of recurrent ischemic events or death.

Methods: Present meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement. Database search was done in Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception to May 2021 using pre-defined search strategy. Additional studies were identified from reference lists from included studies, reviews and previous meta-analyses. Outcome measures were ischaemic stroke, ischaemic stroke or transient ischaemic attack (TIA), and death.

Results: Two RCTs and 64 observational studies were included in the meta-analysis. While the outcome measures of stroke, stroke or TIA and death were numerically higher with antiplatelet use, there were no statistically significant differences between antiplatelets and anticoagulants.

Conclusion: We found no significant difference between antiplatelet and anticoagulation treatment after extracranial artery dissection. The choice of treatment should be tailored to individual cases.

背景：涉及颈内动脉或椎动脉的颅外动脉夹层是 50 岁以下成年人中风的主要原因。目前尚无确凿证据表明抗血小板或抗凝剂更适合治疗颅外动脉夹层：目的：确定在治疗颅外动脉夹层以二级预防复发性缺血事件或死亡时，抗血小板药物和抗凝药物是否各有优势：本荟萃分析遵循《系统综述和荟萃分析首选报告项目》（Preferred Reporting Items for Systematic reviews and Meta-Analyses，PRISMA）2020声明。采用预先定义的检索策略，在 Medline、Cochrane 对照试验中央注册中心 (CENTRAL) 和 ClinicalTrials.gov 中进行了数据库检索，检索时间从开始到 2021 年 5 月。从纳入研究的参考文献列表、综述和以往的荟萃分析中确定了其他研究。结果指标为缺血性中风、缺血性中风或短暂性脑缺血发作（TIA）和死亡：荟萃分析纳入了两项研究性临床试验和 64 项观察性研究。虽然使用抗血小板药物的中风、中风或 TIA 和死亡的结果指标在数量上更高，但抗血小板药物和抗凝药物之间在统计学上没有显著差异：结论：我们发现颅外动脉夹层后抗血小板和抗凝治疗之间没有明显差异。结论：我们发现颅外动脉夹层后抗血小板治疗和抗凝治疗没有明显差异。

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引用次数: 0

Long-term benefit of pallidal deep brain stimulation in a patient with VPS16-associated dystonia 对vps16相关肌张力障碍患者进行苍白质深部脑刺激的长期疗效

Q2 Medicine

Neurological research and practice

Pub Date : 2022-05-30 DOI: 10.1186/s42466-022-00185-w

J. Petry-Schmelzer, Joohyun Park, T. Haack, V. Visser-Vandewalle, M. Barbe, G. Wunderlich

引用次数: 3

Recovery of intracranial stenoses in varicella zoster virus vasculitis after long-term treatment with valacyclovir and prednisolone 缬昔洛韦和泼尼松长期治疗水痘带状疱疹病毒性血管炎后颅内狭窄的恢复

Q2 Medicine

Neurological research and practice

Pub Date : 2022-05-16 DOI: 10.1186/s42466-022-00180-1

M. Kraemer, D. Strunk, Jana Becker, R. Veltkamp, P. Berlit

引用次数: 3

Residents as teachers in Neurology: a Germany-wide survey on the involvement of neurological residents in clinical teaching 神经内科住院医师作为教师:一项德国范围内关于神经内科住院医师参与临床教学的调查

Q2 Medicine

Neurological research and practice

Pub Date : 2022-05-09 DOI: 10.1186/s42466-022-00170-3

Anne-Sophie Biesalski, L. Tönges, Isabelle von Kirchbauer, Eileen Gülke, Hanna Eisenberg, F. Ippen, F. Schmidt-Graf

引用次数: 0

Intracranial bleeding under vitamin K antagonists or direct oral anticoagulants: results of the RADOA registry 服用维生素K拮抗剂或直接口服抗凝剂后颅内出血:RADOA登记结果

Q2 Medicine

Neurological research and practice

Pub Date : 2022-05-02 DOI: 10.1186/s42466-022-00183-y

W. Pfeilschifter, E. Lindhoff-Last, Ali Alhashim, Barbara Zydek, S. Lindau, S. Konstantinides, O. Grottke, U. Nowak‐Göttl, C. von Heymann, I. Birschmann, J. Beyer-Westendorf, P. Meybohm, A. Greinacher, E. Herrmann

引用次数: 4

On the quest for hidden ovarian teratomas in therapy-refractory anti-NMDA receptor encephalitis: a case report 在治疗难治性抗nmda受体脑炎中寻找隐藏的卵巢畸胎瘤:1例报告

Q2 Medicine

Neurological research and practice

Pub Date : 2022-04-25 DOI: 10.1186/s42466-022-00181-0

C. Cirkel, Anna Cirkel, G. Royl, A. Frydrychowicz, L. Tharun, S. Deichmann, A. Rody, T. Münte, B. Machner

引用次数: 2

A mobile battery-powered brain perfusion ultrasound (BPU) device designed for prehospital stroke diagnosis: correlation to perfusion MRI in healthy volunteers. 设计用于院前中风诊断的移动电池供电脑灌注超声（BPU）设备：与健康志愿者灌注MRI的相关性

Q2 Medicine

Neurological research and practice

Pub Date : 2022-04-11 DOI: 10.1186/s42466-022-00179-8

Mustafa Kilic, Fabien Scalzo, Chandler Lyle, Dobri Baldaranov, Maximilian Dirnbacher, Tristan Honda, David S Liebeskind, Felix Schlachetzki

Background: Early prehospital stroke identification is crucial for goal directed hospital admission especially in rural areas. However, clinical prehospital stroke scales are designed to identify any stroke but cannot sufficiently differentiate hemorrhagic from ischemic stroke, including large vessel occlusion (LVO) amenable to mechanical thrombectomy. We report on a novel small, portable and battery driven point-of-care ultrasound system (SONAS®) specifically developed for mobile non-invasive brain perfusion ultrasound (BPU) measurement after bolus injection of an echo-enhancing agent suitable for the use in prehospital stroke diagnosis filling a current, unmet and critical need for LVO identification.

Methods: In a phase I study of healthy volunteers we performed comparative perfusion-weighted magnetic resonance imaging (PWI) and BPU measurements, including safety analysis.

Results: Twelve volunteers (n = 7 females, n = 5 males, age ranging between 19 and 55 years) tolerated the measurement extremely well including analysis of blood-brain barrier integrity, and the correlation coefficient between the generated time kinetic curves after contrast agent bolus between PWI and BPU transducers ranged between 0.89 and 0.76.

Conclusions: Mobile BPU using the SONAS® device is feasible and safe with results comparable to PWI. When applied in conjunction with prehospital stroke scales this may lead to a more accurate stroke diagnosis and patients bypassing regular stroke units to comprehensive stroke centers. Further studies are needed in acute stroke patients and in the prehospital phase including assessment of immediate and long-term morbidity and mortality in stroke.

Trial registration: Clinical trials.gov, registered 28.Sep.2017, Identifier: NCT03296852.

背景：院前卒中的早期识别对于目标明确的入院治疗至关重要，尤其是在农村地区。然而，临床院前中风量表旨在识别任何中风，但不能充分区分出血性和缺血性中风，包括可进行机械取栓术的大血管闭塞（LVO）。我们报告了一种新型的小型、便携式、电池驱动的护理点超声系统（SONAS®），该系统专门开发用于在注射回声增强剂后进行移动式无创脑灌注超声（BPU）测量，适合用于院前中风诊断，满足了目前尚未满足的识别 LVO 的关键需求：在一项针对健康志愿者的 I 期研究中，我们进行了灌注加权磁共振成像（PWI）和 BPU 测量的比较，包括安全性分析：结果：12 名志愿者（女性 7 人，男性 5 人，年龄在 19 岁至 55 岁之间）对测量（包括血脑屏障完整性分析）的耐受性非常好，PWI 和 BPU 传感器在注射造影剂后生成的时间动力学曲线之间的相关系数介于 0.89 和 0.76 之间：使用 SONAS® 设备进行移动 BPU 是可行且安全的，其结果可与 PWI 相媲美。如果与院前卒中量表结合使用，可获得更准确的卒中诊断，患者可绕过常规卒中单元前往综合卒中中心。需要对急性中风患者和院前阶段进行进一步研究，包括评估中风的近期和远期发病率和死亡率：临床试验.gov，2017年9月28日注册，标识符：NCT03296852：NCT03296852。

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引用次数: 0

Transcranial Doppler sonography and the effect of haematopoietic stem cell transplantation in sickle cell disease 经颅多普勒超声与造血干细胞移植治疗镰状细胞病的疗效

Q2 Medicine

Neurological research and practice

Pub Date : 2022-04-04 DOI: 10.1186/s42466-022-00175-y

Sylvia Thurn, Katharina Kleinschmidt, Irena Kovačič, C. Wendl, R. Linker, S. Corbacioglu, F. Schlachetzki

引用次数: 2

Polyradiculitis and encephalomyelitis in the same patient following a SARS-CoV-2 vaccination 同一患者在接种SARS-CoV-2疫苗后出现多根炎和脑脊髓炎

Q2 Medicine

Neurological research and practice

Pub Date : 2022-03-28 DOI: 10.1186/s42466-022-00177-w

J. Finsterer

引用次数: 0

Diagnosing SARS-CoV-2 vaccination associated rhombencephalitis requires comprehensive work-up and exclusion of differentials 诊断严重急性呼吸系统综合征冠状病毒2型疫苗接种相关菱形脑炎需要全面检查并排除差异

Q2 Medicine

Neurological research and practice

Pub Date : 2022-03-21 DOI: 10.1186/s42466-022-00178-9

J. Finsterer, F. Scorza, C. Scorza, A. Fiorini

引用次数: 2

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