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Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma. 针对炎症因子进行化学预防和癌症拦截，以应对恶性间皮瘤。
Oncoscience
Pub Date : 2024-05-23 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.605
Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg

Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive and treatment-resistant malignancy. Consequently, novel approaches are urgently needed to treat mesothelioma and prevent or reduce the overall incidence of this fatal disease. In this research perspective, we review the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. We discuss the different preclinical mouse models used for these investigations and the inflammatory factors that may be potential targets for mesothelioma prevention. Preliminary studies with naturally occurring phytochemicals and synthetic agents are reviewed. Results of previous clinical chemoprevention trials in populations exposed to asbestos and considerations regarding future trials are also presented.

间皮瘤是一种无法治愈的间皮内膜癌症，通常由接触石棉引起。石棉引起的炎症是间皮瘤发病的一个重要诱因，遗传因素也是导致这种进展迅速且难治的恶性肿瘤的一个因素。因此，治疗间皮瘤并预防或降低这种致命疾病的总体发病率迫切需要新的方法。在这一研究视角中，我们回顾了石棉诱导的间皮瘤的化学预防和癌症阻断进展现状。我们讨论了用于这些研究的不同临床前小鼠模型，以及可能成为间皮瘤预防潜在靶点的炎症因子。我们还回顾了利用天然植物化学物质和合成制剂进行的初步研究。此外，还介绍了以前在暴露于石棉的人群中进行的临床化学预防试验的结果以及对未来试验的考虑。
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引用次数: 0
Entering the golden age for antibody-drug conjugates in gynecologic cancer. 进入妇科癌症抗体药物结合的黄金时代。
Oncoscience
Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.604
Michelle Greenman, Blair McNamara, Levent Mutlu, Alessandro D Santin
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引用次数: 0
Role of Erk5 expressed in bone marrow mesenchymal stem cells on bone homeostasis and its potential applications in cancer treatment. 骨髓间充质干细胞中表达的 Erk5 对骨稳态的作用及其在癌症治疗中的潜在应用。
Oncoscience
Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.601
Tetsuhiro Horie, Eiichi Hinoi
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引用次数: 0
Primary hepatic angiosarcoma: Treatment options for a rare tumor. 原发性肝血管肉瘤：罕见肿瘤的治疗方案。
Oncoscience
Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.602
Gregory L Guzik, Ankit Mangla
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引用次数: 0
Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer. PET/CT 成像中的深度学习辅助病灶分割：前列腺癌挽救性放射治疗的可行性研究
Oncoscience
Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.603
Richard L J Qiu, Chih-Wei Chang, Xiaofeng Yang
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引用次数: 0
Restoring our ubiquitination machinery to overcome resistance in cancer therapy. 恢复泛素化机制，克服癌症治疗中的抗药性。
Oncoscience
Pub Date : 2024-05-06 eCollection Date: 2024-01-01 DOI: 10.18632/oncoscience.600
Xiaoling Li, Ping Mu
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引用次数: 0
PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs PH 结合基团作为药物设计的平台：蛋白酶激活受体（PAR）的启示
Oncoscience
Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.599
J. K. Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, R. Bar-Shavit
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引用次数: 0
The price of hope: CAR-T therapy in pediatric leukemia 希望的代价小儿白血病的 CAR-T 疗法
Oncoscience
Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.598
Alex Hoover
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引用次数: 0
Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy 免疫疗法之外的高突变尿路上皮癌治疗机会
Oncoscience
Pub Date : 2024-04-25 DOI: 10.18632/oncoscience.596
Ioannis A. Voutsadakis
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引用次数: 0
Exploring oncogenic driver molecular alterations in Hispanic/Latin American cancer patients: A call for enhanced molecular understanding 探索西班牙裔/拉美裔癌症患者的致癌驱动分子改变：呼吁加强分子认识
Oncoscience
Pub Date : 2024-04-22 DOI: 10.18632/oncoscience.597
Rafael Parra-Medina
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引用次数: 0
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