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GLP-1 agonists: A hidden challenge for airway management GLP-1激动剂:气道管理的隐藏挑战。
Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1016/j.redare.2025.501991
M.A. Fernández-Vaquero , C.A. Puga-Carrasco , J.A. Sastre
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引用次数: 0
Inter-observer reliability of gastric ultrasound and level of agreement with clinical evaluation in adult patients requiring emergency surgery 需要急诊手术的成人患者胃超声的观察者间可靠性及其与临床评价的一致程度
Pub Date : 2026-01-01 Epub Date: 2026-01-12 DOI: 10.1016/j.redare.2026.501994
J.C. Villalba , J.M. Quintero , C.E. Melo , D.F. Reyes , J.P. Tovar , A. Perlas

Introduction

Pulmonary aspiration of gastric contents is a major perioperative complication with a mortality rate of 75% and severe morbidity of 14%. The risk increases in emergency surgeries and gastric ultrasound may be useful to establish gastric content and inform aspiration risk assessment. In this study we describe the degree of agreement between pre-surgical clinical evaluation and gastric ultrasound, in the identification of full stomach in adult patients requiring emergency surgery.

Materials and methods

Descriptive observational cross-sectional study of diagnostic tests. The analysis included all adult patients with pathologies requiring emergency surgeries between August 2023 and May 2024 at Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Colombia. The Kappa index was calculated between the two tests (Clinical evaluation vs. Gastric ultrasound), and the level of agreement between them was determined.

Results

A total of 57 patients were included in the study. Age, median (range): 51 (18–83), of whom 64.9% were male. The main types of surgeries were general surgery (80.7%), followed by trauma (19.3%). The majority of the population was classified as ASA 3. The most common comorbidities were Arterial Hypertension and type 2 Diabetes Mellitus. Fasting time ranged from 12 to 24 hours. There was a high level of agreement among the examiners for determining a full stomach using point-of-care (POCUS) gastric ultrasound, with a concordance level of 0.88 (p < 0.001). In contrast, there was a low level of agreement between the clinical and sonographic evaluation for gastric content assessment, with a concordance level of -0.03 (p 0.768).

Conclusion

Our results suggest that gastric ultrasound has a high level of reproducibility in the emergency surgical setting and can provide information beyond the clinical assessment.
胃内容物肺误吸是围手术期的主要并发症,死亡率为75%,严重的发病率为14%。急诊手术和胃超声可能有助于确定胃内容物并为误吸风险评估提供信息。在这项研究中,我们描述了术前临床评估和胃超声之间的一致程度,在确定成年患者的胃饱需要紧急手术。材料和方法:诊断试验的描述性观察性横断面研究。该分析包括2023年8月至2024年5月期间在哥伦比亚内华达Hernando Moncaleano Perdomo大学医院就诊的所有需要急诊手术的成年患者。计算两项试验(临床评价与胃超声)之间的Kappa指数,并确定两者之间的一致程度。结果:共纳入57例患者。年龄中位数(范围):51岁(18-83岁),其中64.9%为男性。手术类型以普通外科为主(80.7%),其次为创伤外科(19.3%)。大多数人被归类为ASA 3。最常见的合并症是动脉高血压和2型糖尿病。禁食时间从12小时到24小时不等。在使用即时护理(POCUS)胃超声检测胃是否满的问题上,检查人员之间的一致性很高,一致性水平为0.88 (p)。结论:我们的研究结果表明,胃超声在急诊手术环境中具有很高的可重复性,可以提供临床评估之外的信息。
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引用次数: 0
Beyond compliance: Patient risk, ERAS adherence, and postoperative outcomes through explainable machine learning 超越依从性:通过可解释的机器学习,患者风险、ERAS依从性和术后结果。
Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.1016/j.redare.2026.501990
J. Ripollés-Melchor , Á.V. Espinosa , A. Abad-Motos , A. Abad-Gurumeta , P. Galán-Menéndez , A. Zorrilla-Vaca , R. Navarro-Pérez , A. Ruiz-Escobar , J. Fernanz-Antón , A. Suárez-de-la-Rica , C. Aldecoa , the EuroPOWER Study Investigators Group

Background

Enhanced Recovery After Surgery (ERAS) protocols improve outcomes after colorectal surgery, but adherence remains variable and may interact with patient risk. Traditional compliance scores lack granularity to explore these dynamics. We aimed to use interpretable machine learning to quantify the contribution of individual ERAS items and clinical features to postoperative complications, and to identify data-driven ERAS phenotypes.

Methods

This was a secondary analysis of the EuroPOWER cohort (NCT04889798), a prospective European study including 2841 adults undergoing elective colorectal surgery. Two Extreme Gradient Boosting models were trained to predict in-hospital complications: a complete model (clinical variables + 23 ERAS items) and an ERAS-only model. Both were interpreted using Shapley Additive Explanations (SHAP). In the complete model, SHAP matrices were clustered to derive phenotypes. Feature importance, adherence, and complication rates were compared descriptively.

Results

The complete model achieved an AUC of 0.627. SHAP analysis identified frailty, ASA class, BMI, and age as leading predictors, followed by early mobilisation, nutritional care, and thromboprophylaxis. Three phenotypes were identified, with complication rates of 17.7%, 27.1%, and 41.1%, corresponding to robust, intermediate, and frail profiles. The ERAS-only model showed similar discrimination (area under the curve 0.642), but reduced interpretability. SHAP redundancy analysis supported inclusion of all ERAS items.

Conclusions

The clinical effect of ERAS adherence appears to be modulated by baseline vulnerability and implementation patterns. SHAP-based models enable transparent risk attribution and phenotype identification, supporting more targeted ERAS strategies and future development of automated quality monitoring tools.
背景:增强术后恢复(ERAS)方案可改善结直肠手术后的预后,但依从性仍存在差异,并可能与患者风险相互作用。传统的遵从性评分缺乏探究这些动态的粒度。我们的目标是使用可解释的机器学习来量化单个ERAS项目和临床特征对术后并发症的贡献,并确定数据驱动的ERAS表型。方法:这是对EuroPOWER队列(NCT04889798)的二次分析,这是一项前瞻性欧洲研究,包括2,841名接受选择性结直肠手术的成年人。训练两个极端梯度增强模型来预测院内并发症:一个完整模型(临床变量+ 23个ERAS项目)和一个仅ERAS模型。两者均采用Shapley加性解释(SHAP)进行解释。在完整的模型中,SHAP矩阵被聚类以获得表型。描述性地比较了特征重要性、依从性和并发症发生率。结果:完整模型的AUC为0.627。SHAP分析确定虚弱、ASA等级、BMI和年龄是主要预测因素,其次是早期活动、营养护理和血栓预防。确定了三种表型,并发症发生率分别为17.7%,27.1%和41.1%,对应于健壮,中等和虚弱的表型。ERAS-only模型具有相似的判别性(曲线下面积0.642),但可解释性降低。SHAP冗余分析支持纳入所有ERAS项目。结论:ERAS依从性的临床效果似乎受到基线脆弱性和实施模式的调节。基于shap的模型能够实现透明的风险归因和表型识别,支持更有针对性的ERAS策略和未来自动化质量监控工具的发展。
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引用次数: 0
Reflections on: «New-onset chronic and neuropathic pain in survivors of severe COVID-19: A secondary analysis of the PAIN-COVID Trial» 反思:“严重COVID-19幸存者的新发慢性和神经性疼痛:pain - covid试验的二次分析”。
Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1016/j.redare.2025.501996
A. Alcántara Montero , P.J. Ibor Vidal
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引用次数: 0
Use of saline solution to reverse interscalene block-induced phrenic nerve palsy: A case report 应用生理盐水逆转斜角肌间阻滞引起的膈神经麻痹1例。
Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.redare.2025.501851
A.M. Castro-Alemán, J.A. Estupiñán-Tibaduiza, R.P. Altamirano-Muñoz, J.C. Altuve-Quiroz
Brachial plexus block at the interscalene level is a regional anaesthetic technique widely used to provide analgesia in shoulder and upper extremity surgery; However, it is associated with a high incidence of phrenic nerve block with diaphragmatic paralysis which has clinical implications in patients with underlying respiratory disease, showing respiratory difficulty symptoms. As consequence, it has been contraindicated in certain population groups. Once diaphragmatic paralysis and respiratory symptoms are established, management is supportive and expectant. In recent years, the administration or “washing” with normal saline solution has been described with the same approach, to reverse the phrenic nerve block and thus the respiratory symptoms. We present the first case of successful reversal of phrenic nerve block with saline in Latin America.
斜角肌间水平臂丛阻滞是一种广泛应用于肩部和上肢手术的区域麻醉技术;然而,膈神经阻滞伴膈肌麻痹的高发与膈神经阻滞相关,膈肌麻痹对有潜在呼吸系统疾病的患者有临床意义,表现为呼吸困难症状。因此,它在某些人群中是禁忌的。一旦确定膈肌麻痹和呼吸道症状,治疗是支持和期待的。近年来,用生理盐水给药或“冲洗”也采用了同样的方法,以逆转膈神经阻滞,从而缓解呼吸道症状。我们提出的第一例成功逆转膈神经阻滞与生理盐水在拉丁美洲。
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引用次数: 0
Preoperative cognitive function assessment: Feasibility and outcomes 术前认知功能评估:可行性和结果。
Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.redare.2025.501857
B. Tena, A. Fervienza, I. Gracia, N. Fábregas
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引用次数: 0
Platelet-rich plasma injections improve functional results over pulsed radiofrequency in ganglion impar treatments for coccydynia 富血小板血浆注射改善功能结果比脉冲射频神经节损伤治疗尾骨痛。
Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI: 10.1016/j.redare.2025.501929
J. Pilco Inga , A. Fervienza Sánchez , J.J. Velázquez Fragoso , M. Fa-Binefa , I. Moya Molinas

Introduction

Coccydynia is a painful condition commonly related to trauma or repetitive stress. While most cases respond to conservative management, a subset of patients requires minimally invasive interventions. Platelet-rich plasma (PRP) has recently emerged as a biological treatment alternative, promoting tissue repair. This study aimed to compare the clinical efficacy of PRP injections versus pulsed radiofrequency (PRF) at the ganglion impar in patients with coccydynia refractory to conservative treatment.

Methods

A retrospective cohort study was conducted on 40 consecutive patients treated for coccydynia. 20 received PRP injections and 20 underwent PRF at the ganglion impar. Functional disability was measured by the Oswestry Disability Index (ODI) and pain intensity was assessed using the Visual Analogue Scale (VAS) at baseline and at six months. Statistical analysis included t-tests and multivariable regression models adjusted for baseline characteristics.

Results

Both groups showed improvement in pain and function. There were no significant differences in pre- or post-treatment VAS scores between the two groups. However, the mean change in ODI scores was significantly greater in the PRP group (−9.6 ± 4.2) compared to the PRF group (−5.4 ± 6.3), with a statistically significant difference in functional improvement (p = 0.018), and a clinically relevant improvement (≥30% reduction in ODI) was achieved in 85% of cases versus 45%, respectively (p = 0.02). The adjusted analysis confirmed the superiority of PRP after controlling for baseline differences.

Conclusion

PRP injections at the ganglion impar demonstrated superior improvement in functional outcomes compared to PRF in patients with refractory coccydynia. These findings support the use of PRP as a potentially more effective minimally invasive treatment, though prospective studies with longer follow-up are needed to confirm these results.
简介:尾骨痛是一种通常与创伤或重复性压力有关的疼痛状况。虽然大多数病例对保守治疗有反应,但一小部分患者需要微创干预。富血小板血浆(PRP)最近成为一种生物治疗替代方案,促进组织修复。本研究旨在比较PRP注射与脉冲射频(PRF)治疗难治性尾骨痛患者神经节损伤的临床疗效。方法:对40例连续治疗的尾骨痛患者进行回顾性队列研究。20例接受PRP注射,20例在神经节处接受PRF。在基线和6个月时,采用Oswestry残疾指数(ODI)测量功能残疾,使用视觉模拟量表(VAS)评估疼痛强度。统计分析包括t检验和多变量回归模型调整基线特征。结果:两组患者疼痛及功能均有改善。两组治疗前和治疗后的VAS评分无显著差异。然而,与PRF组(-5.4±6.3)相比,PRP组ODI评分的平均变化(-9.6±4.2)显著大于PRF组(-5.4±6.3),在功能改善方面存在统计学差异(p = 0.018), 85%的病例实现了临床相关的改善(ODI降低≥30%),分别为45% (p = 0.02)。在控制基线差异后,校正分析证实了PRP的优越性。结论:与PRF相比,在神经节处注射PRP对难治性尾骨痛患者的功能结果有更好的改善。这些发现支持使用PRP作为一种潜在的更有效的微创治疗,尽管需要更长时间随访的前瞻性研究来证实这些结果。
{"title":"Platelet-rich plasma injections improve functional results over pulsed radiofrequency in ganglion impar treatments for coccydynia","authors":"J. Pilco Inga ,&nbsp;A. Fervienza Sánchez ,&nbsp;J.J. Velázquez Fragoso ,&nbsp;M. Fa-Binefa ,&nbsp;I. Moya Molinas","doi":"10.1016/j.redare.2025.501929","DOIUrl":"10.1016/j.redare.2025.501929","url":null,"abstract":"<div><h3>Introduction</h3><div>Coccydynia is a painful condition commonly related to trauma or repetitive stress. While most cases respond to conservative management, a subset of patients requires minimally invasive interventions. Platelet-rich plasma (PRP) has recently emerged as a biological treatment alternative, promoting tissue repair. This study aimed to compare the clinical efficacy of PRP injections versus pulsed radiofrequency (PRF) at the ganglion impar in patients with coccydynia refractory to conservative treatment.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted on 40 consecutive patients treated for coccydynia. 20 received PRP injections and 20 underwent PRF at the ganglion impar. Functional disability was measured by the Oswestry Disability Index (ODI) and pain intensity was assessed using the Visual Analogue Scale (VAS) at baseline and at six months. Statistical analysis included <em>t</em>-tests and multivariable regression models adjusted for baseline characteristics.</div></div><div><h3>Results</h3><div>Both groups showed improvement in pain and function. There were no significant differences in pre- or post-treatment VAS scores between the two groups. However, the mean change in ODI scores was significantly greater in the PRP group (−9.6 ± 4.2) compared to the PRF group (−5.4 ± 6.3), with a statistically significant difference in functional improvement (<em>p</em> = 0.018), and a clinically relevant improvement (≥30% reduction in ODI) was achieved in 85% of cases versus 45%, respectively (<em>p</em> = 0.02). The adjusted analysis confirmed the superiority of PRP after controlling for baseline differences.</div></div><div><h3>Conclusion</h3><div>PRP injections at the ganglion impar demonstrated superior improvement in functional outcomes compared to PRF in patients with refractory coccydynia. These findings support the use of PRP as a potentially more effective minimally invasive treatment, though prospective studies with longer follow-up are needed to confirm these results.</div></div>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":"72 10","pages":"Article 501929"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in anesthesiology: Severe subglottic stenosis 麻醉学的挑战:严重的声门下狭窄。
Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI: 10.1016/j.redare.2025.501842
L. Gómez-López, R. Bergé Ramos, A. Vallejo Tarrat, J. Doménech de la Lastra
{"title":"Challenges in anesthesiology: Severe subglottic stenosis","authors":"L. Gómez-López,&nbsp;R. Bergé Ramos,&nbsp;A. Vallejo Tarrat,&nbsp;J. Doménech de la Lastra","doi":"10.1016/j.redare.2025.501842","DOIUrl":"10.1016/j.redare.2025.501842","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":"72 10","pages":"Article 501842"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosing paradoxical fat embolism syndrome after cemented hip arthroplasty 骨水泥髋关节置换术后悖论性脂肪栓塞综合征的诊断。
Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI: 10.1016/j.redare.2025.501841
S. Maia , A. Carneiro , M. Vargas , B. Xavier , S. Caramelo
The diagnosis of cerebral fat embolism syndrome (FES) is not linear. In this case report, a 79-year-old woman underwent urgent cemented hip arthroplasty 24 h after a femoral neck fracture. Immediately after the procedure she had a brief episode of altered state of consciousness. After 4 h, she presented with multiple neurological symptoms which led to activation of the stroke alert system. Various new neurological deficits appeared during the day. She had 2 brain CT scans, which were normal. Transthoracic echocardiogram showed a patent foramen ovale with an exuberant aneurysm. Electroencephalogram showed nonconvulsive status epilepticus, which was promptly treated. Brain MRI showed findings compatible with cerebral FES. After ruling out acute ischaemic stroke, conditions that lead to multiple embolic strokes in different vascular territories had to be considered due to the diverse neurological deficits. The embolization hypothesis was also supported by the sudden onset of the symptoms. Even though FES is an exclusion diagnosis, the patient’s brain MRI showed the distinct radiographic features of fat microembolism. Perioperative neurological deficits are not uncommon, particularly in elderly patients. Accurate diagnosis and appropriate management are crucial to ensure favourable outcomes and prevent long-term sequelae.
脑脂肪栓塞综合征(FES)的诊断不是线性的。在这个病例报告中,一位79岁的女性在股骨颈骨折24小时后接受了紧急骨水泥髋关节置换术。手术后,她立即出现了短暂的意识状态改变。4小时后,她出现了多种神经系统症状,导致中风警报系统激活。白天出现了各种新的神经功能缺陷。她做了两次脑部CT扫描,都正常。经胸超声心动图显示卵圆孔未闭伴增生动脉瘤。脑电图显示非惊厥性癫痫持续状态,并及时治疗。脑MRI显示与脑FES相符。在排除急性缺血性中风后,由于不同的神经功能缺陷,必须考虑导致不同血管区域的多发性栓塞性中风的情况。栓塞假说也被症状的突然发作所支持。尽管FES是一种排除性诊断,但患者的脑部MRI显示出明显的脂肪微栓塞的影像学特征。围手术期神经功能缺损并不罕见,特别是在老年患者中。准确的诊断和适当的管理对于确保良好的结果和预防长期后遗症至关重要。
{"title":"Diagnosing paradoxical fat embolism syndrome after cemented hip arthroplasty","authors":"S. Maia ,&nbsp;A. Carneiro ,&nbsp;M. Vargas ,&nbsp;B. Xavier ,&nbsp;S. Caramelo","doi":"10.1016/j.redare.2025.501841","DOIUrl":"10.1016/j.redare.2025.501841","url":null,"abstract":"<div><div>The diagnosis of cerebral fat embolism syndrome (FES) is not linear. In this case report, a 79-year-old woman underwent urgent cemented hip arthroplasty 24 h after a femoral neck fracture. Immediately after the procedure she had a brief episode of altered state of consciousness. After 4 h, she presented with multiple neurological symptoms which led to activation of the stroke alert system. Various new neurological deficits appeared during the day. She had 2 brain CT scans, which were normal. Transthoracic echocardiogram showed a patent foramen ovale with an exuberant aneurysm. Electroencephalogram showed nonconvulsive status epilepticus, which was promptly treated. Brain MRI showed findings compatible with cerebral FES. After ruling out acute ischaemic stroke, conditions that lead to multiple embolic strokes in different vascular territories had to be considered due to the diverse neurological deficits. The embolization hypothesis was also supported by the sudden onset of the symptoms. Even though FES is an exclusion diagnosis, the patient’s brain MRI showed the distinct radiographic features of fat microembolism. Perioperative neurological deficits are not uncommon, particularly in elderly patients. Accurate diagnosis and appropriate management are crucial to ensure favourable outcomes and prevent long-term sequelae.</div></div>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":"72 10","pages":"Article 501841"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on: “Comparison of serratus plane and erector spinae plane blocks for postoperative analgesia in unilateral breast surgery” 思考:“单侧乳房手术后使用锯肌平面与竖脊平面阻滞镇痛的比较”。
Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.redare.2025.501927
R. M. Sethuraman, R. Aravindan, Y. Mariam
{"title":"Reflections on: “Comparison of serratus plane and erector spinae plane blocks for postoperative analgesia in unilateral breast surgery”","authors":"R. M. Sethuraman,&nbsp;R. Aravindan,&nbsp;Y. Mariam","doi":"10.1016/j.redare.2025.501927","DOIUrl":"10.1016/j.redare.2025.501927","url":null,"abstract":"","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":"72 10","pages":"Article 501927"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revista espanola de anestesiologia y reanimacion
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