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Validity of estimated aortic pulse wave velocity measured during the 6-minute walk test to predict anaerobic fitness before major non-cardiac surgery. 在 6 分钟步行测试中测量的主动脉脉搏波速度估计值在预测非心脏大手术前的有氧体能方面的有效性。
Pub Date : 2024-09-06 DOI: 10.1016/j.redare.2024.09.002
J Ripollés-Melchor, M I Monge García, A Ruiz-Escobar, E Sáez-Ruiz, B Algar-Yañez, A Abad-Motos, A Abad-Gurumeta

Background: This study aimed to assess the efficacy of estimated preoperative aortic pulse wave velocity (AoPWV) to discriminate between low and high 6 min walk test (6MWT) distance in patients awaiting major non-cardiac surgery.

Methods: Prospective observational study in 133 patients undergoing non cardiac surgery. AoPWV and the distance walked during a 6MWT were assessed. Receiver operating characteristic (ROC) curve analysis was used to determine two different AoPWV cut-points for predicting a distance of 427 metres in the 6MWT. We also calculated lower and upper AoPWV cut-points (probability ≥ 0.75) for predicting a distance of < 427 metres, ≥ 427 metres, and also 563 metres in the 6MWT.

Results: The ROC curve analysis for the < 427 metre distance revealed an area under the curve (AUC) of 0.68 (95% confidence interval 0.56-0.79) and an AUC of 0.72 (95% confidence interval 0.61-0.83) for > 563 metres. Patients with AoPWV > 10.97 m/s should be considered high risk, while those with < 9.42 m/s can be considered low risk.

Conclusions: AoPWV is a simple, non-invasive, useful clinical tool for identifying and stratifying patients awaiting major non-cardiac surgery. In situations of clinical uncertainty, additional measures should be taken to assess the risk.

背景:本研究旨在评估估计的术前主动脉脉搏波速度(AoPWV)在区分等待接受非心脏大手术的患者6分钟步行测试(6MWT)距离过短和过长方面的有效性:方法:对 133 名接受非心脏手术的患者进行前瞻性观察研究。方法:对 133 名接受非心脏手术的患者进行了前瞻性观察研究,评估了患者的 AoPWV 和 6MWT 步行距离。使用接收者操作特征曲线(ROC)分析确定了两个不同的 AoPWV 切点,用于预测 6MWT 步行 427 米的距离。我们还计算了预测 6MWT 距离< 427 米、≥ 427 米和 563 米的较低和较高 AoPWV 切点(概率≥ 0.75):对<427米距离的ROC曲线分析显示,曲线下面积(AUC)为0.68(95%置信区间为0.56-0.79),对>563米距离的曲线下面积(AUC)为0.72(95%置信区间为0.61-0.83)。AoPWV>10.97米/秒的患者应被视为高风险,而AoPWV<9.42米/秒的患者可被视为低风险:AoPWV是一种简单、无创、有用的临床工具,可用于识别和分层等待非心脏大手术的患者。在临床不确定的情况下,应采取其他措施来评估风险。
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引用次数: 0
Intraoperative Goal-Directed Hemodynamic Therapy through Fluid Administration to Optimize the Stroke Volume: A Meta-Analysis of Randomized Controlled Trials. 通过输液优化卒中量的术中目标导向血流动力学疗法:随机对照试验的 Meta 分析。
Pub Date : 2024-09-05 DOI: 10.1016/j.redare.2024.09.004
J Ripollés-Melchor, Á V Espinosa, P Fernández-Valdes-Bango, R Navarro-Pérez, A Abad-Motos, J V Lorente, M J Colomina, E Sáez-Ruiz, A Abad-Gurumeta, M I Monge-García

Objective: To evaluate the clinical impact of optimizing stroke volume (SV) through fluid administration as part of goal-directed hemodynamic therapy (GDHT) in adult patients undergoing elective major abdominal surgery.

Methods: This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered in the PROSPERO database in January 2024. The intervention was defined as intraoperative GDHT based on the optimization or maximization of SV through fluid challenges, or by using dynamic indices of fluid responsiveness, including stroke volume variation, pulse pressure variation, and plethysmography variation index compared to usual fluid management. The primary outcome was postoperative complications. Secondary outcome variables included postoperative acute kidney injury (AKI), length of stay (LOS), intraoperative fluid administration, and 30-day mortality.

Results: A total of 29 randomized controlled trials (RCTs) met the inclusion criteria. There were no significant differences in the incidence of postoperative complications (RR 0.89; 95% CI, 0.78 to 1.00), postoperative AKI (OR 0.97; (95% IC, 0.55 to 1.70), and mortality (OR 0.80; 95% CI, 0.50 to 1.29). GDHT was associated with a reduced LOS compared to usual care (SMD: -0.17 [-0.32; - 0.03]). The subgroup in which hydroxyethyl starch was used for hemodynamic optimization was associated with fewer complications (RR 0.79; 95% CI, 0.65 to 0.94), whereas the subgroup of patients in whom crystalloids were used was associated with an increased risk of postoperative complications (RR 1.08; 95% CI, 1.04 to 1.12).

Conclusions: In adults undergoing major surgery, goal-directed hemodynamic therapy focused on fluid-based stroke volume optimization did not reduce postoperative morbidity and mortality.

目的评估作为目标导向血液动力学疗法(GDHT)的一部分,通过输液优化搏出量(SV)对接受择期腹部大手术的成人患者的临床影响:本系统综述和荟萃分析根据系统综述和荟萃分析首选报告项目(PRISMA)声明进行,并于 2024 年 1 月在 PROSPERO 数据库中注册。干预被定义为术中 GDHT,其基础是通过液体挑战优化或最大化 SV,或使用液体反应性动态指数,包括与常规液体管理相比的每搏容量变化、脉压变化和胸透变化指数。主要结果是术后并发症。次要结果变量包括术后急性肾损伤(AKI)、住院时间(LOS)、术中输液量和 30 天死亡率:共有 29 项随机对照试验(RCT)符合纳入标准。术后并发症(RR 0.89;95% CI,0.78 至 1.00)、术后 AKI(OR 0.97;95% IC,0.55 至 1.70)和死亡率(OR 0.80;95% CI,0.50 至 1.29)的发生率无明显差异。与常规护理相比,GDHT 与缩短 LOS 相关(SMD:-0.17 [-0.32; - 0.03])。使用羟乙基淀粉优化血液动力学的亚组并发症较少(RR 0.79;95% CI,0.65 至 0.94),而使用晶体液的亚组患者术后并发症风险增加(RR 1.08;95% CI,1.04 至 1.12):对于接受大手术的成人患者,以优化液体搏出量为重点的目标导向血液动力学疗法并不能降低术后发病率和死亡率。
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引用次数: 0
Recommendations of the Pre-anaesthesia Teleconsultation Task Force. 麻醉前远程会诊工作组的建议。
Pub Date : 2024-09-05 DOI: 10.1016/j.redare.2024.09.001
Ana Aroca Tanarro, Rubén Casans Francés, Manuel Ángel Gómez-Ríos, Esther Mendez Arias, María Otero Pérez, Luis Quecedo Gutierrez, Victor Rojas Pernia, Alfredo Abad Gurumeta

The main objectives of the pre-anaesthesia consultation are to establish the patient's anaesthesia and surgical risk, evaluate and optimize their health status, provide the patient with information and preoperative recommendations, and fulfil the legally established bureaucratic obligations. The incorporation of information technologies - e-Health - has maximised the efficiency of pre-anaesthesia assessments and provided patients with an added benefit. The SEDAR Task Force has developed a digital framework as an alternative to the conventional pre-anaesthesia assessment process, and has put forward a series of policies and technical recommendations for the incorporation of different types of pre-anaesthesia teleconsultation services in hospital anaesthesiology departments. We also put forward an evaluation tool that includes several quality indicators on which to base continuous improvements in healthcare.

麻醉前咨询的主要目的是确定患者的麻醉和手术风险,评估和优化其健康状况,为患者提供信息和术前建议,并履行法律规定的官僚义务。信息技术(电子健康)的融入最大限度地提高了麻醉前评估的效率,并为患者带来了额外的好处。SEDAR 工作组制定了一个数字框架,作为传统麻醉前评估流程的替代方案,并提出了一系列政策和技术建议,以便在医院麻醉科纳入不同类型的麻醉前远程会诊服务。我们还提出了一种评估工具,其中包括若干质量指标,作为持续改进医疗服务的依据。
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引用次数: 0
Use of fluid therapy in perioperative adult patients: a narrative review. 围手术期成人患者使用液体疗法:叙述性综述。
Pub Date : 2024-09-05 DOI: 10.1016/j.redare.2024.09.003
M J Colomina, P Galán Menéndez, J Ripollés-Melchor

The administration of intravenous fluids is the most common intervention in hospitalised patients in the perioperative setting and critical care units. The aim of this narrative review is to provide an overview of balanced solutions for fluid therapy in the perioperative period in adult patients, and to review new trends and solutions in fluid therapy. The evidence was grouped into 3 areas: intraoperative fluid administration, fluid administration in critically ill patients, and the importance / benefit of balanced crystalloid solutions. Although a number of high-quality studies have been published in recent years, the scientific evidence regarding the type of fluid, the dose, and rate of administration is still limited. The choice of fluid therapy during the perioperative period must be tailored to patient-specific factors, the nature of the surgery, expected fluid loss, and other relevant factors. Finally, more robust clinical evidence and physician training is of the utmost importance.

静脉输液是围手术期住院患者和重症监护病房最常见的干预措施。本综述旨在概述成年患者围手术期液体治疗的平衡解决方案,并回顾液体治疗的新趋势和解决方案。证据分为三个方面:术中输液、重症患者输液以及平衡晶体液的重要性/益处。尽管近年来发表了许多高质量的研究报告,但有关液体类型、剂量和给药速度的科学证据仍然有限。围术期液体疗法的选择必须根据患者的具体因素、手术性质、预期液体流失量以及其他相关因素来确定。最后,最重要的是要有更可靠的临床证据和对医生的培训。
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引用次数: 0
The risk of malignant hyperthermia in neuromyotonia is low 神经肌张力障碍患者发生恶性高热的风险很低。
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2024.02.005
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引用次数: 0
Congenital diaphragmatic hernia, Morgagni-Larrey type 先天性膈疝,moragni - larrey型。
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2023.11.003
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引用次数: 0
Gasserian ganglion stimulation for refractory trigeminal neuropathic pain 刺激加瑟神经节治疗难治性三叉神经痛
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2024.04.008

Background and objective

Painful trigeminal neuropathy is a complex clinical entity due to its severity and refractoriness to pharmacological and interventional management. We describe our experience in treating refractory painful trigeminal neuropathy (RPTN) with gasserian ganglion stimulation (GGS).

Materials and methods

Six patients with RPTN were treated with GGS in our Unit between 2019 and 2022. The following data were collected: socio-demographic characteristics, triggering event, duration of the disease and treatment received prior to surgery, pre- and post-intervention visual analogue scale (VAS) score, follow-up time, and pre- and post-intervention functionality and quality of life.

Results

All patients were women who had received aggressive first-, second-, and third-line pharmacological, non-pharmacological, and interventional management before being referred for GGS. Patients reported a 50%–72% decrease in pain on VAS and improved functionality during follow-up.

Conclusions

GGS is a promising therapeutic alternative for patients with RPTN. Although the initial outcomes and experience are encouraging, RPTN is recommended on the basis of safety, reproducibility, and trends observed in clinical practice.

背景和目的疼痛性三叉神经病变是一种复杂的临床实体,因为其严重性以及对药物和介入治疗的耐受性。我们介绍了本单位在 2019 年至 2022 年期间用刺激神经节疗法(GGS)治疗难治性疼痛性三叉神经病(RPTN)的经验。收集了以下数据:社会人口学特征、诱发事件、病程和术前接受的治疗、干预前后的视觉模拟量表(VAS)评分、随访时间以及干预前后的功能和生活质量。结果所有患者均为女性,在转诊接受 GGS 治疗之前,她们已接受了积极的一线、二线和三线药物、非药物和介入治疗。随访期间,患者报告 VAS 疼痛减少了 50%-72%,功能也有所改善。尽管最初的结果和经验令人鼓舞,但基于安全性、可重复性和临床实践中观察到的趋势,建议采用 RPTN。
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引用次数: 0
Role of VV ECMO tracheal surgery and carinal resection: Two case reports VV ECMO 气管手术和气管切除术的作用:两例报告
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2024.02.025

The aim of this study is to describe the anaesthesia management of two patients undergoing carinal resection under veno-venous extracorporeal membrane oxygenation (VV ECMO). In both cases, anaesthesia was induced and then maintained with inhalational agents during pneumonectomy and mediastinoscopy (respectively). Then the jugular and femoral veins were cannulated and VV ECMO was started after heparinization. One of the patients presented bleeding during surgery, which was treated with low-dose vasopressors (norepinephrine) and transfusion of platelets, fresh frozen plasma, and concentrated red blood cells. During VV ECMO, anaesthesia was maintained with target-controlled infusion of propofol. VV ECMO can be expected to improve surgical conditions in tracheal surgery; however, it is still a novel technique in this context. In selected patients, it would guarantee ventilatory support during carinal resection, but it is essential to carefully plan anaesthesia maintenance and prepare for VV ECMO-related complications. This technique should only be used in tertiary centres with experience in VV ECMO management.

本研究旨在描述两名在静脉体外膜氧合(VV ECMO)下接受贲门切除术的患者的麻醉管理情况。在这两个病例中,在进行肺切除术和纵隔镜检查时,分别用吸入剂诱导和维持麻醉。然后插入颈静脉和股静脉,肝素化后开始 VV ECMO。其中一名患者在手术过程中出现出血,医生使用低剂量血管加压药(去甲肾上腺素)和输注血小板、新鲜冰冻血浆和浓缩红细胞进行治疗。在 VV ECMO 过程中,通过靶控输注异丙酚维持麻醉。VV ECMO有望改善气管手术的手术条件,但在这方面仍是一项新技术。对于经过选择的患者,它能保证在气管切除术中提供通气支持,但必须仔细规划麻醉维持,并为 VV ECMO 相关并发症做好准备。这项技术只能在具有 VV ECMO 管理经验的三级中心使用。
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引用次数: 0
Hyperlacticaemia in children with status asthmaticus. The Stewart approach 哮喘状态儿童的高乳酸血症。斯图尔特方法
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2024.04.010

Background

Patients with status asthmaticus (SA) frequently present with lactic acidosis (LA). Our goal is to identify the nature of this LA using the Stewart physicochemical model and to identify the independent factors associated with LA in children with SA.

Methods

Analytical study of a retrospective cohort using a nested case-control design. Twenty-eight episodes of SA in 24 children were included. Patients admitted to a paediatric intensive care unit (PICU) for SA over a 9-year period were recruited consecutively. Data were analysed using the Stewart model and the Strong Ion Calculator. Data were analysed using descriptive statistics and regression models were fitted within the general linear model.

Results

Hyperlacticaemia (Lact[mM/L] = 3.905 [95% CI = 3.018–4.792]) and acidosis (pH = 7.294 [95% CI = 7.241–7.339]) were observed in 18 episodes (15 patients; 62.5%). According to the Stewart model, acidosis was caused by a decrease in strong ion difference. Initially, pCO2 was high (pCO2[mmHg] = 45.806 [95% CI = 37.314–54.298]) but the net unmeasured ion (NUI) component was normal (NUI = −4,461 [95% CI = −3.51 to −5.412]), and neither changed significantly over the clinical course. There was no need to determine pyruvate, as the NUI was normal and the LA was type B (non-hypoxic, lactate/pyruvate < 25). We observed a correlation (P = .023) between LA and intramuscular epinephrine administered on arrival at hospital, but not between LA and the cumulative dose of nebulized salbutamol.

Conclusions

Most patients with SA presented LA. The Stewart model confirmed that LA is not hypoxic, probably due to sympathomimetic-related glycolysis.

背景哮喘(SA)患者经常出现乳酸酸中毒(LA)。我们的目标是利用斯图尔特理化模型确定这种乳酸酸中毒的性质,并确定与哮喘儿童乳酸酸中毒相关的独立因素。研究纳入了 24 名儿童的 28 例 SA。连续招募了9年期间因SA入住儿科重症监护室(PICU)的患者。数据采用斯图尔特模型和强离子计算器进行分析。结果在 18 次病例(15 名患者;62.5%)中观察到高乳酸血症(乳酸[mM/L] = 3.905 [95% CI = 3.018-4.792])和酸中毒(pH = 7.294 [95% CI = 7.241-7.339])。根据斯图尔特模型,酸中毒是由强离子差下降引起的。最初,pCO2 偏高(pCO2[mmHg] = 45.806 [95% CI = 37.314-54.298]),但净未测量离子(NUI)成分正常(NUI = -4,461 [95% CI = -3.51 至 -5.412]),两者在临床过程中均无明显变化。由于 NUI 正常且 LA 为 B 型(非缺氧、乳酸/丙酮酸 <25),因此无需测定丙酮酸。我们观察到 LA 与到达医院时肌肉注射的肾上腺素之间存在相关性(P = .023),但 LA 与雾化沙丁胺醇的累积剂量之间不存在相关性。Stewart 模型证实,LA 并非缺氧,可能是由于拟交感神经相关的糖酵解所致。
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引用次数: 0
Veno-venal extracorporeal membrane oxygenation to support whole-lung lavage in a severe case of pulmonary alveolar proteinosis 静脉体外膜肺氧合支持肺泡蛋白沉积症重症病例的全肺灌洗
Pub Date : 2024-08-01 DOI: 10.1016/j.redare.2023.12.005

We present the case of a 71-year-old woman with severe bilateral primary alveolar proteinosis admitted for bilateral whole lung lavage (WLL) with a double-lumen endotracheal tube. She had a cardiac arrest of respiratory origin during the procedure and recovered after one minute of advanced resuscitation. A second LLP was scheduled under respiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO). During this second WLL the patient was completely VV-ECMO-dependent, and the procedure was successfully completed. She was gradually weaned over the next 48 h. The patient was finally discharged after clinical improvement and home oxygen therapy was discontinued. WLL is the treatment of choice for severe cases of alveolar proteinosis. In rare cases the intervention may be poorly tolerated due to the degree of lung involvement. This case illustrates how VV-ECMO support is an option that may benefit this subgroup of at-risk patients.

我们为您介绍一例患有严重双侧原发性肺泡蛋白沉积症的 71 岁女性病例,她入院时使用双腔气管插管进行双侧全肺灌洗(WLL)。她在手术过程中呼吸心跳骤停,经过一分钟的高级复苏后恢复。在静脉体外膜肺氧合(VV-ECMO)呼吸支持下,安排了第二次 LLP。在第二次 LLP 期间,患者完全依赖 VV-ECMO,手术顺利完成。在接下来的 48 小时内,她逐渐断奶。患者最终在临床好转后出院,并停止了家庭氧疗。肺泡蛋白沉积症是严重肺泡蛋白沉积症的首选治疗方法。在极少数病例中,由于肺部受累的程度不同,患者对这种治疗方法的耐受性可能很差。本病例说明了 VV-ECMO 支持是如何使这部分高危患者受益的。
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引用次数: 0
期刊
Revista espanola de anestesiologia y reanimacion
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