Bojun Li, M. Heldner, M. Arnold, J. Coutinho, S. Zuurbier, J. Meijers, H. Kohler, V. Schroeder
Coagulation factor XIII (FXIII) is activated in the last stage of the coagulation cascade in the presence of thrombin and Ca 2 þ by cleavage and release of the activation peptide (FXIII activation peptide, AP-FXIII) from the A-subunit and disso-ciation of the carrier B-subunits. Activated FXIII then cross-links fi brin fi bers and incorporates anti fi brinolytic proteins into the clot. Therefore, FXIII has a crucial role in stabilizing fi brin: it determines clot properties and fi brinolysis, and contributes to clot formation in every acute thrombotic event. 1 Consequently, FXIII is consumed during acute thrombotic events leading to a reduction in systemic circulating FXIII plasma levels which are also associated with outcome, e.g., in acute myocardial infarction, 2 stroke, 3 – 5 and venous thromboembolism. 6 – 9 In patients with acute stroke, we could detect circulating free AP-FXIII
{"title":"Coagulation Factor XIII in Cerebral Venous Thrombosis","authors":"Bojun Li, M. Heldner, M. Arnold, J. Coutinho, S. Zuurbier, J. Meijers, H. Kohler, V. Schroeder","doi":"10.1055/s-0039-1693487","DOIUrl":"https://doi.org/10.1055/s-0039-1693487","url":null,"abstract":"Coagulation factor XIII (FXIII) is activated in the last stage of the coagulation cascade in the presence of thrombin and Ca 2 þ by cleavage and release of the activation peptide (FXIII activation peptide, AP-FXIII) from the A-subunit and disso-ciation of the carrier B-subunits. Activated FXIII then cross-links fi brin fi bers and incorporates anti fi brinolytic proteins into the clot. Therefore, FXIII has a crucial role in stabilizing fi brin: it determines clot properties and fi brinolysis, and contributes to clot formation in every acute thrombotic event. 1 Consequently, FXIII is consumed during acute thrombotic events leading to a reduction in systemic circulating FXIII plasma levels which are also associated with outcome, e.g., in acute myocardial infarction, 2 stroke, 3 – 5 and venous thromboembolism. 6 – 9 In patients with acute stroke, we could detect circulating free AP-FXIII","PeriodicalId":94220,"journal":{"name":"TH open : companion journal to thrombosis and haemostasis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79200839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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