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Horizontal Guided Bone Regeneration: L-PRF Bone-Block Vs A Mixture of Autogenous Bone with Deproteinized Bovine Bone Mineral. A Split-Mouth RCT Study with 25 Months Follow-Up.
Pub Date : 2025-01-31 DOI: 10.11607/jomi.11095
Rutger A L Dhondt, Marc Quirynen, Pierre Lahoud, Simone Cortellini, Andy Temmerman

Purpose: This study aims to assess the differences between a leukocyte- and platelet-rich fibrin (L-PRF) and deproteinized bovine bone mineral block and a combination of 50% autogenous bone (AB) and 50% deproteinized bovine bone mineral (DBBM) as grafting material for horizontal guided bone regeneration (GBR).

Materials and methods: This randomized double-blind split-mouth clinical trial included 13 subjects requiring bilateral horizontal bone augmentation. Each patient received both treatment modalities: one side of the jaw was treated by GBR with the L-PRF and deproteinized bovine bone mineral block, and the other side with a 50/50 mixture of AB and DBBM. Cone beam computed tomography (CBCT) scans were used to evaluate horizontal bone width (HBW) and buccal bone thickness (BBT) at various time points: baseline (T0), immediately post-augmentation (T1), at implant placement (T2), and one year after abutment connection (T4). Bone sounding (BS) was also used to verify CBCT measurements.

Results: No statistically significant differences were found in HBW gain between test (L-PRF) and control (AB/DBBM) sites at any timepoint. Both sites showed significant HBW loss post-implant placement, with more bone volume lost at higher crestal levels (Sh0 > Sh2 > Sh4). At the Sh2 level, 48.8% of the HBW gain at T1 was lost by T4 in test sites, and 46.2% in control sites. Similarly, BBT at Sh2 reduced from 4.7 ± 1.0 mm to 1.3 ± 1.5 mm in test sites and from 2.1 ± 1.0 mm to 0.9 ± 0.8 mm in control sites. Both groups of sites had one complication, resulting in a 91.6% success rate for both treatments. The cumulative survival rate of implants was 100% at 16 months, with a mean interproximal bone level (IBL) loss of 0.2 ± 0.9 mm and 0.1 ± 0.6 mm for test and control sites, respectively.

Conclusions: No statistically significant differences were found between the AB/DBBM composite graft and the L-PRF and bovine bone mineral block for horizontal GBR. Significant resorption of grafted volume occurs within 25 months, continuing post-implant placement. Further research with larger sample sizes is needed to confirm these findings and optimize GBR techniques.

{"title":"Horizontal Guided Bone Regeneration: L-PRF Bone-Block Vs A Mixture of Autogenous Bone with Deproteinized Bovine Bone Mineral. A Split-Mouth RCT Study with 25 Months Follow-Up.","authors":"Rutger A L Dhondt, Marc Quirynen, Pierre Lahoud, Simone Cortellini, Andy Temmerman","doi":"10.11607/jomi.11095","DOIUrl":"https://doi.org/10.11607/jomi.11095","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess the differences between a leukocyte- and platelet-rich fibrin (L-PRF) and deproteinized bovine bone mineral block and a combination of 50% autogenous bone (AB) and 50% deproteinized bovine bone mineral (DBBM) as grafting material for horizontal guided bone regeneration (GBR).</p><p><strong>Materials and methods: </strong>This randomized double-blind split-mouth clinical trial included 13 subjects requiring bilateral horizontal bone augmentation. Each patient received both treatment modalities: one side of the jaw was treated by GBR with the L-PRF and deproteinized bovine bone mineral block, and the other side with a 50/50 mixture of AB and DBBM. Cone beam computed tomography (CBCT) scans were used to evaluate horizontal bone width (HBW) and buccal bone thickness (BBT) at various time points: baseline (T0), immediately post-augmentation (T1), at implant placement (T2), and one year after abutment connection (T4). Bone sounding (BS) was also used to verify CBCT measurements.</p><p><strong>Results: </strong>No statistically significant differences were found in HBW gain between test (L-PRF) and control (AB/DBBM) sites at any timepoint. Both sites showed significant HBW loss post-implant placement, with more bone volume lost at higher crestal levels (Sh0 > Sh2 > Sh4). At the Sh2 level, 48.8% of the HBW gain at T1 was lost by T4 in test sites, and 46.2% in control sites. Similarly, BBT at Sh2 reduced from 4.7 ± 1.0 mm to 1.3 ± 1.5 mm in test sites and from 2.1 ± 1.0 mm to 0.9 ± 0.8 mm in control sites. Both groups of sites had one complication, resulting in a 91.6% success rate for both treatments. The cumulative survival rate of implants was 100% at 16 months, with a mean interproximal bone level (IBL) loss of 0.2 ± 0.9 mm and 0.1 ± 0.6 mm for test and control sites, respectively.</p><p><strong>Conclusions: </strong>No statistically significant differences were found between the AB/DBBM composite graft and the L-PRF and bovine bone mineral block for horizontal GBR. Significant resorption of grafted volume occurs within 25 months, continuing post-implant placement. Further research with larger sample sizes is needed to confirm these findings and optimize GBR techniques.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative Analysis of Implant-Bone Interface After Implant Placement Implementing Condensation Technique In Vitro.
Pub Date : 2025-01-31 DOI: 10.11607/jomi.11080
Yuriy Garaev, Nina K Anderson, Rafael Delgado-Ruiz, Georgios E Romanos

The release of titanium nanoparticles during implant placement in dense bone is a significant concern, as it can potentially have adverse effects on the peri-implant tissues and an impact on the etiology of peri-implant diseases. The objective of this study was to examine the presence of titanium nanoparticles at the bone-implant interface during implant placement utilizing the bone condensation technique in vitro. Artificial Type IV bone slices (4mm thick) were securely held in place with a vice. Two groups of implants were placed. One group (test group) was placed under the condensation technique using cylindrical osteotomes. The other group (control group) was placed following the traditional surgical protocol. Implants were placed in parallel between bone slices held in a vice. Three groups of implant designs (6 implants in each group) were inserted into the bone. Two implant designs consisted of implants made of pure titanium (grade 4), while the third implant design group was constructed of titanium alloy (Ti6Al4V). Subsequently, the blocks were separated, and the peri-implant bone interface was qualitatively evaluated for titanium presence using X-ray-fluorescence spectrometry (XFS) at the coronal, middle, and apical thirds of osteotomies (n=12/ implant system). Descriptive statistical analysis showing the mean values (+/-SD) of titanium nanoparticles was performed. No detectable titanium levels were identified in the control group of titanium alloy-implants compared to pure titanium-implants. In contrast, the test group of all implant systems showed presence of titanium nanoparticles in coronal, middle, and apical thirds. Our results indicate that bone condensation technique is associated with titanium release during implant placement in vitro. These findings were shown for both pure titanium- and titanium alloy-dental implants.

{"title":"Qualitative Analysis of Implant-Bone Interface After Implant Placement Implementing Condensation Technique In Vitro.","authors":"Yuriy Garaev, Nina K Anderson, Rafael Delgado-Ruiz, Georgios E Romanos","doi":"10.11607/jomi.11080","DOIUrl":"https://doi.org/10.11607/jomi.11080","url":null,"abstract":"<p><p>The release of titanium nanoparticles during implant placement in dense bone is a significant concern, as it can potentially have adverse effects on the peri-implant tissues and an impact on the etiology of peri-implant diseases. The objective of this study was to examine the presence of titanium nanoparticles at the bone-implant interface during implant placement utilizing the bone condensation technique in vitro. Artificial Type IV bone slices (4mm thick) were securely held in place with a vice. Two groups of implants were placed. One group (test group) was placed under the condensation technique using cylindrical osteotomes. The other group (control group) was placed following the traditional surgical protocol. Implants were placed in parallel between bone slices held in a vice. Three groups of implant designs (6 implants in each group) were inserted into the bone. Two implant designs consisted of implants made of pure titanium (grade 4), while the third implant design group was constructed of titanium alloy (Ti6Al4V). Subsequently, the blocks were separated, and the peri-implant bone interface was qualitatively evaluated for titanium presence using X-ray-fluorescence spectrometry (XFS) at the coronal, middle, and apical thirds of osteotomies (n=12/ implant system). Descriptive statistical analysis showing the mean values (&#43;/-SD) of titanium nanoparticles was performed. No detectable titanium levels were identified in the control group of titanium alloy-implants compared to pure titanium-implants. In contrast, the test group of all implant systems showed presence of titanium nanoparticles in coronal, middle, and apical thirds. Our results indicate that bone condensation technique is associated with titanium release during implant placement in vitro. These findings were shown for both pure titanium- and titanium alloy-dental implants.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Dental Implant Diameters on Prosthesis Complications: a Systematic Review and Meta-analysis. 牙科植入物直径对修复体并发症的影响:系统回顾与元分析》。
Pub Date : 2025-01-31 DOI: 10.11607/jomi.10964
Yu-Ting Yeh, Lan-Lin Chiou, Hsuan-Hung Chen, Guo- Hao Lin, Richard T Kao, Donald A Curtis

Purpose: This systematic review and meta-analysis aims to analyze the risk of prosthesis complications across different implant diameters.

Materials and methods: An electronic search across PubMed (MEDLINE), Embase, Scopus, and Cochrane Central Register of Controlled Trials until December 2023 was performed. Studies comparing implant prosthesis complications among extra-narrow (<3.0 mm), narrow (≥3.0 to <3.75 mm), standard (≥3.75 to <5 mm), and wide-diameter (≥5 mm) implants were included. Meta-analyses were performed to evaluate the risk ratio of prosthesis complications across different diameters, particularly in non-full arch implant-supported fixed dental prostheses (ISFDP).

Results: Eighteen clinical studies were included. In non-full arch ISFDP, the most prevalent complication was screw loosening in narrow, standard, and wide-diameter implants (17.28%, 4.08% and 12.45%, respectively), and decementation (3.4%) in extra-narrow diameter implants. In implant overdentures, extra-narrow, narrow and standard-diameter implants demonstrated high rates of retentive cap wear (58.33%, 80.49% and 70%, respectively), whereas wide-diameter implants had 16.67% overdenture repair. The meta-analyses showed a risk ratio of 0.20 (95% confidence interval= 0.04 to 0.94, p= 0.04) and 0.17 (95% CI= 0.06 to 0.45, p< 0.0004) for abutment fracture in single crowns and ISFDP comparing narrow versus standard-diameter implants. No significant differences in risk ratios were observed for screw loosening, decementation, porcelain chipping, fracture, or screw fracture among the different diameter groups.

Conclusions: This systematic review highlights that screw loosening and retentive cap wear are the most common prosthesis complications in ISFDP and overdentures, regardless of implant diameter. While narrow-diameter implants have a lower risk of abutment fracture compared to standard-diameter implants, clinicians should carefully consider patient characteristics, implant locations, and abutment features when selecting the ideal implant diameter.

{"title":"Influence of Dental Implant Diameters on Prosthesis Complications: a Systematic Review and Meta-analysis.","authors":"Yu-Ting Yeh, Lan-Lin Chiou, Hsuan-Hung Chen, Guo- Hao Lin, Richard T Kao, Donald A Curtis","doi":"10.11607/jomi.10964","DOIUrl":"https://doi.org/10.11607/jomi.10964","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aims to analyze the risk of prosthesis complications across different implant diameters.</p><p><strong>Materials and methods: </strong>An electronic search across PubMed (MEDLINE), Embase, Scopus, and Cochrane Central Register of Controlled Trials until December 2023 was performed. Studies comparing implant prosthesis complications among extra-narrow (<3.0 mm), narrow (≥3.0 to <3.75 mm), standard (≥3.75 to <5 mm), and wide-diameter (≥5 mm) implants were included. Meta-analyses were performed to evaluate the risk ratio of prosthesis complications across different diameters, particularly in non-full arch implant-supported fixed dental prostheses (ISFDP).</p><p><strong>Results: </strong>Eighteen clinical studies were included. In non-full arch ISFDP, the most prevalent complication was screw loosening in narrow, standard, and wide-diameter implants (17.28%, 4.08% and 12.45%, respectively), and decementation (3.4%) in extra-narrow diameter implants. In implant overdentures, extra-narrow, narrow and standard-diameter implants demonstrated high rates of retentive cap wear (58.33%, 80.49% and 70%, respectively), whereas wide-diameter implants had 16.67% overdenture repair. The meta-analyses showed a risk ratio of 0.20 (95% confidence interval= 0.04 to 0.94, p= 0.04) and 0.17 (95% CI= 0.06 to 0.45, p< 0.0004) for abutment fracture in single crowns and ISFDP comparing narrow versus standard-diameter implants. No significant differences in risk ratios were observed for screw loosening, decementation, porcelain chipping, fracture, or screw fracture among the different diameter groups.</p><p><strong>Conclusions: </strong>This systematic review highlights that screw loosening and retentive cap wear are the most common prosthesis complications in ISFDP and overdentures, regardless of implant diameter. While narrow-diameter implants have a lower risk of abutment fracture compared to standard-diameter implants, clinicians should carefully consider patient characteristics, implant locations, and abutment features when selecting the ideal implant diameter.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Radiographic Outcomes of Single-Unit Implant- Supported Restorations: A 12-Month Cross-Sectional Clinical Study. 单单元种植体支撑修复体的临床和影像学结果:一项为期12个月的横断面临床研究。
Pub Date : 2025-01-17 DOI: 10.11607/jomi.11233
Nur Pektaş, Özer İşisağ

Purpose: This retrospective clinical study aims to analyze single-unit implant-supported restorations' clinical and radiographic outcomes comprehensively.

Materials and methods: In this retrospective study, patients who had undergone 12 months of implant-supported singleunit fixed prosthetic treatment were scanned from the archives, and a hundred patients were included in the study. Implant success and survival rates were assessed according to the consensus decisions published at the International Oral Implantology Congress in 2007. Prosthetic complications such as chipping, screw loosening, and decementation were also evaluated. In addition, success/survival rates and prosthetic compositions were associated with some surgical and prosthetic parameters.

Results: According to the success/survival criteria, 88% of the implants were successful, 10% had satisfactory survival, and 2% had compromised survival. The risk of satisfactory or compromised survival was 62.5 times higher in individuals with inadequately keratinized mucosa compared to those with adequately keratinized mucosa (p < 0.001). It was also 5.736 times greater for extractions due to periodontal disease versus endodontic reasons (p = 0.010) and 4.629 times higher for implants with diameters less than 3.75 mm compared to those between 3.75 mm and 5 mm (p = 0.037). Screw loosening was observed in 15% of the evaluated restorations, decementation in 13% and chipping in 4%, and the risk of screw loosening was 4.444 times higher for screw retention abutments compared to standard abutments (p=0.015).

Conclusion: Insufficient keratinized mucosa, periodontal problems leading to tooth extractions, and the use of narrowdiameter implants can negatively affect the success of implant procedures. Loosening in screw-retained restorations is due solely to screw loosening, which is a high risk for screwretained restorations. Loosening in cement-retained restorations, on the other hand, is caused by the decementation of the prosthetic restoration or loosening of the abutment screw supporting the restoration.

目的:本回顾性临床研究旨在全面分析单单元种植体支持修复体的临床和影像学结果。材料和方法:本回顾性研究从档案中扫描接受过12个月种植体支持单单元固定假体治疗的患者,共纳入100例患者。根据2007年国际口腔种植大会发表的共识决定评估种植成功率和存活率。假体并发症如脱落、螺钉松动和复位也进行了评估。此外,成功/存活率和假体成分与一些手术和假体参数相关。结果:根据成功/生存标准,88%的种植体成功,10%的种植体生存满意,2%的种植体生存受损。与角化黏膜充分者相比,角化黏膜不充分者生存期满意或受损的风险高62.5倍(p < 0.001)。因牙周病而拔牙比因牙髓病而拔牙多5.736倍(p = 0.010),直径小于3.75 mm比直径在3.75 mm到5 mm之间多4.629倍(p = 0.037)。评估的修复体中有15%发生螺钉松动,13%发生退化,4%发生碎裂,螺钉保留基台发生螺钉松动的风险是标准基台的4.444倍(p=0.015)。结论:黏膜角化不充分、牙周问题导致拔牙以及使用窄径种植体会对种植手术的成功产生负面影响。螺钉保留的修复体松动仅仅是由于螺钉松动,这对螺钉保留的修复体来说是高风险的。另一方面,骨水泥保留修复体的松动是由假体修复体的退化或支撑修复体的基台螺钉松动引起的。
{"title":"Clinical and Radiographic Outcomes of Single-Unit Implant- Supported Restorations: A 12-Month Cross-Sectional Clinical Study.","authors":"Nur Pektaş, Özer İşisağ","doi":"10.11607/jomi.11233","DOIUrl":"https://doi.org/10.11607/jomi.11233","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective clinical study aims to analyze single-unit implant-supported restorations' clinical and radiographic outcomes comprehensively.</p><p><strong>Materials and methods: </strong>In this retrospective study, patients who had undergone 12 months of implant-supported singleunit fixed prosthetic treatment were scanned from the archives, and a hundred patients were included in the study. Implant success and survival rates were assessed according to the consensus decisions published at the International Oral Implantology Congress in 2007. Prosthetic complications such as chipping, screw loosening, and decementation were also evaluated. In addition, success/survival rates and prosthetic compositions were associated with some surgical and prosthetic parameters.</p><p><strong>Results: </strong>According to the success/survival criteria, 88% of the implants were successful, 10% had satisfactory survival, and 2% had compromised survival. The risk of satisfactory or compromised survival was 62.5 times higher in individuals with inadequately keratinized mucosa compared to those with adequately keratinized mucosa (p < 0.001). It was also 5.736 times greater for extractions due to periodontal disease versus endodontic reasons (p = 0.010) and 4.629 times higher for implants with diameters less than 3.75 mm compared to those between 3.75 mm and 5 mm (p = 0.037). Screw loosening was observed in 15% of the evaluated restorations, decementation in 13% and chipping in 4%, and the risk of screw loosening was 4.444 times higher for screw retention abutments compared to standard abutments (p=0.015).</p><p><strong>Conclusion: </strong>Insufficient keratinized mucosa, periodontal problems leading to tooth extractions, and the use of narrowdiameter implants can negatively affect the success of implant procedures. Loosening in screw-retained restorations is due solely to screw loosening, which is a high risk for screwretained restorations. Loosening in cement-retained restorations, on the other hand, is caused by the decementation of the prosthetic restoration or loosening of the abutment screw supporting the restoration.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivariate Analysis of the Influence of Primary and Secondary Stability in Relation to Dental Implant Characteristics: A Clinical Study of 445 Implants. 445颗种植体的临床研究:初级和次级稳定性对种植体特性影响的多变量分析。
Pub Date : 2025-01-17 DOI: 10.11607/jomi.11254
Fabián Pérez-González, Santiago Bazal-Bonelli, Luis Sánchez-Labrador, Luis Miguel Sáez-Alcaide, Héctor González-Menéndez, Carlos Cobo-Vázquez, Jorge Cortés-Bretón Brinkmann

Purpose: Implant stability (IS) is crucial to the success of any implant-based therapy. The present work aimed to determine the relationship between primary and secondary stability and a range of variables.

Material and methods: This retrospective cohort study included a total of 169 patients, who received 445 dental implants. A case history for each participant was created. Data collection included each patient's age, implant design, length and diameter, bone type, and surgical factors. Implant Stability Quotient (ISQ) values were measured at baseline (T0: primary stability) and T1 (secondary stability). To calculate the ISQ values at T0, T1 and their differences in the variables age, design, length and diameter, a multivariate ANOVA test was performed to determine which variables acted as confounding factors and to adjust the ISQ values to these variables.

Results: The main variables age, design, length and diameter were adjusted to their confounding factors. Regarding primary (T0) and secondary (T1) stability, statistically significant differences (p<0.05) were only found in implant diameter, with the larger the diameter, the greater the stability. In all the other main variables, no statistically significant differences were found for primary and secondary stability.

Conclusions: It may be concluded, within the limitations of the study, that the implant diameter variable is the one that significantly affects the primary and secondary stability of the implant.

目的:种植体稳定性(IS)是任何种植体治疗成功的关键。本工作旨在确定主要和次要稳定性和一系列变量之间的关系。材料和方法:本回顾性队列研究共纳入169例患者,共445例种植体。为每个参与者创建了一个病例历史。数据收集包括每位患者的年龄、种植体设计、长度和直径、骨类型和手术因素。在基线(T0:主要稳定性)和T1(次要稳定性)时测量种植体稳定商(ISQ)值。为了计算T0, T1时的ISQ值及其在年龄,设计,长度和直径变量中的差异,进行了多变量方差分析,以确定哪些变量是混杂因素,并根据这些变量调整ISQ值。结果:主要变量年龄、设计、长度和直径调整为其混杂因素。初级(T0)和次级(T1)稳定性差异有统计学意义(p)结论:在研究范围内,可以得出结论,种植体直径变量是影响种植体初级和次级稳定性的显著变量。
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引用次数: 0
Outcomes of Surgical Treatment of Peri-Implantitis: A Retrospective Cohort Study. 种植体周围炎手术治疗的结果:一项回顾性队列研究。
Pub Date : 2025-01-17 DOI: 10.11607/jomi.11018
Claudia Ros-Alcaraz, Maria Camila Erazo-Puentes, Octavi Camps-Font, Marta García-García, Rui Figueiredo, Eduard Valmaseda-Castellón

Purpose: The available scientific evidence on the effectiveness of the surgical treatment of peri-implantitis is limited. The aim of this study was to assess the risk of recurrence or disease progression in patients with peri-implantitis that underwent surgical treatment.

Materials and methods: A retrospective cohort study was carried out in patients subjected to peri-implant surgery between 2015 and 2021, and with a minimum follow-up of 12 months. Data were analyzed using simple binary logistic regression models at patient level and generalized estimation equations at implant level.

Results: A total of 34 patients and 103 implants were analyzed (70 undergoing resective techniques and 33 regenerative procedures). Fifteen patients (44.12%) experienced peri-implantitis recurrence and one patient (2.9%) lost one implant. No differences were found between the surgical techniques (p = 0.56). A history of periodontitis (ORa = 4.62; 95%CI: 1.14 to 18.75; p = 0.032), maxillary location (ORa = 9.69; 95%CI: 1.81 to 51.87; p = 0.008) and two implants treated per procedure (ORa = 31.68; 95%CI: 3.91 to 256.54; p = 0.001) were seen to increase the risk of recurrence.

Conclusions: Almost half of all patients (44%) undergoing surgical treatment of periimplantitis will present disease progression or recurrence. This risk seems to be higher in patients with several treated implants, with a history of periodontal disease, or when the maxilla is involved.

目的:关于手术治疗种植体周围炎的有效性,现有的科学证据有限。本研究的目的是评估接受手术治疗的种植体周围炎患者复发或疾病进展的风险。材料与方法:对2015 - 2021年间行种植体周围手术的患者进行回顾性队列研究,随访时间至少为12个月。在患者水平使用简单的二元逻辑回归模型,在种植体水平使用广义估计方程对数据进行分析。结果:共分析了34例患者和103个种植体(70例进行了切除技术,33例进行了再生手术)。种植体周围炎复发15例(44.12%),种植体丢失1例(2.9%)。手术技术间无差异(p = 0.56)。牙周炎病史(ORa = 4.62;95%CI: 1.14 ~ 18.75;p = 0.032),上颌定位(ORa = 9.69;95%CI: 1.81 ~ 51.87;p = 0.008),每次手术治疗2个种植体(ORa = 31.68;95%CI: 3.91 ~ 256.54;P = 0.001)会增加复发风险。结论:几乎一半(44%)接受手术治疗的患者会出现疾病进展或复发。在接受过多次治疗的种植体患者、有牙周病史的患者或上颌受损伤的患者中,这种风险似乎更高。
{"title":"Outcomes of Surgical Treatment of Peri-Implantitis: A Retrospective Cohort Study.","authors":"Claudia Ros-Alcaraz, Maria Camila Erazo-Puentes, Octavi Camps-Font, Marta García-García, Rui Figueiredo, Eduard Valmaseda-Castellón","doi":"10.11607/jomi.11018","DOIUrl":"https://doi.org/10.11607/jomi.11018","url":null,"abstract":"<p><strong>Purpose: </strong>The available scientific evidence on the effectiveness of the surgical treatment of peri-implantitis is limited. The aim of this study was to assess the risk of recurrence or disease progression in patients with peri-implantitis that underwent surgical treatment.</p><p><strong>Materials and methods: </strong>A retrospective cohort study was carried out in patients subjected to peri-implant surgery between 2015 and 2021, and with a minimum follow-up of 12 months. Data were analyzed using simple binary logistic regression models at patient level and generalized estimation equations at implant level.</p><p><strong>Results: </strong>A total of 34 patients and 103 implants were analyzed (70 undergoing resective techniques and 33 regenerative procedures). Fifteen patients (44.12%) experienced peri-implantitis recurrence and one patient (2.9%) lost one implant. No differences were found between the surgical techniques (p = 0.56). A history of periodontitis (ORa = 4.62; 95%CI: 1.14 to 18.75; p = 0.032), maxillary location (ORa = 9.69; 95%CI: 1.81 to 51.87; p = 0.008) and two implants treated per procedure (ORa = 31.68; 95%CI: 3.91 to 256.54; p = 0.001) were seen to increase the risk of recurrence.</p><p><strong>Conclusions: </strong>Almost half of all patients (44%) undergoing surgical treatment of periimplantitis will present disease progression or recurrence. This risk seems to be higher in patients with several treated implants, with a history of periodontal disease, or when the maxilla is involved.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paired-Related Homeobox 1-Positive Cells Are Needed for Osseointegration. 骨结合需要成对相关同源框 1 阳性细胞
Pub Date : 2024-12-11 DOI: 10.11607/jomi.10852
Xi Feng, Haicheng Wang, Yuteng Weng, Yongliang Chen, Jie Huang, Zuolin Wang

Purpose: To explore the contribution of paired-related homeobox 1-positive (Prrx1+) cells to the implant-induced osseointegration process in adult alveolar bone and the potential underlying mechanisms.

Materials and methods: Crerecombinase-induced lineage tracing and cell ablation were conducted in a murine dental implant model. Scratch and transwell assays were used to assess MC3T3-E1 cell migration after paired-related homeobox 1 overexpression. Single-cell RNA sequencing was applied to identify potential genes involved in Prrx1+ cell-driven osteogenesis.

Results: Prrx1+ cells were observed to accumulate in the peri-implant area in a time-dependent manner; the number of these cells was found to reach its maximum on day 14. Osseointegration in mice was noticeably impaired after ablation of Prrx1+ cells. Further, it was discovered that Prrx1 promotes MC3T3-E1 cell migration, a process which is indispensable for sound healing of peri-implant tissue. Finally, semaphorin 3C (Sema3C) was detected exclusively and abundantly expressed by Prrx1+ cells. Knockdown of Sema3C in Prrx1+ cells significantly weakened their osteogenic potential.

Conclusions: Our data suggest that Prrx1+ cells contribute to the osseointegration process under stress stimulation and Sema3C may play a critical role in Prrx1+ cell-driven osteogenesis. Prrx1 could significantly promote MC3T3-E1 cell migration.

目的:探讨成对相关同源染色体 1 阳性细胞对成人牙槽骨种植体诱导的骨结合过程的贡献及其潜在的内在机制:在小鼠牙种植模型中进行了Cre重组酶诱导的品系追踪和细胞消融。使用划痕和跨孔试验评估配对相关同源染色体 1 过度表达后 MC3T3-E1 细胞的迁移。应用单细胞RNA测序鉴定参与配对相关同源染色体1阳性细胞驱动成骨的潜在基因:结果:观察到成对相关homeobox 1-阳性细胞以时间依赖性的方式在种植体周围区域聚集。这些细胞的数量在第 14 天达到最大值。消减配对相关同源染色体 1 阳性细胞后,小鼠的骨结合明显受损。此外,研究还发现配对相关同形体 1 能促进 MC3T3- E1 细胞迁移,而这一过程是种植体周围组织健全愈合所不可或缺的。最后,在配对相关同源框 1 阳性的细胞中检测到了大量表达的semaphorin 3C。在配对相关同工酶 1- 阳性细胞中敲除 Semaphorin 3C 会显著削弱其成骨潜能:我们的数据表明,配对相关同工酶1阳性细胞在应力刺激下有助于骨结合过程,而半aphorin 3C 可能在配对相关同工酶1阳性细胞驱动的成骨过程中发挥关键作用。配对相关同源框 1 能显著促进 MC3T3-E1 细胞迁移。
{"title":"Paired-Related Homeobox 1-Positive Cells Are Needed for Osseointegration.","authors":"Xi Feng, Haicheng Wang, Yuteng Weng, Yongliang Chen, Jie Huang, Zuolin Wang","doi":"10.11607/jomi.10852","DOIUrl":"10.11607/jomi.10852","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the contribution of paired-related homeobox 1-positive (Prrx1&#43;) cells to the implant-induced osseointegration process in adult alveolar bone and the potential underlying mechanisms.</p><p><strong>Materials and methods: </strong>Crerecombinase-induced lineage tracing and cell ablation were conducted in a murine dental implant model. Scratch and transwell assays were used to assess MC3T3-E1 cell migration after paired-related homeobox 1 overexpression. Single-cell RNA sequencing was applied to identify potential genes involved in Prrx1&#43; cell-driven osteogenesis.</p><p><strong>Results: </strong>Prrx1&#43; cells were observed to accumulate in the peri-implant area in a time-dependent manner; the number of these cells was found to reach its maximum on day 14. Osseointegration in mice was noticeably impaired after ablation of Prrx1&#43; cells. Further, it was discovered that Prrx1 promotes MC3T3-E1 cell migration, a process which is indispensable for sound healing of peri-implant tissue. Finally, semaphorin 3C (Sema3C) was detected exclusively and abundantly expressed by Prrx1&#43; cells. Knockdown of Sema3C in Prrx1&#43; cells significantly weakened their osteogenic potential.</p><p><strong>Conclusions: </strong>Our data suggest that Prrx1&#43; cells contribute to the osseointegration process under stress stimulation and Sema3C may play a critical role in Prrx1&#43; cell-driven osteogenesis. Prrx1 could significantly promote MC3T3-E1 cell migration.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"893-903"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracorporeal Shockwave Therapy (ESWT)-A Novel Method for Transferring Oral Implant Primary Failures to Final Clinical Success: A Test Case Report Followed up for More Than 6 Years. 体外冲击波疗法 (ESWT),一种将口腔种植失败转为最终临床成功的新方法:超过 6 年的试验病例跟踪报告。
Pub Date : 2024-12-11 DOI: 10.11607/jomi.10820
Luis Amengual, Manuel Brañes, Francisco Marchesani, Leopodo Parada, Maria Constanza Jara, Tomas Albrektsson

Purpose: To evaluate the feasibility of reversing a primary failure through therapeutic mechanical stimulation induced by transcutaneous application of acoustic waves (extracorporeal shockwave therapy [ESWT]) in the peri-implant tissues.

Materials and methods: This clinical report evaluates the outcome of a new protocol proposed to treat a primary failure (loosened oral implant): application of three cycles of ESWT (one session per week for 3 consecutive weeks) with an equivalent positive energy of 0.18 mJ/mm2 (therapeutic dose: 2,000 pulses, 8 Hz, 4.0 bar). Standardized intraoral radiographs and CBCT scans were taken, the implant stability quotient (ISQ) was determined, and clinical evaluations were performed.

Results: It was possible to verify a progressive increase in ISQ values after the ESWT protocol: 17 initially, 46 at 2 months, and 68 at 4 months. This led to successful implant prosthetic rehabilitation (35 Ncm). Follow-up evaluations at 6 years confirm that the new bone-implant interface is preserved and that ESWT is a safe, noninvasive treatment.

Conclusions: In the context of the new dynamic model of osseointegration (the foreign body equilibrium), this represents the first report of a host-implant equilibrium reestablished after an early implant failure process. However, more studies are needed to determine both the medical device and the most effective therapeutic range for clinical applications of this technology in oral implantology.

目的:评估通过经皮声波疗法(ESWT)对种植体周围组织进行治疗性机械刺激来逆转初次失败的可行性。材料和方法:本临床报告评估了为治疗原发性失败(口腔种植体松动)而提出的新方案的效果;ESWT 应用三个周期,每周一次,连续 3 周,等效正能量为 0.18 mJ/mm²(治疗剂量:2000 脉冲/8 赫兹/4.0 巴)。进行了标准化的口内X光片、锥形束计算机断层扫描(CBCT)、种植体稳定性商数(ISQ)和临床评估:结果:经过 ESWT 治疗后,ISQ 值逐渐增加:17(初始值)、46(两个月后)和 68(四个月后),从而成功实现了种植修复(测量值为 35 N/cm)。6 年的随访评估证实,新的骨-种植体界面得到了保护,ESWT 是一种安全的非侵入性治疗方法:结论:在新的骨结合动态模型--异物平衡(FBE)的背景下,这是第一例在早期失败过程后重建宿主-种植体平衡的报告。不过,有必要进行研究,以确定在口腔种植中临床应用该技术的医疗设备和最有效的治疗范围。
{"title":"Extracorporeal Shockwave Therapy (ESWT)-A Novel Method for Transferring Oral Implant Primary Failures to Final Clinical Success: A Test Case Report Followed up for More Than 6 Years.","authors":"Luis Amengual, Manuel Brañes, Francisco Marchesani, Leopodo Parada, Maria Constanza Jara, Tomas Albrektsson","doi":"10.11607/jomi.10820","DOIUrl":"10.11607/jomi.10820","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility of reversing a primary failure through therapeutic mechanical stimulation induced by transcutaneous application of acoustic waves (extracorporeal shockwave therapy [ESWT]) in the peri-implant tissues.</p><p><strong>Materials and methods: </strong>This clinical report evaluates the outcome of a new protocol proposed to treat a primary failure (loosened oral implant): application of three cycles of ESWT (one session per week for 3 consecutive weeks) with an equivalent positive energy of 0.18 mJ/mm2 (therapeutic dose: 2,000 pulses, 8 Hz, 4.0 bar). Standardized intraoral radiographs and CBCT scans were taken, the implant stability quotient (ISQ) was determined, and clinical evaluations were performed.</p><p><strong>Results: </strong>It was possible to verify a progressive increase in ISQ values after the ESWT protocol: 17 initially, 46 at 2 months, and 68 at 4 months. This led to successful implant prosthetic rehabilitation (35 Ncm). Follow-up evaluations at 6 years confirm that the new bone-implant interface is preserved and that ESWT is a safe, noninvasive treatment.</p><p><strong>Conclusions: </strong>In the context of the new dynamic model of osseointegration (the foreign body equilibrium), this represents the first report of a host-implant equilibrium reestablished after an early implant failure process. However, more studies are needed to determine both the medical device and the most effective therapeutic range for clinical applications of this technology in oral implantology.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"922-930"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immediate Placement and Loading of Maxillary Single-Tooth Scalloped Implants and Digitally Customized Restorations: A 5-Year Prospective Study of Marginal Bone Level. 上颌单牙扇形种植体和数字化定制修复体的即刻植入和加载:边缘骨水平的 5 年前瞻性研究。
Pub Date : 2024-12-11 DOI: 10.11607/jomi.10965
Antoine N Berberi

Purpose: To evaluate over 5 years the mesial, distal, palatal, and buccal bone levels as well as the buccal bone thickness surrounding scalloped implants that were immediately placed and loaded with provisional crowns fixed on final prefabricated abutments.

Materials and methods: A total of 18 implants were placed and immediately loaded using CAD/CAM technology in 18 patients to replace a single tooth in the anterior maxilla. The marginal bone levels around the scalloped implant necks were measured mesially and distally using intraoral standardized radiographs after crown placement as well as at the 1-, 3-, and 5-year follow-ups. CBCT para-axial cut images were used to measure the bone level buccally and palatally from the implant neck to the bone-to-implant contact (BIC) 5 years after loading. These images were used to evaluate the thickness of the buccal bone at the implant neck and 4 mm apically both immediately after implant placement (T0) and 5 years later.

Results: All implants were assessed clinically and radiologically after 5 years. No implant failure was recorded, and the average marginal bone variation for mesial and distal sites was as follows: 0.114 ±0.135 mm at crown cementation, 0.239 ± 0.158 mm 1 year later, 0.233 ± 0.182 mm 3 years later, and 0.180 ± 0.182 mm 5 years later. Our findings indicate that at T0, the average thickness of the buccal bone was 2.27 mm at the implant neck (M0; ranging from 1.9 to 2.4 mm) and 2.33 mm at 4 mm apical to the implant neck (M1; ranging from 1.9 to 2.9 mm). At 5 years postoperative (T4), the mean had decreased to 1.94 mm at M0 (ranging from 1.7 to 2.3 mm) and 2.14 mm at M1 (ranging from 1.8 to 2.4 mm). After 5 years of functional loading, the mean changes at the buccal and palatal bone for all implants were +0.187 ± 0.52 mm and +0.06 ± 0.38 mm, respectively. Minor prosthetic problems were observed over the 5 years, including incisal ceramic chipping in two crowns and replacement of two crowns due to esthetic reasons after 1 year. No loosening of crowns or abutments was reported.

Conclusions: Scalloped-neck implants demonstrated a comparable behavior to regular-neck implants with similar designs in immediate placement and temporization protocol over a 5-year period.

材料和方法:采用计算机辅助设计/计算机辅助制造技术,为18名患者植入18颗种植体,并用临时牙冠固定在最终预制基台上。在牙冠固定后以及 1 年、3 年和 5 年后,使用口内标准化 X 光片测量了扇形种植体颈部中、远端的边缘骨水平。锥形束计算机断层扫描准轴切面图像用于测量种植体植入5年后颊侧和腭侧从种植体颈部到种植体与骨接触处的骨水平,并评估种植体植入后立即和5年后种植体颈部和根尖4毫米处的颊骨厚度:所有种植体均在 5 年后接受了临床和放射学评估。没有种植失败的记录,牙冠固位时中轴和远轴处的平均边缘骨变异为 0.114 ± 0.135 毫米,1 年后为 0.239 ± 0.158 毫米,3 年后为 0.233 ± 0.182 毫米,5 年后为 0.180 ± 0.182 毫米。我们的研究结果表明,在 T0 期,种植体颈 M0 处的颊骨平均厚度为 2.27 毫米(从 1.9 毫米到 2.4 毫米不等),种植体颈 M1 距根尖 4 毫米处的颊骨平均厚度为 2.33 毫米(从 1.9 毫米到 2.9 毫米不等)。到了 T4,M0 的平均值下降到 1.94 mm(范围在 1.7 mm 到 2.3 mm 之间),M1 的平均值下降到 2.14 mm(范围在 1.8 mm 到 2.4 mm 之间)。5 年后,所有种植体的颊骨和腭骨的平均变化分别为 +0.187 ± 0.52 毫米和 +0.06 ± 0.38 毫米。五年来,修复体出现了一些小问题:两个牙冠出现了切缘陶瓷崩裂,两个牙冠在一年后因美观原因被更换。没有出现牙冠或基台松动的情况:在为期五年的即刻种植和临时修复方案中,扇形颈部种植体的表现与具有类似设计的普通颈部种植体相当。
{"title":"Immediate Placement and Loading of Maxillary Single-Tooth Scalloped Implants and Digitally Customized Restorations: A 5-Year Prospective Study of Marginal Bone Level.","authors":"Antoine N Berberi","doi":"10.11607/jomi.10965","DOIUrl":"10.11607/jomi.10965","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate over 5 years the mesial, distal, palatal, and buccal bone levels as well as the buccal bone thickness surrounding scalloped implants that were immediately placed and loaded with provisional crowns fixed on final prefabricated abutments.</p><p><strong>Materials and methods: </strong>A total of 18 implants were placed and immediately loaded using CAD/CAM technology in 18 patients to replace a single tooth in the anterior maxilla. The marginal bone levels around the scalloped implant necks were measured mesially and distally using intraoral standardized radiographs after crown placement as well as at the 1-, 3-, and 5-year follow-ups. CBCT para-axial cut images were used to measure the bone level buccally and palatally from the implant neck to the bone-to-implant contact (BIC) 5 years after loading. These images were used to evaluate the thickness of the buccal bone at the implant neck and 4 mm apically both immediately after implant placement (T0) and 5 years later.</p><p><strong>Results: </strong>All implants were assessed clinically and radiologically after 5 years. No implant failure was recorded, and the average marginal bone variation for mesial and distal sites was as follows: 0.114 ±0.135 mm at crown cementation, 0.239 ± 0.158 mm 1 year later, 0.233 ± 0.182 mm 3 years later, and 0.180 ± 0.182 mm 5 years later. Our findings indicate that at T0, the average thickness of the buccal bone was 2.27 mm at the implant neck (M0; ranging from 1.9 to 2.4 mm) and 2.33 mm at 4 mm apical to the implant neck (M1; ranging from 1.9 to 2.9 mm). At 5 years postoperative (T4), the mean had decreased to 1.94 mm at M0 (ranging from 1.7 to 2.3 mm) and 2.14 mm at M1 (ranging from 1.8 to 2.4 mm). After 5 years of functional loading, the mean changes at the buccal and palatal bone for all implants were &#43;0.187 ± 0.52 mm and &#43;0.06 ± 0.38 mm, respectively. Minor prosthetic problems were observed over the 5 years, including incisal ceramic chipping in two crowns and replacement of two crowns due to esthetic reasons after 1 year. No loosening of crowns or abutments was reported.</p><p><strong>Conclusions: </strong>Scalloped-neck implants demonstrated a comparable behavior to regular-neck implants with similar designs in immediate placement and temporization protocol over a 5-year period.</p>","PeriodicalId":94230,"journal":{"name":"The International journal of oral & maxillofacial implants","volume":"0 0","pages":"884-892"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Ti-Base-Supported Implant Restoration on Peri- implant Conditions: A Systematic Review and Meta-analysis. 钛基托种植体修复对种植体周围条件的影响:系统回顾与元分析
Pub Date : 2024-12-11 DOI: 10.11607/jomi.10924
Han-Pang Liu, Sieu Yien Chiam, Hom-Lay Wang

Purpose: To conduct a systematic review and meta-analysis to examine the impact of titanium (Ti) base-supported single-implant restorations on peri-implant conditions.

Materials and methods: Six randomized controlled trials (RCTs) comprising 274 implants met the inclusion criteria and were chosen for data analysis. A random-effects model was employed for the meta-analysis.

Results: Data from this study revealed that the Ti-basegroup exhibited a small but statistically significant increase in peri-implant marginal bone loss (MBL; mean difference = 0.088 mm; 95% CI = 0.003 to 0.17; P = .041) compared to the one-piece abutment group. These effects were consistent in the subgroup analysis of regularly threaded implants compared to the microthreaded subgroup. No significant differences were observed between the Ti-base group and the abutment group concerning probing depth (PD), bleeding on probing (BoP), and the risk of prosthetic-related complications.

Conclusions: The use of a Ti-base in a single implant-supported restorationis associated with a slight increase in peri-implant MBL, while other peri-implant health parameters show no significant correlation. Therefore, the evidence of the impact that Ti-bases have on the peri-implant conditions of single implant-supported restorations is insufficient based on the findings of the present meta-analysis.

目的:本系统综述和荟萃分析旨在研究钛基底支持的单颗种植体修复体对种植体周围条件的影响:我们选择了六项随机对照试验(RCT)进行数据分析,共有 274 个种植体符合纳入标准。荟萃分析采用随机效应模型:研究数据显示,与一体式基台组相比,钛基台组的种植体周围边缘骨质流失略有增加,但具有统计学意义(平均值差异 = 0.088,95% 置信区间 = 0.003 到 0.17,P = 0.041)。在常规螺纹种植体与微螺纹种植体的亚组分析中,这些影响是一致的。然而,在探诊深度(PD)、探诊出血量(BOP)和修复体相关并发症的风险方面,钛基底组与基台组之间没有观察到明显的差异:结论:在单种植体支持修复中使用钛基底与种植体周围边缘骨丧失的轻微增加有关,而其他种植体周围健康参数则没有明显的相关性。因此,根据这项荟萃分析的结果来确定钛基底对单种植体支持修复体种植体周围条件的影响是不够的。
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The International journal of oral & maxillofacial implants
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