Annals of dermatology最新文献

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Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss. 家族史和男性雄激素性脱发与女性脱发的关系。

Annals of dermatology

Pub Date : 2023-10-01 DOI: 10.5021/ad.22.221

Sang-Hoon Lee, Hyun Kang, Won-Soo Lee

Background: Male androgenetic alopecia (MAGA) is often accompanied by female pattern hair loss (FPHL). However, the risk factors related to MAGA with FPHL are unclear.

Objective: To investigate demographic and laboratory factors related to MAGA with FPHL.

Methods: This retrospective case-control study was performed in a single tertiary care center for MAGA with FPHL between March 2012 and September 2021. Eligible patients were males >12 years old diagnosed with androgenetic alopecia by a dermatologist. The patients were subdivided into MAGA with FPHL and MAGA without FPHL groups. Comorbidities as well as demographic, laboratory, and disease-specific variables were compared between the two groups. Data analysis was conducted between October 2021 and February 2022. The independent samples t-test, Mann-Whitney U test, and chi-squared test were used to assess the factors that contributed to MAGA with FPHL.

Results: Of 469 patients with MAGA, 309 (65.9%) had FPHL, which was a much higher rate than previously reported. Among the variables, only matrilineal (odds ratio, 1.605; 95% confidence interval, 1.014~2.541) and maternal history (odds ratio, 4.705; confidence interval, 1.632~13.559) of androgenetic alopecia were significantly associated with MAGA with FPHL. In the MAGA with FPHL group, a significant positive correlation was noted between body mass index and the type F score (r=0.114, p=0.025).

Conclusion: In this case-control study, patients with MAGA and a maternal history of androgenetic alopecia were at risk of FPHL. Therefore, early screening may benefit these patients.

背景：男性雄激素性脱发（MAGA）常伴有女性型脱发（FPHL）。然而，与FPHL的MAGA相关的风险因素尚不清楚。目的：调查与MAGA伴FPHL相关的人口统计学和实验室因素。方法：本回顾性病例对照研究于2012年3月至2021年9月在一家三级医疗中心进行。符合条件的患者是皮肤科医生诊断为雄激素性脱发的12岁以上男性。将患者分为有FPHL的MAGA组和无FPHL的MAGA组。比较两组患者的合并症以及人口统计学、实验室和疾病特异性变量。数据分析在2021年10月至2022年2月期间进行。使用独立样本t检验、Mann-Whitney U检验和卡方检验来评估FPHL导致MAGA的因素。结果：469名MAGA患者中，309名（65.9%）患有FPHL，这一比率远高于先前报道。在这些变量中，只有母系（比值比1.605；95%置信区间1.014~2.541）和母系病史（比值比4.705；置信区间1.632~13.559）的雄激素性脱发与MAGA和FPHL显著相关。在伴有FPHL的MAGA组中，体重指数与F型评分呈正相关（r=0.114，p=0.025）。结论：在本病例对照研究中，有雄激素性脱发病史的MAGA患者有发生FPHL的风险。因此，早期筛查可能对这些患者有益。

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引用次数: 0

Effect of a Temperature-Adjustable Cryotherapy Device on Mice with Lysophosphatidic Acid-Induced Pruritus. 温度可调冷冻治疗装置对溶血磷脂酸诱导的小鼠瘙痒的影响。

Annals of dermatology

Pub Date : 2023-10-01 DOI: 10.5021/ad.21.195

Mi Hee Kwack, Chang Hyun Song, Seongjin Lee, Gi Ung Ha, Gun-Ho Kim, Weon Ju Lee

引用次数: 0

Percutaneous Bleomycin Sclerotherapy: A Useful Therapeutic Option for Ganglion Cysts. 经皮博来霉素硬化疗法：治疗神经节囊肿的有效选择。

Annals of dermatology

Pub Date : 2023-10-01 DOI: 10.5021/ad.21.245

Kihyuk Shin, Won-Ku Lee, Sang-Hyeon Won, Hyang-Suk You, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim, Hoon-Soo Kim

引用次数: 0

A Case of Primary Cutaneous Perivascular Epithelioid Cell Tumor. 原发性皮肤血管周类上皮细胞瘤1例。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.20.322

Haneul Oh, Byeong Geun Park, Il-Hwan Kim

A primary cutaneous perivascular epithelioid cell tumor (pcPEComa) is an extremely rare mesenchymal tumor composed of perivascular epithelioid cells, a distinctive neoplastic cell with no known normal counterpart 1 . They usually show both melanocytic and smooth muscle differentiation 2 . A

引用次数: 0

Seborrheic Dermatitis: A Case of an Atypical Side Effect of Atypical Antipsychotics. 脂溢性皮炎：一例非典型抗精神病药物的非典型副作用。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.20.270

Ramy Bishay, Janis Chang, Chih-Peng Chang

引用次数: 0

A Case Report of Rubinstein-Taybi Syndrome Presenting with Extensive Keloid Formation and Review of Literature. Rubinstein-Taybi综合征伴广泛瘢痕疙瘩的病例报告及文献复习。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.20.320

Jee-Woo Kim, Jung Min Ko, Dong Yoon Lee, Jung-Won Shin

Rubinstein-Taybi syndrome (RSTS) is an extremely rare genetic disorder affecting multi-organ systems. A tendency to form keloid is one of the common dermatologic manifestations. We describe a 23-year-old female presented with extensive keloids which developed spontaneously. She had typical facial features, broad thumbs, and dental defects, which were suspicious features of genetic syndrome. Direct sequencing for cyclic-AMP-regulated enhancer binding protein revealed a novel mutation. So far, 23 cases of RSTS have been reported in Korean literature. To the best of our knowledge, this is the first report in Korea to describe confirmed case of RSTS with extensive keloids as a chief manifestation.

鲁宾斯坦-塔比综合征（RSTS）是一种影响多器官系统的极为罕见的遗传性疾病。瘢痕疙瘩的形成是常见的皮肤病表现之一。我们描述了一位23岁的女性，表现为广泛的瘢痕疙瘩，它是自发发展的。她有典型的面部特征、宽拇指和牙齿缺陷，这些都是遗传综合征的可疑特征。环腺苷酸调节增强子结合蛋白的直接测序揭示了一种新的突变。到目前为止，韩国文献中已经报道了23例RSTS病例。据我们所知，这是韩国首次报道以广泛瘢痕疙瘩为主要表现的RSTS确诊病例。

引用次数: 0

Coexistence of Subcutaneous Panniculitis-Like T-Cell Lymphoma and Dermatomyositis in a 12-Year-Old Boy. 一名12岁男孩皮下泛炎样T细胞淋巴瘤和皮肌炎并存。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.20.310

Ruoqu Wei, Haifei Liu, Zhen Zhang, Fuying Chen, Jiawen Chen, Qianyue Xu, Hong Yu, Jianying Liang, Zhirong Yao

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is an extremely rare, indolent skin malignancy that can be difficult to distinguish from autoimmune disease-associated panniculitides. Here, we describe a 12-year-old boy who was diagnosed at age 7 years with dermatomyositis with classical manifestations, including poikiloderma, Gottron's sign, and symmetric muscle weakness. Recently, the boy presented multiple subcutaneous nodules and fever. Histopathological examination and immunohistochemical staining revealed coexistence of SPTL. To our knowledge, this is the first case of dermatomyositis accompanied with SPTL. This case alert clinical physicians of the possibility of SPTL should be considered when a patient with dermatomyositis has new lesions presenting as nodules and unknown fever.

皮下脂膜炎样T细胞淋巴瘤（SPTL）是一种极为罕见的无痛性皮肤恶性肿瘤，很难与自身免疫性疾病相关的脂膜炎区分开来。在这里，我们描述了一名12岁的男孩，他在7岁时被诊断为皮肌炎，具有典型的表现，包括硬皮病、戈特龙征和对称性肌无力。最近，男孩出现多个皮下结节和发烧。组织病理学检查和免疫组织化学染色显示SPTL共存。据我们所知，这是第一例皮肌炎伴SPTL。该病例提醒临床医生，当皮肌炎患者出现新的结节性病变和不明发热时，应考虑SPTL的可能性。

引用次数: 0

Molluscum Contagiosum Mimicking Verruca Vulgaris on the Sole. 在鞋底上模仿普通疣的传染性软体动物。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.21a.064

Seung Hui Seok, Moon Soo Yoon, Jung U Shin

引用次数: 0

New Onset of Alcohol Flushing in an Atopic Dermatitis Patient Treated with Dupilumab. Dupilumab治疗的特应性皮炎患者出现新的酒精性潮红。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.21b.038

Hoon Choi, Dong Hyun Shim, Min Sung Kim, Bong Seok Shin, Chan Ho Na

: Dupilumab is a monoclonal antibody that targets the alpha subunit of the interleukin-4 receptor. It has been used as an effective treatment for moderate to severe atopic dermatitis (AD) patients 1 . The adverse events include conjunctivitis, herpes simplex virus infection, and injection site reaction in varying proportions 1 . A 20-year-old male patient visited our hospital with pruritic erythematous plaques on the entire body from childhood. Based on the clinical findings, AD was diagnosed, and treatment with cyclosporine 100~200 mg was prescribed for more than one year. Because the cyclosporine treatment had not been effective, dupilumab administration was initiated. Subsequently, the patient’s clinical symptoms improved rapidly; however, after several months, he complained of facial flushing within a few minutes of consuming small amounts of alcohol (Fig. 1). He complained that this symptom lasted for less than one hour and had never occurred before treatment with dupilumab. No medications or topical agents were being taken concurrently. We considered the flushing in this patient as a rare adverse event that could occur after treatment with dupilumab, and the patient was educated to avoid alcohol consumption during the post-treatment period. Flushing is a transient erythema that most commonly occurs in the face because of an increase in cutaneous blood flow following vasodilation. One of the causes is the use of vasoactive substances, which include medication, food, and alcohol 2 . Alcohol flushing is caused by an increase in the acetaldehyde level due to deficiency or inactivity of aldehyde dehydrogenase 2 (ALDH2), which plays a major role in alcohol metabolism

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引用次数: 0

Pleomorphic Adenoma Arising from Post-Auricular Heterotopic Salivary Gland Tissue. 耳后异位唾液腺组织引起的多形性腺瘤。

Annals of dermatology

Pub Date : 2023-05-01 DOI: 10.5021/ad.20.273

Yeona Kim, Dae-Lyong Ha, Jin-Hwa Son, Jungsoo Lee, Hoon-Soo Kim, Hyun-Chang Ko, Byungsoo Kim, Moon-Bum Kim, Kihyuk Shin

引用次数: 0

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