Pub Date : 2026-02-24DOI: 10.1158/2159-8290.CD-NW2026-0017
Based on data from the U.S. National Center for Health Statistics, researchers have found that occupation may influence the risk of cancer mortality among working adults, ages 20 to 64. Broadly speaking, men working in construction and extraction-for instance, roofers and mining machine operators-and women working in transportation had the highest mortality rates. Numerous factors beyond carcinogen exposure, such as job stressors leading to tobacco and alcohol use, inconsistent income, and limited health-care access could explain why.
{"title":"Occupation May Influence Risk of Cancer Mortality.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0017","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-NW2026-0017","url":null,"abstract":"<p><p>Based on data from the U.S. National Center for Health Statistics, researchers have found that occupation may influence the risk of cancer mortality among working adults, ages 20 to 64. Broadly speaking, men working in construction and extraction-for instance, roofers and mining machine operators-and women working in transportation had the highest mortality rates. Numerous factors beyond carcinogen exposure, such as job stressors leading to tobacco and alcohol use, inconsistent income, and limited health-care access could explain why.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1158/2159-8290.cd-nw2026-0016
Two recent studies of CAR T cells targeting tumor-associated macrophages have shown that “armoring” these engineered cells with the ability to express the cytokine IL12 makes them more effective at eradicating solid tumors and leads to sustained remodeling of the immunosuppressive tumor microenvironment.
{"title":"“Armoring” CAR T Cells Bolsters Activity against Solid Tumors","authors":"","doi":"10.1158/2159-8290.cd-nw2026-0016","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-nw2026-0016","url":null,"abstract":"Two recent studies of CAR T cells targeting tumor-associated macrophages have shown that “armoring” these engineered cells with the ability to express the cytokine IL12 makes them more effective at eradicating solid tumors and leads to sustained remodeling of the immunosuppressive tumor microenvironment.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"52 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1158/2159-8290.CD-RW2026-024
{"title":"Sympathetic Nerves Regulate Immunosurveillance in the Skin.","authors":"","doi":"10.1158/2159-8290.CD-RW2026-024","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2026-024","url":null,"abstract":"","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-13DOI: 10.1158/2159-8290.cd-nw2026-0015
Artificial intelligence systems are beginning to function as “co-scientists” in cancer research, generating drug candidates, prioritizing immunotherapy targets, and guiding experimental design. Emerging platforms now extend beyond analysis and hypothesis generation to participate directly in laboratory workflows, signaling a shift toward AI-augmented discovery across the oncology pipeline.
{"title":"AI Co-Scientists Move to the Front Lines of Cancer Research","authors":"","doi":"10.1158/2159-8290.cd-nw2026-0015","DOIUrl":"https://doi.org/10.1158/2159-8290.cd-nw2026-0015","url":null,"abstract":"Artificial intelligence systems are beginning to function as “co-scientists” in cancer research, generating drug candidates, prioritizing immunotherapy targets, and guiding experimental design. Emerging platforms now extend beyond analysis and hypothesis generation to participate directly in laboratory workflows, signaling a shift toward AI-augmented discovery across the oncology pipeline.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"32 1","pages":""},"PeriodicalIF":28.2,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-11DOI: 10.1158/2159-8290.CD-NW2026-0012
A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.
{"title":"Neoantigen Vaccine Spurs Broad Immune Responses.","authors":"","doi":"10.1158/2159-8290.CD-NW2026-0012","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-NW2026-0012","url":null,"abstract":"<p><p>A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.</p>","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":" ","pages":"OF1"},"PeriodicalIF":33.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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