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Rheumatoid factor titers, but not Fc fragments, may be strongly associated with drug survival of anti-TNF agents in patients with rheumatoid arthritis. 类风湿因子滴度(而非 Fc 片段)可能与类风湿性关节炎患者服用抗肿瘤坏死因子药物的存活率密切相关。
Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.01643
Huseyin Kaplan, Gizem Cengiz, Isa Cuce, Senem Sas, Emre Senkoy, Mustafa Calis, Orhun Ozturk, Huseyin Demir, Mehmet Kirnap

Objective: To investigate the effects of both the Fc fragment in tumor necrosis factor (TNF) inhibitors and rheumatoid factor (RF) titers on treatment survival, disease activity, and laboratory parameters in patients with rheumatoid arthritis (RA).

Methods: In this retrospective cohort study, patients with RA who had started any anti-TNF therapy between January 2017 and March 2020 and who had stayed on this treatment for at least six months were included. The data of the patients were compared separately according to continuation or discontinuation of treatment and the presence or absence of Fc portion in the structure of anti-TNFs. Patients who were taking certolizumab pegol (CZP) without the Fc fragment were placed in the "without Fc group" (wo/Fc), while patients who were taking other drugs (adalimumab, etanercept, golimumab, and infliximab) were placed in the "with Fc group" (w/Fc).

Results: Among the 221 RA patients whose data were available, 52 patients met the inclusion criteria and were included in the study. There was a significant difference in the DAS28-CRP score between wo/Fc group and w/Fc group in the third month of treatment (p=0.012). However, this difference did not persist at the sixth month of treatment (p=0.384). According to the cox-regression results, RF titers were determined to have a significant impact on the drug survival of anti-TNF agents when adjustments were made for the effects of other candidate predictors (Hazard ratio: 1.007 (1.002-1.012), p=0.009).

Conclusion: Our results suggest that compared to the Fc fragment, RF titers were the more important risk factor in survival of anti-TNF drugs.

目的研究肿瘤坏死因子(TNF)抑制剂中的Fc片段和类风湿因子(RF)滴度对类风湿性关节炎(RA)患者的治疗存活率、疾病活动性和实验室指标的影响:在这项回顾性队列研究中,纳入了在 2017 年 1 月至 2020 年 3 月期间开始接受任何抗肿瘤坏死因子治疗并持续治疗至少 6 个月的 RA 患者。根据患者是否继续或停止治疗,以及抗肿瘤坏死因子结构中是否存在 Fc 部分,分别比较了患者的数据。服用不含Fc片段的certolizumab pegol(CZP)的患者被归入 "不含Fc组"(wo/Fc),而服用其他药物(阿达木单抗、依那西普、戈利木单抗和英夫利昔单抗)的患者被归入 "含Fc组"(w/Fc):在有数据可查的 221 名 RA 患者中,有 52 名患者符合纳入标准并被纳入研究。在治疗的第三个月,wo/Fc 组与 w/Fc 组的 DAS28-CRP 评分有明显差异(p=0.012)。然而,这种差异在治疗的第六个月并没有持续(P=0.384)。根据cox-回归结果,在对其他候选预测因子的影响进行调整后,RF滴度对抗肿瘤坏死因子药物的存活率有显著影响(危险比:1.007 (1.002-1.012),p=0.009):我们的研究结果表明,与 Fc 片段相比,RF 滴度是影响抗肿瘤坏死因子药物存活率的更重要的风险因素。
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引用次数: 0
Evaluation of MMP-9, MMP-13, MMP-21, and TIMP-1 expressions in malign melanom, dysplastic nevi, and banal nevi. 评估恶性黑色素瘤、发育不良痣和普通痣中 MMP-9、MMP-13、MMP-21 和 TIMP-1 的表达。
Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.69009
Meryem Yuvruk, Rabia Burcin Girgin, Ebru Zemheri

Objective: Although the role of MMPs in the pathogenesis of melanoma is known, few studies have investigated their role in the development of nevi and dysplastic nevi. This study aims to search the expression differences of MMP-9, MMP-13, MMP-21, and TIMP-1 between malignant melanoma (MM), intradermal nevi (IDN), and dysplastic nevi (DN).

Methods: MMP-9, MMP-13, MMP-21, and TIMP-1 antibodies were studied immunohistochemically for 60 cases in our pathology clinic archive between 2013 and 2014.

Results: The MM group had the highest expression percentage and intensity for MMP-9 (p<0.001). There was no statistical significance between MMP-13 expression intensities of lesion cells and stromal cells and stromal expression intensities (p>0.05). MMP-21 lesion staining intensities in DN and MM compared to IDN were statistically significant (p=0.001, p=0.011, respectively). For TIMP-1, there was a significant difference between the IDN and the MM group regarding the staining proportion of lesion cells (p<0.01). There was a statistically significant difference in all groups according to lesion cells' expression intensity. (IDN-DN p<0.001, IDN-MM p=0.044, DN-MM p<0.001).

Conclusion: The following markers can be helpful when lesions cannot be differentiated; increased staining proportions and intensity of MMP-9 in both lesion and stromal cells favor MM in cases where MM and IDN cannot be differentiated. The increased MMP-13 staining proportion of lesion cells can favor DN in cases where the pathologist cannot differentiate DN and MM. Intense expression of MMP-21 by lesion cells can be a potential marker for evaluating the lesion in favor of DN in cases where DN and IDN cannot be differentiated. The high expression intensity of TIMP-1 in lesion cells can favor DN in cases where there is ambiguity between DN and MM. High expression proportion and intensity of stromal cells of TIMP-1 can be useable in favor of MM in cases where MM and DN cannot be differentiated.

研究目的虽然MMPs在黑色素瘤发病机制中的作用已众所周知,但很少有研究调查它们在痣和发育不良痣的发病中的作用。本研究旨在探讨 MMP-9、MMP-13、MMP-21 和 TIMP-1 在恶性黑色素瘤(MM)、皮内痣(IDN)和发育不良痣(DN)中的表达差异:方法:对2013年至2014年间本院病理门诊档案中的60例病例的MMP-9、MMP-13、MMP-21和TIMP-1抗体进行免疫组化研究:MM组的MMP-9表达比例和强度最高(P0.05)。与 IDN 相比,DN 和 MM 组的 MMP-21 病变染色强度有统计学意义(分别为 p=0.001 和 p=0.011)。就 TIMP-1 而言,IDN 组和 MM 组病变细胞的染色比例差异显著(p 结论:当病变无法区分时,以下标记物可能会有所帮助;在 MM 和 IDN 无法区分的病例中,病变细胞和基质细胞中 MMP-9 染色比例和强度的增加有利于 MM。在病理学家无法区分DN和MM的病例中,病变细胞中MMP-13染色比例的增加有利于DN。在 DN 和 IDN 无法区分的情况下,病变细胞强烈表达的 MMP-21 可作为评估病变的潜在标志物,有利于 DN。如果病变细胞中 TIMP-1 的表达强度较高,则在 DN 和 MM 难以区分的病例中会更倾向于 DN。在无法区分 MM 和 DN 的病例中,TIMP-1 在基质细胞中的高表达比例和高表达强度可能有利于 MM。
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引用次数: 0
Bioinformatics approach for searching for natural products in vector-borne disease management. 在病媒传播疾病管理中搜索天然产品的生物信息学方法。
Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.87523
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

Vector-borne disease is an important public health problem. This disease is common in tropical areas and affects millions of people. The control and management of disease is an important consideration. Effective treatment is important in management of patients infected with vector-borne disease. A common problem in therapeutic management of the patient is the lack of an effective drug. Therefore, it is necessary to find a new effective drug for managing vector-borne disease. To search for a new drug, new technologies are applicable. Bioinformatics technologies are useful in new drug search. Application of the bioinformatics technologies in new anti-vector-borne disease drug search is interesting. In this review, the author briefly discusses the use of bioinformatics technology in searching for natural products in vector-borne disease management. Concepts and examples of some important diseases are presented.

病媒传染病是一个重要的公共卫生问题。这种疾病在热带地区很常见,影响着数百万人。疾病的控制和管理是一个重要的考虑因素。有效的治疗对病媒传染病患者的管理非常重要。病人治疗管理中的一个常见问题是缺乏有效的药物。因此,有必要寻找一种新的有效药物来控制病媒传播疾病。要寻找新药,就必须采用新技术。生物信息学技术在寻找新药方面非常有用。生物信息学技术在抗病媒传染病新药搜索中的应用很有意义。在这篇综述中,作者简要讨论了生物信息学技术在病媒传播疾病管理中天然产品搜索中的应用。文中介绍了一些重要疾病的概念和实例。
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引用次数: 0
Factors associated with acute kidney injury in patients undergoing transcatheter aortic valve implantation: Short-term outcomes and impact of right heart failure. 经导管主动脉瓣植入术患者急性肾损伤的相关因素:短期疗效和右心衰竭的影响。
Pub Date : 2024-04-24 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.87864
Dilek Aslan Kutsal, Sait Terzi

Objective: Transcatheter aortic valve implantation (TAVI) was developed as an alternative to surgery for symptomatic, high-risk patients with severe aortic stenosis (AS). Acute kidney injury, a major complication of TAVI, is associated with a poor prognosis. In our study, we planned to investigate the effect of right heart failure on the development of acute kidney injury after TAVI and other factors contributing to the development of AKI.

Methods: Between January 2015 and December 2020, 198 patients who underwent TAVI due to severe symptomatic aortic stenosis at Dr. Siyami Ersek Cardiovascular Surgery Hospital were screened. Local ethics committee approval was obtained (HNEAH-KAEK 2021/134-3343). Transthoracic echocardiographic findings and laboratory evaluations were recorded. Patients were evaluated according to Acute Kidney Injury Network (AKIN) criteria.

Results: The rate of AKI after TAVI was found to be 41.9%. The mean age of patients who developed AKI was higher (80.90±6.8). AKI development rates were higher in the female gender (68.7%) and patients with hypertension (44.8%). It was observed that the risk of developing AKI was higher in patients who underwent TAVI and developed AKI afterwards, especially in patients with stage-3 and stage-4 advanced CKD before TAVI (p<0.01) We did not find an independent relationship between AKI and right-heart failure in our analysis.

Conclusion: We observed that chronic kidney disease before TAVI, advanced age, and female gender are important determinants of the development of AKI after TAVI. Although a relationship between TAVI and right heart failure has not been demonstrated, large-scale studies are needed in the future.

目的:经导管主动脉瓣植入术(TAVI)是为无症状、高风险的重度主动脉瓣狭窄(AS)患者提供的一种手术替代方案。急性肾损伤是 TAVI 的主要并发症,与不良预后有关。在我们的研究中,我们计划调查右心衰对TAVI术后急性肾损伤发生的影响,以及导致AKI发生的其他因素:方法:2015 年 1 月至 2020 年 12 月期间,在 Siyami Ersek 医生心血管外科医院筛查了 198 名因严重症状性主动脉瓣狭窄而接受 TAVI 的患者。该研究获得了当地伦理委员会的批准(HNEAH-KAEK 2021/134-3343)。记录了经胸超声心动图检查结果和实验室评估结果。根据急性肾损伤网络(AKIN)标准对患者进行评估:结果:TAVI术后AKI发生率为41.9%。发生 AKI 的患者平均年龄较高(80.90±6.8)。女性(68.7%)和高血压患者(44.8%)的 AKI 发生率较高。据观察,在接受 TAVI 后发生 AKI 的患者中,尤其是在 TAVI 前患有 CKD 3 期和 4 期晚期的患者中,发生 AKI 的风险更高(p 结论:我们观察到,TAVI 前的慢性肾病、高龄和女性性别是 TAVI 后发生 AKI 的重要决定因素。虽然 TAVI 与右心衰竭之间的关系尚未得到证实,但未来仍需进行大规模研究。
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引用次数: 0
A potential biomarker of disease activity in systemic lupus erythematosus, systemic immune-inflammation index. 系统性红斑狼疮疾病活动的潜在生物标志物--系统性免疫炎症指数。
Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.90132
Muhammed Recai Akdogan, Meltem Alkan Melikoglu

Objective: Biomarkers using routine laboratory tests accurately presenting systemic lupus erythematosus (SLE) disease activity may have important practical values in clinical settings. The primary purpose of this study was to investigate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII; neutrophil X platelet/lymphocyte) as potential biomarkers of disease activity in cases with SLE.

Methods: In this case-control observational study, cases with SLE and demographically similar healthy controls were included. For clinical evaluation demographic features, disease duration and drugs were recorded. SLE clinical disease activity was assessed with SLEDAI scores. For laboratory assessments; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and C3-C4 levels and anti-dsDNA positivity were recorded. Based on the simultaneous complete blood count (CBC) of the participants NLR, PLR and SII were calculated. The correlation between clinical and laboratory data was analyzed.

Results: 68 cases with SLE (64 women, 8 men) and 69 controls (65 women, 4 men) were included in this investigation. The demographic features of the cases and controls were similar. ESR, CRP, NLR, PLR and SII scores were statistically higher in cases with SLE than controls (p<0.000). Statistically significant positive correlations between SLEDAI and NLR, PLR and SII scores were demonstrated (p=0.01, r=0.505; 0.414; 0.698, respectively). We determined a cut-off value of SII as 681,3 presenting 77% sensitivity and 76% specificity to discriminate no-mild disease activity and moderate-higher SLE disease activity status. The SII cut-off value was determined as 681,3 presenting 77% sensitivity and 76% specificity (p<0.000, and AUC=0.930).

Conclusion: CBC indices were shown to be higher in cases with SLE than healthy controls in our study. By presenting a strong correlation with disease activity and discriminating ability of disease status, SII might serve as a biomarker supporting clinical evaluation in SLE.

目的:利用常规实验室检查准确显示系统性红斑狼疮(SLE)疾病活动的生物标志物在临床上可能具有重要的实用价值。本研究的主要目的是调查中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和全身免疫炎症指数(SII;中性粒细胞 X 血小板/淋巴细胞)作为系统性红斑狼疮病例疾病活动性潜在生物标志物的情况:在这项病例对照观察研究中,纳入了系统性红斑狼疮病例和人口统计学特征相似的健康对照组。临床评估记录了人口统计学特征、病程和用药情况。系统性红斑狼疮的临床疾病活动性以 SLEDAI 评分进行评估。在实验室评估方面,记录了红细胞沉降率(ESR)、C反应蛋白(CRP)和C3-C4水平以及抗dsDNA阳性率。根据参与者的同期全血细胞计数(CBC),计算出 NLR、PLR 和 SII。分析了临床和实验室数据之间的相关性:本次调查共纳入 68 名系统性红斑狼疮患者(64 名女性,8 名男性)和 69 名对照组患者(65 名女性,4 名男性)。病例和对照组的人口统计学特征相似。从统计学角度看,系统性红斑狼疮患者的血沉、CRP、NLR、PLR 和 SII 评分均高于对照组(p 结论:系统性红斑狼疮患者的血沉、CRP、NLR、PLR 和 SII 评分均高于对照组:在我们的研究中,系统性红斑狼疮患者的 CBC 指数高于健康对照组。SII 与疾病活动性密切相关,对疾病状态有很强的鉴别能力,可作为支持系统性红斑狼疮临床评估的生物标志物。
{"title":"A potential biomarker of disease activity in systemic lupus erythematosus, systemic immune-inflammation index.","authors":"Muhammed Recai Akdogan, Meltem Alkan Melikoglu","doi":"10.14744/nci.2023.90132","DOIUrl":"https://doi.org/10.14744/nci.2023.90132","url":null,"abstract":"<p><strong>Objective: </strong>Biomarkers using routine laboratory tests accurately presenting systemic lupus erythematosus (SLE) disease activity may have important practical values in clinical settings. The primary purpose of this study was to investigate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII; neutrophil X platelet/lymphocyte) as potential biomarkers of disease activity in cases with SLE.</p><p><strong>Methods: </strong>In this case-control observational study, cases with SLE and demographically similar healthy controls were included. For clinical evaluation demographic features, disease duration and drugs were recorded. SLE clinical disease activity was assessed with SLEDAI scores. For laboratory assessments; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and C3-C4 levels and anti-dsDNA positivity were recorded. Based on the simultaneous complete blood count (CBC) of the participants NLR, PLR and SII were calculated. The correlation between clinical and laboratory data was analyzed.</p><p><strong>Results: </strong>68 cases with SLE (64 women, 8 men) and 69 controls (65 women, 4 men) were included in this investigation. The demographic features of the cases and controls were similar. ESR, CRP, NLR, PLR and SII scores were statistically higher in cases with SLE than controls (p<0.000). Statistically significant positive correlations between SLEDAI and NLR, PLR and SII scores were demonstrated (p=0.01, r=0.505; 0.414; 0.698, respectively). We determined a cut-off value of SII as 681,3 presenting 77% sensitivity and 76% specificity to discriminate no-mild disease activity and moderate-higher SLE disease activity status. The SII cut-off value was determined as 681,3 presenting 77% sensitivity and 76% specificity (p<0.000, and AUC=0.930).</p><p><strong>Conclusion: </strong>CBC indices were shown to be higher in cases with SLE than healthy controls in our study. By presenting a strong correlation with disease activity and discriminating ability of disease status, SII might serve as a biomarker supporting clinical evaluation in SLE.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 2","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of post-acute-COVID-19, and long-COVID symptoms with a questionnaire: Within one year, a longitudinal study. 用问卷评估急性-COVID-19 后症状和长期-COVID 症状:一年内纵向研究。
Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.58908
Canan Emiroglu, Murat Dicle, Serap Demirelli Ozagar, Suleyman Gorpelioglu, Cenk Aypak

Objective: Long-term consequences of COVID-19 vary widely, representing a growing global health challenge. The aim of this report was to define the presence of symptoms in post-acute-COVID-19 syndrome (PCS) patients and to assess the frequency, associated factors, and the spectrum of persistent symptoms.

Methods: In this longitudinal study, 487 adults with a previously diagnosed "Severe Acute Respiratory Syndrome Coronavirus 2" (SARS-CoV-2) who admitted to COVID-19 follow-up outpatient clinic between December 1, 2020 and November 31, 2021 were interviewed face-to-face three times. Data was collected on patient demographics, comorbidities, and symptoms. A questionnaire of 160 questions was asked and organized into the following: identification and consent, socio-demographic/epidemiological characteristics, previous medical history, diagnosis and clinical presentation of acute COVID-19, as well as systematic symptoms. Data were evaluated using univariate comparisons and multiple logistic regression.

Results: The most prevalent symptoms among all PCS patients during their initial visit were dyspnea, weakness, forgetfulness, fatigue, and arthralgia respectively. The most common symptoms in patients with 6 months or more time from discharge to follow-up at the first and second visits, appear to be persistent. While incidence rates decreased by the third visit, the five most common symptoms remained the same. The possibility of weakness and arthralgia was found to be higher in non-hospitalized patients. Females were associated with the most common persistent symptoms and the strongest association was with arthralgia.

Conclusion: A large number of COVID-19 survivors had continuing symptoms at the first year of post-COVID-19-infection. Neither the presence of comorbidities of the patient nor smoking status were associated with the severity of PCS symptoms. A better understanding of the mechanisms, predisposing factors and evaluation require a multidisciplinary team approach.

目的:COVID-19 的长期后果差异很大,是一项日益严峻的全球健康挑战。本报告的目的是确定 COVID-19 后综合征(PCS)患者的症状,并评估持续症状的频率、相关因素和范围:在这项纵向研究中,487 名曾被诊断为 "严重急性呼吸系统综合征冠状病毒 2"(SARS-CoV-2)的成人在 2020 年 12 月 1 日至 2021 年 11 月 31 日期间到 COVID-19 后续门诊就诊,并接受了三次面对面访谈。收集的数据包括患者的人口统计学特征、合并症和症状。调查问卷共 160 个问题,内容包括:身份识别和同意、社会人口学/流行病学特征、既往病史、急性 COVID-19 的诊断和临床表现以及系统症状。采用单变量比较和多元逻辑回归对数据进行了评估:所有 PCS 患者初诊时最常见的症状分别是呼吸困难、乏力、健忘、疲劳和关节痛。第一次和第二次就诊时,从出院到随访有 6 个月或更长时间的患者最常见的症状似乎是持续性的。虽然第三次就诊时的发病率有所下降,但最常见的五种症状保持不变。在非住院患者中,出现乏力和关节痛的可能性较高。女性与最常见的持续性症状有关,而与关节痛的关系最为密切:结论:许多 COVID-19 幸存者在感染 COVID-19 后的第一年仍有持续症状。患者的合并症和吸烟状况都与 PCS 症状的严重程度无关。要更好地了解 PCS 的发病机制、诱发因素和评估方法,需要多学科团队合作。
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引用次数: 0
Should we rely on frozen section during the reimplantation stage of revision knee arthroplasty? 在翻修膝关节置换术的再植阶段,我们是否应该依靠冷冻切片?
Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.90699
Aydan Kilicarslan, Kaan Yuksel, Nuran Sungu

Objective: To compare Frozen Section (FS) results during the reimplantation stage of revision knee arthroplasty, in patients without clinical signs of infection but with preoperative inconclusive serum inflammatory markers.

Methods: Sections were revisited the day after surgery. Intraoperative FS (iFS) was accepted as positive when the presence of >5 polymorphonuclear neutrophils (PMNLs) in 5 separate high-power fields was determined according to the consensus criteria of the International Consensus on Musculoskeletal Infection. The clinical outcomes, cultures and diagnostic values of iFS and review FS (rFS) were analyzed.

Results: No complications developed after reimplantation in 66 (84.6%) of the 78 evaluated patients. Complications developed in 12 patients, six of whom were treated with re-explantation, four with arthrodesis and two with above-the-knee amputation. Both iFS and rFS yielded insignificant sensitivity and specificity (25% and 45.5%, 25% and 45%, respectively). There was no statistically significant difference between definitive culture and iFS and rFS.

Conclusion: iFS evaluation is insufficient to exclude recovery from periprosthetic joint infection (PJI). Diagnosis of recurrence of infection in patients with indefinite serum inflammatory markers between the explantation and reimplantation interval remains challenging due to massive fibrosis that makes proper tissue sampling difficult. The attending physician should closely monitor clinical findings.

目的比较无临床感染迹象但术前血清炎症指标不确定的患者在翻修膝关节置换术再植入阶段的冰冻切片(FS)结果:方法:术后第二天重新检查切片。根据国际肌肉骨骼感染共识标准,术中FS(iFS)在5个独立的高倍视野中出现>5个多形核中性粒细胞(PMNL)即为阳性。对iFS和复查FS(rFS)的临床结果、培养和诊断价值进行了分析:结果:在78名接受评估的患者中,有66人(84.6%)在再植后未出现并发症。12名患者出现了并发症,其中6人接受了再植术,4人接受了关节置换术,2人接受了膝上截肢术。iFS和rFS的敏感性和特异性(分别为25%和45.5%,25%和45%)均不显著。结论:iFS评估不足以排除假体周围关节感染(PJI)复发的可能性。由于大量纤维化导致难以进行适当的组织取样,因此对于血清炎症标志物间隔时间不确定的患者,诊断感染复发仍具有挑战性。主治医生应密切关注临床结果。
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引用次数: 0
Comparison of two different respiratory monitoring systems with 4D-CT images for target volume definition in patients undergoing para-aortic nodal irradiation. 两种不同的呼吸监测系统与 4D-CT 图像在主动脉旁结节照射患者靶体积定义方面的比较。
Pub Date : 2024-04-17 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.06856
Sefika Arzu Ergen, Songul Karacam, Tuba Kurt Catal, Fazilet Oner Dincbas, Didem Colpan Oksuz, Ismet Sahinler

Objective: Today, respiratory movement can be monitored and recorded with different methods during a simulation on a four-dimensional (4D) computed tomography (CT) device to be used in radiotherapy planning. A synchronized respiratory monitoring system (RPM) with an externally equipped device is one of these methods. Another method is to create 4D images of the patient's breathing phases without the need for extra equipment, with an anatomy-based software program integrated into the CT device. Our aim is to compare the RPM system and the software system (Deviceless) which are two different respiratory monitoring methods used in tracking moving targets during 4D-CT imaging and to assess their clinical usability.

Methods: Ten patients who underwent paraaortic nodal irradiation were enrolled. The simulation was performed using intravenous contrast material on a 4D-CT device with both respiratory monitoring methods. The right/left kidneys and renal arteries were chosen as references to evaluate abdominal organ movement. It was then manually contoured one by one on both sets of images. The images were compared volumetrically and geometrically after rigid reconstruction. The similarity between the contours was determined by the Dice index. Wilcoxon test was used for statistical comparisons.

Results: The motion of the kidneys in all three directions was found to be 0.0 cm in both methods. The shifts in the right/left renal arteries were submillimetric. The Dice index showed a high similarity in both kidney and renal artery contours.

Conclusion: In our study, no difference was found between RPM and Deviceless systems used for tracking and detection of moving targets during simulation in 4D-CT. Both methods can be used safely for radiotherapy planning according to the available possibilities in the clinic.

目的:如今,在用于放射治疗计划的四维计算机断层扫描(CT)设备上进行模拟时,可以采用不同的方法监测和记录呼吸运动。带有外部设备的同步呼吸监测系统(RPM)就是其中一种方法。另一种方法是无需额外设备,通过集成到 CT 设备中的基于解剖学的软件程序来创建患者呼吸阶段的 4D 图像。我们的目的是比较 RPM 系统和软件系统(Deviceless)这两种在 4D-CT 成像过程中用于追踪移动目标的不同呼吸监测方法,并评估其临床实用性:方法:选取 10 名接受主动脉旁结节照射的患者。使用静脉注射造影剂在 4D-CT 设备上进行模拟,同时使用两种呼吸监测方法。选择右/左肾和肾动脉作为评估腹部器官运动的参考。然后在两组图像上逐一进行人工轮廓分析。刚性重建后,对图像进行体积和几何比较。轮廓之间的相似度由 Dice 指数决定。统计比较采用 Wilcoxon 检验:结果:在两种方法中,肾脏在三个方向上的移动均为 0.0 厘米。右/左肾动脉的移动都是亚毫米级的。Dice 指数显示肾脏和肾动脉轮廓高度相似:在我们的研究中,发现 RPM 和无 Deviceless 系统在 4D-CT 模拟过程中跟踪和检测移动目标时没有区别。根据临床可用的可能性,这两种方法都可以安全地用于放射治疗规划。
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引用次数: 0
Evaluation of patients diagnosed with brain death in the intensive care unit: 10 years of tertiary center experience in Istanbul. 对重症监护室中被诊断为脑死亡的患者进行评估:伊斯坦布尔三级医疗中心的 10 年经验。
Pub Date : 2024-04-17 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.06937
Kadir Arslan, Ayca Sultan Sahin

Objective: Early and accurate diagnosis of brain death in intensive care units (ICU) is essential for organ transplantation. This study aimed to evaluate the cases diagnosed with brain death in the ICU of a tertiary center in Istanbul.

Methods: The cases diagnosed as brain death in the ICU during the ten years between January 2013 and September 2022 were evaluated retrospectively. The demographic characteristics of the patients, the diagnosis of hospitalization in the ICU, the time from arrival to the ICU until the diagnosis of brain death, the somatic survival time after the diagnosis of brain death, the acceptance rate of organ donation by the families and the organs removed were evaluated.

Results: A total of 44 patients were diagnosed with brain death. The mean age of the cases was 39.7±17.4 years, and 63% were male. The most common hospitalization diagnosis was intracranial hemorrhage (81.8%). Traffic accidents, hypertensive and aneurysm-related hemorrhages, gunshot wounds, and falls from height were the most common causes of intracranial hemorrhage. Patients were admitted to the ICU most frequently from the emergency department (54%). The mean time to brain death was 7.9±6.2 days, and the somatic survival time was 1.9±1.9 days in patients who did not receive organ transplantation. While the apnea test was positive in 91% of the cases, the apnea test could not be completed in 9% of the cases. While relatives of 7% (n=3) of the cases accepted organ donation, a patient was not allowed to be an organ donor for medical reasons. Organ transplantation was performed in two patients (5%).

Conclusion: As in the whole world, getting treatment as soon as possible for the patients waiting on the organ transplant list in Turkiye by increasing the number of organs to be obtained from cadavers. In cases with suspected brain death in the ICU, diagnosing brain death as soon as possible and conducting family interviews with trained organ transplant coordinators will increase the number of cadaver donors. However, we think policies should be developed to ensure that society is informed and encouraged about brain death and organ donation.

目的:在重症监护病房(ICU)及早准确诊断脑死亡对器官移植至关重要。本研究旨在评估伊斯坦布尔一家三级医疗中心重症监护室中被诊断为脑死亡的病例:方法:对 2013 年 1 月至 2022 年 9 月这十年间在 ICU 诊断为脑死亡的病例进行了回顾性评估。方法:对 2013 年 1 月至 2022 年 9 月这十年间在重症监护室诊断为脑死亡的病例进行回顾性评估,评估内容包括患者的人口统计学特征、在重症监护室的住院诊断、从到达重症监护室到诊断为脑死亡的时间、诊断为脑死亡后的体外存活时间、家属接受器官捐献的比率以及摘除的器官:共有 44 名患者被诊断为脑死亡。平均年龄为(39.7±17.4)岁,男性占 63%。最常见的住院诊断是颅内出血(81.8%)。交通事故、高血压和动脉瘤相关出血、枪伤和高处坠落是最常见的颅内出血原因。患者最常从急诊科进入重症监护室(54%)。平均脑死亡时间为(7.9±6.2)天,未接受器官移植的患者的体外存活时间为(1.9±1.9)天。91%的病例呼吸暂停测试呈阳性,但有9%的病例无法完成呼吸暂停测试。虽然有 7% 的病例(3 人)的亲属接受了器官捐献,但有一名患者因医疗原因不能成为器官捐献者。两名患者(5%)进行了器官移植:与全世界一样,在土耳其,通过增加从遗体中获取器官的数量,使器官移植名单上的患者尽快得到治疗。对于重症监护室中的疑似脑死亡病例,尽快诊断脑死亡并与经过培训的器官移植协调员进行家属面谈将增加遗体捐献者的数量。然而,我们认为应制定政策,确保社会了解并鼓励脑死亡和器官捐献。
{"title":"Evaluation of patients diagnosed with brain death in the intensive care unit: 10 years of tertiary center experience in Istanbul.","authors":"Kadir Arslan, Ayca Sultan Sahin","doi":"10.14744/nci.2023.06937","DOIUrl":"https://doi.org/10.14744/nci.2023.06937","url":null,"abstract":"<p><strong>Objective: </strong>Early and accurate diagnosis of brain death in intensive care units (ICU) is essential for organ transplantation. This study aimed to evaluate the cases diagnosed with brain death in the ICU of a tertiary center in Istanbul.</p><p><strong>Methods: </strong>The cases diagnosed as brain death in the ICU during the ten years between January 2013 and September 2022 were evaluated retrospectively. The demographic characteristics of the patients, the diagnosis of hospitalization in the ICU, the time from arrival to the ICU until the diagnosis of brain death, the somatic survival time after the diagnosis of brain death, the acceptance rate of organ donation by the families and the organs removed were evaluated.</p><p><strong>Results: </strong>A total of 44 patients were diagnosed with brain death. The mean age of the cases was 39.7±17.4 years, and 63% were male. The most common hospitalization diagnosis was intracranial hemorrhage (81.8%). Traffic accidents, hypertensive and aneurysm-related hemorrhages, gunshot wounds, and falls from height were the most common causes of intracranial hemorrhage. Patients were admitted to the ICU most frequently from the emergency department (54%). The mean time to brain death was 7.9±6.2 days, and the somatic survival time was 1.9±1.9 days in patients who did not receive organ transplantation. While the apnea test was positive in 91% of the cases, the apnea test could not be completed in 9% of the cases. While relatives of 7% (n=3) of the cases accepted organ donation, a patient was not allowed to be an organ donor for medical reasons. Organ transplantation was performed in two patients (5%).</p><p><strong>Conclusion: </strong>As in the whole world, getting treatment as soon as possible for the patients waiting on the organ transplant list in Turkiye by increasing the number of organs to be obtained from cadavers. In cases with suspected brain death in the ICU, diagnosing brain death as soon as possible and conducting family interviews with trained organ transplant coordinators will increase the number of cadaver donors. However, we think policies should be developed to ensure that society is informed and encouraged about brain death and organ donation.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 2","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of cranial magnetic resonance imaging findings in pediatric epilepsy: A single-center experience. 头颅磁共振成像结果在小儿癫痫中的作用:单中心经验。
Pub Date : 2024-02-01 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.39581
Ozge Yapici, Tugce Aksu Uzunhan

Objective: The aim of this study was to investigate cranial magnetic resonance imaging (MRI) findings in different age groups and genders in pediatric epilepsy, to determine the percentages of etiologic factors, and to evaluate the association between MRI positivity and treatment resistance.

Methods: Cranial MRIs of 359 patients with epilepsy aged 1 month to 18 years were retrospectively evaluated. Etiologic factors as an underlying cause of epilepsy were classified as previous parenchymal damage, hippocampal sclerosis, malformations of cortical development, tumor, neurocutaneous syndrome, myelination disorder, vascular anomaly, metabolic/genetic/neurodegenerative diseases, encephalitis, and an uncategorized "other" group. Data were transferred to IBM SPSS Statistics 25.0 (SPSS Inc., Chicago, IL, USA), and descriptive statistics, correlation analyses, chi-square, and t-tests were performed.

Results: Among the patients included in the study, 141 (39.3%) had pathological findings on MRI related to the etiology. Previous parenchymal damage (39.7%) was the most common etiologic cause in all age groups. Regarding the relationship between drug resistance and MRI positivity, MRI positivity was observed in 72% of drug-resistant cases, while a complete response to therapy was found in 67.6% of MRI-negative cases.

Conclusion: MRI guides clinicians to determine the presence of an etiologic factor as the underlying cause of childhood epilepsy before treatment planning. MRI positivity is a remarkable indicator of response to antiseizure drug treatment and drug resistance.

研究目的本研究旨在调查不同年龄组和性别的小儿癫痫患者的头颅磁共振成像(MRI)结果,确定致病因素的百分比,并评估 MRI 阳性与治疗耐药性之间的关联:方法:对359名1个月至18岁的癫痫患者的头颅磁共振成像进行回顾性评估。作为癫痫潜在病因的病因分为既往实质损害、海马硬化、皮质发育畸形、肿瘤、神经皮肤综合征、髓鞘化障碍、血管异常、代谢/遗传/神经退行性疾病、脑炎和未分类的 "其他 "组。数据被转入 IBM SPSS Statistics 25.0(SPSS 公司,芝加哥,伊利诺斯州,美国),并进行了描述性统计、相关性分析、卡方检验和 t 检验:在纳入研究的患者中,141 人(39.3%)在磁共振成像上发现了与病因相关的病理结果。在所有年龄组中,先前的实质损伤(39.7%)是最常见的病因。关于耐药性与磁共振成像阳性之间的关系,72%的耐药病例观察到磁共振成像阳性,而67.6%的磁共振成像阴性病例对治疗有完全反应:结论:磁共振成像可指导临床医生在制定治疗计划前确定儿童癫痫的潜在病因。磁共振成像阳性是抗癫痫药物治疗反应和耐药性的一个重要指标。
{"title":"The role of cranial magnetic resonance imaging findings in pediatric epilepsy: A single-center experience.","authors":"Ozge Yapici, Tugce Aksu Uzunhan","doi":"10.14744/nci.2023.39581","DOIUrl":"10.14744/nci.2023.39581","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate cranial magnetic resonance imaging (MRI) findings in different age groups and genders in pediatric epilepsy, to determine the percentages of etiologic factors, and to evaluate the association between MRI positivity and treatment resistance.</p><p><strong>Methods: </strong>Cranial MRIs of 359 patients with epilepsy aged 1 month to 18 years were retrospectively evaluated. Etiologic factors as an underlying cause of epilepsy were classified as previous parenchymal damage, hippocampal sclerosis, malformations of cortical development, tumor, neurocutaneous syndrome, myelination disorder, vascular anomaly, metabolic/genetic/neurodegenerative diseases, encephalitis, and an uncategorized \"other\" group. Data were transferred to IBM SPSS Statistics 25.0 (SPSS Inc., Chicago, IL, USA), and descriptive statistics, correlation analyses, chi-square, and t-tests were performed.</p><p><strong>Results: </strong>Among the patients included in the study, 141 (39.3%) had pathological findings on MRI related to the etiology. Previous parenchymal damage (39.7%) was the most common etiologic cause in all age groups. Regarding the relationship between drug resistance and MRI positivity, MRI positivity was observed in 72% of drug-resistant cases, while a complete response to therapy was found in 67.6% of MRI-negative cases.</p><p><strong>Conclusion: </strong>MRI guides clinicians to determine the presence of an etiologic factor as the underlying cause of childhood epilepsy before treatment planning. MRI positivity is a remarkable indicator of response to antiseizure drug treatment and drug resistance.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 1","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10861434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Northern clinics of Istanbul
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