Revista clinica espanola最新文献

英文中文

Impact of heart failure on in-hospital mortality during admissions for other conditions 心力衰竭对其他疾病住院期间住院死亡率的影响。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502387

J.M. García Vallejo , C. Martel Vera , S. González Sosa , A. Santana García , S. Blanco Tajes , M.N. Sánchez Vadillo , A. Conde Martel

Background and objective

Acute heart failure (AHF) is a frequent cause of hospitalization and has been extensively studied. However, its characteristics when it appears secondarily during admission for other pathologies are less well defined. The aim of this study was to analyze the clinical characteristics, prognostic factors and evolution of AHF in patients hospitalized for other causes, diagnosed by interconsultation to Internal Medicine (IM).

Materials and methods

Observational study that included patients diagnosed with AHF after consultation with IM (2020–2022). Demographic and clinical characteristics, admission reasons, type of heart disease, triggering factors, in-hospital mortality and associated factors were collected.

Results

Of 1583 consultations, 347 patients (21.9%) were diagnosed with AHF. The mean age was 79.9 (±10.3 years) and 184 (53%) were female. 76% came from surgical services. The most frequent comorbidities were hypertension, dyslipidemia and atrial fibrillation. Most patients had hypertensive etiology and preserved ejection fraction (68.6%). The main triggers were infections, anemia and fluid overload. In 50% of the cases, AHF was the debut of HF. In-hospital mortality was 20.5%, 26.4% at one-year follow up, and 39.7% were readmitted. In-hospital mortality was associated with older age (p = 0.031), elevated NT-proBNP (p = 0.048) and lower hemoglobin (p = 0.004) and albumin (p = 0.006) levels.

Conclusions

Patients who develop AHF during admission for other pathologies present advanced age, multiple comorbidities and high mortality. Early detection of triggering factors and identification of prognostic factors could help to optimize their management and improve their outcome.

背景与目的：急性心力衰竭（Acute heart failure， AHF）是一种常见的住院原因，已被广泛研究。然而，当它在其他病理入院时次要出现时，其特征就不那么明确了。本研究的目的是分析AHF的临床特点，预后因素和演变的其他原因住院的患者，诊断内科（IM）会诊。材料和方法：观察性研究，纳入与IM会诊后诊断为AHF的患者（2020-2022）。收集患者的人口学和临床特征、入院原因、心脏病类型、诱发因素、住院死亡率及相关因素。结果：在1583例咨询中，347例（21.9%）患者被诊断为AHF。平均年龄79.9（±10.3岁），女性184例（53%）。76%来自外科服务。最常见的合并症是高血压、血脂异常和心房颤动。大多数患者有高血压病因，并保留了射血分数（68.6%）。主要的诱因是感染、贫血和体液过量。在50%的病例中，AHF是HF的首次发病。住院死亡率为20.5%，1年随访时为26.4%，再入院率为39.7%。住院死亡率与年龄较大（p = 0.031）、NT-proBNP升高（p = 0.048）、血红蛋白（p = 0.004）和白蛋白（p = 0.006）水平降低有关。结论：住院期间因其他病理发生AHF的患者表现为高龄、多重合并症和高死亡率。早期发现诱发因素和确定预后因素有助于优化其管理和改善其预后。

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引用次数: 0

Survey to evaluate the usefulness of a clinical ethics committee service and analyze the most frequent ethical conflicts in clinical ethics consulting at the Ramón y Cajal University Hospital 调查评估临床伦理委员会服务的有效性，并分析Ramón y Cajal大学医院临床伦理咨询中最常见的伦理冲突。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502390

C. de la Pinta , A. Domínguez , V.M. Gallego Gasqué , M.E. Castillo , P. Fernández Martín , A. Helguera , P. Gómez Blasco , G. de los Santos

Introduction

The Ethics committee (EC) are an essential part of the health institutions, however, in many occasions their response capacity is slow, being organs perceived as distant from the clinical practice. This means that they receive limited consultations, leaving many decisions to the sole discretion of the physician in charge.

Material and methods

A prospective study was designed based on anonymous surveys for professionals, family members and patients attended at the Hospital Ramón y Cajal. The analysis included a description of demographic variables, information on knowledge of the EC and on ethical-health care conflicts.

Results

Between December 2023 and March 2024, 394 responses were received. A total of 108 patients and family members (52% patients, 48% family members) were included, of whom 46 were men and 62 were women with a median age of 64 (range 20–90). 84% considered the decision support provided by a CEAS team to be useful. 85% believed that this would improve the quality of their care. The professionals included 83 men, 202 women and 1 other (aged 23–54). The most represented groups were doctors (55%). 53% were not familiar with the CEAS. 9% had requested help from the CEAS and 19% had attended training. 48% were aware of clinical ethics consulting. 37% acknowledged facing ethical problems, resolving them by consulting a colleague (68%). 84% saw the usefulness of consulting with other professionals.

Conclusions

This work reflects knowledge about CEAS, the needs of patients, family members and professionals, and the most common ethical conflicts in our environment.

伦理委员会（EC）是卫生机构的重要组成部分，然而，在许多情况下，他们的反应能力是缓慢的，被认为是远离临床实践的器官。这意味着他们接受的咨询有限，许多决定都由负责的医生自行决定。材料和方法：对在Ramón y Cajal医院就诊的专业人员、家属和患者进行匿名调查，设计了一项前瞻性研究。分析包括对人口变量的描述、关于欧共体知识的信息以及关于伦理-保健冲突的信息。结果：在2023年12月至2024年3月期间，收到了394份回复。共纳入108例患者及家属（52%患者，48%家属），其中男性46例，女性62例，中位年龄64岁（范围20-90岁）。84%的人认为CEAS团队提供的决策支持是有用的。85%的人认为这将提高他们的护理质量。专业人员包括83名男性，202名女性和1名其他（23-54岁）。最具代表性的群体是医生（55%）。53%不熟悉CEAS。9%的人曾向行政咨询中心寻求帮助，19%的人曾参加培训。48%的受访者了解临床伦理咨询。37%的人承认面临道德问题，并通过咨询同事来解决问题（68%）。84%的人认为与其他专业人士进行咨询很有用。结论：这项工作反映了对CEAS的了解，患者、家庭成员和专业人员的需求，以及我们环境中最常见的伦理冲突。

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引用次数: 0

Exploring the diversity of 1p36 microdeletion syndrome in patients diagnosed in adulthood 探讨1p36微缺失综合征在成年患者中的多样性。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502397

Á. García Tellado , M. García Castro , A. Sariego Jamardo , N. Puente Ruiz

引用次数: 0

Primary cutaneous anaplastic large cell lymphoma: diagnosis following the progression of chronic skin lesions 原发性皮肤间变性大细胞淋巴瘤：慢性皮肤病变进展后的诊断。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502395

A. Castillo Leonet , A.S. Collado Martín , I. Cabezón Estévanez

引用次数: 0

Impact of arterial hypertension on ocular vascular ischemia 高血压对眼血管缺血的影响。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502389

L. Castilla-Guerra , A.J. Gómez-Escobar , E. Gutiérrez-Sánchez , P. Luque-Linero , R. Dominguez Álvarez , M. Gandullo Moro , M.Á. Rico-Corral

Introduction

At the ocular level, hypertension causes retinal, choroidal and optic nerve lesions, and can be complicated by obstructive and ischaemic phenomena. We set out to assess the impact of hypertension on the different types of ocular vascular ischemia.

Patients and methods

Retrospective case-control study of patients seen in a vascular risk consultation. All patients underwent pulse wave velocity (PWV), ABI and carotid Doppler ultrasound.

Results

187 patients were included, 76 retinal venous occlusions (RVO), 21 retinal arterial occlusions (RAO), 28 non-arteritic ischaemic neuropathies (NAION) and 62 hypertensive controls without ocular ischaemia (CP). Mean age was 64 (±11), 68 (±10), 61 (±10) and 56 (±11) years in RVO, RAO, NAION, and PC respectively (P = 0.92). RVOs had a higher frequency of hypertension (71.4%), dyslipidaemia (55%) and diabetes (47.6%) (P = 0.001, P = 0.001 and P = 0.028 respectively) compared to the other groups. In relation to subclinical organ damage, patients with RVO had higher PWV 10.7 m/s (p = 0.004), pulse pressure 66 mmHg (p = 0.009), and vascular age 66.4 years (p = 0.005), with no differences in IMT, presence of carotid plaques or ITB. The occurrence of ocular ischaemia correlated with age (p = 0.009), DM2 (p = 0.027), dyslipidaemia (p = 0.047) and presence of plaques (p = 0.019).

Conclusions

Hypertension is a constant in vascular ocular ischaemic pathology, having a greater impact due to arterial stiffness in RVO. Age, diabetes, dyslipidaemia and the presence of plaques will increase the appearance of ocular ischemia.

在眼水平，高血压可引起视网膜、脉络膜和视神经病变，并可并发梗阻性和缺血性现象。我们开始评估高血压对不同类型的眼部血管缺血的影响。患者和方法：血管危险会诊患者的回顾性病例对照研究。所有患者均行脉搏波速度（PWV）、ABI及颈动脉多普勒超声检查。结果：纳入187例患者，其中视网膜静脉闭塞（RVO） 76例，视网膜动脉闭塞（RAO） 21例，非动脉缺血性神经病变（NAION） 28例，无眼缺血（CP）的高血压对照组62例。RVO、RAO、NAION、PC的平均年龄分别为64（±11）岁、68（±10）岁、61（±10）岁、56（±11）岁（P = 0.92）。RVOs组高血压（71.4%）、血脂异常（55%）和糖尿病（47.6%）发生率高于其他各组（P = 0.001、P = 0.001和P = 0.028）。与亚临床器官损害相关，RVO患者的PWV为10.7 m/s (p = 0.004)，脉压为66 mmHg (p = 0.009)，血管年龄为66.4岁（p = 0.005），而IMT、颈动脉斑块或ITB的存在无差异。眼部缺血的发生与年龄（p = 0.009）、DM2 （p = 0.027）、血脂异常（p = 0.047）、斑块存在（p = 0.019）相关。结论：高血压在血管性眼缺血病理中是一个常数，在RVO中由于动脉僵硬而有更大的影响。年龄、糖尿病、血脂异常和斑块的存在都会增加眼缺血的出现。

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引用次数: 0

Practical management of heart failure in hospital at home: recommendations from the Spanish Society of Internal Medicine and the Spanish Society of Hospital at Home 家庭医院心力衰竭的实际管理：来自西班牙内科学会和西班牙家庭医院学会的建议

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502399

Ruiz-Castellano M. , Aguiar D. , Aguilar-Rodríguez F. , Cubo P , Flox G. , Murcia J.M. , Coloma E. , Gracia V.M. , Vicente C. , Salamanca-Bautista P.

Heart failure (HF) is a major cause of morbidity, mortality, and hospital admissions worldwide. Home hospitalization (HaH) has emerged as an effective alternative, enhancing patient care and optimizing healthcare resources. This expert consensus document, endorsed by the Spanish Society of Internal Medicine (SEMI) and the Spanish Society of Home Hospitalization (SEHAD), provides practical recommendations for the management of HF in HaH settings. It outlines patient selection criteria, parameters for assessing congestion, and treatment protocols. The document emphasizes the use of telemonitoring and point-of-care ultrasound (POCUS). Therapeutic optimization, clinical follow-up, and patient education are fundamental. It also addresses comorbidity management and the integration of palliative care. Certification of HF care units and the strengthening of interdisciplinary collaboration are key to improving healthcare quality. HaH presents itself as an effective strategy for the comprehensive management of HF, reducing hospital-related complications and promoting patient-centered care.

心力衰竭（HF）是世界范围内发病率、死亡率和住院率的主要原因。家庭住院（HaH）已成为一种有效的替代方案，可加强患者护理并优化医疗保健资源。这份专家共识文件由西班牙内科学会（SEMI）和西班牙家庭住院学会（SEHAD）批准，为在医院环境中管理心衰提供了实用建议。它概述了患者的选择标准、评估充血的参数和治疗方案。该文件强调使用远程监测和即时超声（POCUS）。治疗优化、临床随访和患者教育是基础。它还涉及合并症管理和姑息治疗的整合。心衰护理单位的认证和加强跨学科合作是提高医疗保健质量的关键。体外循环是一种有效的心衰综合治疗策略，可减少与医院相关的并发症，促进以患者为中心的护理。

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引用次数: 0

Epidemiology of rhinovirus/enterovirus infection in hospitalized patients 住院患者鼻病毒/肠病毒感染的流行病学研究。

Revista clinica espanola

Pub Date : 2025-12-01 DOI: 10.1016/j.rceng.2025.502391

B. Lopez-Villalba , L. Tejedor-Cantero , M. Toquero-Asensio , V. Fernández-Espinilla , C. Hernán-García , S. Rojo-Rello , C. Prada-García , J.M. Eiros-Bouza , J. Castrodeza-Sanz

Background and Objective

Rhinovirus/enterovirus (RV/EV), commonly known for causing mild colds, has emerged as a significant cause of hospitalization. The objective of the study is to analyze the characteristics of patients hospitalized for viral respiratory infections, with an emphasis on RV/EV.

Methodology

This retrospective study was conducted between 2019 and 2022 at the University Clinical Hospital of Valladolid. Data from 1,528 cases were analyzed, sourced from medical records and microbiological tests (Biofire Respiratory y NxTAG respiratory panel).

Results

RV/EV was the most common respiratory virus (42.6%). There was a slight predominance of cases in males. 44.6% had a hospital stay of 2–7 days. The average hospitalization incidence was 3 per 1,000 adults per year. Children aged 0–15 years are at higher risk of RV/EV infection, with a 1.5 times higher probability in single infections (OR 1.496; 95% CI 1.147−1.952; p = 0.003), 7 times in coinfections with other respiratory viruses (OR 6.887; 95% CI 3.928–12.045; p < 0.01), and 8 times in coinfections with RSV (OR 8.580; 95% CI 3.866−19.041; p < 0.01). RV/EV is associated with a higher risk of asthma exacerbation (OR 2.545; 95% CI 1.336−4.851; p = 0.005) and COPD exacerbation (OR 1.781; 95% CI 1.022−3.103; p = 0.042), but a lower probability of bronchiolitis (OR 0.236; 95% CI 0.117−0.474; p < 0.01).

Conclusion

This study identifies RV/EV as the main respiratory virus in hospitalized patients, with a greater impact on those under 15 years and over 60 years. Seasonality and the coexistence of multiple viruses complicate its behaviour. These findings underscore the importance of preventive strategies and the need for continued research on its health impact.

背景和目的：鼻病毒/肠道病毒（RV/EV）通常以引起轻度感冒而闻名，现已成为住院治疗的重要原因。本研究的目的是分析病毒性呼吸道感染住院患者的特征，重点是RV/EV。方法：这项回顾性研究于2019年至2022年在巴利亚多利德大学临床医院进行。分析了1,528例病例的数据，这些数据来自医疗记录和微生物测试（Biofire Respiratory y NxTAG呼吸面板）。结果：RV/EV是最常见的呼吸道病毒（42.6%）。病例中男性略占优势。44.6%住院时间为2 ~ 7天。每年平均住院率为千分之三。0 ~ 15岁儿童感染RV/EV的风险较高，单次感染的概率为1.5倍（OR为1.496；95% CI为1.147 ~ 1.952;p = 0.003），合并其他呼吸道病毒感染的概率为7倍(OR为6.887；95% CI为3.928 ~ 12.045；p结论：本研究确定RV/EV为住院患者呼吸道病毒的主要感染类型，15岁以下和60岁以上患者的影响更大。季节性和多种病毒的共存使其行为复杂化。这些发现强调了预防战略的重要性以及继续研究其对健康影响的必要性。

{"title":"Epidemiology of rhinovirus/enterovirus infection in hospitalized patients","authors":"B. Lopez-Villalba , L. Tejedor-Cantero , M. Toquero-Asensio , V. Fernández-Espinilla , C. Hernán-García , S. Rojo-Rello , C. Prada-García , J.M. Eiros-Bouza , J. Castrodeza-Sanz","doi":"10.1016/j.rceng.2025.502391","DOIUrl":"10.1016/j.rceng.2025.502391","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Rhinovirus/enterovirus (RV/EV), commonly known for causing mild colds, has emerged as a significant cause of hospitalization. The objective of the study is to analyze the characteristics of patients hospitalized for viral respiratory infections, with an emphasis on RV/EV.</div></div><div><h3>Methodology</h3><div>This retrospective study was conducted between 2019 and 2022 at the University Clinical Hospital of Valladolid. Data from 1,528 cases were analyzed, sourced from medical records and microbiological tests (Biofire Respiratory y NxTAG respiratory panel).</div></div><div><h3>Results</h3><div>RV/EV was the most common respiratory virus (42.6%). There was a slight predominance of cases in males. 44.6% had a hospital stay of 2–7 days. The average hospitalization incidence was 3 per 1,000 adults per year. Children aged 0–15 years are at higher risk of RV/EV infection, with a 1.5 times higher probability in single infections (OR 1.496; 95% CI 1.147−1.952; p = 0.003), 7 times in coinfections with other respiratory viruses (OR 6.887; 95% CI 3.928–12.045; p < 0.01), and 8 times in coinfections with RSV (OR 8.580; 95% CI 3.866−19.041; p < 0.01). RV/EV is associated with a higher risk of asthma exacerbation (OR 2.545; 95% CI 1.336−4.851; p = 0.005) and COPD exacerbation (OR 1.781; 95% CI 1.022−3.103; p = 0.042), but a lower probability of bronchiolitis (OR 0.236; 95% CI 0.117−0.474; p < 0.01).</div></div><div><h3>Conclusion</h3><div>This study identifies RV/EV as the main respiratory virus in hospitalized patients, with a greater impact on those under 15 years and over 60 years. Seasonality and the coexistence of multiple viruses complicate its behaviour. These findings underscore the importance of preventive strategies and the need for continued research on its health impact.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"225 10","pages":"Article 502391"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of body fat distribution by ultrasound as a risk factor for mortality and readmission in patients admitted for sepsis 超声评估体脂分布作为败血症患者死亡率和再入院的危险因素。

Revista clinica espanola

Pub Date : 2025-11-01 DOI: 10.1016/j.rceng.2025.502369

J.T. Algado-Rabasa , I. Ribes-Mengual , E. Ronda-Perez , N. Algado-Selles

Background

Sepsis is a serious condition with high mortality. Body fat can influence the production of inflammatory cytokines at the systemic level, leading to adverse outcomes; therefore, the distribution of body fat may have prognostic value. The objective is to evaluate whether there is a relationship between the distribution of body fat measured by ultrasound and prognosis in patients admitted with sepsis.

Methods

A prospective cohort study was conducted in patients admitted for sepsis at a Spanish hospital between September 2023 and June 2024. The risk of mortality and readmission at 30 and 90 days was calculated based on the ratio of ultrasound measurements of subcutaneous fat (SAT) and visceral fat (VAT). The hazard ratio (HR) and 95% confidence interval for mortality and readmission were estimated based on the VAT/SAT ratio.

Results

62 patients were included. The median age was 77 years. The risk of mortality at 30 and 90 days post-admission was: for patients with VAT/SAT > 5.85, 18% and 35% respectively, and for patients with VAT/SAT < 5.85, 3% and 6.1%. The adjusted HR for mortality was 6.6 (95% CI: 1.4–30.6; p = 0.016). The risk of readmission at 30 and 90 days in patients with VAT/SAT > 8.03 was 46% and 80%, respectively, and in patients with VAT/SAT < 8.03, 23% and 30%. The HR for readmission was 3.1 (95% CI: 1.1–8.5; p = 0.026).

Conclusions

An increase in the VAT/SAT ratio, measured by ultrasound, is a risk factor for mortality and readmission in patients admitted for sepsis.

背景：脓毒症是一种严重的疾病，死亡率高。体脂可以在全身水平上影响炎症细胞因子的产生，导致不良后果；因此，体脂分布可能具有预测价值。目的是评估脓毒症住院患者超声测量体脂分布与预后之间是否存在关系。方法：对2023年9月至2024年6月在西班牙一家医院因败血症入院的患者进行前瞻性队列研究。根据超声测量皮下脂肪（SAT）和内脏脂肪（VAT）的比例计算30天和90天的死亡率和再入院风险。根据VAT/SAT比值估计死亡率和再入院的风险比（HR）和95%置信区间。结果：纳入62例患者。中位年龄为77岁。入院后30天和90天的死亡风险分别为：VAT/SAT为5.85、18%和35%，VAT/SAT为8.03的患者分别为46%和80%。结论：超声测量的VAT/SAT比值升高是脓毒症患者死亡和再入院的危险因素。

{"title":"Assessment of body fat distribution by ultrasound as a risk factor for mortality and readmission in patients admitted for sepsis","authors":"J.T. Algado-Rabasa , I. Ribes-Mengual , E. Ronda-Perez , N. Algado-Selles","doi":"10.1016/j.rceng.2025.502369","DOIUrl":"10.1016/j.rceng.2025.502369","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis is a serious condition with high mortality. Body fat can influence the production of inflammatory cytokines at the systemic level, leading to adverse outcomes; therefore, the distribution of body fat may have prognostic value. The objective is to evaluate whether there is a relationship between the distribution of body fat measured by ultrasound and prognosis in patients admitted with sepsis.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted in patients admitted for sepsis at a Spanish hospital between September 2023 and June 2024. The risk of mortality and readmission at 30 and 90 days was calculated based on the ratio of ultrasound measurements of subcutaneous fat (SAT) and visceral fat (VAT). The hazard ratio (HR) and 95% confidence interval for mortality and readmission were estimated based on the VAT/SAT ratio.</div></div><div><h3>Results</h3><div>62 patients were included. The median age was 77 years. The risk of mortality at 30 and 90 days post-admission was: for patients with VAT/SAT > 5.85, 18% and 35% respectively, and for patients with VAT/SAT < 5.85, 3% and 6.1%. The adjusted HR for mortality was 6.6 (95% CI: 1.4–30.6; <em>p</em> = 0.016). The risk of readmission at 30 and 90 days in patients with VAT/SAT > 8.03 was 46% and 80%, respectively, and in patients with VAT/SAT < 8.03, 23% and 30%. The HR for readmission was 3.1 (95% CI: 1.1–8.5; <em>p</em> = 0.026).</div></div><div><h3>Conclusions</h3><div>An increase in the VAT/SAT ratio, measured by ultrasound, is a risk factor for mortality and readmission in patients admitted for sepsis.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"225 9","pages":"Article 502369"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medium-sized vessel uptake on PET/CT as a clue to extracranial giant cell arteritis PET/CT中等血管摄取作为颅外巨细胞动脉炎的线索。

Revista clinica espanola

Pub Date : 2025-11-01 DOI: 10.1016/j.rceng.2025.502378

Á. García Tellado , B. Lucas-Velázquez , J. Pardo Lledías

引用次数: 0

Iron deficiency and iron deficiency anemia and their association with pulmonary embolism 缺铁和缺铁性贫血及其与肺栓塞的关系。

Revista clinica espanola

Pub Date : 2025-11-01 DOI: 10.1016/j.rceng.2025.502382

N. Báez-Ferrer , J. Monllor-Méndez , D. Álvarez-Luis , L. Hernández-Chinea , A.W. Al-Hayani-Al-Hantoosh , A. Domínguez-Rodríguez

Introduction

Iron deficiency (ID) has not been associated with pulmonary embolism (PE). The aim was to assess whether ID is associated with an increased likelihood of developing PE within the subsequent 12 months.

Patients and methods

Retrospective observational study. Patients with PE during follow-up were selected as cases, and those without the event as controls. Patients with chronic diseases, cancer, fractures, or recent hospital admissions were excluded.

Results

A total of 43 cases and 199 controls were enrolled. The mean age was 61 ± 21 years. ID increased the risk of PE at 12 months with an odds ratio of 2.15 (95% confidence interval (CI95%): 1.01–4.58; P = .046). Survival analysis showed more than a two-fold increase in the risk of developing PE in the presence of prior ID (hazard ratio: 2.37 (CI95%: 1.30–4.31; P = .05)).

Conclusion

ID may represent an increased risk of PE in the 12 months following its detection.

铁缺乏（ID）与肺栓塞（PE）无关。目的是评估ID是否与随后12个月内发生PE的可能性增加有关。患者和方法：回顾性观察研究。随访期间发生PE的患者作为病例，未发生PE的患者作为对照。患有慢性疾病、癌症、骨折或近期住院的患者被排除在外。结果：共纳入病例43例，对照组199例。平均年龄61岁 ± 21岁。ID增加了12个月时PE的风险，比值比为2.15(95%可信区间（CI95%）： 1.01-4.58；P = .046)。生存分析显示，先前存在ID的患者发生PE的风险增加了两倍以上（风险比：2.37 (CI95%: 1.30-4.31; P = .05)）。结论：ID可能在其检测后的12个月内增加PE的风险。

{"title":"Iron deficiency and iron deficiency anemia and their association with pulmonary embolism","authors":"N. Báez-Ferrer , J. Monllor-Méndez , D. Álvarez-Luis , L. Hernández-Chinea , A.W. Al-Hayani-Al-Hantoosh , A. Domínguez-Rodríguez","doi":"10.1016/j.rceng.2025.502382","DOIUrl":"10.1016/j.rceng.2025.502382","url":null,"abstract":"<div><h3>Introduction</h3><div>Iron deficiency (ID) has not been associated with pulmonary embolism (PE). The aim was to assess whether ID is associated with an increased likelihood of developing PE within the subsequent 12 months.</div></div><div><h3>Patients and methods</h3><div>Retrospective observational study. Patients with PE during follow-up were selected as cases, and those without the event as controls. Patients with chronic diseases, cancer, fractures, or recent hospital admissions were excluded.</div></div><div><h3>Results</h3><div>A total of 43 cases and 199 controls were enrolled. The mean age was 61±21 years. ID increased the risk of PE at 12 months with an odds ratio of 2.15 (95% confidence interval (CI95%): 1.01–4.58; <em>P</em>  =.05)).</div></div><div><h3>Conclusion</h3><div>ID may represent an increased risk of PE in the 12 months following its detection.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"225 9","pages":"Article 502382"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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