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Measles outbreak transmission in the ER waiting room: the role of vaccination. 麻疹疫情在急诊室候诊室的传播:疫苗接种的作用。
Pub Date : 2024-10-03 DOI: 10.1016/j.rceng.2024.10.002
A Hernández-Aceituno, I Falcón García, E Marrero Marichal, D Sanabria Curbelo, Á Torres Lana, E Larumbe-Zabala

Background: Measles is one of the most contagious infectious diseases. Spain was declared free of endemic measles transmission in 2017. However, less than half of EU/EEA countries have achieved vaccination coverage goals and measles outbreaks have been reported recently, some of them in healthcare facilities. The aim of this study was to present an outbreak in the pediatric emergency (ER) waiting room affecting a vaccinated healthcare worker.

Methods: Descriptive study of an outbreak whose transmission occurred in the pediatric ER waiting room of a tertiary level hospital on the island of Tenerife (Canary Islands) in April 2024.

Results: Between April 23 and May 12, 2024, four PCR-confirmed measles cases were identified, resulting in 407 contacts in healthcare center waiting rooms. One of the cases was a 26-year-old male nurse who had been correctly vaccinated with two doses of measles, mumps, and rubella vaccine during childhood. Between May 7 and 10, during his infective period, he took two two-and-a-half-hour flights and lived together with nine people during a trip. No evidence of infection has been identified among the individuals with whom he lived neither the passengers and crew of the two flights.

Conclusions: In the emergency waiting room, an unvaccinated girl gave measles to two infants who were not yet old enough to be vaccinated and to a nurse who had been properly vaccinated as an infant. Despite generating more than 300 close contacts, the nurse did not infect anyone, suggesting that vaccination may help prevent both infection and transmission of measles.

背景:麻疹是传染性最强的传染病之一。西班牙于 2017 年宣布消除了麻疹的地方性传播。然而,只有不到一半的欧盟/欧洲经济区国家实现了疫苗接种覆盖目标,最近有报道称发生了麻疹疫情,其中一些疫情发生在医疗机构。本研究旨在介绍在儿科急诊室(ER)候诊室爆发的影响到一名已接种疫苗的医护人员的麻疹疫情:方法:对 2024 年 4 月发生在特内里费岛(加那利群岛)一家三级医院儿科急诊室候诊室的疫情进行描述性研究:结果:2024 年 4 月 23 日至 5 月 12 日期间,发现了四例 PCR 确诊的麻疹病例,导致 407 人在医疗中心候诊室接触过麻疹患者。其中一个病例是一名 26 岁的男护士,他在儿童时期曾正确接种过两剂麻疹、腮腺炎和风疹疫苗。5 月 7 日至 10 日,在他的感染期内,他乘坐了两次两个半小时的航班,并在旅途中与 9 个人住在一起。在与他同住的人中,既没有发现感染的证据,也没有发现两次航班的乘客和机组人员:在急诊候诊室,一名未接种疫苗的女孩将麻疹传染给了两名尚未到接种疫苗年龄的婴儿和一名在婴儿时期接种过疫苗的护士。尽管产生了 300 多名密切接触者,但该护士没有感染任何人,这表明接种疫苗可能有助于预防麻疹的感染和传播。
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引用次数: 0
Executive summary of the consensus document on point-of-care ultrasound implementation: recommendations from the Clinical Ultrasound Working Groups of SEMI, SEDAR, SEGG, SEMERGEN, SEMES, SEMFYC, and SEMG. 护理点超声实施共识文件执行摘要:SEMI、SEDAR、SEGG、SEMERGEN、SEMES、SEMFYC 和 SEMG 的临床超声工作组的建议。
Pub Date : 2024-10-03 DOI: 10.1016/j.rceng.2024.10.001
Y Tung-Chen

Point-of-Care Ultrasound has significantly evolved, establishing itself as an essential tool in daily medical practice, especially in various clinical contexts. This consensus document, supported by several Spanish medical societies, proposes guidelines for the effective integration of ultrasound in healthcare, promoting its standardization and ensuring the quality and systematic application of this technique. The working groups, composed of experts from different specialties, conducted a comprehensive review of the literature in MEDLINE and extensively discussed recommendations to formulate a coherent and practical set of guidelines for different application areas: hospital and out-of-hospital emergencies and critical care, primary care, and outpatient hospital care, hospitalization. The methodology included virtual meetings and confidential voting to reach a consensus on the relevant recommendations. Ultrasound was highlighted as fundamental in the initial approach to various pathologies, such as abdominal, thoracic, and musculoskeletal issues, facilitating quick and accurate diagnoses, and reducing the need for unnecessary referrals. Furthermore, this technique has proven valuable in emergencies and critical care, guiding procedures and enhancing the safety and efficiency of clinical interventions. These guidelines not only serve as a framework for clinical practice, education, and research but also aim to ensure that professionals are adequately trained and that ultrasound evaluations are performed to a standard of excellence. The purpose of these recommendations is to standardize and facilitate the adoption of this clinical tool in the daily practice of healthcare, thus improving the quality of the services provided in its various possible applications.

护理点超声波技术已经取得了长足的发展,成为日常医疗实践中必不可少的工具,尤其是在各种临床环境中。这份共识文件得到了西班牙多个医学协会的支持,提出了将超声技术有效融入医疗保健的指导原则,促进了超声技术的标准化,并确保了这项技术的高质量和系统化应用。工作组由来自不同专业的专家组成,他们对 MEDLINE 上的文献进行了全面审查,并对建议进行了广泛讨论,以便针对不同的应用领域制定一套连贯实用的指南:医院和院外急诊与重症监护、初级护理、医院门诊护理和住院治疗。该方法包括虚拟会议和保密投票,以便就相关建议达成共识。与会者强调,超声波是初步处理各种病症(如腹部、胸部和肌肉骨骼问题)的基本方法,有助于快速准确地做出诊断,并减少不必要的转诊。此外,这项技术在急诊和重症监护中也被证明非常有价值,它可以指导手术,提高临床干预的安全性和效率。这些指南不仅是临床实践、教育和研究的框架,还旨在确保专业人员得到充分的培训,并按照卓越的标准进行超声评估。这些建议的目的是规范和促进在日常医疗实践中采用这一临床工具,从而提高在各种可能的应用中提供服务的质量。
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引用次数: 0
The predictive value of estimated pulse wave velocity (ePWV) combined with BMI for newly diagnosed diabetes 估计脉搏波速度(ePWV)与体重指数(BMI)相结合对新诊断糖尿病的预测价值。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.001

Purpose

Estimated pulse wave velocity (ePWV) and body mass index (BMI) are significant predictors of new-onset diabetes. This study aims to evaluate the impact and predictive value of combining ePWV and BMI on the incidence of new-onset diabetes.

Methods

A secondary analysis was conducted on a cohort study by Rich Healthcare (China), involving 211,833 eligible participants. Logistic regression analysis identified factors influencing diabetes occurrence, while ROC curve analysis assessed the predictive value of ePWV, BMI, and their combination for new-onset diabetes.

Results

Over a mean follow-up period of 3.12 years, 3,000 men (1.41%) and 1,174 women (0.55%) were diagnosed with diabetes. Logistic regression revealed that BMI, triglycerides, alanine aminotransferase, blood urea nitrogen, creatinine clearance rate, ePWV, and family history of diabetes are high-risk factors for new-onset diabetes. The combination of ePWV and BMI provided a higher area under the ROC curve (0.822) compared to ePWV or BMI alone.

Conclusion

Elevated levels of ePWV and BMI are independent risk factors for new-onset diabetes. Combining these measures enhances predictive accuracy compared to using either indicator alone.
目的:估计脉搏波速度(ePWV)和体重指数(BMI)是预测新发糖尿病的重要指标。本研究旨在评估 ePWV 和体重指数相结合对新发糖尿病发病率的影响和预测价值:方法:对富康医疗集团(中国)的一项队列研究进行了二次分析,该研究涉及 211,833 名符合条件的参与者。逻辑回归分析确定了影响糖尿病发生的因素,而 ROC 曲线分析评估了 ePWV、BMI 及其组合对新发糖尿病的预测价值:在平均 3.12 年的随访期内,有 3,000 名男性(1.41%)和 1,174 名女性(0.55%)被诊断为糖尿病。逻辑回归显示,体重指数、甘油三酯、丙氨酸氨基转移酶、血尿素氮、肌酐清除率、ePWV 和糖尿病家族史是新发糖尿病的高危因素。与单纯的 ePWV 或 BMI 相比,ePWV 和 BMI 的组合提供了更高的 ROC 曲线下面积(0.822):结论:ePWV 和 BMI 水平升高是新发糖尿病的独立风险因素。结论:ePWV 和 BMI 水平升高是新发糖尿病的独立风险因素,与单独使用其中一个指标相比,结合使用这些指标可提高预测准确性。
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引用次数: 0
Association between serum neurofilament light chains (sNfL) and neurologic disorders in a representative sample of US adults: a cross-sectional study 美国成年人代表性样本中血清神经丝蛋白轻链 (sNfL) 与神经系统疾病之间的关系:一项横断面研究。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.002

Background

While increased neurofilament light chain (NfL) in serum concentrations are linked to the progression of several neurological conditions, their distribution and implications within the general adult population remain largely unexplored. The current research aims to clarify the relationship between serum NfL levels and neurological disorders in a broad and representative population sample.

Methods

We utilized information gathered from 1751 adults involved in the 2013–2014 cycle of the National Health and Nutrition Examination Survey . Our analytical approach encompassed logistic regression, smoothed curve fitting, and subgroup analyses to identify potential correlations between serum NfL levels and neurological conditions, such as depression, severe hearing and visual impairments, stroke, subjective memory deficits, and sleep problems.

Results

After adjusting for all confounders, we found that higher serum NfL levels were significantly associated with increased risks of depression, stroke, subjective memory deficits, and longer sleep duration (p < 0.05). Subgroup analyses supported these findings. Additionally, BMI significantly influenced the relationship between serum NfL levels and long-term subjective memory decline.

Conclusion

Our research shows that higher serum NfL levels are strongly related to an elevated risk for several neurological disorders. These findings highlight the role of serum NfL serving as a critical marker for early detection and monitoring of neurological conditions, emphasizing its importance in both clinical and public health settings.
背景:虽然血清中神经丝蛋白轻链(NfL)浓度的升高与多种神经系统疾病的进展有关,但其在普通成年人群中的分布和影响在很大程度上仍未得到探讨。目前的研究旨在通过广泛且具有代表性的人群样本,阐明血清中 NfL 水平与神经系统疾病之间的关系:我们利用了参加 2013-2014 年度美国国家健康与营养调查(NHANES)的 1751 名成年人的信息。我们的分析方法包括逻辑回归、平滑曲线拟合和亚组分析,以确定血清 NfL 水平与神经系统疾病(包括抑郁症、严重听力和视力障碍、中风、主观记忆缺陷和睡眠问题)之间的潜在相关性:结果:在对混杂因素进行调整后,我们发现血清 NfL 浓度越高,患抑郁症、中风、主观记忆障碍和睡眠时间越长的风险越高(p 结论:我们的研究表明,血清 NfL 浓度越高,患抑郁症、中风、主观记忆障碍和睡眠时间越长的风险越高:我们的研究表明,较高的血清 NfL 水平与多种神经系统疾病的风险升高密切相关。这些发现凸显了血清 NfL 作为早期检测和监测神经系统疾病的重要标志物的作用,强调了其在临床和公共卫生环境中的重要性。
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引用次数: 0
Fear of illness in Kafka's Metamorphosis 特别文章:卡夫卡《变形记》中的疾病恐惧。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.004
F. Tornero-Romero , M. Morante-Ruiz , L. Alberto Gonzales-Campos
This year marks 100 years since the death of Franz Kafka. Often in general medicine, and internal medicine in particular, doctors face situations in which they position themselves as the only guarantor of the patient in relation to society and how it conceives the disease. Many times, patients come to us without a diagnosis or with the fear of it; sometimes also rejected by their environment. This short text addresses this current topic, paying tribute to the brilliant writer and his best-known work, Metamorphosis.
今年是弗朗茨-卡夫卡逝世 100 周年。在全科医学,尤其是内科医学中,医生经常面临这样的情况,即他们将自己定位为病人与社会以及社会对疾病的看法之间的唯一保证人。很多时候,病人来就诊时并没有诊断结果,或者对诊断结果心存恐惧,有时还会遭到周围环境的排斥。这篇短文探讨了这一当前的话题,向这位杰出的作家及其最著名的作品《变形记》致敬。
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引用次数: 0
The RICA-2 registry: design and baseline characteristics of the first 1,000 patients RICA-2 登记:首批 1,000 名患者的设计和基线特征。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.008
J.C. Trullàs , M.C. Moreno-García , V. Mittelbrunn-Alquézar , A. Conde-Martel , L. Soler-Rangel , M. Montero-Pérez-Barquero , J. Casado , M. Sánchez-Marteles , J.C. Arévalo-Lorido , J. Pérez-Silvestre

Background and objective

Heart failure (HF) is a syndrome of epidemic proportions and one of the main reasons for hospital admission. Patient registries provide real-world clinical practice information which is complementary to clinical trials. RICA-2 is a registry of the Spanish Society of Internal Medicine. Its main goal is to know the clinical and epidemiological characteristics and prognostic factors of patients with HF treated in Internal Medicine Departments. The objective of this study is to present the design of the RICA-2, the baseline characteristics of the first 1000 patients included and their comparison with those of the historical cohort of the RICA registry.

Methods

Observational, multicentre and prospective study of patients with HF with the following inclusion criteria: age equal to or greater than 18 years old, diagnosis of HF according to the European Guidelines, indistinct inclusion in decompensation or stable phase, of patients with de novo HF or chronic HF, regardless of left ventricular ejection fraction, aetiology and comorbidities.

Results

RICA-2 patients have advanced age (83 years old) and 51% are women. The comorbidity burden is higher than in the RICA registry (5 points in the Charlson comorbidity index), with predominating chronic decompensated HF (74%), hypertensive aetiology (39%) and preserved ejection fraction (52%). Most patients are pre-frail or vulnerable and are at risk of malnutrition.

Conclusion

The RICA-2 represents a contemporary cohort of patients that will provide us with clinical, epidemiological and prognostic information on patients with acute and chronic HF treated in Internal Medicine.
背景和目的:心力衰竭(HF)是一种流行性综合征,也是入院治疗的主要原因之一。患者登记可提供真实世界的临床实践信息,是临床试验的补充。RICA-2 是西班牙内科医学会的一个登记处。其主要目的是了解在内科接受治疗的高血压患者的临床和流行病学特征以及预后因素。本研究旨在介绍 RICA-2 的设计、首批纳入的 1000 名患者的基线特征及其与 RICA 登记历史队列的比较:方法:观察性、多中心和前瞻性研究,研究对象为符合以下纳入标准的心房颤动患者:年龄大于或等于18岁,根据欧洲指南诊断为心房颤动,未明确纳入失代偿期或稳定期,"新发 "心房颤动或慢性心房颤动患者,无论左心室射血分数、病因和合并症如何:RICA-2患者年龄偏高(83岁),51%为女性。合并症负担高于 RICA 登记(夏尔森合并症指数为 5 分),以慢性失代偿性心房颤动(74%)、高血压病因(39%)和射血分数保留(52%)为主。结论:RICA-2 代表了一个当代患者群,将为我们提供内科治疗的急慢性心房颤动患者的临床、流行病学和预后信息。
{"title":"The RICA-2 registry: design and baseline characteristics of the first 1,000 patients","authors":"J.C. Trullàs ,&nbsp;M.C. Moreno-García ,&nbsp;V. Mittelbrunn-Alquézar ,&nbsp;A. Conde-Martel ,&nbsp;L. Soler-Rangel ,&nbsp;M. Montero-Pérez-Barquero ,&nbsp;J. Casado ,&nbsp;M. Sánchez-Marteles ,&nbsp;J.C. Arévalo-Lorido ,&nbsp;J. Pérez-Silvestre","doi":"10.1016/j.rceng.2024.07.008","DOIUrl":"10.1016/j.rceng.2024.07.008","url":null,"abstract":"<div><h3>Background and objective</h3><div>Heart failure (HF) is a syndrome of epidemic proportions and one of the main reasons for hospital admission. Patient registries provide real-world clinical practice information which is complementary to clinical trials. RICA-2 is a registry of the Spanish Society of Internal Medicine. Its main goal is to know the clinical and epidemiological characteristics and prognostic factors of patients with HF treated in Internal Medicine Departments. The objective of this study is to present the design of the RICA-2, the baseline characteristics of the first 1000 patients included and their comparison with those of the historical cohort of the RICA registry.</div></div><div><h3>Methods</h3><div>Observational, multicentre and prospective study of patients with HF with the following inclusion criteria: age equal to or greater than 18 years old, diagnosis of HF according to the European Guidelines, indistinct inclusion in decompensation or stable phase, of patients with <em>de novo</em> HF or chronic HF, regardless of left ventricular ejection fraction, aetiology and comorbidities.</div></div><div><h3>Results</h3><div>RICA-2 patients have advanced age (83 years old) and 51% are women. The comorbidity burden is higher than in the RICA registry (5 points in the Charlson comorbidity index), with predominating chronic decompensated HF (74%), hypertensive aetiology (39%) and preserved ejection fraction (52%). Most patients are pre-frail or vulnerable and are at risk of malnutrition.</div></div><div><h3>Conclusion</h3><div>The RICA-2 represents a contemporary cohort of patients that will provide us with clinical, epidemiological and prognostic information on patients with acute and chronic HF treated in Internal Medicine.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"224 8","pages":"Pages 522-533"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How does the risk of malnutrition evolve in elderly patients one year after hospital discharge? Results of a prospective cohort 老年患者出院一年后营养不良的风险如何演变?前瞻性队列研究结果。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.003
A. Marne-Ortega , L. Corral-Gudino , P. Miramontes-González , M. Gabella-Martín
{"title":"How does the risk of malnutrition evolve in elderly patients one year after hospital discharge? Results of a prospective cohort","authors":"A. Marne-Ortega ,&nbsp;L. Corral-Gudino ,&nbsp;P. Miramontes-González ,&nbsp;M. Gabella-Martín","doi":"10.1016/j.rceng.2024.07.003","DOIUrl":"10.1016/j.rceng.2024.07.003","url":null,"abstract":"","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"224 8","pages":"Pages 549-551"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for mortality in coronavirus disease 2019 patients with silent hypoxemia 2019年冠状病毒病无声低氧血症患者死亡的风险因素。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.06.010

Objective

To describe the predictors of mortality in hospitalized patients with severe acute respiratory syndrome (SARS) due to COVID-19 presenting with silent hypoxemia.

Material and methods

Retrospective cohort study of hospitalized patients with SARS due to COVID-19 and silent hypoxemia at admission, in Brazil, from January to June 2021. The primary outcome of interest was in-hospital death. Multivariable logistic regression analysis was performed.

Results

Of 46,102 patients, the mean age was 59 ± 16 years, and 41.6% were female. During hospitalization, 13,149 patients died. Compared to survivors, non-survivors were older (mean age, 66 vs. 56 years; P < 0.001), less frequently female (43.6% vs. 40.9%; P < 0.001), and more likely to have comorbidities (74.3% vs. 56.8%; P < 0.001). Non-survivors had higher needs for invasive mechanical ventilation (42.4% vs. 6.6%; P < 0.001) and intensive care unit admission (56.9% vs. 20%; P < 0.001) compared to survivors. In the multivariable regression analysis, advanced age (OR 1.04; 95%CI 1.037–1.04), presence of comorbidities (OR 1.54; 95%CI 1.47–1.62), cough (OR 0.74; 95%CI 0.71–0.79), respiratory distress (OR 1.32; 95%CI 1.26–1.38), and need for non-invasive respiratory support (OR 0.37; 95%CI 0.35–0.40) remained independently associated with death.

Conclusions

Advanced age, presence of comorbidities, and respiratory distress were independent risk factors for mortality, while cough and requirement for non-invasive respiratory support were independent protective factors against mortality in hospitalized patients due to SARS due to COVID-19 with silent hypoxemia at presentation.
摘要描述因 COVID-19 引起的严重急性呼吸系统综合征(SARS)住院患者出现无声低氧血症时的死亡率预测因素:回顾性队列研究:2021 年 1 月至 6 月期间,在巴西对因 COVID-19 感染严重急性呼吸系统综合征(SARS)且入院时出现无声低氧血症的住院患者进行研究。主要研究结果为住院死亡。结果显示,在 46102 名患者中,平均住院日死亡率为 0.5%:46102名患者中,平均年龄为59±16岁,41.6%为女性。住院期间,13149 名患者死亡。与幸存者相比,非幸存者的年龄更大(平均年龄为 66 岁对 56 岁;P 结论:幸存者的年龄更大,合并症更多:高龄、合并症和呼吸窘迫是导致死亡的独立危险因素,而咳嗽和需要无创呼吸支持是导致因 COVID-19 引起的非典住院病人死亡的独立保护因素。
{"title":"Risk factors for mortality in coronavirus disease 2019 patients with silent hypoxemia","authors":"","doi":"10.1016/j.rceng.2024.06.010","DOIUrl":"10.1016/j.rceng.2024.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the predictors of mortality in hospitalized patients with severe acute respiratory syndrome<span> (SARS) due to COVID-19 presenting with silent hypoxemia.</span></div></div><div><h3>Material and methods</h3><div><span>Retrospective cohort study<span> of hospitalized patients with SARS due to COVID-19 and silent hypoxemia at admission, in Brazil, from January to June 2021. The primary outcome of interest was in-hospital death. Multivariable </span></span>logistic regression analysis was performed.</div></div><div><h3>Results</h3><div>Of 46,102 patients, the mean age was 59 ± 16 years, and 41.6% were female. During hospitalization, 13,149 patients died. Compared to survivors, non-survivors were older (mean age, 66 <em>vs.</em> 56 years; <em>P</em> &lt; 0.001), less frequently female (43.6% <em>vs.</em> 40.9%; <em>P</em> &lt; 0.001), and more likely to have comorbidities (74.3% <em>vs.</em> 56.8%; <em>P</em><span> &lt; 0.001). Non-survivors had higher needs for invasive mechanical ventilation (42.4% </span><em>vs.</em> 6.6%; <em>P</em><span> &lt; 0.001) and intensive care unit admission (56.9% </span><em>vs.</em> 20%; <em>P</em><span> &lt; 0.001) compared to survivors. In the multivariable regression analysis, advanced age (OR 1.04; 95%CI 1.037–1.04), presence of comorbidities (OR 1.54; 95%CI 1.47–1.62), cough<span> (OR 0.74; 95%CI 0.71–0.79), respiratory distress (OR 1.32; 95%CI 1.26–1.38), and need for non-invasive respiratory support (OR 0.37; 95%CI 0.35–0.40) remained independently associated with death.</span></span></div></div><div><h3>Conclusions</h3><div>Advanced age, presence of comorbidities, and respiratory distress were independent risk factors for mortality, while cough and requirement for non-invasive respiratory support were independent protective factors against mortality in hospitalized patients due to SARS due to COVID-19 with silent hypoxemia at presentation.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"224 8","pages":"Pages 485-493"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol consumption in elderly people. What is the real magnitude of the problem? 老年人饮酒。问题的实际严重程度如何?
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.007
I. Fernández Castro , M. Marcos Martín , I. Novo Veleiro
The harmful effects of alcohol consumption have been well studied in the general population, but in the group of people over 80 years of age there is not much information regarding its relevance. It is estimated than 30%–40% of this population consumes alcohol regularly and around 10% engage in high-risk consumption. Furthermore, potential interactions between this substance and commonly consumed drugs in this age group, like oral antidiabetics, anticoagulants and antibiotics, may pose a risk of serious complications.
In this sense, the aim of the present work was to analyze the magnitude of alcohol consumption within people over 80 years of age and the impact it has on their health. A narrative review of the available literature on the topic was carried out, which showed that alcohol consumption in people over 80 years of age is common in our environment and is associated with multiple complications and the development of different pathologies. The correct quantification of alcohol consumption in very elderly people must be integrated into the daily clinical practice of Medicine in general and Internal Medicine in particular.
关于饮酒的有害影响,在普通人群中已有大量研究,但对于 80 岁以上的老年人群,有关其相关性的信息却不多。据估计,这一人群中有 30% 至 40% 的人经常饮酒,约 10% 的人饮酒风险较高。此外,这种物质与该年龄段人群常服用的药物(如口服抗糖尿病药、抗凝血药和抗生素)之间的潜在相互作用可能会带来严重并发症的风险。因此,本研究旨在分析 80 岁以上老年人的饮酒量及其对健康的影响。我们对有关该主题的现有文献进行了叙述性回顾,结果表明,80 岁以上老年人饮酒在我们的环境中很常见,并且与多种并发症和不同病症的发展有关。正确量化高龄老人的饮酒量必须纳入医学,特别是内科学的日常临床实践中。
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引用次数: 0
Cardiac amyloidosis worsens prognosis in patients with heart failure: findings from the PREVAMIC study 心脏淀粉样变性会加重心力衰竭患者的预后:PREVAMIC 研究的结果。
Pub Date : 2024-10-01 DOI: 10.1016/j.rceng.2024.07.006
R. Ruiz Hueso , P. Salamanca Bautista , M.A. Quesada Simón , S. Yun , A. Conde Martel , J.L. Morales Rull , I. Fiteni Mera , D. Abad Pérez , I. Páez Rubio , Ó. Aramburu Bodas

Background and objectives

Cardiac amyloidosis (CA) is a common pathology in elderly patients that usually presents as heart failure (HF). However, it is not clear whether CA associated with HF has a worse prognosis compared with HF due to other etiologies.

Material and methods

Prospective, observational cohort study that recruited patients ≥65 years of age with HF in 30 Spanish centers. The cohort was divided according to whether the patients had AC or not. Patients were followed for 1 year.

Results

A total of 484 patients were included in the analysis. The population was elderly (median 86 years) and 49% were women CA was present in 23.8 % of the included patients. In the CA group, there was a lower prevalence of diabetes mellitus and valvular disease. At one year of follow-up, mortality was significantly more frequent in patients with CA compared to those without (33.0 vs.14.9%, p < 0.001). However, there were no differences between both groups in visits to the emergency room or readmissions. In the multivariate analysis, the variables that were shown to predict all-cause mortality at one year of follow-up were chronic kidney disease (HR 1.75 (1.01–3.05) p 0.045), NT-proBNP levels (HR 2.51 (1.46–4.30) p < 0.001), confusion (HR 2.05 (1.01–4.17), p 0.048), and the presence of CA (HR 1.77 (1.11–2.84), p 0.017).

Conclusion

The presence of CA in elderly patients with HF is related to a worse prognosis at one year of follow-up. Early diagnosis of the pathology and multidisciplinary management can help improve patient outcomes.
背景和目的:心脏淀粉样变性(CA)是老年患者的一种常见病,通常表现为心力衰竭(HF)。然而,与其他病因导致的心力衰竭相比,与心力衰竭相关的心脏淀粉样变性是否预后更差尚不清楚:前瞻性、观察性队列研究,在 30 个西班牙中心招募年龄≥ 65 岁的高血压患者。根据患者是否患有交流性心脏病对队列进行了划分。对患者进行了为期一年的随访:共有 484 名患者纳入分析。分析对象为老年人(中位数为 86 岁),49% 为女性,其中 23.8% 的患者患有冠心病。在CA组中,糖尿病和瓣膜病的发病率较低。在一年的随访中,有CA的患者死亡率明显高于无CA的患者(33.0%对14.9%,P 结论:有CA的患者死亡率明显高于无CA的患者:老年心房颤动患者出现 CA 与随访一年后的预后较差有关。早期病理诊断和多学科治疗有助于改善患者的预后。
{"title":"Cardiac amyloidosis worsens prognosis in patients with heart failure: findings from the PREVAMIC study","authors":"R. Ruiz Hueso ,&nbsp;P. Salamanca Bautista ,&nbsp;M.A. Quesada Simón ,&nbsp;S. Yun ,&nbsp;A. Conde Martel ,&nbsp;J.L. Morales Rull ,&nbsp;I. Fiteni Mera ,&nbsp;D. Abad Pérez ,&nbsp;I. Páez Rubio ,&nbsp;Ó. Aramburu Bodas","doi":"10.1016/j.rceng.2024.07.006","DOIUrl":"10.1016/j.rceng.2024.07.006","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Cardiac amyloidosis (CA) is a common pathology in elderly patients that usually presents as heart failure (HF). However, it is not clear whether CA associated with HF has a worse prognosis compared with HF due to other etiologies.</div></div><div><h3>Material and methods</h3><div>Prospective, observational cohort study that recruited patients ≥65 years of age with HF in 30 Spanish centers. The cohort was divided according to whether the patients had AC or not. Patients were followed for 1 year.</div></div><div><h3>Results</h3><div>A total of 484 patients were included in the analysis. The population was elderly (median 86 years) and 49% were women CA was present in 23.8 % of the included patients. In the CA group, there was a lower prevalence of diabetes mellitus and valvular disease. At one year of follow-up, mortality was significantly more frequent in patients with CA compared to those without (33.0 vs.14.9%, p &lt; 0.001). However, there were no differences between both groups in visits to the emergency room or readmissions. In the multivariate analysis, the variables that were shown to predict all-cause mortality at one year of follow-up were chronic kidney disease (HR 1.75 (1.01–3.05) p 0.045), NT-proBNP levels (HR 2.51 (1.46–4.30) p &lt; 0.001), confusion (HR 2.05 (1.01–4.17), p 0.048), and the presence of CA (HR 1.77 (1.11–2.84), p 0.017).</div></div><div><h3>Conclusion</h3><div>The presence of CA in elderly patients with HF is related to a worse prognosis at one year of follow-up. Early diagnosis of the pathology and multidisciplinary management can help improve patient outcomes.</div></div>","PeriodicalId":94354,"journal":{"name":"Revista clinica espanola","volume":"224 8","pages":"Pages 494-502"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revista clinica espanola
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