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Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats. 石提取物对大鼠实验性头部创伤模型神经保护作用的研究。

Turkish neurosurgery

Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.37599-22.2

Adil Can Karaoglu, Ibrahim Burak Atci, Nail Demirel, Okan Turk, Canan Hurdag, Ozgur Baran, Nuriye Guzin Ozdemir, Ayhan Kocak, Muhammet Teoman Karakurt

Aim: To investigate the neuroprotective effect of shilajit extract in experimental head trauma.

Material and methods: Three groups of 33 Sprague Dawley Albino strain male rats were included in the study. Group 1 (n=11): trauma but not treated. Group 2 (n=11): trauma and treated with 0.5 mL / rat saline Group 3 (n=11): 150 mg / kg shilajit extract was administered intraperitoneally in the treatment of trauma. Following the head trauma, the indicated treatments were applied to the 2nd and 3rd groups at the first, twenty-four and forty-eighth hours. Brain tissues and blood samples were taken after the control animals were sacrificed at the 72nd hour in all groups after trauma. Sections prepared from cerebral cortex and ca1 region were examined with hematoxylin eosin and luxol fast blue staining. Total antioxidant capacity, total oxidant capacity and oxidative stress index were measured from blood samples taken after routine procedures.

Results: The number of red neurons and the severity of edema were significantly higher in both the cerebral cortex and the ca1 region in the group treated with trauma only and in the group administered saline after trauma compared to the group that received shilajit extract after trauma. The total antioxidant capacity increased significantly in blood samples taken only from the group treated with trauma and saline in post-trauma treatment compared to the group given post-traumatic shilajit extract, while shilajit extract given due to traumatic brain injury significantly decreased the total oxidant capacity and oxidative stress index values compared to the other groups.

Conclusion: Shilajit extract has been shown to have a neuroprotective effect in the treatment of acute traumatic brain injury. Our study showed that shilajit may be a useful option in the treatment of secondary brain injury, in humans.

目的：本研究旨在探讨西拉吉特提取物对实验性颅脑损伤的神经保护作用。材料和方法：本研究包括三组33只Sprague-Dawley-Albino品系雄性大鼠。第1组（n:11）：外伤但未治疗。第2组（n:11）：创伤并用0.5mL/大鼠生理盐水治疗第3组（n:121）：腹膜内给予150 mg/kg shilajit提取物治疗创伤。头部创伤后，第2组和第3组分别在第1、24和48小时进行指定治疗。在创伤后72小时处死对照动物后，各组均采集脑组织和血液样本。从大脑皮层和ca1区制备的切片用血毒毒素-伊红和luxol快速蓝染色进行检查。从常规手术后采集的血液样本中测量总抗氧化能力、总氧化能力和氧化应激指数。结果：与创伤后接受shilajit提取物的组相比，仅接受创伤治疗的组和创伤后给予盐水的组的大脑皮层和ca1区的红色神经元数量和水肿严重程度均显著较高。与创伤后给予shilajit提取物的组相比，仅从创伤后治疗中接受创伤和生理盐水治疗的组中采集的血液样本的总抗氧化能力显著增加，而与其他组相比，因创伤性脑损伤而给予shilagit提取物的总氧化能力和氧化应激指数值显著降低。结论：结果；Shilajit提取物已被证明在治疗急性创伤性脑损伤中具有神经保护作用。我们的研究表明，shilajit可能是治疗人类继发性脑损伤的一种有用的选择。

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引用次数: 0

Microvascular Patch Graft Angioplasty of the Common Carotid Arteries in Rats. 大鼠颈总动脉微血管贴片移植血管成形术

Turkish neurosurgery

Pub Date : 2021-11-02 DOI: 10.5137/1019-5149.JTN.36478-21.2

Zongyu Xiao, Ji Wang

Background: Microvascular patch graft angioplasty is one of the most important revascularization techniques in cerebrovascular neurosurgery. It is necessary for surgeons to develop the microvascular patch graft angioplasty technique in the laboratory before performing it in a real human body.

Objective: To provide a training model for microvascular patch graft angioplasty of the common carotid arteries (CCAs) in rats.

Methods: Using male Sprague-Dawley rats (n=20), an oval-shaped arterial patch 3 mm in length and 1.2 mm in width was prepared from a segment of left CCA, and a linear longitudinal arteriotomy 3 mm in length was made along the anterior aspect of the right CCA, then the arterial patch graft was anastomosed to the right CCA with 10-0 sutures in an interrupted fashion. Patency was assessed immediately and 30 minutes after the procedure.

Results: All microvascular patch graft angioplasties of the rat common carotid arteries were successful, and all the patency rates immediately after the operation and thirty minutes after the restoration of blood flow were 100%.

Conclusion: The training model for microvascular patch angioplasty with rat CCAs can serve as a training tool for mastering the procedure, and this technique could provide an alternative strategy for the surgical repair of microvascular aneurysms and microvascular vessel injuries.

背景：微血管补片移植血管成形术是脑血管神经外科最重要的血管重建技术之一。外科医生有必要先在实验室中掌握微血管补片移植血管成形术的技术，然后再在真实人体上进行手术：为大鼠颈总动脉（CCA）微血管补片移植血管成形术提供训练模型：方法：使用雄性 Sprague-Dawley 大鼠（n=20），从一段左侧 CCA 上制备一个长 3 毫米、宽 1.2 毫米的椭圆形动脉补片，沿右侧 CCA 的前侧做一个长 3 毫米的线性纵向动脉切口，然后用 10-0 缝线以间断方式将动脉补片移植吻合到右侧 CCA 上。术后立即和 30 分钟后评估通畅情况：结果：大鼠颈总动脉微血管补片移植血管成形术全部成功，术后即刻和术后 30 分钟血流恢复后的通畅率均为 100%：大鼠颈总动脉微血管补片血管成形术的训练模型可作为掌握该手术的训练工具，该技术可为微血管动脉瘤和微血管损伤的手术修复提供一种替代策略。

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