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Osteoplastic Pterional Craniotomy: Success Rate of Surgery in Patient Aspect. 骨质疏松性翼状胬肉开颅术:患者方面的手术成功率。
Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.43674-23.1
Eyup Varol, Furkan Avci, Mustafa Umut Etli, Ali Fatih Ramazanoglu, Serdar Onur Aydin, Abuzer Gungor, Mehmet Resit Onen, Cumhur Kaan Yaltirik

Aim: To evaluate the effect of osteoplastic pterional craniotomy on temporal hollowing and its sequelae.

Material and methods: A total of 97 patients who underwent pterional craniotomy for an aneurysm were analyzed retrospectively. Of these 97 patients, 63 underwent surgery via the conventional pterional approach and 34 underwent surgery via the osteoplastic pterional approach. The temporal muscle volume was calculated bilaterally on CT images obtained in the sixth postoperative month. The results obtained in the conventional and osteoplastic approaches were compared.

Results: Of the 97 included patients, 45 were female and 52 were male. The mean patient age was 50.37 years. In the conventional group, 31 were female and 32 were male. In the osteoplastic group, 14 were female and 20 were male. The temporal muscle volume difference between the operated and non-operated side was not statistically significant in the osteoplastic group. However, the volume was slightly lesser on the operated side than on the non-operated side in the conventional group.

Conclusion: The osteoplastic pterional approach is superior to the conventional approach in preserving the muscle volume and function. Patients who underwent osteoplastic craniotomy demonstrated higher levels of satisfaction with their facial appearance compared to those who underwent craniotomy using the conventional pterional approach.

目的:翼点入路在神经外科是一种常见的手术方法,但它有广泛的并发症,包括颞部凹陷。大多数翼点开颅术后颞叶凹陷的患者在余生中都有心理、身体和社会问题。本研究的目的是探讨骨修复翼点开颅术对颞叶凹陷及其后遗症的影响。材料与方法:对97例经翼点开颅动脉瘤手术的患者进行回顾性分析。其中63例为常规翼点入路,34例为骨修复翼点入道。在术后6个月的双侧CT上计算颞肌体积,并比较传统翼点入路和骨修复入路之间的差异。结果:97名患者被纳入研究,其中45名为女性,52名为男性。这些患者的平均年龄为50.37岁。在常规组的患者中,31人为女性,32人为男性。在骨修复组的患者中,14人为女性,20人为男性。骨整形入路组的左右颞肌体积差异没有统计学意义,而传统翼点入路组与非手术侧相比,颞肌体积略有下降。结论:本研究表明,骨修复翼点入路在保持肌肉体积和功能方面优于传统翼点入法。与使用传统翼点入路进行开颅手术的患者相比,接受骨修复开颅手术的病人对自己的面部外观表现出更高的满意度。
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引用次数: 0
Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats. 石提取物对大鼠实验性头部创伤模型神经保护作用的研究。
Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.37599-22.2
Adil Can Karaoglu, Ibrahim Burak Atci, Nail Demirel, Okan Turk, Canan Hurdag, Ozgur Baran, Nuriye Guzin Ozdemir, Ayhan Kocak, Muhammet Teoman Karakurt

Aim: To investigate the neuroprotective effect of shilajit extract in experimental head trauma.

Material and methods: Three groups of 33 Sprague Dawley Albino strain male rats were included in the study. Group 1 (n=11): trauma but not treated. Group 2 (n=11): trauma and treated with 0.5 mL / rat saline Group 3 (n=11): 150 mg / kg shilajit extract was administered intraperitoneally in the treatment of trauma. Following the head trauma, the indicated treatments were applied to the 2nd and 3rd groups at the first, twenty-four and forty-eighth hours. Brain tissues and blood samples were taken after the control animals were sacrificed at the 72nd hour in all groups after trauma. Sections prepared from cerebral cortex and ca1 region were examined with hematoxylin eosin and luxol fast blue staining. Total antioxidant capacity, total oxidant capacity and oxidative stress index were measured from blood samples taken after routine procedures.

Results: The number of red neurons and the severity of edema were significantly higher in both the cerebral cortex and the ca1 region in the group treated with trauma only and in the group administered saline after trauma compared to the group that received shilajit extract after trauma. The total antioxidant capacity increased significantly in blood samples taken only from the group treated with trauma and saline in post-trauma treatment compared to the group given post-traumatic shilajit extract, while shilajit extract given due to traumatic brain injury significantly decreased the total oxidant capacity and oxidative stress index values compared to the other groups.

Conclusion: Shilajit extract has been shown to have a neuroprotective effect in the treatment of acute traumatic brain injury. Our study showed that shilajit may be a useful option in the treatment of secondary brain injury, in humans.

目的:本研究旨在探讨西拉吉特提取物对实验性颅脑损伤的神经保护作用。材料和方法:本研究包括三组33只Sprague-Dawley-Albino品系雄性大鼠。第1组(n:11):外伤但未治疗。第2组(n:11):创伤并用0.5mL/大鼠生理盐水治疗第3组(n:121):腹膜内给予150 mg/kg shilajit提取物治疗创伤。头部创伤后,第2组和第3组分别在第1、24和48小时进行指定治疗。在创伤后72小时处死对照动物后,各组均采集脑组织和血液样本。从大脑皮层和ca1区制备的切片用血毒毒素-伊红和luxol快速蓝染色进行检查。从常规手术后采集的血液样本中测量总抗氧化能力、总氧化能力和氧化应激指数。结果:与创伤后接受shilajit提取物的组相比,仅接受创伤治疗的组和创伤后给予盐水的组的大脑皮层和ca1区的红色神经元数量和水肿严重程度均显著较高。与创伤后给予shilajit提取物的组相比,仅从创伤后治疗中接受创伤和生理盐水治疗的组中采集的血液样本的总抗氧化能力显著增加,而与其他组相比,因创伤性脑损伤而给予shilagit提取物的总氧化能力和氧化应激指数值显著降低。结论:结果;Shilajit提取物已被证明在治疗急性创伤性脑损伤中具有神经保护作用。我们的研究表明,shilajit可能是治疗人类继发性脑损伤的一种有用的选择。
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引用次数: 0
Microvascular Patch Graft Angioplasty of the Common Carotid Arteries in Rats. 大鼠颈总动脉微血管贴片移植血管成形术
Pub Date : 2021-11-02 DOI: 10.5137/1019-5149.JTN.36478-21.2
Zongyu Xiao, Ji Wang

Background: Microvascular patch graft angioplasty is one of the most important revascularization techniques in cerebrovascular neurosurgery. It is necessary for surgeons to develop the microvascular patch graft angioplasty technique in the laboratory before performing it in a real human body.

Objective: To provide a training model for microvascular patch graft angioplasty of the common carotid arteries (CCAs) in rats.

Methods: Using male Sprague-Dawley rats (n=20), an oval-shaped arterial patch 3 mm in length and 1.2 mm in width was prepared from a segment of left CCA, and a linear longitudinal arteriotomy 3 mm in length was made along the anterior aspect of the right CCA, then the arterial patch graft was anastomosed to the right CCA with 10-0 sutures in an interrupted fashion. Patency was assessed immediately and 30 minutes after the procedure.

Results: All microvascular patch graft angioplasties of the rat common carotid arteries were successful, and all the patency rates immediately after the operation and thirty minutes after the restoration of blood flow were 100%.

Conclusion: The training model for microvascular patch angioplasty with rat CCAs can serve as a training tool for mastering the procedure, and this technique could provide an alternative strategy for the surgical repair of microvascular aneurysms and microvascular vessel injuries.

背景:微血管补片移植血管成形术是脑血管神经外科最重要的血管重建技术之一。外科医生有必要先在实验室中掌握微血管补片移植血管成形术的技术,然后再在真实人体上进行手术:为大鼠颈总动脉(CCA)微血管补片移植血管成形术提供训练模型:方法:使用雄性 Sprague-Dawley 大鼠(n=20),从一段左侧 CCA 上制备一个长 3 毫米、宽 1.2 毫米的椭圆形动脉补片,沿右侧 CCA 的前侧做一个长 3 毫米的线性纵向动脉切口,然后用 10-0 缝线以间断方式将动脉补片移植吻合到右侧 CCA 上。术后立即和 30 分钟后评估通畅情况:结果:大鼠颈总动脉微血管补片移植血管成形术全部成功,术后即刻和术后 30 分钟血流恢复后的通畅率均为 100%:大鼠颈总动脉微血管补片血管成形术的训练模型可作为掌握该手术的训练工具,该技术可为微血管动脉瘤和微血管损伤的手术修复提供一种替代策略。
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引用次数: 0
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Turkish neurosurgery
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