Burns & Trauma最新文献

Children constitute a key population for scar prevention and treatment because of the unique features of their skin's physiological structure and psychosomatic growth. Currently, most approaches to pediatric scar management are formulated with reference to adult-related consensuses and guidelines, which fail to fully account for the specific characteristics of pediatric scars and their distinct needs in relation to growth and development. As a result, there are controversies regarding specific prevention and treatment strategies. To address this limitation, the Chinese Burn Association brought together domestic and international experts from disciplines relevant to the field of scar prevention and treatment. Guided by evidence-based medical evidence, drawing on domestic and international literature, and integrating the clinical experience of specialist physicians, the branch first conducted consultations on clinical issues and then organized multiple rounds of expert meetings for discussions. Eventually, the Clinical practice guideline for pediatric scar prevention and treatment (2025 edition) was developed. Focusing on 10 key aspects of pediatric scar prevention and treatment, the guideline formulates 20 recommendation opinions. It also elaborates on the remaining controversial issues in this field, aiming to provide scientific guidance for the entire process of prevention, treatment, and rehabilitation of scars in children aged 1-14 years.

Research shows that the microbiome of the skin is present as an active contributor to wound healing processes by moving past its historical infection-related function. The review investigates how commensal and probiotic bacteria affect immunomodulation while accelerating epithelial growth, together with tissue repair processes. Researchers use modern methods to link immunological concepts with material science along with synthetic biological techniques to study engineered probiotics which transform current wound treatments. The research study represents an extensive integration of recent findings concerning probiotic-mediated immunomodulatory operations and engineered approaches that improve probiotic delivery systems and their performance during skin wound healing procedures. Recent genetically engineered Lactobacillus reuteri strains that express chemokines like CXCL12 have been found to promote wound healing to an accelerated rate in animal models, and pre-clinical phases of clinical trials in the setting of diabetic foot ulcers (DFU) has demonstrated safety and therapeutic potential. Simultaneously, another live biotherapeutic product has been validated in terms of regenerative and immunomodulatory properties in animal models and in a clinical trial, a multi-cytokine-integrated strain of Lactococcus cremoris secreting FGF-2, IL-4, and CSF-1 promoted faster wound healing in diabetic mice and healed 83% of subjects in a Phase I DFU study. The range of probiotic therapies for trauma care expands due to advancements in probiotic delivery using materials and membrane vesicles derived from probiotics. This review builds a detailed framework that connects core immune functions with modern engineering methods for developing smart wound healing systems that combine engineered probiotics with bioresponsive materials and real-time monitoring systems. Engineered probiotics promise to become an alternative strategy for treating chronic wounds and infection-related complications that currently create significant medical problems.