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An Unexpected Partner in Diabetic Ketoacidosis: Dorsal Pancreatic Agenesis 糖尿病酮症酸中毒的意外伴侣:胰腺背侧发育不全。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.10.404
Aida Izquierdo-Martínez MD , Soralla Civantos-Modino PhD , Gloria Cánovas-Molina MD , Belén Mora-Hernández MD , David Bernal-Bello PhD
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引用次数: 0
What Can We Learn From Studying Diabetes in Diverse Populations? 我们能从不同人群的糖尿病研究中学到什么?
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2024.01.003
Elizabeth A.C. Sellers MD, MSc, FRCPC
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引用次数: 0
Impact of Antenatal Care Modifications on Gestational Diabetes Outcomes During the COVID-19 Pandemic COVID-19 大流行期间产前护理调整对妊娠糖尿病结果的影响
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.12.002
Alexandra Berezowsky MD , Nir Melamed MD , Beth Murray-Davis PhD , Joel Ray MD , Sarah McDonald MD , Jon Barrett MD , Michael Geary MD , Elena Colussi-Pelaez MB, BCh, BAO , Howard Berger MD

Background

Many of the adverse outcomes of gestational diabetes mellitus (GDM) are linked to excessive fetal growth, which is strongly mediated by the adequacy of maternal glycemic management. The COVID-19 pandemic led to a rapid adoption of virtual care models. We aimed to compare glycemic management, fetal growth, and perinatal outcomes before and during the COVID-19 pandemic.

Methods

A retrospective cohort study was conducted between 2017 and 2020. Singleton pregnancies complicated by GDM were included in the study. The cohort was stratified into “before” and “during” COVID-19 subgroups, using March 11, 2020, as the demarcation time point. Women who began their GDM follow-up starting March 11, 2020, and thereafter were allocated to the COVID-19 era, whereas women who delivered before the demarcation point served as the pre–COVID-19 era. The primary outcome was the rate of large-for-gestational-age (LGA) neonates. Secondary outcomes included select maternal and neonatal adverse outcomes.

Results

Seven hundred seventy-five women were included in the analysis, of which 187 (24.13%) were followed during the COVID-19 era and 588 (75.87%) before the COVID-19 era. One hundred seventy-one of the 187 women (91.44%) followed during COVID-19 had at least 1 virtual follow-up visit. No virtual follow-up visits occurred before the COVID-19 era. There was no difference in the rate of LGA neonates between groups on both univariate (5.90% vs 7.30%, p=0.5) and multivariate analyses, controlling for age, ethnicity, parity, body mass index, gestational weight gain, chronic hypertension, smoking, and hypertensive disorders in pregnancy (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 0.49 to 2.51, p=0.80). In the multivariate analysis, there was no difference in composite neonatal outcome between groups (GDM diet: aOR 1.40, 95% CI 0.81 to 2.43, p=0.23; GDM medical treatment: aOR 1.20, 95% CI 0.63 to 2.43, p=0.5).

Conclusions

After adjusting for differences in baseline variables, the combined virtual mode of care was not associated with a higher rate of LGA neonates or other adverse perinatal outcomes in women with GDM. Larger studies are needed to better understand the specific impact of virtual care on less common outcomes in pregnancies with GDM.

目的妊娠期糖尿病的许多不良后果都与胎儿生长过快有关,而胎儿生长过快与孕产妇血糖控制是否适当密切相关。COVID-19 大流行促使人们迅速采用虚拟护理模式。我们旨在比较 COVID-19 大流行之前和期间的血糖控制、胎儿生长和围产期结局。方法在 2017 年至 2020 年期间进行了一项回顾性队列研究。研究纳入了合并妊娠糖尿病的单胎妊娠。以 2020 年 3 月 11 日为分界时间点,将队列分为 COVID-19 前和 COVID-19 期间两个亚组。从 2020 年 3 月 11 日及以后开始随访 GDM 的妇女被分配到 COVID-19 时代,而在分界点之前分娩的妇女则作为 COVID-19 前时代。主要结果是大胎龄新生儿率。结果 775 名产妇被纳入分析,其中 187 人(24.13%)在 COVID-19 时代接受随访,588 人(75.87%)在 COVID-19 时代之前接受随访。在 COVID-19 期间接受随访的 187 名妇女中有 171 名(91.44%)接受过至少一次虚拟随访。在 COVID-19 时代之前,没有进行过虚拟随访。在单变量分析(5.90% vs 7.30%,P=0.5)和多变量分析(控制年龄、种族、奇偶数、体重指数、妊娠体重增加、慢性高血压、吸烟和妊娠期高血压疾病)中,两组间的大胎龄新生儿比率没有差异(aOR 1.11 CI 0.49 至 2.51,P=0.80)。在多变量分析中,两组间的新生儿综合结局没有差异(GDM-饮食治疗的 aOR 1.40(0.81 至 2.43,CI 95%,p=0.23;GDM-药物治疗的 aOR 1.20(0.63 至 2.43,CI 95%,p=0.5))。需要进行更大规模的研究,以进一步评估虚拟护理对妊娠期糖尿病孕妇较不常见结局的具体影响。
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引用次数: 0
Dried Blood Spot Test for Glycated Hemoglobin Measurement in Pediatric Diabetes Care 儿童糖尿病护理中A1c测定的干血点试验。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.10.401
Mallory McNiven MD , Netusha Thevaranjan MD, MSc , Daphne Yau MD, MSc , James Robertson MD , Oluwafemi Oluwole PhD , Joshua Buse PhD , Mark Inman MD, FRCPC

Background

The dried blood spot (DBS) card is a novel collection method for measuring glycated hemoglobin (A1C) in individuals with diabetes mellitus. The potential benefits of DBS specimens compared with traditional phlebotomy include a reduction in required total blood volume, reduced procedural pain, and an ability for self-initiated collection. DBS cards for A1C measurement have been validated in the adult population, but there is a paucity of pediatric data.

Methods

The aim of this study was to validate the use of A1C measurement by DBS cards in comparison to venous A1C and to identify potential barriers to implementing this novel approach. Venous and DBS card A1C samples were collected simultaneously from 62 patients at their local laboratory and transported to the central provincial lab for analysis. Correlation analyses compared venous and DBS A1C with data rescaling performed to account for the DBS–venous interassay difference.

Results

Mean venous A1C was 7.49% and DBS A1C was 7.26%, with an interassay difference of 0.23%. Data showed a strong, positive correlation between A1C collection methods (r=0.86, p<0.001); this was further strengthened at lower A1C values (A1C <7.5%, r=0.87, p<0.0001). A stronger relationship emerged when the data were rescaled to account for the DBS–venous interassay difference (r=0.8935, p<0.0001).

Conclusions

Given the potential feasibility, practicality, accessibility, cost-effectiveness, and performance characteristics of the DBS A1C, especially at lower A1C values hovering around the diagnostic threshold for diabetes, this study provides supporting evidence for consideration of the use of DBS A1C testing in pediatric diabetes care.

背景:干血点(DBS)卡是一种新的测量糖尿病患者糖化血红蛋白A1c的采集方法。与传统的静脉切开术相比,DBS标本的潜在好处是减少了所需的总血容量,减少了手术疼痛,并能够自行采集。用于A1c测量的DBS卡已在成年人群中得到验证,但缺乏儿科数据。方法:本研究的目的是验证DBS卡测量A1c与静脉A1c的比较,并确定实施这种新方法的潜在障碍。在当地实验室同时从62名患者身上采集静脉和DBS卡A1c样本,并将其运至中央省级实验室进行分析。相关性分析将静脉和DBS A1c与数据重新缩放进行了比较,以说明DBS静脉分析间的差异。结果:平均静脉A1c为7.49%;DBS为7.26%;批间差异0.23%。数据显示,A1c采集方法之间的正相关(r=0.86,P结论:鉴于DBS A1c的潜在可行性、实用性和可及性、成本效益和性能特征,特别是在较低的A1c值徘徊在糖尿病诊断阈值附近时,本研究为考虑在儿科糖尿病护理中使用DBS A1c检测提供了支持性证据。
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引用次数: 0
Looking at Diabetes Through Different Lenses: Focus Groups Conducted With Somali Canadian Families and Their Health-care Providers 从不同的角度看糖尿病:与索马里加拿大家庭及其卫生保健提供者进行的焦点小组。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.11.004
Arin C. Deveci MSc , Muskaan Gurnani MD , Margaret C. Wolfe-Wylie MD , Andrea Regina PhD , Kristina Cordeiro MA , Malini G. Dave MD , Farid H. Mahmud MD , Jill Hamilton MD, FRCPC

Objectives

In Toronto, many families with Somali backgrounds have children living with type 1 diabetes (T1D). At our clinic, children with African and Caribbean backgrounds have higher glycated hemoglobin than children from European backgrounds. In this study, we explored the experiences and perspectives of Somali Canadian families with children living with T1D, as well as health-care professionals (HCPs) who care for them, to better understand how T1D impacts these families.

Methods

We conducted 3 separate focus groups with Somali Canadian parents of children with T1D (n=11), Somali Canadian adolescents with T1D (n=5), and HCPs who treat patients with diabetes (n=9), respectively. A grounded theory approach to data analysis was applied to identify themes.

Results

Four key themes emerged: 1) the general impact of living with diabetes, 2) the challenges of self-management, 3) uncertainty on whose job it is to manage the diabetes, and 4) how cultural differences between Canada and Somalia impact diabetes management. There was discordance in the perspectives of families and HCPs for all themes, but especially themes 1 and 3. Parents focussed on the social impact of diabetes and behavioural indicators of management success, whereas HCPs emphasized clinical measures. Families believed children should take charge of their diabetes self-management early on, whereas HCPs believed the children were not developmentally ready for this responsibility.

Conclusions

Differing perspectives of patients, families, and HCPs may lead to diverging expectations for treatment and management. Families and practitioners must work together to identify barriers to care and build strategies to promote competency and resilience in the self-management of T1D.

在多伦多,许多索马里背景的家庭都有患有1型糖尿病(T1D)的孩子。在我们的诊所,来自非洲和加勒比背景的儿童的HbA1c高于来自欧洲背景的儿童。本研究探讨了索马里裔加拿大人患有T1D儿童的家庭的经历和观点,以及照顾他们的医疗保健专业人员(HCP),以更好地了解T1D对这些家庭的影响。方法:我们分别对索马里裔加拿大人T1D儿童的父母(n=11)、索马里裔加拿大人T1D青少年(n=5)和糖尿病HCPs (n=9)进行了三个独立的焦点小组研究。采用扎根理论方法进行数据分析,以确定主题。结果:出现了四个关键主题:1)糖尿病患者生活的一般影响,2)自我管理的挑战,3)管理糖尿病工作的不确定性,以及4)加拿大和索马里之间的文化差异如何影响糖尿病管理。在所有主题中,家庭和HCP的观点都不一致,但主题1和主题3尤其不一致。家长关注糖尿病的社会影响和管理成功的行为指标,而医护人员则强调临床措施。家庭认为孩子应该在早期负责他们的糖尿病自我管理,而HCPs认为孩子们还没有发育好承担这一责任。结论:患者、家庭和医护人员的不同观点可能导致对治疗和管理的不同期望。家庭和从业者必须共同努力,确定护理的障碍,并制定策略,以提高T1D患者自我管理的能力和弹性。
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引用次数: 0
Fasted C-Peptide Distribution and Associated Clinical Factors in Adults With Longstanding Type 1 Diabetes: Analysis of the Canadian Study of Longevity in Type 1 Diabetes 成人长期1型糖尿病患者的空腹C肽分布及相关临床因素:加拿大1型糖尿病长寿研究的分析。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.11.001
Sebastien O. Lanctôt BSc , Leif Erik Lovblom BSc, MSc, PhD , Evan J.H. Lewis PhD , Michelle Morris DDS , Nancy Cardinez NP , Daniel Scarr MSc , Abdulmohsen Bakhsh MD , Mohammad I. Abuabat , Julie A. Lovshin MD, PhD , Yuliya Lytvyn PhD , Geneviève Boulet MD , Alexandra Bussières MD , Michael H. Brent MD , Narinder Paul MD , Vera Bril MD , David Z.I. Cherney MD, PhD , Bruce A. Perkins MD, MPH

Objective

Although insulin production is reportedly retained in many people with longstanding type 1 diabetes (T1D), the magnitude and relevance of connecting peptide (C-peptide) production are uncertain. In this study, we aimed to define fasted C-peptide distributions and associated clinical factors.

Methods

In a cross-sectional analysis of the Canadian Study of Longevity, fasted serum and urinary C-peptide was measured in 74 patients with longstanding T1D (duration ≥50 years) and 75 age- and sex-matched controls. Extensive phenotyping for complications was performed and patient-reported variables were included. C-peptide distributions were analyzed, and multivariable logistic regression was used to assess the variable association in participants with T1D.

Results

The 74 participants with T1D had a mean age of 66±8 years, a disease duration of 54 (interquartile range 52 to 58) years, and a glycated hemoglobin (A1C) of 7.4%±0.8% (56.8±9.15 mmol/mol). The 75 controls had a mean age of 65±8 years and an A1C of 5.7%±0.4% (38.4±4.05 mmol/mol). Participants with T1D had lower fasted serum C-peptide than controls (0.013±0.022 vs 1.595±1.099 nmol/L, p<0.001). Of the participants with T1D, C-peptide was detectable in 30 of 73 (41%) serum samples, 32 of 74 (43%) urine samples, and 48 of 74 (65%) for either serum or urine. The variables independently associated with detectable serum or urinary C-peptide were lower total daily insulin requirement (odds ratio 2.351 [for 1 lower unit/kg], p=0.013) and lower hypoglycemia worry score (odds ratio 1.059 [for 1 point lower on the worry subscore of the Hypoglycemia Fear Survey], p=0.030).

Conclusions

Although detectable C-peptide in longstanding diabetes was common, the magnitude of concentration was extremely low when compared with age- and sex-matched controls. Despite minimal detectability, its presence is validated by lower insulin requirements and strongly associated with lower hypoglycemia worry.

目的:尽管据报道,在许多长期患有1型糖尿病的患者中,胰岛素的产生仍然存在,但C肽产生的幅度和相关性尚不确定。我们旨在确定禁食C肽的分布和相关的临床因素。方法:在加拿大长寿研究的横断面分析中,测量了74名长期T1D(持续时间≥50年)患者和75名年龄和性别匹配的对照组的禁食血清和尿C肽。对并发症进行了广泛的表型分析,并纳入了患者报告的变量。分析了C肽的分布,并使用多变量逻辑回归来检验T1D参与者的变量相关性。结果:74名T1D参与者的平均年龄为66±8岁,糖尿病持续时间为54[52,58]年,HbA1C为7.4±0.8%(56.8±9.15 mmol/mol)。75名对照组的平均年龄为65±8岁,HbA1C为5.7±0.4%(38.4±4.05 mmol/mol)。T1D患者的空腹血清C肽低于对照组(0.013 nmol/L±0.022 vs.1.595 nmol/L士1.099,P结论:虽然可检测的C肽在长期糖尿病中很常见,但与年龄和性别匹配的对照组相比,其浓度极低。尽管可检测性很低,但其存在可通过较低的胰岛素需求来验证,并与较低的低血糖担忧密切相关。
{"title":"Fasted C-Peptide Distribution and Associated Clinical Factors in Adults With Longstanding Type 1 Diabetes: Analysis of the Canadian Study of Longevity in Type 1 Diabetes","authors":"Sebastien O. Lanctôt BSc ,&nbsp;Leif Erik Lovblom BSc, MSc, PhD ,&nbsp;Evan J.H. Lewis PhD ,&nbsp;Michelle Morris DDS ,&nbsp;Nancy Cardinez NP ,&nbsp;Daniel Scarr MSc ,&nbsp;Abdulmohsen Bakhsh MD ,&nbsp;Mohammad I. Abuabat ,&nbsp;Julie A. Lovshin MD, PhD ,&nbsp;Yuliya Lytvyn PhD ,&nbsp;Geneviève Boulet MD ,&nbsp;Alexandra Bussières MD ,&nbsp;Michael H. Brent MD ,&nbsp;Narinder Paul MD ,&nbsp;Vera Bril MD ,&nbsp;David Z.I. Cherney MD, PhD ,&nbsp;Bruce A. Perkins MD, MPH","doi":"10.1016/j.jcjd.2023.11.001","DOIUrl":"10.1016/j.jcjd.2023.11.001","url":null,"abstract":"<div><h3>Objective</h3><p>Although insulin production is reportedly retained in many people with longstanding type 1 diabetes (T1D), the magnitude and relevance of connecting peptide (C-peptide) production are uncertain. In this study, we aimed to define fasted C-peptide distributions and associated clinical factors.</p></div><div><h3>Methods</h3><p><span>In a cross-sectional analysis of the Canadian Study of Longevity, fasted serum and urinary C-peptide was measured in 74 patients with longstanding T1D (duration ≥50 years) and 75 age- and sex-matched controls. Extensive phenotyping for complications was performed and patient-reported variables were included. C-peptide distributions were analyzed, and multivariable </span>logistic regression was used to assess the variable association in participants with T1D.</p></div><div><h3>Results</h3><p>The 74 participants with T1D had a mean age of 66±8 years, a disease duration of 54 (interquartile range 52 to 58) years, and a glycated hemoglobin (A1C) of 7.4%±0.8% (56.8±9.15 mmol/mol). The 75 controls had a mean age of 65±8 years and an A1C of 5.7%±0.4% (38.4±4.05 mmol/mol). Participants with T1D had lower fasted serum C-peptide than controls (0.013±0.022 vs 1.595±1.099 nmol/L, p&lt;0.001). Of the participants with T1D, C-peptide was detectable in 30 of 73 (41%) serum samples, 32 of 74 (43%) urine samples, and 48 of 74 (65%) for either serum or urine. The variables independently associated with detectable serum or urinary C-peptide were lower total daily insulin requirement (odds ratio 2.351 [for 1 lower unit/kg], p=0.013) and lower hypoglycemia worry score (odds ratio 1.059 [for 1 point lower on the worry subscore of the Hypoglycemia Fear Survey], p=0.030).</p></div><div><h3>Conclusions</h3><p>Although detectable C-peptide in longstanding diabetes was common, the magnitude of concentration was extremely low when compared with age- and sex-matched controls. Despite minimal detectability, its presence is validated by lower insulin requirements and strongly associated with lower hypoglycemia worry.</p></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of COVID-19 Lockdown on Occurrence of Acute Complications of Type 1 and Type 2 Diabetes and Overall Glycemic Management Covid-19 锁定对糖尿病急性并发症发生率和总体血糖控制的影响
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.jcjd.2023.12.001
Richa Parihar MD, FRCPC, Simrit Rana BSc, Zubin Punthakee MD, FRCPC, Hertzel Gerstein MD, FRCPC, Manoela Braga MD, FRCPC, Marie Pigeyre MD, PhD

Objectives

The association of diabetes, and COVID-19 infection has been studied extensively; however, the occurrence of diabetic ketoacidosis (DKA) or hyperglycemic/hyperosmolar states (HHS) in adults during the lockdown has not been well characterized. In this study, we aimed to identify the impact of the lockdown on occurrence and severity of DKA/HHS admissions and glycemic management.

Methods

A retrospective chart review was conducted of patients admitted to Hamilton Health Sciences with a diagnosis of DKA or HHS from April to September 2019 (pre-lockdown) and from April to September 2020 (lockdown). Adult (≥18 years old) nonpregnant patients with a single admission in the study period were included for study.

Results

There were 229 admissions related to diabetes, with 171 admissions meeting the inclusion criteria (n=92 pre-lockdown, n=79 lockdown). In the lockdown group, 51.8% of the patients had type 2 diabetes mellitus, with 96.2% of admissions secondary to DKA. When comparing the 2 periods, the lockdown group trended toward higher rates of death (5.4% vs 10.1%, p=0.247) and euglycemic DKA (17.6% vs 24.4%, p=0.403). There were more new diagnoses of type 1 diabetes mellitus in the lockdown group compared with the pre-lockdown group (7.3% vs 16.7%, p=0.230). The average glycated hemoglobin was lower in the lockdown group compared with the pre-lockdown group (11.8% vs 10.4%, p=0.032).

Conclusions

Overall, this study is among the first in Canada to assess the impact of the COVID-19 lockdown on admissions due to DKA and HHS. Although no significant differences were noted in severity of admissions, there was a trend toward more new diagnoses of type 1 diabetes mellitus presenting in DKA during the lockdown period.

无摘要
{"title":"Impact of COVID-19 Lockdown on Occurrence of Acute Complications of Type 1 and Type 2 Diabetes and Overall Glycemic Management","authors":"Richa Parihar MD, FRCPC,&nbsp;Simrit Rana BSc,&nbsp;Zubin Punthakee MD, FRCPC,&nbsp;Hertzel Gerstein MD, FRCPC,&nbsp;Manoela Braga MD, FRCPC,&nbsp;Marie Pigeyre MD, PhD","doi":"10.1016/j.jcjd.2023.12.001","DOIUrl":"10.1016/j.jcjd.2023.12.001","url":null,"abstract":"<div><h3>Objectives</h3><p>The association of diabetes, and COVID-19 infection has been studied extensively; however, the occurrence of diabetic ketoacidosis (DKA) or hyperglycemic/hyperosmolar states (HHS) in adults during the lockdown has not been well characterized. In this study, we aimed to identify the impact of the lockdown on occurrence and severity of DKA/HHS admissions and glycemic management.</p></div><div><h3>Methods</h3><p>A retrospective chart review was conducted of patients admitted to Hamilton Health Sciences with a diagnosis of DKA or HHS from April to September 2019 (pre-lockdown) and from April to September 2020 (lockdown). Adult (≥18 years old) nonpregnant patients with a single admission in the study period were included for study.</p></div><div><h3>Results</h3><p><span>There were 229 admissions related to diabetes, with 171 admissions meeting the inclusion criteria (n=92 pre-lockdown, n=79 lockdown). In the lockdown group, 51.8% of the patients had type 2 diabetes mellitus, with 96.2% of admissions secondary to DKA. When comparing the 2 periods, the lockdown group trended toward higher rates of death (5.4% vs 10.1%, p=0.247) and euglycemic DKA (17.6% vs 24.4%, p=0.403). There were more new diagnoses of type 1 diabetes mellitus in the lockdown group compared with the pre-lockdown group (7.3% vs 16.7%, p=0.230). The average </span>glycated hemoglobin was lower in the lockdown group compared with the pre-lockdown group (11.8% vs 10.4%, p=0.032).</p></div><div><h3>Conclusions</h3><p>Overall, this study is among the first in Canada to assess the impact of the COVID-19 lockdown on admissions due to DKA and HHS. Although no significant differences were noted in severity of admissions, there was a trend toward more new diagnoses of type 1 diabetes mellitus presenting in DKA during the lockdown period.</p></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138573156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open-source Artificial Pancreas Systems Are Safe and Effective When Supported In-clinic: Outcomes in 248 Consecutive Type 1 Diabetes Clients 开源人工胰腺系统在临床上得到支持时是安全有效的:248名连续1型患者的结果。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.jcjd.2023.09.003
Praveen Samuel MBBS , Nabeel Khan BSc , Gerri Klein RN , Sergey Skobkarev MS , Benjamin Mammon BSc, MD , Marc Fournier Dipl , Kate Hawke MBBS, FRACP , Arthur Weissinger PhD , Tom Elliott MBBS

Objective

Our aim in this study was to determine the safety, glycemia, and quality of life (QoL) associated with in-clinic installation and management of supported open-source artificial pancreas systems (SOSAPS) in type 1 diabetes (T1D).

Methods

This investigation is a retrospective cohort study of consecutive SOSAPS users at a Canadian diabetes centre. SOSAPS were offered to all moderately tech-savvy T1D clients on sensor-augmented multiple daily injection or pump, able to pay for hardware, and willing to sign a consent and waiver document. SOSAPS were installed and maintained by clinic staff at no cost to clients. iPhone users were assigned to either Loop (n=108) or iPhone artificial pancreas systems (iAPS; n=114) and Android users to Android-type APS (n=24). Outcomes included severe hypoglycemia and diabetic ketoacidosis (DKA), time in range (TIR) 4.0 to 10.0 mmol/L, time below range (TBR) <4 mmol/L, glucose management indicator (GMI), mean sensor glucose (MSG), change in glycated hemoglobin (A1C), and QoL.

Results

Two hundred forty-eight subjects (131 males, 117 females), with a mean age of 36 years and diabetes duration of 21 years, experienced 3 episodes of severe hypoglycemia and no DKA over a follow-up of 17 months. TIR rose by 16%, from 64% to 80% (p<0.0001); TBR fell by 1.0%, from 3.5% to 2.5% (p=0.001); MSG fell from 9.0 to 8.1 mmol/L (p<0.001); GMI fell from 7.3% to 6.7% (p<0.001); and A1C fell from 7.2% to 6.7% (p<0.0001). QoL scores were healthy before and improved after SOSAPS.

Conclusions

Clients with T1D using SOSAPS and supported with no-cost care to the client (software, technology, and physician/physician assistant) safely achieved improved TIR, GMI, A1C, and QoL.

目的:确定1型糖尿病(T1D)患者在临床安装和管理支持的开源人工胰腺系统(SOSAPS)时的安全性、血糖和生活质量(QoL)。方法:这是一项对加拿大糖尿病中心连续使用SOSAPS的回顾性队列研究。SOSAPS提供给所有技术娴熟的T1D客户,他们使用传感器增强MDI或泵,能够支付硬件费用,并愿意签署同意书和弃权书。SOSAPS由诊所工作人员免费安装和维护。iPhone用户被分配到Loop(n=108)或iAPS(n=114),Android用户被分配给AAPS(n=24)。结果包括严重低血糖和DKA,范围内时间(TIR)4.0-10.0mmol/L,范围外时间(TBR)结果:248名受试者(131M,117F)平均年龄36岁,糖尿病持续时间21年,在17个月的随访中经历了3次严重低血糖发作,无DKA。TIR从64%上升到80%,上升了16%(结论:T1D客户使用SOSAPS,并在无需任何费用的情况下为客户提供支持(软件、技术和医生/医生助理),安全地实现了TIR、GMI、A1c和生活质量的改善。
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引用次数: 0
The Impact of Blood Glucose Test Strips Reimbursement Limits on Utilization, Costs, and Health-care Utilization in British Columbia 不列颠哥伦比亚省血糖试纸报销限额对使用情况、成本和医疗保健使用的影响
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.jcjd.2023.08.005
Ademola Joshua Itiola MPH, MSc , Lucy Cheng MSc , Wei Zhang PhD , Tara Gomes PhD , Baiju R. Shah MD, PhD , Michael R. Law PhD

Objective

People living with diabetes and not using insulin may not derive clinically significant benefit from routine glucose self-monitoring. As a result, in 2015, British Columbia (BC) introduced quantity restrictions for blood glucose test strips (BGTS) coverage in public plans. We studied the impact of this policy on utilization, costs, and health-care utilization.

Methods

We identified a cohort of adults (≥18 years old) with diabetes between 2013 and 2019. Using BC’s administrative data, we studied utilization and costs among individuals with at least one PharmaCare-eligible BGTS claim. Using interrupted time-series analysis, we studied cost savings and determined the level of policy adherence. In addition, we investigated longitudinal changes in all-cause and diabetes-specific physician visits, all-cause hospitalizations, and health-care spending in the 3 to 5 years after policy implementation.

Results

Over the study period, 279.7 million BGTS were eligible for PharmaCare coverage, on which the government spent $124.3 million. After policy implementation, we observed an immediate decline in average utilization and PharmaCare expenditure on BGTS, leading to an estimated $44.6 million in savings between 2015 and 2019 (95% confidence interval $16.9 to $72.3 million). We found no association between the policy’s implementation and health services utilization or overall health-care spending over the long term.

Conclusions

Restricting reimbursement for BGTS in BC resulted in significant cost savings without any attendant increase in health services utilization over the subsequent 5 years. This disinvestment freed up resources that could be channeled toward other interventions.

目标未使用胰岛素的糖尿病患者可能无法从常规血糖自我监测中获得显著的临床益处。因此,不列颠哥伦比亚省(BC)于 2015 年在公共计划中引入了血糖试纸(BGTS)的数量限制。我们研究了这一政策对利用率、成本和医疗保健利用率的影响。方法我们确定了 2013 年至 2019 年期间患有糖尿病的成年人队列(≥18 岁)。利用卑诗省的行政数据,我们研究了至少有一项符合 "医药保健 "资格的 BGTS 申请的个人的使用情况和成本。通过间断时间序列分析,我们研究了成本节约情况,并确定了政策遵守水平。此外,我们还调查了政策实施后 3 到 5 年内全因和糖尿病特异性就诊、全因住院以及医疗保健支出的纵向变化。政策实施后,我们观察到 BGTS 的平均使用率和 PharmaCare 支出立即下降,估计在 2015 年至 2019 年期间可节省 4460 万美元(95% 置信区间为 1690 万美元至 7230 万美元)。我们发现,从长期来看,该政策的实施与医疗服务利用率或总体医疗支出之间并无关联。结论不列颠哥伦比亚省限制对 BGTS 的报销,在随后的 5 年中节省了大量成本,但医疗服务利用率并未随之增加。取消投资释放出的资源可用于其他干预措施。
{"title":"The Impact of Blood Glucose Test Strips Reimbursement Limits on Utilization, Costs, and Health-care Utilization in British Columbia","authors":"Ademola Joshua Itiola MPH, MSc ,&nbsp;Lucy Cheng MSc ,&nbsp;Wei Zhang PhD ,&nbsp;Tara Gomes PhD ,&nbsp;Baiju R. Shah MD, PhD ,&nbsp;Michael R. Law PhD","doi":"10.1016/j.jcjd.2023.08.005","DOIUrl":"10.1016/j.jcjd.2023.08.005","url":null,"abstract":"<div><h3>Objective</h3><p>People living with diabetes and not using insulin may not derive clinically significant benefit from routine glucose self-monitoring. As a result, in 2015, British Columbia (BC) introduced quantity restrictions for blood glucose test strips (BGTS) coverage in public plans. We studied the impact of this policy on utilization, costs, and health-care utilization.</p></div><div><h3>Methods</h3><p>We identified a cohort of adults (≥18 years old) with diabetes between 2013 and 2019. Using BC’s administrative data, we studied utilization and costs among individuals with at least one PharmaCare-eligible BGTS claim. Using interrupted time-series analysis, we studied cost savings and determined the level of policy adherence. In addition, we investigated longitudinal changes in all-cause and diabetes-specific physician visits, all-cause hospitalizations, and health-care spending in the 3 to 5 years after policy implementation.</p></div><div><h3>Results</h3><p>Over the study period, 279.7 million BGTS were eligible for PharmaCare coverage, on which the government spent $124.3 million. After policy implementation, we observed an immediate decline in average utilization and PharmaCare expenditure on BGTS, leading to an estimated $44.6 million in savings between 2015 and 2019 (95% confidence interval $16.9 to $72.3 million). We found no association between the policy’s implementation and health services utilization or overall health-care spending over the long term.</p></div><div><h3>Conclusions</h3><p>Restricting reimbursement for BGTS in BC resulted in significant cost savings without any attendant increase in health services utilization over the subsequent 5 years. This disinvestment freed up resources that could be channeled toward other interventions.</p></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10559317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Intersection of Informatics and Diabetes: Harnessing Technology to Improve Care 信息学与糖尿病的交集:利用技术改善护理
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.jcjd.2023.12.005
Alexander Singer MB BCh BAO, CCFP, FCFP, Conrad Pow, Braden O'Neill MD, DPhil, CCFP
{"title":"The Intersection of Informatics and Diabetes: Harnessing Technology to Improve Care","authors":"Alexander Singer MB BCh BAO, CCFP, FCFP,&nbsp;Conrad Pow,&nbsp;Braden O'Neill MD, DPhil, CCFP","doi":"10.1016/j.jcjd.2023.12.005","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.12.005","url":null,"abstract":"","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139744393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Canadian Journal of Diabetes
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