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Screening and Diagnosis of Chronic Kidney Disease in Adults Living With Diabetes: A Retrospective Cohort Study Using the Canadian Primary Care Sentinel Surveillance Network 糖尿病患者慢性肾病的筛查和诊断:利用加拿大初级保健哨点监测网络开展的一项回顾性队列研究。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.08.001
Jason E. Black MSc , David J.T. Campbell MD, PhD , Paul E. Ronksley PhD , Kerry A. McBrien MD, MPH , Tyler S. Williamson PhD

Objectives

In Canada, regional evaluations of screening practices for chronic kidney disease (CKD) among people with diabetes highlight areas for improvement; however, national estimates are notably absent. Estimates of CKD incidence often discount the expected decline in estimated glomerular filtration rate (eGFR) associated with age; age-adaptive thresholds may help account for this. We describe the frequency of screening and diagnosis of CKD among adults with diabetes from a nationally representative primary care cohort.

Methods

In this retrospective cohort study, we used electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network. We followed adult patients (≥18 years of age) with diabetes without CKD at baseline for 5 years starting in 2014. We determined the frequency of urine albumin-to-creatinine ratio (uACr) and/or eGFR testing over time. We identified incident CKD diagnoses based on eGFR measurements using fixed-threshold and age-adaptive definitions and quantified the incidence proportion and rate.

Results

We analyzed records from 37,604 patients with diabetes. Only 13% of patients had yearly eGFR and uACr testing for CKD, although roughly 60% had non-yearly use of both tests in 5 years. eGFR testing was performed more frequently than uACr testing (94.1% vs 76.6% having testing over follow-up). We found increased incidence proportions (14.6% vs 6.0%) and rates (33.1 vs 13.4 diagnoses per 1,000 person-years) of CKD using the fixed-threshold compared with age-adaptive definition.

Conclusions

Our study presents the first national understanding of screening practices for CKD among people with diabetes in Canada. Specifically, increased use of uACr testing should be encouraged for early detection of changes in kidney function.
导言:在加拿大,对糖尿病患者慢性肾脏病(CKD)筛查方法的地区性评估强调了需要改进的地方;但是,明显缺乏全国性的评估。对慢性肾脏病发病率的估计通常会忽略与年龄相关的 eGFR 预期下降;年龄适应性阈值可能有助于解释这一点。我们描述了具有全国代表性的初级保健队列中成年糖尿病患者筛查和诊断 CKD 的频率:在这项回顾性队列研究中,我们使用了加拿大初级医疗哨点监测网络(CPCSSN)的电子病历数据。从 2014 年开始,我们对基线为无慢性肾脏病的成年糖尿病患者(18 岁以上)进行了为期 5 年的跟踪调查。我们确定了随时间推移进行 ACR 和/或 eGFR 检测的频率。我们使用固定阈值和年龄适应性定义,根据 eGFR 测量结果确定了 CKD 诊断事件,并量化了发病比例和发病率:我们分析了 37 604 名糖尿病患者的记录。只有 13% 的患者每年进行一次 eGFR 和 ACR 检测,以确定是否患有 CKD,但大约 60% 的患者在 5 年内没有每年进行这两项检测。eGFR 检测的频率高于 ACR 检测(94.1% 的患者在随访期间进行过检测,而 76.6% 的患者在随访期间进行过检测)。我们发现,与年龄适应性定义相比,使用固定阈值的 CKD 发病率(14.6% 对 6.0%)和诊断率(33.1 对 13.4/1000 人-年)均有所上升:我们的研究首次在全国范围内了解了加拿大糖尿病患者的 CKD 筛查情况。我们的研究首次在全国范围内了解了加拿大糖尿病患者的慢性肾功能衰竭筛查方法,特别是应鼓励更多地使用 ACR 检测来早期发现肾功能的变化。
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引用次数: 0
Ramadan-Induced Lifestyle Changes: Effects on Sleep and Physical Activity in Nonfasting Individuals With Type 1 Diabetes 斋月对非禁食型 1 型糖尿病患者体育活动障碍、睡眠模式和体能的影响。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.09.146
Warda Lahouel MSc , Mohamed Amine Bouzid PhD , Faten Hadj Kacem MD , Omar Hammouda PhD , Haitham Rebai Pr , Hamdi Frikha MD , Mohamed Abid MD , Mouna Mnif MD , Sémah Tagougui PhD

Objectives

In this study, we aimed to identify sleep patterns, physical fitness, and barriers to physical activity (PA) during Ramadan observance in a cohort of nonfasting individuals with type 1 diabetes (T1D).

Methods

Sixty-one nonfasting individuals with T1D, age 28.34±9.43 years (ranging from 15 to 54 years), completed questionnaires before and during Ramadan. The questionnaires included 3 assessment instruments: the Barriers to Physical Activity in Type 1 Diabetes (BAPAD1), the Pittsburgh Sleep Quality Index (PSQI), and the International Physical Activity Questionnaire.

Results

During Ramadan, there was no significant change in BAPAD1 scores compared to before Ramadan (p=0.378). The primary barriers encompassed hypoglycemia risk, work schedules, diabetes control, and fatigue. Moreover, subjective sleep quality deteriorated during Ramadan compared to the pre-Ramadan period (p<0.001). Sleep duration decreased by 58 minutes (p<0.01) and was associated with later bedtimes and more awakenings. There was a notable decrease in PA levels (p=0.042), particularly for vigorous activities (p=0.017), whereas sedentary time showed a significant increase (p=0.008).

Conclusions

Ramadan observance did not affect barriers to PA in individuals with T1D despite alteration of sleep patterns and PA levels. Lifestyle alterations associated with Ramadan observance significantly impact individuals with T1D who are not fasting, resulting in reduced PA, shortened sleep duration, and increased sedentary time.
目的:本研究旨在探讨 1 型糖尿病(T1D)非禁食患者在斋月期间的睡眠模式、体能和体育锻炼(PA)障碍 方法:61 名非禁食的 1 型糖尿病患者(29 名女性,32 名男性)完成了斋月前和斋月期间的问卷调查,其中包括体育锻炼障碍(BAPAD1)、匹兹堡睡眠质量指数(PSQI)和国际体育锻炼问卷(IPAQ)等评估:结果:在斋月期间,BAPAD1 的得分没有显著增加(P=0.378)。主要障碍包括低血糖风险、工作时间安排、糖尿病控制和疲劳。PSQI 分数显著增加(P=0.378):斋月活动并不影响 T1D 患者的体育锻炼障碍,尽管睡眠模式和体育锻炼方式有所改变。斋月活动引起的生活方式改变对未禁食的 T1D 患者有很大影响,导致体育锻炼减少、睡眠时间缩短和久坐时间增加。
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引用次数: 0
Women’s and Partners’ Experiences With a Closed-loop Insulin Delivery System to Manage Type 1 Diabetes in the Postpartum Period 妇女及其伴侣使用闭环胰岛素输送系统管理产后 1 型糖尿病的经验。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.08.005
Maira Quintanilha RD, PhD , Jennifer M. Yamamoto MD, MSc , Breanne Aylward MSc , Denice S. Feig MD, MSc , Patricia Lemieux MD , Helen R. Murphy MD , Ronald J. Sigal MD, MPH , Josephine Ho MD, MSc , Heidi Virtanen MSc , Susan Crawford MSc , Lois E. Donovan MD, FRCPC , Rhonda C. Bell PhD

Objectives

Closed-loop insulin delivery has the potential to offer women with type 1 diabetes a break from intense diabetes self-care efforts postpartum. Our aim in this study was to explore the views and opinions of hybrid closed-loop users and their partners in the first 24 weeks postpartum.

Methods

This qualitative study was embedded in a controlled study of women with type 1 diabetes randomized to closed-loop insulin delivery (MiniMed 670G or 770G; Medtronic, Minneapolis, Minnesota, United States) or sensor-augmented pump use for 1 to 11 weeks 6 days postpartum, with all on closed-loop delivery from 12 to 24 weeks postpartum. Semistructured interviews were conducted with 16 study participants and their partners at 12 and 24 weeks postpartum. Thematic analyses were used to examine participants’ and partners’ experiences.

Results

Participants’ positive perceptions of closed-loop use related to reduced hypoglycemia, in contrast to previous experiences with nonautomated insulin delivery. These perceptions were balanced against frustrations with the system, allowing blood glucose levels to be higher than desired. Closed-loop use did not influence infant feeding choice, but infant feeding and care impacted participants’ diabetes management. Partners expressed uncertainty about the closed loop taking away control from participants who were highly skilled with diabetes self-management.

Conclusions

Participants reported that closed-loop insulin delivery resulted in less time spent in hypoglycemia when compared with the previously used nonautomated delivery. However, participants desired a greater understanding of the workings of the closed-loop algorithm. Our study provides potential users with realistic expectations about the experience with the MiniMed 670G or 770G closed-loop system in the postpartum period.
背景:闭环胰岛素给药有可能让1型糖尿病妇女在产后从紧张的糖尿病自我护理工作中解脱出来。目的:探讨混合闭环用户及其伴侣在产后24周内的观点和意见:这项定性研究包含在一项对照研究中,研究对象是 1 型糖尿病女性患者,她们在产后 1-11 周 6 天内被随机分配使用(MiniMed™ 670G/770G)闭环胰岛素输送系统或传感器增强泵,并在产后 12-24 周内全部使用闭环胰岛素输送系统。在产后 12 周和 24 周,对 16 名研究参与者及其伴侣进行了半结构式访谈。对参与者及其伴侣的经历进行了主题分析:与以往使用非自动化胰岛素给药的经验相比,参与者对闭环使用减少低血糖有积极的看法。但也有一些人对系统使血糖水平高于他们的期望值而感到沮丧。闭环系统的使用并不影响婴儿的喂养选择。然而,婴儿喂养和护理影响了参与者的糖尿病管理。合作伙伴对闭环系统剥夺了对糖尿病自我管理非常熟练的参与者的控制权表示不确定:与以前使用的非自动化胰岛素给药相比,参与者认为闭环疗法减少了低血糖时间。然而,参与者希望更多地了解闭环算法的工作原理。这项研究为潜在用户提供了对 MiniMed™ 670G/770G 闭环产后用户体验的现实期望。
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引用次数: 0
Glycemic Management in Diabetic Foot Ulcers: A Comparative Analysis of Wound and Wound-free Periods in Adults With Type 1 and Type 2 Diabetes 糖尿病足溃疡的血糖控制:1 型和 2 型糖尿病成人患者伤口和无伤口期的比较分析。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.08.007
Salman Z. Bhat MD , Noora Al-Hajri MD, MPH , Sarah Kanbour MD , Muzzammil Ahmadzada BS , Alexander Borovoy BA , Mohammed S. Abusamaan MD, MPH , Joseph K. Canner MHS , Caitlin Nass NP , Ronald L. Sherman DPM , Kathryn F. Hines PA-C, MS, MBA , Caitlin W. Hicks MD, MS , Christopher J. Abularrage MD , Nestoras Mathioudakis MD, MHS

Objective

Our aim in this study was to determine whether there are differences in glycemia during wound and wound-free states among individuals with diabetes at a multidisciplinary diabetic foot and wound clinic from 2012 to 2019.

Methods

We conducted a retrospective analysis of prospectively collected data over 7.4 years from the Johns Hopkins Multidisciplinary Diabetic Foot and Wound Clinic. Participants with diabetic foot ulcers were observed during at least one wound period and one wound-free period and had at least one glycated hemoglobin (A1C) measurement in both a wound period and a wound-free period. The A1C measurements were aggregated and summarized across wound and wound-free periods, and compared using the Wilcoxon matched-pairs signed rank test.

Results

Two hundred six eligible participants with a total of 623 wounds were included in this analysis. Participants were followed for a median period of 2.4 years (876 days). There were no significant differences in mean, minimum, and maximum A1C between the aggregate wound and wound-free periods, with median values of 7.6% (interquartile range [IQR] 6.6% to 9.1%) and 7.5% (IQR 6.6% to 9.1%) for mean A1C (p=0.43), 6.9% (IQR 6.0% to 8.0%) and 6.8% (6.0% to 8.1%) for minimum A1C (p=0.78), and 8.6% (IQR 7.1% to 10.9%) and 8.5% (IQR 7.0% to 10.7%) for maximum A1C (p=0.06) in the wound and wound-free periods, respectively.

Conclusions

This retrospective study shows similar levels of A1C during wound and wound-free periods; however, given the limitations of missing A1C and small sample size, further studies leveraging continuous glucose monitoring are needed to determine whether glycemia worsens in the setting of a DFU.
目的:确定 2012-2019 年期间在多学科糖尿病足和伤口诊所就诊的糖尿病患者在伤口和无伤口状态下的血糖是否存在差异:我们对约翰霍普金斯大学多学科糖尿病足和伤口诊所 7.4 年来的前瞻性数据进行了回顾性分析。对患有糖尿病足溃疡(DFU)的参与者进行了至少一次伤口期和一次无伤口期的观察,并在伤口期和无伤口期进行了至少一次血红蛋白 A1C(A1C)测量。结果:206 名符合条件的参与者共 623 处伤口被纳入本次分析。参与者的随访时间中位数为 2.4 年(876 天)。总伤口期和无伤口期的平均、最低和最高 A1C 没有明显差异,平均 A1C 的中位数(四分位间 [IQR])值分别为 7.6% (6.6%, 9.1%) 和 7.5% (6.6%, 9. 1%) (见表 2)。平均 A1C 值为 7.6% (6.6%, 9.1%) 和 7.5% (6.6%, 9.1%) (p = 0.43),最低 A1C 值为 6.9% (6.0%, 8.0%) 和 6.8% (6.0%, 8.1%) (p = 0.78),最大 A1C 值为 8.6% (7.1%, 10.9%) 和 8.5% (7.0%, 10.7%) (p = 0.06):这项回顾性研究显示,伤口期和无伤口期的 A1C 水平相似,但鉴于 A1C 缺失和样本量较小的局限性,需要利用连续血糖监测 (CGM) 数据开展进一步研究,以了解 DFU 是否会导致血糖恶化。
{"title":"Glycemic Management in Diabetic Foot Ulcers: A Comparative Analysis of Wound and Wound-free Periods in Adults With Type 1 and Type 2 Diabetes","authors":"Salman Z. Bhat MD ,&nbsp;Noora Al-Hajri MD, MPH ,&nbsp;Sarah Kanbour MD ,&nbsp;Muzzammil Ahmadzada BS ,&nbsp;Alexander Borovoy BA ,&nbsp;Mohammed S. Abusamaan MD, MPH ,&nbsp;Joseph K. Canner MHS ,&nbsp;Caitlin Nass NP ,&nbsp;Ronald L. Sherman DPM ,&nbsp;Kathryn F. Hines PA-C, MS, MBA ,&nbsp;Caitlin W. Hicks MD, MS ,&nbsp;Christopher J. Abularrage MD ,&nbsp;Nestoras Mathioudakis MD, MHS","doi":"10.1016/j.jcjd.2024.08.007","DOIUrl":"10.1016/j.jcjd.2024.08.007","url":null,"abstract":"<div><h3>Objective</h3><div>Our aim in this study was to determine whether there are differences in glycemia during wound and wound-free states among individuals with diabetes at a multidisciplinary diabetic foot and wound clinic from 2012 to 2019.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of prospectively collected data over 7.4 years from the Johns Hopkins Multidisciplinary Diabetic Foot and Wound Clinic. Participants with diabetic foot ulcers were observed during at least one wound period and one wound-free period and had at least one glycated hemoglobin (A1C) measurement in both a wound period and a wound-free period. The A1C measurements were aggregated and summarized across wound and wound-free periods, and compared using the Wilcoxon matched-pairs signed rank test.</div></div><div><h3>Results</h3><div>Two hundred six eligible participants with a total of 623 wounds were included in this analysis. Participants were followed for a median period of 2.4 years (876 days). There were no significant differences in mean, minimum, and maximum A1C between the aggregate wound and wound-free periods, with median values of 7.6% (interquartile range [IQR] 6.6% to 9.1%) and 7.5% (IQR 6.6% to 9.1%) for mean A1C (p=0.43), 6.9% (IQR 6.0% to 8.0%) and 6.8% (6.0% to 8.1%) for minimum A1C (p=0.78), and 8.6% (IQR 7.1% to 10.9%) and 8.5% (IQR 7.0% to 10.7%) for maximum A1C (p=0.06) in the wound and wound-free periods, respectively.</div></div><div><h3>Conclusions</h3><div>This retrospective study shows similar levels of A1C during wound and wound-free periods; however, given the limitations of missing A1C and small sample size, further studies leveraging continuous glucose monitoring are needed to determine whether glycemia worsens in the setting of a DFU.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"48 8","pages":"Pages 517-523.e2"},"PeriodicalIF":2.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Experiences With Hospitalization Due to Diabetes in Alberta, Canada: A Cohort Study Using Survey and Administrative Data 加拿大艾伯塔省患者因糖尿病住院的经历--利用调查和管理数据进行的队列研究。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.10.005
Kyle A. Kemp PhD , Paul Fairie PhD , Maria J. Santana PhD, MPharm, MRPharmS

Objectives

Individuals living with diabetes are often hospitalized. Despite this, little is known about their experiences with hospital care. In this study, we examined the comprehensive experiences of patients hospitalized due to diabetes in Alberta, Canada, and compared them with those of patients hospitalized for other chronic conditions.

Methods

We conducted a retrospective cohort study that linked survey data with inpatient records. Survey data were collected using the Canadian Patient Experiences Survey–Inpatient Care (CPES-IC) instrument. Results from 37 questions were classified as percent in “top box,” which reflects the most positive answer choice. We also examined the association between overall experience and demographic and clinical factors among those living with diabetes.

Results

Over a 7-year period, 12,593 surveys (2,288 with diabetes and 10,305 with other chronic conditions) were obtained. Patients hospitalized due to diabetes had lower “top-box” scores on 24 questions, higher scores on 3 questions, and the remaining 10 questions showed no difference between groups. Those hospitalized due to diabetes indicated potential areas for improvement. These included receiving information about their condition and about the admission process, the nighttime quietness of their hospital room, being informed about possible side effects of new medications, and pain control. Overall experience was also shown to vary according to demographic and clinical factors.

Conclusions

We found that individuals hospitalized due to diabetes reported lower experience scores than those hospitalized due to other chronic conditions. Our findings may be used to develop strategies to improve the patient experience among this cohort.
目标:糖尿病患者经常住院治疗。尽管如此,人们对他们的住院治疗经历却知之甚少。我们研究了加拿大艾伯塔省因糖尿病住院的患者的综合经历,并与因其他慢性病住院的患者进行了比较:我们进行了一项回顾性队列研究,将调查数据与住院记录联系起来。调查数据采用加拿大住院患者体验调查(CPES-IC)工具收集。37 个问题的结果被归类为 "顶部方框 "中的百分比,这反映了最积极的答案选择。我们还研究了糖尿病患者的总体体验与人口统计学和临床因素之间的关联:在七年时间里,我们共收到 12,593 份调查问卷(其中 2,288 份为糖尿病问卷,10,305 份为其他慢性病问卷)。因糖尿病住院的患者在 24 个问题上的 "最高分 "较低,在 3 个问题上得分较高,其余 10 个问题在组间没有差异。因糖尿病住院的患者指出了可能需要改进的地方。其中包括获得有关病情和入院流程的信息、夜间病房的安静程度、了解新药物可能产生的副作用以及疼痛控制。总体体验也因人口统计学和临床因素的不同而有所差异:我们发现,因糖尿病住院的患者的体验得分低于因其他慢性病住院的患者。我们的研究结果可用于制定改善该群体患者就医体验的策略。
{"title":"Patient Experiences With Hospitalization Due to Diabetes in Alberta, Canada: A Cohort Study Using Survey and Administrative Data","authors":"Kyle A. Kemp PhD ,&nbsp;Paul Fairie PhD ,&nbsp;Maria J. Santana PhD, MPharm, MRPharmS","doi":"10.1016/j.jcjd.2024.10.005","DOIUrl":"10.1016/j.jcjd.2024.10.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Individuals living with diabetes are often hospitalized. Despite this, little is known about their experiences with hospital care. In this study, we examined the comprehensive experiences of patients hospitalized due to diabetes in Alberta, Canada, and compared them with those of patients hospitalized for other chronic conditions.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study that linked survey data with inpatient records. Survey data were collected using the Canadian Patient Experiences Survey–Inpatient Care (CPES-IC) instrument. Results from 37 questions were classified as percent in “top box,” which reflects the most positive answer choice. We also examined the association between overall experience and demographic and clinical factors among those living with diabetes.</div></div><div><h3>Results</h3><div>Over a 7-year period, 12,593 surveys (2,288 with diabetes and 10,305 with other chronic conditions) were obtained. Patients hospitalized due to diabetes had lower “top-box” scores on 24 questions, higher scores on 3 questions, and the remaining 10 questions showed no difference between groups. Those hospitalized due to diabetes indicated potential areas for improvement. These included receiving information about their condition and about the admission process, the nighttime quietness of their hospital room, being informed about possible side effects of new medications, and pain control. Overall experience was also shown to vary according to demographic and clinical factors.</div></div><div><h3>Conclusions</h3><div>We found that individuals hospitalized due to diabetes reported lower experience scores than those hospitalized due to other chronic conditions. Our findings may be used to develop strategies to improve the patient experience among this cohort.</div></div>","PeriodicalId":9565,"journal":{"name":"Canadian Journal of Diabetes","volume":"48 8","pages":"Pages 544-550"},"PeriodicalIF":2.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Sodium-Glucose Cotransporter-2 Inhibitors in Adults Aged ≥65 Years With Type 2 Diabetes and Cardiovascular Disease: A Cross-sectional Study of Different Drug Funding Policies 阿尔伯塔省和曼尼托巴省 2 型糖尿病和心血管疾病患者(年龄≥ 65 岁)使用 SGLT-2 抑制剂的比例低于安大略省(2018-2020 年):不同药物资助政策的横断面研究》。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.09.003
Megan L. McCreary MD , Roseanne O. Yeung MD, MPH , Donna P. Manca MD, MCISc , Michelle Greiver MD, MSc , Alexander G. Singer MB, BAO, BCh , Darren Lau MD, PhD, FRCPC

Objectives

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) provide heart and kidney benefits in adults with diabetes and cardiovascular disease (CVD). Public drug coverage policies for SGLT2is differ by province in Canada. In this study, we describe the potential effects of prior authorization/step therapy (PA/ST) and relatively high income-based deductibles, compared with regular benefit status with modest copay, on SGLT2i prescriptions in high-risk adults.

Methods

This investigation was a cross-sectional study of adults ≥65 years of age with type 2 diabetes and CVD and taking at least 1 antihyperglycemic agent from 2019 to 2020. Using electronic medical record data obtained from primary care practices, we compared SGLT2i use (2019 to 2020) in Alberta (PA/ST, modest copay) and Manitoba (PA/ST, relatively high income-based deductible) vs Ontario (regular benefit status, modest copay). Poisson regression was used to adjust for confounders, including age, sex, glycated hemoglobin, and other medication use. Other diabetes medications were estimated as control cases.

Results

We included 3,191 adults (average age 75 years, 31% women). SGLT2i use was lowest in Manitoba (15.6%), followed by Alberta (25.9%), and highest in Ontario (31.9%). After adjustment, compared with Ontario, SGLT2i prescriptions were lower in Alberta (prevalence ratio [PR] 0.80, 95% confidence interval [CI] 0.71 to 0.91, p<0.001) and Manitoba (PR 0.48, 95% CI 0.39 to 0.59, p<0.001).

Conclusions

PA/ST and relatively high deductibles are associated with reduced SGLT2i prescribing---PA/ST by approximately 20% in Alberta and Manitoba, and relatively high deductibles by an additional relative reduction of 40% in Manitoba. PA/ST and cost-sharing policies should be flexible and responsive to changing evidence of clinical benefit.
目标:钠-葡萄糖共转运体 2 抑制剂(SGLT2i)对成人糖尿病和心血管疾病(CVD)患者的心脏和肾脏有益。加拿大各省对 SGLT2i 的公共药物覆盖政策各不相同。我们的研究旨在描述预先授权/阶梯疗法(PA/ST)和相对较高的基于收入的免赔额与适度自付的常规福利状况相比,对高风险成人 SGLT2i 处方的潜在影响:横断面研究:使用来自初级保健实践的电子病历数据,对 2019 年至 2020 年期间年龄≥ 65 岁、患有 2 型糖尿病和心血管疾病、服用≥ 1 种降糖药的患者进行研究。我们比较了阿尔伯塔省(PA/ST,适度自费)和马尼托巴省(PA/ST,基于收入的免赔额相对较高)与安大略省(常规福利状态,适度自费)的 SGLT2i 使用情况(2019-2020 年)。采用泊松回归调整混杂因素,包括年龄、性别、糖化血红蛋白和其他药物使用情况。其他糖尿病药物作为对照病例进行估算:我们纳入了 3191 名成年人(平均年龄 75 岁,31% 为女性)。SGLT2i使用率最低的是马尼托巴省(15.6%),其次是阿尔伯塔省(25.9%),最高的是安大略省(31.9%)。经调整后,与安大略省相比,阿尔伯塔省(患病率比 [PR] 0.80,95% CI [0.71-0.91],p < 0.001)和曼尼托巴省(患病率比 0.48 [0.39-0.59],p < 0.001)的 SGLT2i 处方量较低:在艾伯塔省和马尼托巴省,PA/ST 和相对较高的免赔额与 SGLT2i 处方的减少有关,PA/ST 减少了约 20%,而在马尼托巴省,相对较高的免赔额又相对减少了 40%。PA/ST和费用分担政策应灵活应对不断变化的临床获益证据。
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引用次数: 0
Rising Prevalence of Gestational Diabetes Mellitus in Ontario: A Population-based Study 安大略省妊娠糖尿病发病率上升:基于人口的研究。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.10.001
Hardil A. Bhatt BSc , Gillian L. Booth MD, MSc , Ghazal Fazli PhD , Calvin Ke MD, PhD , Chris Kenaszchuk MSc , Lorraine L. Lipscombe MD, MSc , Sarah Mah PhD , Laura C. Rosella PhD , Deva Thiruchelvam MSc , Baiju R. Shah MD, PhD

Objectives

Gestational diabetes mellitus (GDM) is a common pregnancy complication. Studies have shown that the prevalence of GDM is rising worldwide. In this study, we aimed to describe the prevalence of GDM in Ontario, Canada, between 2015 and 2021.

Methods

Population-based linked health-care administrative databases were used to identify women with GDM via a validated algorithm. Age-standardized GDM prevalence was described for each year between 2015 and 2021. Crude GDM prevalence trends were stratified according to age and income, and trend over time was evaluated using negative binomial regression.

Results

Crude GDM prevalence was 9.5% within this period, with age-standardized prevalence increasing by 35% over the duration of the study (p<0.0001). Prevalence declined in the first year of the COVID-19 pandemic, but it rose again the next year. Prevalence was directly associated with age (p<0.0001) and inversely associated with income (p=0.04), but these disparities did not change over time.

Conclusions

GDM prevalence is rising, but the transient decline in the first year of the pandemic may reflect forgone GDM screening. Disparities in prevalence by age and income are not worsening. GDM is creating a growing burden for the health-care system, particularly for lower income individuals.
目的:妊娠糖尿病(GDM)是一种常见的妊娠并发症。以往的研究表明,全球各国的 GDM 患病率都在上升。我们旨在描述 2015 年至 2021 年加拿大安大略省的 GDM 患病率:方法:使用基于人口的关联医疗保健管理数据库,通过验证算法识别患有 GDM 的妇女。对 2015 年至 2021 年期间每年的年龄标准化 GDM 患病率进行了描述。根据年龄和收入对 GDM 的粗患病率趋势进行分层,并使用负二项回归法评估随时间变化的趋势:结果:在此期间,GDM 的粗患病率为 9.5%,年龄标准化患病率在研究期间增加了 35%(p 结论:GDM 的患病率正在上升:GDM 患病率正在上升,但在大流行第一年出现的短暂下降可能反映出放弃了 GDM 筛查。不同年龄和不同收入人群的患病率差异并未恶化。GDM 给医疗系统造成的负担越来越重,尤其是对低收入人群而言。
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引用次数: 0
Supported Open-source Artificial Pancreas Systems in Type 1 Diabetes With Suboptimal Glycemia 在血糖不达标的 1 型糖尿病患者中支持开源人工胰腺系统。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.09.002
Kate Hawke MBBS, FRACP , Tom Elliott MBBS, FRCPC
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引用次数: 0
A Qualitative Exploration of Participant Experiences in the Avoiding Diabetes After Pregnancy Trial in Moms (ADAPT-M) 对 "避免妈妈怀孕后患糖尿病试验"(ADAPT-M)参与者经历的定性研究。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.08.006
Katelyn Sushko PhD , Shannon Weissman MD, MSc , Dominika Bhatia BSc, PhD , Paige Alliston RD, MHSc , Lorraine Lipscombe MD, MSc, FRCPC , Diana Sherifali RN, PhD

Objectives

Gestational diabetes mellitus (GDM), a temporary condition of pregnancy, identifies women at high risk of developing subsequent type 2 diabetes mellitus (T2D). Lifestyle interventions have been shown to reduce the risk of developing T2D after GDM. However, they often have low attendance and adherence rates. The Avoiding Diabetes After Pregnancy Trial in Moms (ADAPT-M) program is a 24-week, home-based postpartum program aimed at bridging the gap from prenatal care to T2D prevention for women with GDM. Our objective was to explore the experiences of participants who completed the ADAPT-M program, to elicit their perceived benefits and opportunities for improvement.

Methods

This was a qualitative descriptive study wherein we conducted semistructured interviews with 21 women with previous GDM who participated in the ADAPT-M program in Ontario, Canada. Transcripts were analyzed using NVivo software using a conventional content analysis approach.

Results

Two themes describing the experience of women who underwent the ADAPT-M lifestyle-based coaching program emerged: 1) the benefits of a supportive relationship between coaches and participants; and 2) a desire for more from the program, including peer support, more customization, and addressing emotional needs.

Conclusions

Our findings support the importance of fostering supportive health-care relationships in T2D prevention programs for postpartum women with a history of GDM. Enhanced customization, emotional support, and opportunities for peer support should be considered in the development of future programming to better meet the needs of participants.
背景:妊娠期糖尿病(GDM)是一种暂时性的妊娠病症,可识别出随后罹患 2 型糖尿病(T2D)的高风险妇女。生活方式干预已被证明可降低妊娠糖尿病后患 T2D 的风险。然而,这些干预措施的参与率和坚持率往往很低。避免妊娠后糖尿病母亲试验(ADAPT-M)是一项为期 24 周的家庭产后计划,旨在弥补 GDM 妇女从产前保健到 T2D 预防之间的差距。我们的目的是探索完成 ADAPT-M 计划的参与者的经验,以了解她们所感受到的益处和改进机会:这是一项定性描述性研究,我们对 21 名曾患过 GDM 的妇女进行了半结构化访谈,她们参加了加拿大安大略省的 ADAPT-M 项目。访谈记录在 NVivo 中使用传统的内容分析方法进行分析:结果:有两个主题描述了参加 ADAPT-M 基于生活方式的辅导计划的妇女的经历:a) 辅导员与参与者之间的支持性关系带来的益处;b) 希望从该计划中获得更多,包括同伴支持、更多定制以及满足情感需求:我们的研究结果表明,在针对有 GDM 病史的产后妇女的 T2D 预防计划中,培养支持性医疗保健关系非常重要。在制定未来计划时,应考虑加强定制、情感支持和同伴支持机会,以更好地满足参与者的需求。
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引用次数: 0
Prevalence of Long COVID and the Impact on Diabetes Management and Physical Activity Participation in Adults With Type 2 Diabetes: An Australia-wide Cross-sectional Online Survey 2 型糖尿病患者长期 COVID 的患病率及其对糖尿病管理和体育活动参与的影响:澳大利亚全境横断面在线调查。
IF 2.3 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 DOI: 10.1016/j.jcjd.2024.08.004
Emily R. Cox PhD , Ronald C. Plotnikoff PhD , Peter G. Gibson PhD , Shelley E. Keating PhD , Shamasunder Acharya MBBS , Hayley Lewthwaite PhD

Objectives

The aim of this research was to understand the prevalence and impact of long COVID on adults with type 2 diabetes (T2D). Specifically, we sought to identify the proportion of adults with T2D who have had COVID-19 and experienced long COVID symptoms. We also explored how these ongoing symptoms impact diabetes management and physical activity participation.

Methods

Our study was carried out using an online survey of adults in Australia with T2D who had confirmed COVID-19 ≥12 weeks before participation. Respondents were asked to report the presence (and severity) of long COVID symptoms, and, for those with long COVID, the impact of their symptoms on diabetes management (blood glucose, body weight) and physical activity participation (activities of daily living, work/study, exercise).

Results

Survey responses were provided by 1,046 adults with T2D (median age 61.0 [interquartile range 49.8 to 70.0] years; 56.0% men, 42.1% women, and 1% nonbinary/transgender; median T2D duration 10.0 [5.0 to 18.0] years and median time since COVID-19 infection 33.0 [20.3 to 36.1] weeks). Almost one-third (30%) of respondents reported long COVID symptoms (present ≥12 weeks after most recent infection); 40% of respondents with long COVID symptoms reported a worsening of their diabetes management since their COVID-19 infection, with 29% reporting trouble controlling their blood glucose and 43% reporting a higher body weight. Two-thirds of respondents with ongoing symptoms reported that these symptoms moderately to severely impacted their ability to perform activities of daily living, work, and/or exercise. The majority of those with long COVID reported reducing the frequency, duration, and/or intensity of exercise since their COVID-19 infection, with 36.1% not yet returning to their preinfection exercise levels; 66% cited ongoing symptoms as the primary reason for these limitations.

Conclusions

Physical activity is a crucial component of diabetes management. However, the high prevalence of long COVID is hindering participation in this population, as well as deleteriously impacting diabetes management. Developing strategies to support adults with T2D and long COVID to recommence safe levels of physical activity is of critical importance.
研究背景本研究旨在了解长期COVID对2型糖尿病(T2D)患者的患病率和影响。具体来说,就是确定曾患有 COVID-19 并出现长期 COVID 症状的 T2D 患者的比例,并探讨这些持续症状对糖尿病管理和体育活动参与的影响:本研究是一项在线调查,调查对象是澳大利亚的T2D成人患者,他们在参与调查前≥12周已确诊COVID-19。调查要求受访者报告是否存在长期 COVID 症状(以及症状的严重程度),对于存在长期 COVID 症状的受访者,还要报告其症状对糖尿病管理(血糖、体重)和体育活动参与(日常生活活动、工作/学习、运动)的影响:共有 1,046 名 T2D 患者做出了回应(中位年龄 61.0[49.8-70.0] 岁;56.0% 为男性,42.1% 为女性,1% 为非二元/变性人;中位 T2D 病程 10.0[5.0-18.0] 年,自 COVID-19 感染以来的中位时间 33.0[20.3-36.1] 周)。近三分之一(30%)的受访者报告了长期的 COVID 症状(在最近一次感染后出现 12 周或更长时间);40% 有长期 COVID 症状的受访者报告称,自感染 COVID-19 以来,他们的糖尿病控制情况有所恶化,其中 29% 报告称血糖难以控制,43% 报告称体重增加。三分之二有持续症状的受访者表示,这些症状中度至严重影响了他们进行日常生活活动、工作和/或锻炼的能力。感染 COVID-19 后,大多数有长期 COVID 的受访者都表示减少了运动的频率、持续时间和/或强度,36.1% 的受访者尚未恢复到感染前的运动水平;66% 的受访者认为持续症状是主要原因:结论:体育锻炼是糖尿病管理的重要组成部分。结论:体育锻炼是糖尿病管理的重要组成部分,然而,长期 COVID 的高发病率阻碍了这一人群参与体育锻炼,并对糖尿病管理产生了不利影响。制定策略,支持患有 T2D 和长 COVID 的患者重新开始安全水平的体育锻炼至关重要。
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引用次数: 0
期刊
Canadian Journal of Diabetes
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