Pub Date : 2020-07-23DOI: 10.19080/CTOIJ.2020.16.555943
Guran Catalina
The patient presented herself at the hospital in June 2018 with severe anemia (Hgb= 5,4g/dl), mild leucopenia (Le= 3980/mm³) and grade III neutropenia (Ne=557/mm³). She underwent bone marrow biopsy and flow cytometry which established the diagnosis of Large Granular T-cell Leukemia. She was given treatment with Ciclosporine 50mg 6cps/day, which was reduced at 3 cps/day because the patient developed pancytopenia at 6cps/day. The blood count test after 6 months of treatment was greatly improved: she obtained normal levels of hemoglobin and platelets, with the persistence of asymptomatic neutropenia. At the one-year follow-up we had an adequate response, but at the 18 months follow-up she has developed mild pancytopenia, which leads us to believe that she is relapsing under the Ciclosporine treatment.
{"title":"T-Cell Large Granular Lymphocytic Chronic Leukemia: Treatment Experience with Cyclosporine","authors":"Guran Catalina","doi":"10.19080/CTOIJ.2020.16.555943","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555943","url":null,"abstract":"The patient presented herself at the hospital in June 2018 with severe anemia (Hgb= 5,4g/dl), mild leucopenia (Le= 3980/mm³) and grade III neutropenia (Ne=557/mm³). She underwent bone marrow biopsy and flow cytometry which established the diagnosis of Large Granular T-cell Leukemia. She was given treatment with Ciclosporine 50mg 6cps/day, which was reduced at 3 cps/day because the patient developed pancytopenia at 6cps/day. The blood count test after 6 months of treatment was greatly improved: she obtained normal levels of hemoglobin and platelets, with the persistence of asymptomatic neutropenia. At the one-year follow-up we had an adequate response, but at the 18 months follow-up she has developed mild pancytopenia, which leads us to believe that she is relapsing under the Ciclosporine treatment.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85613638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-10DOI: 10.19080/OROAJ.2020.16.555942
D. Nath
Introduction: Head and neck swellings and nodules are commonly seen in the pediatric population with most of the lesions falling in the benign neoplasm category. Auricular tumors are relatively rare with most common swellings being infective or congenital. Giant cell mesenchymal tumors are an entire spectrum of tumors and they are rarely been reported on the pinna. Pilomatricoma is an unusual, relatively rare, slowly growing benign tumor of the skin appendages. The histomorphological features of pilomatricoma are characteristic, but the cytological diagnosis remains problematic because of mimickers with other small round blue cell tumors. Here we present a case of pilomatricoma which presented with diagnostic pitfall in cytological diagnosis Case: A two-and-a-half-month-old female child presented with a slowly growing fleshy pinkish whitish firm swelling at the medial aspect of the right pinna for last 1 month. The swelling was painless and was not associated with other symptoms like fever, discharge from the lesion or external ear, any hearing loss or ulceration and destruction of the surrounding area. FNAC was done and scant blood mixed material aspirated. Smears showed presence of few clusters of mononuclear round blue cells with few spindled cells with fair number of giant cells admixed with very scant amorphous pink material on a hemorrhagic background. A diagnosis of giant cell mesenchymal lesion was made, and histopathology was advised. Histopathological examination revealed presence of giant cells against intradermal keratin admixed with ghost cells and basaloid to mononuclear intermediate cells. A diagnosis of pilomatricoma was made. Conclusion: The case highlights how giant cells on cytology may masquerade as giant cell mesenchymal lesion in a classic case of pilomatricoma from an uncommon location like pinna in a pediatric patient and may act as a diagnostic pitfall for the cytologist.
{"title":"Cytological Diagnosis of Giant Cell Lesions in Infants-A Red Herring","authors":"D. Nath","doi":"10.19080/OROAJ.2020.16.555942","DOIUrl":"https://doi.org/10.19080/OROAJ.2020.16.555942","url":null,"abstract":"Introduction: Head and neck swellings and nodules are commonly seen in the pediatric population with most of the lesions falling in the benign neoplasm category. Auricular tumors are relatively rare with most common swellings being infective or congenital. Giant cell mesenchymal tumors are an entire spectrum of tumors and they are rarely been reported on the pinna. Pilomatricoma is an unusual, relatively rare, slowly growing benign tumor of the skin appendages. The histomorphological features of pilomatricoma are characteristic, but the cytological diagnosis remains problematic because of mimickers with other small round blue cell tumors. Here we present a case of pilomatricoma which presented with diagnostic pitfall in cytological diagnosis Case: A two-and-a-half-month-old female child presented with a slowly growing fleshy pinkish whitish firm swelling at the medial aspect of the right pinna for last 1 month. The swelling was painless and was not associated with other symptoms like fever, discharge from the lesion or external ear, any hearing loss or ulceration and destruction of the surrounding area. FNAC was done and scant blood mixed material aspirated. Smears showed presence of few clusters of mononuclear round blue cells with few spindled cells with fair number of giant cells admixed with very scant amorphous pink material on a hemorrhagic background. A diagnosis of giant cell mesenchymal lesion was made, and histopathology was advised. Histopathological examination revealed presence of giant cells against intradermal keratin admixed with ghost cells and basaloid to mononuclear intermediate cells. A diagnosis of pilomatricoma was made. Conclusion: The case highlights how giant cells on cytology may masquerade as giant cell mesenchymal lesion in a classic case of pilomatricoma from an uncommon location like pinna in a pediatric patient and may act as a diagnostic pitfall for the cytologist.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82457540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-02DOI: 10.19080/CTOIJ.2020.16.555941
D. Khosla
Cutaneous metastasis from gastric cancer is an uncommon manifestation and portends dismal prognosis. A 44-year old male presented with multiple nodules months. On subsequent investigations, primary site of malignancy was found in the stomach. The patient was started on palliative chemotherapy and finally succumbed to disease.
{"title":"Widespread Cutaneous Metastasis as an Initial Clinical Presentation in Gastric Cancer","authors":"D. Khosla","doi":"10.19080/CTOIJ.2020.16.555941","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555941","url":null,"abstract":"Cutaneous metastasis from gastric cancer is an uncommon manifestation and portends dismal prognosis. A 44-year old male presented with multiple nodules months. On subsequent investigations, primary site of malignancy was found in the stomach. The patient was started on palliative chemotherapy and finally succumbed to disease.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86022508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-21DOI: 10.19080/ctoij.2021.19.556004
N. Vaddeboina
We present a case of 71-year-old male who presented with a painless nodular growth on the lateral aspect of left thigh. MRI was suggestive of irregular exophytic lesion in the left gluteal region with enlarged left inguinal nodes. Biopsy suggested malignant adnexal tumor- porocarcinoma. Patient underwent wide local excision followed by adjuvant chemotherapy and radiation. In spite of the aggressive management, patient had a local disease recurrence within 3 months.
{"title":"Eccrine Porocarcinoma, A Rare Aggressive Malignant Adnexal Tumor of the Skin: A Case Report","authors":"N. Vaddeboina","doi":"10.19080/ctoij.2021.19.556004","DOIUrl":"https://doi.org/10.19080/ctoij.2021.19.556004","url":null,"abstract":"We present a case of 71-year-old male who presented with a painless nodular growth on the lateral aspect of left thigh. MRI was suggestive of irregular exophytic lesion in the left gluteal region with enlarged left inguinal nodes. Biopsy suggested malignant adnexal tumor- porocarcinoma. Patient underwent wide local excision followed by adjuvant chemotherapy and radiation. In spite of the aggressive management, patient had a local disease recurrence within 3 months.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84321725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-11DOI: 10.19080/CTOIJ.2020.16.555938
Paras Abbas
A 66-year-old post-menopausal woman presented in oncology department of AECH NORI, with the history of progressively increasing abdominal distension for about 6 months. It was not associated with pain or any other urinary or gynecological symptoms. Her ultrasound abdomen pelvis was done which showed no mass lesion and normal sized ovary on left side while there was a complex lesion measuring 138x12.8x8.2 cm in right adnexa. Right ovary was not separately visualized. Her CT scan showed a large well defined, soft tissue attenuation complex pelvis mass measuring 12.7x10.7x13.8cm in midline slightly more towards right; the lesion had solid as well as cystic components with areas of calcification but no internal fat. No pelvic lymph node enlargement or fluid collection was seen. Patient underwent exploratory laparotomy. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done and peritoneal washings were taken On gross examination the left ovary was 3x1.5x1cm and was attached to fallopian tube, cut surface of the ovary was unremarkable, while the specimen of right ovary comprised of a cyst attached to fallopian tube, the cyst was 14x12 cm and fallopian tube 10x0.3cm in size. It showed solid and cystic areas, it contained yellowish fluid and foci of necrosis were seen.
{"title":"An Unusual Presentation of Brenner Tumor from Northern Pakistan","authors":"Paras Abbas","doi":"10.19080/CTOIJ.2020.16.555938","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555938","url":null,"abstract":"A 66-year-old post-menopausal woman presented in oncology department of AECH NORI, with the history of progressively increasing abdominal distension for about 6 months. It was not associated with pain or any other urinary or gynecological symptoms. Her ultrasound abdomen pelvis was done which showed no mass lesion and normal sized ovary on left side while there was a complex lesion measuring 138x12.8x8.2 cm in right adnexa. Right ovary was not separately visualized. Her CT scan showed a large well defined, soft tissue attenuation complex pelvis mass measuring 12.7x10.7x13.8cm in midline slightly more towards right; the lesion had solid as well as cystic components with areas of calcification but no internal fat. No pelvic lymph node enlargement or fluid collection was seen. Patient underwent exploratory laparotomy. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done and peritoneal washings were taken On gross examination the left ovary was 3x1.5x1cm and was attached to fallopian tube, cut surface of the ovary was unremarkable, while the specimen of right ovary comprised of a cyst attached to fallopian tube, the cyst was 14x12 cm and fallopian tube 10x0.3cm in size. It showed solid and cystic areas, it contained yellowish fluid and foci of necrosis were seen.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75719655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-10DOI: 10.19080/CTOIJ.2020.16.555937
C. McDonald
Summary A 47-year-old man was admitted to an intensive care unit for increasing respiratory distress, persistent diarrhoea and general decline on a background of longstanding myasthenia gravis and metastatic thymic carcinoma. He had recently been involved in a phase 1 clinical trial with the drug FN-1501- an inhibitor of cyclin dependent kinases CDK2/CDK4/CDK6 and tyrosine kinase (TK) FLT3. The patient was found to have severe systolic dysfunction on echocardiography, consistent with myocarditis, for which he required inotropic support. It was only partially responsive to steroid treatment. In combination with the patient’s myasthenia gravis and deconditioning, the myocarditis contributed to the patient’s continued decline and ultimate death. This case explores the possibility that the patient’s myocardial injury and subsequent death was related to the trial drug FN-1501. An association between TK inhibitors and cardiotoxicity has been outlined in the past but the cardiac effects of CDK inhibitors is still in question. There is no data presently implicating FN-1501.
{"title":"Myocarditis in a 47-Year-Old Man with Myasthenia Gravis and Malignant Thymoma Following the Administration of a Tyrosine Kinase/CDK Inhibitor","authors":"C. McDonald","doi":"10.19080/CTOIJ.2020.16.555937","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555937","url":null,"abstract":"Summary A 47-year-old man was admitted to an intensive care unit for increasing respiratory distress, persistent diarrhoea and general decline on a background of longstanding myasthenia gravis and metastatic thymic carcinoma. He had recently been involved in a phase 1 clinical trial with the drug FN-1501- an inhibitor of cyclin dependent kinases CDK2/CDK4/CDK6 and tyrosine kinase (TK) FLT3. The patient was found to have severe systolic dysfunction on echocardiography, consistent with myocarditis, for which he required inotropic support. It was only partially responsive to steroid treatment. In combination with the patient’s myasthenia gravis and deconditioning, the myocarditis contributed to the patient’s continued decline and ultimate death. This case explores the possibility that the patient’s myocardial injury and subsequent death was related to the trial drug FN-1501. An association between TK inhibitors and cardiotoxicity has been outlined in the past but the cardiac effects of CDK inhibitors is still in question. There is no data presently implicating FN-1501.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"182 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89694494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.19080/CTOIJ.2020.16.555934
Tareq Salah
late-Abstract Adjuvant Radiotherapy (RT) is an essential part of Breast cancer treatment with proved survival advantage . Although its radiobiological and clinical advantage becoming a standard of care practice in most centers, Hypofractionation (HF) still of a concern in certain clinical situations. Treatment Protocols are still variable across the ocean and worldwide. With the recent publications of the extreme hypofractionation we have a wide range of evidence-based protocols. This is a review of radiobiological bases and current evidence for hypofractionation in breast cancer radiation therapy starting from the basic science base up to the most recent studies.
{"title":"Adjuvant Hypo Fractionated Whole Breast Radiation therapy: A Review of Literature from Bench to Clinic","authors":"Tareq Salah","doi":"10.19080/CTOIJ.2020.16.555934","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555934","url":null,"abstract":"late-Abstract Adjuvant Radiotherapy (RT) is an essential part of Breast cancer treatment with proved survival advantage . Although its radiobiological and clinical advantage becoming a standard of care practice in most centers, Hypofractionation (HF) still of a concern in certain clinical situations. Treatment Protocols are still variable across the ocean and worldwide. With the recent publications of the extreme hypofractionation we have a wide range of evidence-based protocols. This is a review of radiobiological bases and current evidence for hypofractionation in breast cancer radiation therapy starting from the basic science base up to the most recent studies.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81494215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-12DOI: 10.19080/CTOIJ.2020.16.555933
Anu Bajaj
Weiss and Enzinger described a contemporary vascular tumour formerly denominated as “spindle cell haemangioendothelioma†in 1986, a neoplasm which was considered to represent an unusual variety of low-grade angiosarcoma. However, as the terminology was suggestive of malignant potential, the neoplasm was subsequently designated as a “spindle cell haemangioma†[1].
{"title":"The Endothelial Metamorphoses-Spindle Cell Haemangioma","authors":"Anu Bajaj","doi":"10.19080/CTOIJ.2020.16.555933","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555933","url":null,"abstract":"Weiss and Enzinger described a contemporary vascular tumour formerly denominated as “spindle cell haemangioendothelioma†in 1986, a neoplasm which was considered to represent an unusual variety of low-grade angiosarcoma. However, as the terminology was suggestive of malignant potential, the neoplasm was subsequently designated as a “spindle cell haemangioma†[1].","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"172 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78936740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-07DOI: 10.19080/CTOIJ.2020.16.555931
G. Sharma
Bone metastases are rare in carcinoma penis mostly localized in the axial skeleton .We here present patient of carcinoma penis who progressed to multiple bony sites after surgery in short time interval within 6 months.
{"title":"Skeletal Metastasis in Carcinoma Penis Case Report with Review of Literature","authors":"G. Sharma","doi":"10.19080/CTOIJ.2020.16.555931","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555931","url":null,"abstract":"Bone metastases are rare in carcinoma penis mostly localized in the axial skeleton .We here present patient of carcinoma penis who progressed to multiple bony sites after surgery in short time interval within 6 months.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78289282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-22DOI: 10.19080/CTOIJ.2020.16.555929
P. Wysocki
The SARS-CoV-2 pandemic has a significant influence on the functioning of every aspect of health care, including oncology. There is no doubt, the highest risk of complication or death due to SARS-CoV-2 infection is observed in elderly and patients with comorbidities [1]. Since the majority of cancers (>60%) is diagnosed in patients 65 years of age, cancer patients represent the population at high risk of COVID-19-related complications. Available literature data on the course of COVID-19 in cancer patients are scarce and comprise of two papers and 46 patients [2,3the clinical characteristics of COVID-19-infected cancer patients are largely unknown. PATIENTS AND METHODS In this retrospective cohort study, we included cancer patients with laboratory confirmed COVID-19 from three designated hospitals in Wuhan, China. The clinical data were collected from medical records from Jan 13, 2020, to Feb 26, 2020. Univariate and multivariate analyses were performed to assess the risk factors associated with severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death. RESULTS 28 COVID-19-infected cancer patients were included; 17 (60.7%]. In the first publication, Liang et al. [2] evaluated data on 1590 COVID-19 patients, including 18 (1%) with a cancer diagnosis. The frequency of cancer in this population was 3-times higher than in the general Chinese population (0.29%). The majority of evaluated patients was in follow-up after cancer treatment, and systemic therapy was administered in only six patients. Four patients were diagnosed with lung cancer (2 receiving targeted treatment, 2 – chemotherapy), 1 with renal cell cancer (treated with immunotherapy), 1 with breast cancer (no information on the type of adjuvant treatment). Severe complications associated with COVID-19 were generally more frequent in cancer patients than in the general population (39% vs. 8%), but cancer patients were older (mean age – 63.1 vs. 48.7) and smoked cigarettes (22% vs. 7%). In lung cancer patients, who had undergone chemotherapy or surgery within one month before COVID-19 diagnosis, severe complications were more frequent than in patients in a long-term follow-up 75% vs. 43%, respectively.
{"title":"Systemic Treatment of Cancer Patients during SARS-CoV-2 Pandemic","authors":"P. Wysocki","doi":"10.19080/CTOIJ.2020.16.555929","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.16.555929","url":null,"abstract":"The SARS-CoV-2 pandemic has a significant influence on the functioning of every aspect of health care, including oncology. There is no doubt, the highest risk of complication or death due to SARS-CoV-2 infection is observed in elderly and patients with comorbidities [1]. Since the majority of cancers (>60%) is diagnosed in patients 65 years of age, cancer patients represent the population at high risk of COVID-19-related complications. Available literature data on the course of COVID-19 in cancer patients are scarce and comprise of two papers and 46 patients [2,3the clinical characteristics of COVID-19-infected cancer patients are largely unknown. PATIENTS AND METHODS In this retrospective cohort study, we included cancer patients with laboratory confirmed COVID-19 from three designated hospitals in Wuhan, China. The clinical data were collected from medical records from Jan 13, 2020, to Feb 26, 2020. Univariate and multivariate analyses were performed to assess the risk factors associated with severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death. RESULTS 28 COVID-19-infected cancer patients were included; 17 (60.7%]. In the first publication, Liang et al. [2] evaluated data on 1590 COVID-19 patients, including 18 (1%) with a cancer diagnosis. The frequency of cancer in this population was 3-times higher than in the general Chinese population (0.29%). The majority of evaluated patients was in follow-up after cancer treatment, and systemic therapy was administered in only six patients. Four patients were diagnosed with lung cancer (2 receiving targeted treatment, 2 – chemotherapy), 1 with renal cell cancer (treated with immunotherapy), 1 with breast cancer (no information on the type of adjuvant treatment). Severe complications associated with COVID-19 were generally more frequent in cancer patients than in the general population (39% vs. 8%), but cancer patients were older (mean age – 63.1 vs. 48.7) and smoked cigarettes (22% vs. 7%). In lung cancer patients, who had undergone chemotherapy or surgery within one month before COVID-19 diagnosis, severe complications were more frequent than in patients in a long-term follow-up 75% vs. 43%, respectively.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81769434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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