Pub Date : 2020-12-11DOI: 10.19080/ctoij.2020.17.555966
Hanan Abdelrazek Soliman Abotaleb
{"title":"Study and Analysis of the Conformation Number and the Integral Dose as Evaluation Tools in Head and Neck Tumors: for Advanced 3-Dimensional Conformal Radiation Therapy Techniques","authors":"Hanan Abdelrazek Soliman Abotaleb","doi":"10.19080/ctoij.2020.17.555966","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555966","url":null,"abstract":"","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"30 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82739249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-09DOI: 10.19080/ctoij.2020.17.555965
M. Baig
{"title":"When planning IMRT Technique for Head and Neck Cancer by Radiation Oncologist what needs to know?","authors":"M. Baig","doi":"10.19080/ctoij.2020.17.555965","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555965","url":null,"abstract":"","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80383716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-25DOI: 10.19080/CTOIJ.2020.17.555964
Zvonimir Bosnić
Monoclonal gammopathy of undetermined significance (MGUS) presents a rare premalignant clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein, less than 10% of clonal plasma cells in the bone marrow and absence of multiple myeloma or related lymphoplasmacytic malignancies [1,2]. It is associated with a rate of progression to multiple myeloma or a related malignant condition of 1 percent per year or less [3]. The prevalence of monoclonal gammopathy of undetermined significance among persons 50 years of age or older has not been accurately determined [4]. In previous studies, the frequency of monoclonal immunoglobulins in serum from a normal population has been reported to be 0.5 to 3.6 percent among patients seen in community practice, and usually it was the coincidental finding of MGUS [5-7]. Previous reports expected that the number of living individuals diagnosed with MGUS will be well over a million in next 30 years [8]. Cause current practice guidelines do not recommend routine screening for MGUS in the general population because of the lack of proven benefit and absence of curative or preventive therapy. In this overview, we assume severe difficulities in managment of MGUS in patients aged 60 years and more in primary health care. Abstract
{"title":"Lack of Awareness in Managment and Monitoring of Monoclonal Gammopathy of Undetermined Significance (MGUS) in Patients aged 60 years and more in Primary Health Care: Short Communication","authors":"Zvonimir Bosnić","doi":"10.19080/CTOIJ.2020.17.555964","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.17.555964","url":null,"abstract":"Monoclonal gammopathy of undetermined significance (MGUS) presents a rare premalignant clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein, less than 10% of clonal plasma cells in the bone marrow and absence of multiple myeloma or related lymphoplasmacytic malignancies [1,2]. It is associated with a rate of progression to multiple myeloma or a related malignant condition of 1 percent per year or less [3]. The prevalence of monoclonal gammopathy of undetermined significance among persons 50 years of age or older has not been accurately determined [4]. In previous studies, the frequency of monoclonal immunoglobulins in serum from a normal population has been reported to be 0.5 to 3.6 percent among patients seen in community practice, and usually it was the coincidental finding of MGUS [5-7]. Previous reports expected that the number of living individuals diagnosed with MGUS will be well over a million in next 30 years [8]. Cause current practice guidelines do not recommend routine screening for MGUS in the general population because of the lack of proven benefit and absence of curative or preventive therapy. In this overview, we assume severe difficulities in managment of MGUS in patients aged 60 years and more in primary health care. Abstract","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87884757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-19DOI: 10.19080/ctoij.2020.17.555962
Asmaa El Hussainy
{"title":"CXCR4 Antagonist AMD3100 (Plerixafor) Modulates Immune Responses in the Tumor Microenvironment","authors":"Asmaa El Hussainy","doi":"10.19080/ctoij.2020.17.555962","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555962","url":null,"abstract":"","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89342013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-19DOI: 10.19080/ctoij.2020.17.555961
Asmaa El Hussainy
Background: Cytoreductive surgery (CRS) followed by hyper thermic intraperitoneal chemotherapy (HIPEC) is an evolving treatment for peritoneal carcinomatosis (PC). Mitomycin C (MMC), an alkylating agent, is presently the most commonly used chemotherapeutic agent for hyper thermic intraperitoneal treatment. The spleen has a role in the hematologic response after HIPEC and that splenectomy may enhance hematologic toxicity profiles of MMC. We are presenting a case who developed persistent thrombocytosis After Cytoreductive surgery followed by HIPEC. Case presentation: on routine absence of any cause of essential thrombocytosis. Conclusion: This article to emphasize that Persistent reactive thrombocytosis can occur in a case of peritoneal carcinomatosis after CRS followed by HIPEC.
{"title":"Persistent Thrombocytosis in a Case of Pseudomyxoma Peritonea Post CRS and HIPEC -A Case Report","authors":"Asmaa El Hussainy","doi":"10.19080/ctoij.2020.17.555961","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555961","url":null,"abstract":"Background: Cytoreductive surgery (CRS) followed by hyper thermic intraperitoneal chemotherapy (HIPEC) is an evolving treatment for peritoneal carcinomatosis (PC). Mitomycin C (MMC), an alkylating agent, is presently the most commonly used chemotherapeutic agent for hyper thermic intraperitoneal treatment. The spleen has a role in the hematologic response after HIPEC and that splenectomy may enhance hematologic toxicity profiles of MMC. We are presenting a case who developed persistent thrombocytosis After Cytoreductive surgery followed by HIPEC. Case presentation: on routine absence of any cause of essential thrombocytosis. Conclusion: This article to emphasize that Persistent reactive thrombocytosis can occur in a case of peritoneal carcinomatosis after CRS followed by HIPEC.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85720197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-17DOI: 10.19080/CTOIJ.2020.17.555960
William Pham, T. Pham, Pamela Maldonado
{"title":"Enhancing Mammogram Images with Segmentation and Colorization for Assisting Breast Cancer Detection","authors":"William Pham, T. Pham, Pamela Maldonado","doi":"10.19080/CTOIJ.2020.17.555960","DOIUrl":"https://doi.org/10.19080/CTOIJ.2020.17.555960","url":null,"abstract":"","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86594353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-06DOI: 10.19080/ctoij.2020.17.555959
O. Sager
Background: Hemangiopericytomas arise from the mesenchymal cells with pericytic differentiation. Clinical course of these rare tumors may be aggressive with high propensity for local recurrence and metastases. Radical resection is the treatment of choice for lesions amenable to surgery. Nevertheless, radiation therapy (RT) may have a role in management of hemangiopericytomas either as an adjunctive, salvage or primary treatment, or for palliation of metastases in selected patients. Target volume definition is a critical aspect of RT. Objective: Aim of this study is to assess incorporation of multimodality imaging with magnetic resonance imaging (MRI) into target volume definition for irradiation of hemangiopericytomas. Methods: In this study, treatment volume definition with multimodality imaging by incorporating MRI or by use of computed tomography (CT)-simulation images only was comparatively evaluated for patients with hemangiopericytoma. Results: Ground truth target volume defined by the board-certified radiation oncologists following meticulous evaluation, colleague peer review, collaboration, and ultimate consensus was found to be identical with target determination based on CT-MR fusion based imaging in this study. Conclusion: Accurate target volume determination is an indispensable part of RT for management of hemangiopericytomas. Incorporation of MRI in the target volume definition process may be considered for optimization of treatment volume designation for successful RT applications. Clearly, future studies are required to shed light on this issue.
{"title":"Assessment of Target Volume Definition for Irradiation of Hemangiopericytomas: An Original Article","authors":"O. Sager","doi":"10.19080/ctoij.2020.17.555959","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555959","url":null,"abstract":"Background: Hemangiopericytomas arise from the mesenchymal cells with pericytic differentiation. Clinical course of these rare tumors may be aggressive with high propensity for local recurrence and metastases. Radical resection is the treatment of choice for lesions amenable to surgery. Nevertheless, radiation therapy (RT) may have a role in management of hemangiopericytomas either as an adjunctive, salvage or primary treatment, or for palliation of metastases in selected patients. Target volume definition is a critical aspect of RT. Objective: Aim of this study is to assess incorporation of multimodality imaging with magnetic resonance imaging (MRI) into target volume definition for irradiation of hemangiopericytomas. Methods: In this study, treatment volume definition with multimodality imaging by incorporating MRI or by use of computed tomography (CT)-simulation images only was comparatively evaluated for patients with hemangiopericytoma. Results: Ground truth target volume defined by the board-certified radiation oncologists following meticulous evaluation, colleague peer review, collaboration, and ultimate consensus was found to be identical with target determination based on CT-MR fusion based imaging in this study. Conclusion: Accurate target volume determination is an indispensable part of RT for management of hemangiopericytomas. Incorporation of MRI in the target volume definition process may be considered for optimization of treatment volume designation for successful RT applications. Clearly, future studies are required to shed light on this issue.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77372952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-29DOI: 10.19080/ctoij.2020.17.555957
Sidy Ka
Aim of study: The main postoperative complication of mastectomies with axillary lymph node dissection is the lymphocele that can last many months after the operation. The purpose of our study was to analyze the factors that can contribute to its production. Methods: Sixty-one patients have been included in our study. The follow-up was 6 months. All patients had a mastectomy with axillary node dissection following the Madden technique. All quantities of lymphoceles during postoperative hospitalization and ambulatory care have been noted. Factors linked to patient, disease and treatment have been collected. Results: Sixty-one patients (61) operated at Joliot Curie Institute of Dakar between January and June of 2018 for breast cancer have been included in our study. Amongst the factors linked to patients, the lymphocele production is more significant for obese patients and those with prolonged aPTT (partial thromboplastin time). The weight of surgical specimens from 1001 to 1250 g was associated with greater production. It was the same for a more extensive dissection. Neither surgical factors nor chemotherapy influenced the lymphocele production. However, the extended use of a suction drain causes a more significant production. Conclusion: The production of postoperative lymphocele is heterogenous, varying from a patient to another. Nevertheless, several factors may influence the production of this lymphocele. These factors are bound to patient, sickness and treatment.
{"title":"Post-Mastectomy Lymphocele after Breast Cancer Surgery: Risk Factors Evaluation","authors":"Sidy Ka","doi":"10.19080/ctoij.2020.17.555957","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555957","url":null,"abstract":"Aim of study: The main postoperative complication of mastectomies with axillary lymph node dissection is the lymphocele that can last many months after the operation. The purpose of our study was to analyze the factors that can contribute to its production. Methods: Sixty-one patients have been included in our study. The follow-up was 6 months. All patients had a mastectomy with axillary node dissection following the Madden technique. All quantities of lymphoceles during postoperative hospitalization and ambulatory care have been noted. Factors linked to patient, disease and treatment have been collected. Results: Sixty-one patients (61) operated at Joliot Curie Institute of Dakar between January and June of 2018 for breast cancer have been included in our study. Amongst the factors linked to patients, the lymphocele production is more significant for obese patients and those with prolonged aPTT (partial thromboplastin time). The weight of surgical specimens from 1001 to 1250 g was associated with greater production. It was the same for a more extensive dissection. Neither surgical factors nor chemotherapy influenced the lymphocele production. However, the extended use of a suction drain causes a more significant production. Conclusion: The production of postoperative lymphocele is heterogenous, varying from a patient to another. Nevertheless, several factors may influence the production of this lymphocele. These factors are bound to patient, sickness and treatment.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74971181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-28DOI: 10.19080/ctoij.2020.17.555958
B. Saberi
non-Abstract COVID-19 infection is associated with lymphopenia, occasional thrombocytopenia, and overall leukopenia at hospital admission. ICU admission and mortality risk are associated with an elevated D-dimer (dimerized plasmin fragment D) level and a decreasing lymphocyte count. Platelet count was not a discriminating test on ICU admission or during the hospitalization. Additional routine biomarkers for infected patient risk stratification and for early admission for supportive care in the ICU are urgently needed.
{"title":"Impact of Covid-19 Infection on Hematological Parameters","authors":"B. Saberi","doi":"10.19080/ctoij.2020.17.555958","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555958","url":null,"abstract":"non-Abstract COVID-19 infection is associated with lymphopenia, occasional thrombocytopenia, and overall leukopenia at hospital admission. ICU admission and mortality risk are associated with an elevated D-dimer (dimerized plasmin fragment D) level and a decreasing lymphocyte count. Platelet count was not a discriminating test on ICU admission or during the hospitalization. Additional routine biomarkers for infected patient risk stratification and for early admission for supportive care in the ICU are urgently needed.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83081498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-28DOI: 10.19080/ctoij.2020.17.555956
B. Saberi
Simpson grade “I” resection, is the goal in convexity meningiomas surgery. After craniotomy, by using intraoperative ultrasound, neuronavigation and visual inspection, the junction of the dura with the tumor is defined in a circumferential direction. Dural incision is made at least in one centimeter distance from the tumor in a circumference manner around the tumor. Bipolar cautery is used to the dural attachment center after tumor encircling. This cause the cut margins to be turned outwardly and cause the arachnoid margin to be obviously visualized [1].
{"title":"Surgical Resection Technique for Convexity Meningiomas","authors":"B. Saberi","doi":"10.19080/ctoij.2020.17.555956","DOIUrl":"https://doi.org/10.19080/ctoij.2020.17.555956","url":null,"abstract":"Simpson grade “I” resection, is the goal in convexity meningiomas surgery. After craniotomy, by using intraoperative ultrasound, neuronavigation and visual inspection, the junction of the dura with the tumor is defined in a circumferential direction. Dural incision is made at least in one centimeter distance from the tumor in a circumference manner around the tumor. Bipolar cautery is used to the dural attachment center after tumor encircling. This cause the cut margins to be turned outwardly and cause the arachnoid margin to be obviously visualized [1].","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73750053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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