{"title":"Copper deficiency.","authors":"Reid C Gallant, Lita Cameron, Siraj Mithoowani","doi":"10.1503/cmaj.250072","DOIUrl":"https://doi.org/10.1503/cmaj.250072","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 16","pages":"E456"},"PeriodicalIF":9.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barbara Pesut, Gloria Puurveen, Kelly Ashford, Wendy Duggleby
{"title":"Volunteer navigators to support people with life-limiting illness in the community.","authors":"Barbara Pesut, Gloria Puurveen, Kelly Ashford, Wendy Duggleby","doi":"10.1503/cmaj.241692","DOIUrl":"https://doi.org/10.1503/cmaj.241692","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 16","pages":"E453-E455"},"PeriodicalIF":9.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanne Britto, Hira Mian, Gwynivere A Davies, Amaris K Balitsky
{"title":"Effets toxiques des anticorps bispécifiques.","authors":"Joanne Britto, Hira Mian, Gwynivere A Davies, Amaris K Balitsky","doi":"10.1503/cmaj.241384-f","DOIUrl":"https://doi.org/10.1503/cmaj.241384-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 16","pages":"E459-E460"},"PeriodicalIF":9.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tout, sauf l’amour.","authors":"Diana Toubassi","doi":"10.1503/cmaj.241795-f","DOIUrl":"https://doi.org/10.1503/cmaj.241795-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 16","pages":"E463-E464"},"PeriodicalIF":9.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roland Grad, René Wittmer, Geneviève Bois, Yun Jen, Marc-André Gagnon
{"title":"The \"pause\" on the Canadian Task Force on Preventive Health Care is misguided.","authors":"Roland Grad, René Wittmer, Geneviève Bois, Yun Jen, Marc-André Gagnon","doi":"10.1503/cmaj.152288-l","DOIUrl":"https://doi.org/10.1503/cmaj.152288-l","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 16","pages":"E458"},"PeriodicalIF":9.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"La maladie de Still de l’adulte.","authors":"Nickrooz Grami, Dalton R Budhram, Wayne L Gold","doi":"10.1503/cmaj.241321-f","DOIUrl":"https://doi.org/10.1503/cmaj.241321-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 15","pages":"E440-E441"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hereditary angioedema.","authors":"Kelsey Uminski, Stephen Betschel, Dawn Goodyear","doi":"10.1503/cmaj.241815","DOIUrl":"https://doi.org/10.1503/cmaj.241815","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 15","pages":"E417-E418"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley Bryson, Martha Shepertycky, Terence Wuerz, Philippe Lagacé-Wiens
{"title":"Maladie des légionnaires acquise lors d’une baignade dans un lac de l’Iowa.","authors":"Ashley Bryson, Martha Shepertycky, Terence Wuerz, Philippe Lagacé-Wiens","doi":"10.1503/cmaj.241086-f","DOIUrl":"https://doi.org/10.1503/cmaj.241086-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 15","pages":"E435-E439"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author response to \"Why reduce frequency of print issues if they are well read?\"","authors":"Holly Bodger","doi":"10.1503/cmaj.152185-l","DOIUrl":"https://doi.org/10.1503/cmaj.152185-l","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 15","pages":"E422"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seun Akinfolarin, Divya Shah, Courtney Heffernan, Tamara Samardzic, Angela Lau, Robin Love, Amy Colquhoun, Ryan Cooper, Stacy Valaire, Alexander Doroshenko, Mary Lou Egedahl, Gregory Tyrrell, Richard Long
Background: The COVID-19 pandemic caused major disruptions to essential tuberculosis (TB) services globally. We evaluated the performance of the TB program in Alberta, Canada, in 2 periods - before and during the pandemic - to estimate the impact of those disruptions.
Methods: We applied 10 program performance indicators and their related targets and compared them by period. The performance indicators included a measure of decline in the age- and sex-adjusted incidence by population group, the proportion of recently arrived immigrants screened on time, and 5 case management and 3 close contact management indicators. We measured performance targets by time period and clinic type - outpatient versus virtual. We used interrupted time series analysis to estimate the impact of the COVID-19 pandemic response on timeliness of immigrant screening.
Results: Since 2009, the rate of disease has declined in the Canadian-born but not the foreign-born population. However, the rate of disease by population group was not different prepandemic versus during the pandemic. Program performance was not negatively affected by the pandemic in general, but there was a large reduction in immigration and, in turn, the number of immigrants referred for screening (37.6%) and contacts identified for assessment (71.8%) during the pandemic, associated with improvements to the proportion of referrals assessed (91.7% v. 96.6%, relative risk [RR] 0.949, 95% confidence interval [CI] 0.936-0.962); contacts assessed (81.7% v. 90.0%, RR 0.908, 95% CI 0.875-0.943), and contacts completing treatment of infection (90.4% v. 97.1%, RR 0.931, 95% CI 0.886-0.979). Among patients with TB disease, monitoring of treatment response was suboptimal, whereas other targets were met or nearly met. Virtual clinic performance tended to be worse during the pandemic than the outpatient clinics.
Interpretation: COVID-19-related disruptions were not as substantial in the Alberta TB program as elsewhere, likely because of its centralized operational model and protection of its staff from secondment. However, no progress has been made toward reducing TB incidence. Better resourcing of prevention activity and a more responsive information system should be considered.
背景：2019冠状病毒病大流行对全球结核病基本服务造成严重干扰。我们评估了加拿大阿尔伯塔省结核病规划在大流行之前和期间的绩效，以估计这些中断的影响。方法：采用10项项目绩效指标及其相关指标，按时期进行比较。绩效指标包括按人口群体衡量经年龄和性别调整的发病率下降程度、按时接受筛查的新移民比例，以及5项病例管理和3项密切接触者管理指标。我们根据时间段和诊所类型（门诊vs虚拟）来衡量绩效目标。我们使用中断时间序列分析来估计COVID-19大流行应对对移民筛查及时性的影响。结果：自2009年以来，加拿大出生人口的发病率有所下降，但外国出生人口的发病率没有下降。然而，按人群划分的发病率在大流行前与大流行期间并无不同。总体而言，项目绩效并未受到大流行的负面影响，但移民数量大幅减少，而在大流行期间，转介接受筛查的移民人数（37.6%）和确定接受评估的接触者人数（71.8%）也大幅减少，这与转介接受评估比例的改善有关（91.7%对96.6%，相对风险[RR] 0.949, 95%可信区间[CI] 0.936-0.962）；接触者评估（81.7% vs . 90.0%, RR 0.908, 95% CI 0.875-0.943），接触者完成感染治疗（90.4% vs . 97.1%, RR 0.931, 95% CI 0.886-0.979）。在结核病患者中，对治疗反应的监测是次优的，而其他目标达到或接近达到。大流行期间，虚拟诊所的表现往往比门诊诊所差。解释：在艾伯塔省结核病项目中，与covid -19相关的中断并不像其他地方那样严重，可能是因为其集中运营模式和保护其工作人员不被借调。然而，在减少结核病发病率方面没有取得任何进展。应当考虑为预防活动提供更好的资源，并建立一个反应更迅速的信息系统。
{"title":"Impact of the COVID-19 pandemic on tuberculosis program performance in Alberta, Canada: a population-based evaluation.","authors":"Seun Akinfolarin, Divya Shah, Courtney Heffernan, Tamara Samardzic, Angela Lau, Robin Love, Amy Colquhoun, Ryan Cooper, Stacy Valaire, Alexander Doroshenko, Mary Lou Egedahl, Gregory Tyrrell, Richard Long","doi":"10.1503/cmaj.241411","DOIUrl":"10.1503/cmaj.241411","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic caused major disruptions to essential tuberculosis (TB) services globally. We evaluated the performance of the TB program in Alberta, Canada, in 2 periods - before and during the pandemic - to estimate the impact of those disruptions.</p><p><strong>Methods: </strong>We applied 10 program performance indicators and their related targets and compared them by period. The performance indicators included a measure of decline in the age- and sex-adjusted incidence by population group, the proportion of recently arrived immigrants screened on time, and 5 case management and 3 close contact management indicators. We measured performance targets by time period and clinic type - outpatient versus virtual. We used interrupted time series analysis to estimate the impact of the COVID-19 pandemic response on timeliness of immigrant screening.</p><p><strong>Results: </strong>Since 2009, the rate of disease has declined in the Canadian-born but not the foreign-born population. However, the rate of disease by population group was not different prepandemic versus during the pandemic. Program performance was not negatively affected by the pandemic in general, but there was a large reduction in immigration and, in turn, the number of immigrants referred for screening (37.6%) and contacts identified for assessment (71.8%) during the pandemic, associated with improvements to the proportion of referrals assessed (91.7% v. 96.6%, relative risk [RR] 0.949, 95% confidence interval [CI] 0.936-0.962); contacts assessed (81.7% v. 90.0%, RR 0.908, 95% CI 0.875-0.943), and contacts completing treatment of infection (90.4% v. 97.1%, RR 0.931, 95% CI 0.886-0.979). Among patients with TB disease, monitoring of treatment response was suboptimal, whereas other targets were met or nearly met. Virtual clinic performance tended to be worse during the pandemic than the outpatient clinics.</p><p><strong>Interpretation: </strong>COVID-19-related disruptions were not as substantial in the Alberta TB program as elsewhere, likely because of its centralized operational model and protection of its staff from secondment. However, no progress has been made toward reducing TB incidence. Better resourcing of prevention activity and a more responsive information system should be considered.</p>","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 15","pages":"E403-E412"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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