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Disseminated Intracranial and Spinal Neurenteric Cysts: A Case Report and Literature Review. 播散性颅内和脊神经囊肿:病例报告和文献综述。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9673413
Jan Kuschick Feher, Luis A Marin-Castañeda, Fernando S Juárez-Tovar, Roger Carrillo-Mezo, Gabriela Rosas, Martha Lilia Tena-Suck, Agnès Fleury

Neurenteric cysts (NECs) are rare congenital, benign lesions of the central nervous system (CNS), predominantly located within the spinal cord. However, they may also occur less frequently within the brainstem, fourth ventricle, or cerebellopontine angle (CPA). Originating from anomalous interactions between embryonic layers, NECs are recognized for their potential to compress adjacent structures. We report a unique case of disseminated NECs exhibiting few to absent symptoms, which represents an unusual presentation of this disease, with only six similar reports in the literature. A 22-year-old female presented to our institute with chronic headaches resistant to nonsteroidal anti-inflammatory drugs (NSAIDs). Initially treated for intracranial hypertension (ICH) secondary to a cyst in the quadrigeminal cistern at the age of 17 via neuroendoscopic surgery and subsequent ventriculoperitoneal shunting, she experienced transient relief. However, follow-up at 22 years of age revealed multiple cysts in the basal and spinal cisterns, with MRI findings suggestive of neurocysticercosis. Despite treatment with albendazole and corticosteroids, subsequent MRIs showed no change in the size or number of the cysts. Six years later, symptoms had worsened, previously identified cysts had grown, and the detection of new cysts prompted surgical intervention. Histopathological examination confirmed the presence of NECs. This case highlights the diagnostic challenges posed by NECs, especially in regions endemic for neurocysticercosis, where clinical and radiological findings may initially suggest this condition. It underscores the importance of considering NECs in the differential diagnosis of cystic lesions in the CNS, even in the absence of typical symptoms of spinal cord compression. The recurrence and spread of NECs post-treatment demand a comprehensive management approach, encompassing surgical intervention and close monitoring.

神经细胞囊肿(NECs)是中枢神经系统(CNS)罕见的先天性良性病变,主要位于脊髓内。不过,它们也可能较少发生在脑干、第四脑室或小脑角(CPA)。NEC起源于胚胎层之间的异常相互作用,因其可能压迫邻近结构而被公认。我们报告了一例独特的播散性 NECs 病例,患者几乎没有任何症状,这是该疾病的一种不寻常表现,文献中仅有六例类似报告。一名 22 岁的女性因慢性头痛来我院就诊,对非甾体抗炎药(NSAIDs)产生抗药性。她在17岁时因四叉神经窦囊肿继发颅内高压(ICH),最初通过神经内窥镜手术和随后的脑室腹腔分流术进行治疗,症状得到短暂缓解。然而,22 岁时的随访发现,基底和脊髓贮水池有多个囊肿,核磁共振成像结果提示为神经囊虫病。尽管她接受了阿苯达唑和皮质类固醇治疗,但随后的核磁共振成像显示囊肿的大小和数量均无变化。六年后,症状恶化,之前发现的囊肿又增大了,而且发现了新的囊肿,于是进行了手术治疗。组织病理学检查证实了 NECs 的存在。该病例凸显了NECs给诊断带来的挑战,尤其是在神经囊虫病流行的地区,临床和放射学检查结果最初都可能提示这种疾病。它强调了在中枢神经系统囊性病变的鉴别诊断中考虑 NECs 的重要性,即使没有脊髓受压的典型症状。NECs在治疗后会复发和扩散,因此需要采取综合治疗方法,包括手术干预和密切监测。
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引用次数: 0
New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination. 接种COVID-19疫苗后新发局灶性至双侧强直-阵挛性癫痫发作。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8808334
Chun Seng Phua, Azman Ali Raymond, Shalini Bhaskar

An 18-year-old male presented with new-onset focal to bilateral tonic-clonic seizures 5 days after receiving the first dose of COVID-19 vaccine. 3 days later, an identical seizure occurred lasting 1 min, leading to an acute presentation to the hospital. In hospital, the patient was loaded with intravenous phenytoin and started on levetiracetam with no further seizure recurrence. CT venogram and scalp EEG were unremarkable. MRI brain revealed generalised atrophy with mild bilateral hippocampal atrophy. The patient was maintained on 500 mg levetiracetam twice daily and advised to proceed with subsequent doses of vaccination. Vaccinations have been associated with breakthrough seizures. In this case, COVID-19 vaccination possibly unmasked an underlying predisposition for epilepsy.

一名 18 岁男性在接种第一剂 COVID-19 疫苗 5 天后出现新发局灶性至双侧强直阵挛发作。3 天后,又出现了一次相同的癫痫发作,持续时间为 1 分钟,导致患者急诊入院。在医院,患者接受了静脉注射苯妥英,并开始服用左乙拉西坦,但没有再出现癫痫发作。CT 静脉造影和头皮脑电图均无异常。脑部核磁共振成像显示患者全身萎缩,双侧海马轻度萎缩。患者继续服用 500 毫克左乙拉西坦,每天两次,并被建议继续接种后续剂量的疫苗。疫苗接种与突破性癫痫发作有关。在这个病例中,COVID-19疫苗接种可能揭示了潜在的癫痫易感性。
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引用次数: 0
Endotracheal Oxygen Insufflation Associated with Life-Threatening Barotrauma during Apnea Testing. 在呼吸暂停测试过程中,气管内充氧与危及生命的气压创伤有关。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9518817
Saud Ali Aljasir, Fahad Abdullah Alshammari, Jehan Abdullah Abdul-Aziz Fatani, Abdalrhman Al Saadon, Abdulaziz H Alzeer

Apnea testing is a standard method when diagnosing brain or more specifically brainstem death; however, it is imperative to acknowledge the potential for lung injury during this procedure and follow clinical practice guideline recommendations that may reduce the risk of complications. Two cases of barotrauma leading to pneumothorax occurred during apnea tests that used higher-than-recommended oxygen flow rates. Additional data are necessary to clarify the mechanism and incidence of this life-threatening complication.

呼吸暂停测试是诊断脑死亡或更具体地说是脑干死亡的标准方法;然而,必须认识到在此过程中可能会造成肺损伤,并遵循可降低并发症风险的临床实践指南建议。有两例气压创伤导致气胸的病例是在使用高于建议氧流量的呼吸暂停测试中发生的。需要更多的数据来明确这种危及生命的并发症的机制和发生率。
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引用次数: 0
Severe Neurotoxicity due to Atropa belladonna Poisoning: A Case Report and Literature Review. 颠茄中毒导致的严重神经中毒:病例报告和文献综述。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5411258
Seyed Javad Boskabadi, Sima Ramezaninejad, Zakaria Zakariaei

Atropa belladonna (A. belladonna), commonly known as deadly nightshade, is a poisonous plant belonging to the Solanaceae family. The toxic effects of A. belladonna are attributable to its alkaloid content, which possesses potent anticholinergic properties. These alkaloids are responsible for the plant's toxicity and can cause a range of adverse effects in humans and animals upon ingestion or contact. In this report, we describe two atypical cases of A. belladonna poisoning resulting from accidental ingestion of the plant's raw leaves, which were referred to the emergency room of a poisoning center in northern Iran. Both patients presented with symptoms of anticholinergic toxicity, including dry mouth, mydriasis, tachycardia, and delirium. The patients were managed conservatively with supportive measures, including hydration and administration of benzodiazepines to control agitation and delirium. With appropriate treatment, both patients showed improvement and were discharged from the hospital. A. belladonna intoxication is associated with a range of clinical manifestations, primarily due to its neurotoxic effects. These manifestations may include flushing, mydriasis, tachycardia, ataxia, agitation, delirium, and urinary retention. The severity of symptoms can vary depending on the amount of the toxin ingested and the individual's susceptibility. In severe cases, A. belladonna toxicity can lead to seizures, coma, and even death. These cases highlight the importance of awareness regarding the potential toxicity of A. belladonna and the necessity of prompt and appropriate management of its toxicity. In severe cases, physostigmine may be considered for the treatment of neurological symptoms due to the plant's anticholinergic effects.

颠茄(Atropa belladonna)俗称致命夜来香,是茄科的一种有毒植物。颠茄的毒性作用可归因于其生物碱成分,它具有强大的抗胆碱能特性。这些生物碱是造成该植物毒性的原因,摄入或接触后会对人类和动物造成一系列不良影响。在本报告中,我们描述了两例因误食颠茄生叶而导致的颠茄中毒的非典型病例。两名患者都出现了抗胆碱能中毒症状,包括口干、瞳孔散大、心动过速和谵妄。对患者采取了保守治疗和支持措施,包括补充水分和服用苯二氮卓类药物以控制躁动和谵妄。经过适当治疗后,两名患者的病情均有所好转,并已出院。颠茄中毒会出现一系列临床表现,主要是由于其神经毒性作用。这些表现可能包括潮红、瞳孔散大、心动过速、共济失调、躁动、谵妄和尿潴留。症状的严重程度因摄入的毒素量和个人的易感性而异。严重时,颠茄毒素可导致抽搐、昏迷甚至死亡。这些病例凸显了认识颠茄素潜在毒性的重要性,以及对其毒性进行及时、适当处理的必要性。在严重病例中,由于颠茄草具有抗胆碱能作用,因此可以考虑使用扑尔敏来治疗神经症状。
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引用次数: 0
Rhabdomyolysis Induced by Levetiracetam: A Case Report in Kuwait. 左乙拉西坦诱发横纹肌溶解症:科威特病例报告。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-21 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1234738
Moaz Qureshi, Prakash A Abraham, Abdullah Al-Faras, Omar M Bamasood, Kamal M Matar

Epilepsy is a common disorder caused by a myriad of drugs, of that levetiracetam is being commonly used late because of its strong safety profile and efficacy. With the increasing usage of drugs, some rare side effects may sometimes appear that can escape the most stringent checks, possibly due to the rarity of their occurrence. Rhabdomyolysis is known to occur in some patients owing to a variety of causes, even leading to kidney injury. When a drug has a side effect that is not well recognized in the literature, especially when the side effect can mimic an adverse effect of an uncommon primary illness, identifying the causal factor can be doubly difficult. To date, only limited studies have been published suggesting rhabdomyolysis linked to levetiracetam use. We report the first case of levetiracetam-induced rhabdomyolysis in Kuwait.

癫痫是一种常见疾病,由无数种药物引起,其中左乙拉西坦因其强大的安全性和疗效而被广泛使用。随着药物使用量的增加,有时可能会出现一些罕见的副作用,但可能由于其发生的罕见性,这些副作用可以逃过最严格的检查。众所周知,横纹肌溶解症会因各种原因发生在一些患者身上,甚至导致肾脏损伤。当一种药物的副作用在文献中没有得到很好的确认时,尤其是当这种副作用可以模拟一种不常见的原发性疾病的不良反应时,确定致病因素就会加倍困难。迄今为止,只有有限的研究表明横纹肌溶解症与左乙拉西坦的使用有关。我们报告了科威特首例由左乙拉西坦诱发的横纹肌溶解症病例。
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引用次数: 0
Changes in Corticospinal Tract Consistency after Dry Needling in a Stroke Patient. 中风患者干针治疗后皮质脊髓束一致性的变化
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-14 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5115313
Masoome Ebrahimzadeh, Noureddin Nakhostin Ansari, Iraj Abdollahi, Behnam Akhbari, Jan Dommerholt

Background: Dry needling (DN) is a technique employed to mitigate spasticity and enhance functionality in stroke patients. We report the impact of DN on both corticospinal tract (CST) consistency and wrist flexors spasticity of an individual affected by stroke.

Case: The participant was a 57-year-old male who had experienced an ischemic stroke 9 months prior. The primary outcome measures included fractional anisotropy (FA), asymmetry FA (aFA), ratio FA (rFA), and Modified Modified Ashworth Scale (MMAS). Additionally, secondary outcomes encompassed wrist extension range of motion (ROM) and performance in the box and block test (BBT). These measurements were taken both before and after the administration of DN treatment.

Results: After the application of DN, the mean FA of the ipsilesional CST increased from 0.35 to 0.39, concomitantly with a decline in aFA from 0.18 to 0.13. Notably, the rFA exhibited a pre-DN value of 0.69, which subsequently rose to 0.76 post-DN. Moreover, a significant reduction in MMAS scores was detected, from a score of "3" prior to DN application to a post-DN score of "1". In terms of wrist mobility, both active and passive extension ROM exhibited favorable improvements, with an increase of 12° for active extension and 16° for passive extension. Furthermore, there was a substantial improvement in the BBT score, an indicator of manual dexterity, ascending from 12 to 24.

Conclusion: Enhancements in CST consistency suggest it as a potential mechanism contributing to the observed improvements following DN in this stroke case.

背景:干针疗法(DN)是一种用于缓解中风患者痉挛和增强其功能的技术。我们报告了干针疗法对中风患者皮质脊髓束(CST)一致性和腕屈肌痉挛的影响。主要结果指标包括分数各向异性(FA)、不对称FA(aFA)、比率FA(rFA)和改良改良阿什沃斯量表(MMAS)。此外,次要结果还包括腕关节伸展活动范围(ROM)和箱形阻滞试验(BBT)的表现。这些测量均在使用 DN 治疗前后进行:结果:使用 DN 后,CST 同侧的平均 FA 值从 0.35 增至 0.39,同时 aFA 值从 0.18 降至 0.13。值得注意的是,rFA 在 DN 前为 0.69,DN 后上升至 0.76。此外,MMAS 评分也明显下降,从使用 DN 前的 "3 "分降至 DN 后的 "1 "分。在腕关节活动度方面,主动和被动伸展活动度均有良好改善,主动伸展活动度增加了 12°,被动伸展活动度增加了 16°。此外,作为手部灵活性指标的 BBT 评分也有大幅提高,从 12 分提高到 24 分:结论:CST一致性的增强表明,它是在该中风病例中观察到的 DN 后病情改善的潜在机制。
{"title":"Changes in Corticospinal Tract Consistency after Dry Needling in a Stroke Patient.","authors":"Masoome Ebrahimzadeh, Noureddin Nakhostin Ansari, Iraj Abdollahi, Behnam Akhbari, Jan Dommerholt","doi":"10.1155/2024/5115313","DOIUrl":"10.1155/2024/5115313","url":null,"abstract":"<p><strong>Background: </strong>Dry needling (DN) is a technique employed to mitigate spasticity and enhance functionality in stroke patients. We report the impact of DN on both corticospinal tract (CST) consistency and wrist flexors spasticity of an individual affected by stroke.</p><p><strong>Case: </strong>The participant was a 57-year-old male who had experienced an ischemic stroke 9 months prior. The primary outcome measures included fractional anisotropy (FA), asymmetry FA (aFA), ratio FA (rFA), and Modified Modified Ashworth Scale (MMAS). Additionally, secondary outcomes encompassed wrist extension range of motion (ROM) and performance in the box and block test (BBT). These measurements were taken both before and after the administration of DN treatment.</p><p><strong>Results: </strong>After the application of DN, the mean FA of the ipsilesional CST increased from 0.35 to 0.39, concomitantly with a decline in aFA from 0.18 to 0.13. Notably, the rFA exhibited a pre-DN value of 0.69, which subsequently rose to 0.76 post-DN. Moreover, a significant reduction in MMAS scores was detected, from a score of \"3\" prior to DN application to a post-DN score of \"1\". In terms of wrist mobility, both active and passive extension ROM exhibited favorable improvements, with an increase of 12° for active extension and 16° for passive extension. Furthermore, there was a substantial improvement in the BBT score, an indicator of manual dexterity, ascending from 12 to 24.</p><p><strong>Conclusion: </strong>Enhancements in CST consistency suggest it as a potential mechanism contributing to the observed improvements following DN in this stroke case.</p>","PeriodicalId":9615,"journal":{"name":"Case Reports in Neurological Medicine","volume":"2024 ","pages":"5115313"},"PeriodicalIF":0.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Rhabdomyolysis in a Medical Cadet during Military Training as a Rare Initial Presentation in Calpainopathy. 一名军医学员在军训期间反复发生横纹肌溶解症,这是钙蛋白尿症的一种罕见初始表现。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2775517
Sethapong Lertsakulbunlue, Boonsub Sakboonyarat, Piradee Suwanpakdee, Boonchai Boonyawat

Rhabdomyolysis, an emergency medical condition linked to muscle necrosis and intracellular substances released into the bloodstream, significantly endangers military personnel in heat-stress conditions. Rhabdomyolysis can also be an initial presentation in inherited muscle disorders. This study reports a novel case of calpainopathy (LGMDR1) diagnosed in a 19-year-old male military cadet who initially presented with recurrent rhabdomyolysis during training, a rare presentation in LGMD patients. Furthermore, a persistent creatine kinase (CK) elevation was observed at baseline. The diagnosis was confirmed by identifying a compound heterozygous of a novel frameshift, c.606dup (p.Ala203CysfsTer9), a mutation in exon 4, and a missense, c.956C > T (p.Pro319Leu), a mutation in exon 7 of the CAPN3 gene, via whole exome sequencing. This case highlights the necessity of diagnostic investigation in individuals who have persistent high CK levels during the rhabdomyolysis episodes and possibly CK screening prior to military training to preemptively identify and mitigate complications from undiagnosed muscular dystrophies in military personnel in the future.

横纹肌溶解症是一种与肌肉坏死和细胞内物质释放到血液中有关的紧急医疗状况,严重危害热应激条件下的军事人员。横纹肌溶解症也可能是遗传性肌肉疾病的首发症状。本研究报告了一例新的钙蛋白蛋白酶病(LGMDR1)病例,患者是一名 19 岁的男性军校学员,最初表现为训练期间反复发生横纹肌溶解症,这在 LGMD 患者中十分罕见。此外,基线观察到肌酸激酶(CK)持续升高。通过全外显子组测序,确定了该患者的诊断,即CAPN3基因第4外显子突变c.606dup (p.Ala203CysfsTer9)和第7外显子突变c.956C > T (p.Pro319Leu)的复合杂合子。该病例突出表明,有必要对横纹肌溶解症发作期间 CK 水平持续偏高的患者进行诊断性调查,并在军事训练前进行 CK 筛查,以便在未来预先发现和减轻未确诊的军人肌肉萎缩症并发症。
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引用次数: 0
A Confused Case Diagnosed as Cerebral Infarction or Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. 一个被诊断为脑梗塞或髓鞘寡突胶质细胞蛋白抗体相关疾病的疑难病例。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9941341
Yanan Ding, Li Zhang, Anqi Huang, Xianyue Meng, Xueli Li

In order to discuss the clinical and MRI features, diagnosis, and prevention of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), we reported an adult case of MOG antibody-related disease misdiagnosed as cerebral infarction. This patient's first clinical symptom was limb weakness, that different from previous reports of MOG antibody-related diseases, such as brainstem encephalitis, neuromyelitis optical, and transverse myelitis. The main treatment plan is high-dose corticosteroid therapy combined with immunoglobulin therapy. This case indicated that some MOGAD patients lack of specificity in the clinical manifestations and imaging perhaps would be misdiagnosed as cerebral infarction, encephalitis, immune peripheral neuropathy, MS, NMOSD, and other diseases. For patients with atypical clinical manifestations or imaging, it is especially important to take antibody detection as early as possible to make correct diagnosis and active treatment in time to avoid disability.

为了探讨髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)的临床和磁共振成像特征、诊断和预防,我们报道了一例被误诊为脑梗塞的成人MOG抗体相关疾病。该患者的首发临床症状是四肢无力,这与之前报道的脑干脑炎、光学神经脊髓炎和横贯性脊髓炎等 MOG 抗体相关疾病不同。主要治疗方案是大剂量皮质类固醇治疗联合免疫球蛋白治疗。该病例表明,部分 MOGAD 患者的临床表现和影像学表现缺乏特异性,可能会被误诊为脑梗塞、脑炎、免疫性周围神经病、多发性硬化症、NMOSD 等疾病。对于临床表现或影像学表现不典型的患者,尽早进行抗体检测,及时做出正确诊断和积极治疗,避免致残尤为重要。
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引用次数: 0
Longitudinal Extensive Transverse Myelitis due to Varicella-Zoster Virus Infection in an Undiagnosed HIV-Positive Patient. 一名未确诊的 HIV 阳性患者因水痘-带状疱疹病毒感染引发的纵向广泛横贯性脊髓炎
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-18 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9027198
Elahe Yaghmaei, Ahmad Najafi, Reza Daneshvar Kakhki

Introduction: Longitudinal extensive transverse myelitis (LETM) has four main causes: inflammatory, malnutrition, vascular, and infectious causes. Among the commonly described viral causes leading to LETM are the Herpesviridae family, HIV, and HTLV-1. Case Presentation. A 43-year-old man presented with asymmetric weakness of the lower limbs (the left side was weaker), urinary retention, and flank pain. The symptoms began five days after shingle eruption and progressed over twelve days. He was diagnosed with longitudinal extensive transvers myelitis extending from T4 to T6, which corresponded to the same dermatome involved in shingles. The PCR result of cerebrospinal fluid was positive for varicella-zoster virus with a viral load of 500 copies/ml. Additionally, the initial HIV enzyme-linked immunosorbent assay (ELISA) test was positive, and his CD4 count was 72 cells/mm3. Other lab results were normal. Based on the appearance of LETM in the thoracic MRI at T4-T6, VZV myelitis was diagnosed, and treatment was initiated with acyclovir (30 mg/kg divided daily for twenty-one days), methylprednisolone (1 g/day for three days), prophylactic antibiotics (trimethoprim/sulfamethoxazole, rifampin, and isoniazid), and antiretroviral therapy (dolutegravir and Truvada). After 2-month follow-up, he was nearly free of symptoms.

Conclusion: Infection is one of the critical causes of transverse myelitis. When a patient presents with skin shingles along with myelopathy, varicella-zoster myelitis should be considered, and the patient should be evaluated in terms of immune system dysfunction. Treatment with acyclovir has been shown to be effective in reducing clinical symptoms in such cases.

简介纵向广泛性横贯性脊髓炎(LETM)有四种主要病因:炎症、营养不良、血管和感染。导致纵贯广泛性横贯性脊髓炎的常见病毒性病因包括疱疹病毒科、艾滋病病毒和 HTLV-1。病例介绍。一名 43 岁的男子因下肢不对称无力(左侧较弱)、尿潴留和侧腹疼痛就诊。症状开始于带状疱疹爆发后五天,持续了十二天。他被诊断为从 T4 到 T6 的纵向广泛横贯性脊髓炎,这与带状疱疹涉及的皮节相同。脑脊液的 PCR 结果显示水痘-带状疱疹病毒阳性,病毒载量为 500 拷贝/毫升。此外,初次艾滋病毒酶联免疫吸附试验(ELISA)呈阳性,CD4 细胞计数为 72 cells/mm3。其他化验结果正常。根据胸部核磁共振 T4-T6 位置出现的 LETM,诊断为 VZV 脊髓炎,并开始使用阿昔洛韦(30 毫克/千克,每天一次,共 21 天)、甲强龙(1 克/天,共 3 天)、预防性抗生素(三甲双胍/磺胺甲恶唑、利福平和异烟肼)和抗逆转录病毒疗法(多托曲韦和特鲁瓦达)进行治疗。经过两个月的随访,他的症状基本消失:感染是横贯性脊髓炎的重要病因之一。结论:感染是横贯性脊髓炎的重要原因之一。当患者出现皮肤带状疱疹并伴有脊髓病时,应考虑水痘-带状疱疹性脊髓炎,并对患者的免疫系统功能障碍进行评估。使用阿昔洛韦治疗可有效减轻此类病例的临床症状。
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引用次数: 0
Life-Threatening Anaphylaxis due to Cerebrolysin®. 脑活素®引起的危及生命的过敏性休克。
IF 0.9 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-18 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2332908
Helmut Trimmel, Wolfgang Tauber, Martin Zikeli

In this case report, we describe a well-documented, severe anaphylactic reaction after intravenous administration of cerebrolysin, a neurotrophic agent derived from highly purified porcine brain tissue, consisting of peptides and free amino acids. Cerebrolysin has been in use for decades, in various neurological diseases, but especially stroke and traumatic brain injury, with the aim of enhancing cognitive performance. After administration of cerebrolysin to an 85-year-old male patient suffering from subacute stroke, he developed a fulminant anaphylactic reaction. Following institutional standards, vital functions were quickly restored. The anaphylactic reaction was clearly confirmed by laboratory tests. To date, only rare cases of anaphylaxis due to cerebrolysin have been published in the literature. The current report is intended to raise awareness for the possibility of such a reaction, given the widespread use of cerebrolysin in several indications in mostly critical patients. The case shows how a completely unexpected life-threatening situation can be successfully treated by targeted measures, if the situation is recognized quickly. In light of this event, we consider pathophysiology of allergic reactions and treatment guidelines.

在本病例报告中,我们描述了静脉注射脑溶解素后出现严重过敏反应的有据可查的病例。脑溶解素是从高度纯化的猪脑组织中提取的一种神经营养剂,由多肽和游离氨基酸组成。几十年来,脑溶解素一直被用于治疗各种神经系统疾病,尤其是中风和脑外伤,目的是提高认知能力。一名 85 岁的男性亚急性中风患者在服用脑蛋白酶后,出现了剧烈的过敏反应。按照机构标准,生命功能很快得到恢复。过敏反应经实验室检测得到明确证实。迄今为止,文献中只发表过极少数因脑溶酶类引起的过敏性休克病例。鉴于脑蛋白酵素在多种适应症中广泛用于危重病人,本报告旨在提高人们对这种反应可能性的认识。该病例表明,如果能迅速识别情况,就可以通过有针对性的措施成功治疗完全出乎意料的危及生命的情况。鉴于这一事件,我们考虑了过敏反应的病理生理学和治疗指南。
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引用次数: 0
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