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A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases. 使用一种新的局部植物活性制剂的多模式脱发治疗策略:附5例报告。
Q3 Medicine Pub Date : 2021-02-04 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6659943
Sanusi Umar, Marissa J Carter

Introduction. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Five patients with various hair-loss conditions, including cases of previous treatment failures, are presented. Case Presentation. This is a case series of four women and one man with hair loss due to various causes, four of whom had failed minoxidil treatment for over a year. All patients used the topical treatment as a sole therapy for at least 3 months before the documentation of outcomes, which involved interval changes noted through each patient's account, direct observation, and photography. Discussion. In all patients, we observed significant improvements in hair regrowth in the nape, crown, vertex, and temple areas after 3-15 months of treatment. All patients were highly satisfied with their results and reported no adverse events. Although the use of botanicals in the treatment of hair loss is in an infant stage, the new formulation used in this study demonstrated a good efficacy related to hair growth, warranting further evaluation.

介绍。目前批准的治疗脱发的药物,如外用米诺地尔和口服非那雄胺,可能有次优的疗效或副作用,使一些患者无法继续使用。因此,我们报告了一种新的局部植物制剂gashee的有效性,安全性和耐受性的评估,该制剂含有超过12种植物活性成分,可影响导致脱发的病理生理事件级联中的多个靶点。五位患者的各种脱发条件,包括以前的治疗失败的情况下,提出。案例演示。这是一个四女一男因各种原因脱发的系列病例,其中四人治疗米诺地尔一年多都失败了。所有患者将局部治疗作为唯一治疗至少3个月,然后记录结果,包括通过每位患者的叙述,直接观察和摄影记录的间隔变化。讨论。在所有患者中,经过3-15个月的治疗,我们观察到在颈、冠、顶点和太阳穴区域的头发再生有显著改善。所有患者均对治疗结果非常满意,无不良事件发生。虽然植物药在治疗脱发方面的应用还处于初级阶段,但本研究中使用的新配方显示出与头发生长有关的良好功效,值得进一步评估。
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引用次数: 5
New Onset Granulomatosis with Polyangiitis Associated with COVID-19. 新发肉芽肿病合并多血管炎与COVID-19相关。
Q3 Medicine Pub Date : 2021-01-13 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8877292
Moshe Y Bressler, Naeha Pathak, Kelly Cervellione, Farshad Bagheri, Edward Epstein, Adnan Mir, Rebecca Tamez

The coronavirus disease 2019 (COVID-19) has recently been found to cause cutaneous vasculitis in patients. Granulomatosis with polyangiitis (GPA) is a type of small and medium vessel vasculitis that is often associated with pulmonary issues and has been shown to raise diagnostic complications in COVID-19 infection. In this report, we discuss the first case of new-onset GPA in the setting of active COVID-19 infection. Symptoms often overlap between the two diseases, and while there is no current cure for COVID-19, rapid immunosuppressive initiation can be lifesaving for patients with GPA. Thus, this case is essential in expanding our current knowledge of COVID-19 and its many skin manifestations.

最近发现冠状病毒病2019 (COVID-19)可引起患者皮肤血管炎。肉芽肿病合并多血管炎(GPA)是一种中小型血管炎,通常与肺部问题相关,已被证明可增加COVID-19感染的诊断并发症。在这篇报道中,我们讨论了在COVID-19活动性感染背景下的第一例新发GPA。这两种疾病的症状经常重叠,虽然目前还没有治愈COVID-19的方法,但快速启动免疫抑制疗法可以挽救GPA患者的生命。因此,该病例对于扩大我们目前对COVID-19及其许多皮肤表现的认识至关重要。
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引用次数: 13
Kaposi Varicelliform Eruption in a Patient with Pemphigus Vulgaris: A Case Report and Review of the Literature. 寻常型天疱疮卡波济静脉曲张型爆发1例报告及文献复习。
Q3 Medicine Pub Date : 2020-12-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6695342
Bibisha Baaniya, Sudha Agrawal

Haemorrhagic crusted lesions over pre-existing pemphigus vulgaris erosions should arouse suspicion of Kaposi varicelliform eruption (KVE). Immediate treatment with antivirals helps to prevent mortality and morbidities. Here, we report a case of a 67-year-old male who developed haemorrhagic crusted lesions on pre-existing pemphigus lesions during his hospital stay and obtained almost 90% resolution of cutaneous lesions of Pemphigus vulgaris as well as Kaposi varicelliform eruption within 2 weeks of acyclovir treatment along with the continuation of systemic steroids. We also highlight the review of the literature of other reported cases with its management.

在先前存在的寻常型天疱疮糜烂上出现出血性结痂,应引起卡波西静脉曲张型爆发(KVE)的怀疑。立即使用抗病毒药物治疗有助于预防死亡率和发病率。在这里,我们报告了一个67岁的男性病例,他在住院期间在原有的天疱疮病变上出现出血性结痂病变,在阿昔洛韦治疗的2周内,寻常型天疱疮的皮肤病变和卡波西静脉曲张样皮疹几乎90%的消退,同时继续全身类固醇治疗。我们还重点回顾了其他报告病例的文献及其管理。
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引用次数: 2
Trichotemnomania in an Adolescent Girl: A Case Report of an Asian Child and Literature Review. 一名亚洲青少年女童的拔毛癖病例报告及文献回顾。
Q3 Medicine Pub Date : 2020-12-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6615250
V Thadchanamoorthy, Markandu Thirukumar, Kavinda Dayasiri, N Thamilvannan, Judy Jeyakumar

Trichotemnomania (TT) refers to cutting or shaving of one's own hair as a compulsive act. This condition is reported rarely and may be indicative of an underlying obsessive-compulsive disorder. TT may be misdiagnosed with trichotillomania or other disorders such as alopecia areata, tinea capitis, and postinflammatory scars. The diagnosis of trichotemnomania is confirmed by dermoscopic assessment, histopathological changes of hair, and correlation of these findings with clinical history. A fourteen-year-old adolescent girl presented with focal hair loss over forehead for duration of two-weeks and periodic abnormal breathing and poor sleep for 2-month duration. Besides, she had also lost some of pubic hair and hair on the forearm over preceding 24 hours. This patient was assessed by a team including a paediatrician, gynecologist, dermatologist, and psychiatrist to gather focused medical history and to perform physical examination, laboratory investigations, and dermoscopic assessment. It was revealed that she used to shave or cut regularly following stressful situations across various aspects of her life and hyperventilate as a means of relieving her stress. Eventually, she was diagnosed to have trichotemnomania and was started oral sertraline 50 mg/day for one month. Clinical features and her behaviour improved with regular cognitive behavioural therapy, and hairs were demonstrated to grow up normally with change in behaviour. Currently, she does well at school and is off medications and being followed up at the child guidance clinic. Trichotemnomania is a very rare disorder which is characterised by cutting or shaving of one's own hairs as a compulsive habit. The condition needs careful and detailed assessment by a team of specialists to identify coexisting psychiatric disorders and offer treatment.

拔毛癖(TT)指的是把自己的头发剪掉或剃掉是一种强迫性行为。这种情况很少报道,可能是潜在的强迫症的指示。TT可能被误诊为拔毛症或其他疾病,如斑秃、头癣和炎症后疤痕。毛热症的诊断是通过皮肤镜评估、头发的组织病理学改变以及这些发现与临床病史的相关性来证实的。14岁少女,前额局灶性脱发2周,周期性呼吸异常,睡眠不佳2个月。此外,在过去24小时内,她也失去了一些阴毛和前臂的毛发。由一名儿科医生、妇科医生、皮肤科医生和精神科医生组成的小组对该患者进行评估,收集重点病史,并进行体格检查、实验室检查和皮肤镜评估。据透露,在她生活的各个方面遇到压力情况时,她会定期刮胡子或刮胡子,并通过过度呼吸来缓解压力。最终,她被诊断患有毛热症,并开始口服舍曲林50毫克/天,持续一个月。通过常规的认知行为疗法,她的临床特征和行为都得到了改善,头发也正常生长,行为也有所改变。目前,她在学校表现良好,已经停止服药,并在儿童指导诊所接受跟踪治疗。拔毛癖是一种非常罕见的疾病,其特征是剪掉或剃掉自己的头发,这是一种强迫性的习惯。这种情况需要由专家小组进行仔细和详细的评估,以确定共存的精神疾病并提供治疗。
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引用次数: 1
Multiple Xanthogranulomas in an Adult Patient with Myelodysplastic Syndrome. 成人骨髓增生异常综合征患者多发黄色肉芽肿。
Q3 Medicine Pub Date : 2020-12-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8826715
Marta Martínez-García, Nicolás Silvestre-Torner, Antonio Aguilar-Martínez, Fernando Burgos-Lázaro

Adult multiple xanthogranuloma (XG) is a rare late-onset variant of juvenile XG. It is characterized by the appearance of papules or nodules located preferably on the trunk. A case of a 54-year-old man with myelodysplastic syndrome is presented as a history of interest, who consulted due to the appearance of multiple brownish papules distributed mainly in the trunk. So far, there are only 22 cases of this clinical form reported in the literature, 9 of them associated with malignant hematological processes. We highlight the importance of this entity as a possible cutaneous marker of blood dyscrasias.

成人多发黄色肉芽肿(XG)是一种罕见的迟发性少年XG。其特征是丘疹或结节的外观,最好位于躯干上。一例54岁男性骨髓增生异常综合征患者,因出现多发棕色丘疹,主要分布于躯干而就诊。到目前为止,文献中仅报道了22例这种临床形式,其中9例与恶性血液学过程有关。我们强调这个实体的重要性,作为一个可能的皮肤标记的血液失调。
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引用次数: 1
Verruca Vulgaris and Seborrheic Keratosis Exacerbated by Immunosuppression. 免疫抑制加重寻常疣和脂溢性角化病。
Q3 Medicine Pub Date : 2020-12-02 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6682694
Shohei Iida, Kyoko Sugioka, Makoto Kondo, Yoshiaki Matsushima, Kento Mizutani, Koji Habe, Keiichi Yamanaka

Verruca vulgaris is an infectious disease caused by the human papillomavirus and characterized by hyperkeratotic papules or plaques with a clear boundary. Seborrheic keratosis is a commonly encountered lesion on the face, trunk, or extremities and is described as seborrheic verruca because of its clinical similarity to warts; furthermore, it is occasionally associated with immune suppression, especially in cases of Leser-trélat syndrome. Although these diseases are frequently found in healthy individuals, they typically show a good response to cryotherapy. However, cases in immunosuppressed patients are intractable to therapy. Overall immune status is evaluated via complete blood count (CBC); however, white blood count does not show the exact immune ability, and NK cell activity is often decreased in cases of malignancy. Here, we present two cases of exacerbated verruca vulgaris and seborrheic verruca observed in patients with malignancy. Although the patients seemed to be in good condition and had a normal CBC, immunosuppression was suspected based on the degree of skin rashes. NK cell activity was decreased in both patients, and both cases had malignancy. The measurement of NK cell activity may be a useful approach to evaluate immune status.

寻常疣是一种由人乳头瘤病毒引起的传染病,以边界清晰的角化性丘疹或斑块为特征。脂溢性角化病是一种常见于面部、躯干或四肢的病变,由于其临床与疣相似,故被称为脂溢性疣;此外,它偶尔与免疫抑制有关,特别是在leser - tracimlate综合征的病例中。虽然这些疾病经常在健康个体中发现,但它们通常对冷冻疗法有良好的反应。然而,免疫抑制患者的病例难以治疗。通过全血细胞计数(CBC)评估整体免疫状态;然而,白细胞计数不能显示确切的免疫能力,并且NK细胞活性在恶性肿瘤中经常下降。在此,我们报告两例恶性肿瘤患者的寻常性和脂溢性疣加重。虽然患者似乎情况良好,CBC正常,但根据皮疹的程度怀疑免疫抑制。两例患者NK细胞活性均降低,且均为恶性肿瘤。NK细胞活性的测定可能是评估免疫状态的一种有用的方法。
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引用次数: 2
Dercum's Disease: A Case Report of a Patient Having Both Type 1 and Type 2 Dercum's Disease. 德尔肯氏病:1型和2型德尔肯氏病1例报告。
Q3 Medicine Pub Date : 2020-11-10 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6129706
Cameron Moattari, Richard A Giovane, Stephanie DiGiovanni Kinsely

Dercum's disease, or adiposis dolorosa, is a rare disorder which consists of multiple, painful lipomas within the subcutaneous tissue and has a distribution mainly in the abdomen and extremities. Dercum's disease can be defined as in combination with chronic painful adipose tissue. Although the etiology of Dercum's disease is not clear, it is thought to be a combination of a neurological and endocrine disorder. Treatment for this disease is centered at managing pain. Although there is no standard of care for managing pain, there are different pain management regimes that are promising.

Dercum's病,或称多脂病,是一种罕见的疾病,由皮下组织内的多个疼痛性脂肪瘤组成,主要分布于腹部和四肢。Dercum病可以定义为与慢性疼痛脂肪组织相结合。虽然Dercum病的病因尚不清楚,但它被认为是一种神经和内分泌紊乱的结合。这种疾病的治疗以控制疼痛为中心。虽然没有治疗疼痛的标准,但有不同的疼痛治疗方案是有希望的。
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引用次数: 3
Carbamazepine-Induced Toxic Epidermal Necrolysis Managed by Mobile Teledermatology in COVID-19 Pandemic in Rural Nepal. 尼泊尔农村COVID-19大流行中卡马西平诱导的中毒性表皮坏死松解的移动远程皮肤科治疗
Q3 Medicine Pub Date : 2020-11-06 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8845759
Vikash Paudel, Deepa Chudal

Toxic epidermal necrolysis is a life-threatening dermatological emergency with high mortality if not treated in time. Here we report a case of toxic epidermal necrolysis due to carbamazepine in rural Nepal in COVID-19 pandemic who was successfully treated with the help of mobile teledermatology. The clinical impression of toxic epidermal necrolysis was made from "WhatsApp" video calls using a smart phone. The supportive features were the history of starting of carbamazepine 2 weeks prior for seizure disorder, clinical findings in serial photographs of skin with 40 percent body surface area involvement of necrotic skin lesions and bulla, and involvement of oral mucosa and eyes. The patient was immediately asked to stop carbamazepine and was treated with intravenous fluids and systemic steroids along with symptomatic management. As the whole world was suffering from lockdown due to COVID-19 crisis, it was impossible for the rural area patient to visit a dermatologist. Thus, with the help of paramedics staff in a community health center and mobile teledermatology, the patient was diagnosed as carbamazepine-induced toxic epidermal necrolysis and treated successfully with good outcome.

中毒性表皮坏死松解是一种危及生命的皮肤病急症,如果不及时治疗,死亡率很高。在这里,我们报告了一例发生在尼泊尔农村的卡马西平引起的中毒性表皮坏死松解症,该病例在移动远程皮肤科的帮助下得到了成功的治疗。中毒性表皮坏死松解的临床印象是通过使用智能手机进行“WhatsApp”视频通话。支持的特征是癫痫发作前2周开始使用卡马西平的历史,在皮肤的连续照片中发现40%的体表面积累及坏死的皮肤病变和大疱,以及累及口腔黏膜和眼睛。患者立即被要求停用卡马西平,并接受静脉输液和全身类固醇治疗,同时进行症状管理。由于新型冠状病毒感染症(COVID-19)危机,全世界都处于封锁状态,农村地区的患者无法去看皮肤科医生。因此,在社区卫生中心医护人员和移动远程皮肤科的帮助下,该患者被诊断为卡马西平所致中毒性表皮坏死松解症,治疗成功,效果良好。
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引用次数: 4
Aeromonas hydrophila Survives the Treatment of Posttraumatic Cellulitis in the Shelter of an Obscured Fish-Bone Fragment. 嗜水气单胞菌在鱼骨碎片遮蔽的创伤后蜂窝组织炎治疗中存活下来。
Q3 Medicine Pub Date : 2020-10-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6498950
Areti Ganiatsa, Constantina Gartzonika, Georgios Gaitanis, Paraskevi Voulgari, Stamatina Levidiotou-Stefanou, Ioannis D Bassukas

Fish bone and/or spine puncture injuries can result in infection of the upper extremities with aquatic bacterial pathogens. Additionally, in such injuries, the inoculation of foreign organic material is frequent and may further complicate the clinical presentation and course of the resulting infection. We describe the case of a 45-year-old female patient with a minimal fish rostrum puncture trauma acquired during preparation of fresh fish meal, which resulted in a galloping hand cellulitis. The alarming clinical presentation and the prompt response of the skin infection to clindamycin obscured the presence of inoculated fish rostrum remnants in the tissue that, three weeks later, gave rise to a foreign body granuloma, from which Aeromonas hydrophila was isolated. Final resolution was achieved with an additional two-week doxycycline treatment. In conclusion, the reported case highlights the potential of the accidentally implanted organic material, as are fish bones, not only to transfer uncommon pathogens but also to offer a sanctuary that favors microbial survival despite antibiotic therapy thus enabling latent or recurrent infections.

鱼骨和/或脊椎刺伤可导致上肢感染水生细菌病原体。此外,在此类损伤中,经常会接种外来有机物,这可能会使感染的临床表现和病程更加复杂。我们描述了一例 45 岁女性患者的病例,她在准备鲜鱼餐时受到鱼喙刺伤,导致手部蜂窝组织炎。令人震惊的临床表现和皮肤感染对克林霉素的迅速反应掩盖了组织中存在的接种鱼喙残留物,三周后,这些残留物引发了异物肉芽肿,并从中分离出嗜水气单胞菌。经过两周的强力霉素治疗,病症最终得到缓解。总之,报告的病例凸显了意外植入的有机物(如鱼骨)不仅可能转移不常见的病原体,还可能提供一个庇护所,使微生物在抗生素治疗后仍能存活,从而使感染潜伏或复发。
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引用次数: 0
Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events. 转移性默克尔细胞癌伪装成多重免疫相关不良事件。
Q3 Medicine Pub Date : 2020-09-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8890845
Farees Saqlain, Sophia Z Shalhout, Kevin S Emerick, Tomas G Neilan, Tatyana Sharova, David Michael Miller

Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with pembrolizumab and radiation. Widely metastatic disease eventually revealed on autopsy clinically mimicked immune-related organ insult leading to management with immunosuppressants. The patient also had a biopsy-confirmed immune-related cutaneous adverse event during admission. The case highlights a rare circumstance in which disease progression masqueraded as multiple immune-related end-organ adverse events. Contribution of on-target anti-PD-1 toxicity remains a possibility.

默克尔细胞癌是一种罕见的皮肤神经内分泌癌,具有高的区域和远处转移率和死亡率。在这里,我们报告了一例新的默克尔细胞癌,其表现为左脸颊原发性病变,伴有局部淋巴结受累,并接受了派姆单抗和放射治疗。广泛的转移性疾病最终在尸检中发现,临床模拟免疫相关器官的损害,导致免疫抑制剂的管理。患者入院时也有活检证实的免疫相关皮肤不良事件。该病例强调了一种罕见的情况,在这种情况下,疾病进展伪装成多种免疫相关的终末器官不良事件。靶向抗pd -1毒性仍有可能发挥作用。
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引用次数: 5
期刊
Case Reports in Dermatological Medicine
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