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Confluent and Reticulated Papillomatosis Successfully Treated with Topical Vitamin A Derivative. 局部维生素A衍生物成功治疗汇合性网状乳头状瘤病。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/9467084
Manal Alsulami, Bader Alharbi, Yaser Alotaibi, Fadi Alghamdi, Adel Alsantali

Confluent and reticulated papillomatosis (CARP) is a rare dermatosis that typically develops in adolescents and young adults. Clinical characteristics include hyperkeratotic papules that coalesce centrally with a reticulated pattern peripherally on the central and upper trunk, neck, and axilla. Its etiology is not precisely known, and disordered keratinization has been postulated as one of the etiologies. Treatment options of the disease include systemic (such as antibiotics, antifungals, and retinoids) and topical treatments (such as lactic acid, antifungals, retinoids, salicylic acid, urea, tacrolimus, and vitamin D analogs). We report a case of a 17-year-old boy, otherwise healthy, presented with a new onset of asymptomatic, persistent, and slowly progressing brownish skin lesions over the trunk for 6 months. The diagnosis was revised to CARP based on clinical and histopathological examination. Treatment with topical tretinoin 0.025% cream once daily was begun. There was complete resolution of his lesions at the end of 8 weeks of therapy. There has been no relapse at 2 months follow-up. The effectiveness of tretinoin in this patient supports the theory that CARP is a keratinization disorder. Initiating treatment with topical tretinoin when no limitations for its use would be reasonable as it can provide a safer alternative to systemic therapy.

融合网状乳头状瘤病(鲤鱼)是一种罕见的皮肤病,通常发生在青少年和年轻人。临床特征包括角化性丘疹,在躯干中央和上部、颈部和腋窝周围以网状模式聚集。其病因尚不清楚,角化紊乱被认为是病因之一。该疾病的治疗方案包括全身治疗(如抗生素、抗真菌药物和类维生素a)和局部治疗(如乳酸、抗真菌药物、类维生素a、水杨酸、尿素、他克莫司和维生素D类似物)。我们报告一例17岁的男孩,其他方面健康,表现为无症状,持续,缓慢进展的躯干棕色皮肤病变新发6个月。根据临床和组织病理学检查,诊断修改为鲤鱼。开始使用0.025%维甲酸乳膏治疗,每日一次。治疗8周后病变完全消退。随访2个月无复发。维甲酸在该患者中的有效性支持了CARP是一种角化疾病的理论。在没有使用限制的情况下开始局部维甲酸治疗是合理的,因为它可以为全身治疗提供更安全的选择。
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引用次数: 0
A Case Report and Literature Review of Bilateral Cervical Chondrocutaneous Branchial Remnants. 双侧颈椎软骨皮鳃裂残余1例并文献复习。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/8475270
Yuehua He, Huiling Zhu, Hang Ji, Weining Huang, Zhongrong Liu

Chondrocutaneous branchial remnants (CCBRs) are rare congenital heterotopic tissue formations originating from the first or second embryonic branchial arches. Clinically, CCBRs are characterized predominantly by unilateral and solitary cartilaginous nodules found on the lower neck region. Herein, we present a case of CCBRs in a 9-year-old male patient who presented with horn-shaped projecting masses on either side of the anterior border of the sternocleidomastoid muscle. The pathological report following surgical resection revealed that the lesion was located in the dermis and consisted primarily of hyaline cartilage tissue enclosed by a fibrous capsule, with few local vascular proliferations. Based on the clinical and pathological features, the patient was ultimately diagnosed with congenital bilateral cervical chondrocutaneous branchial remnants.

软骨皮鳃裂残余物是一种罕见的先天性异位组织,起源于第一或第二胚胎鳃裂弓。临床上,ccbr主要表现为单侧和孤立的下颈部软骨结节。在此,我们报告一个9岁男性患者的cbrs病例,他在胸锁乳突肌前缘两侧表现为角状突出肿块。手术切除后的病理报告显示病变位于真皮层,主要由纤维囊包围的透明软骨组织组成,很少有局部血管增生。根据临床和病理特征,患者最终被诊断为先天性双侧颈椎软骨皮鳃裂残余。
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引用次数: 0
Hypopigmented Mycosis Fungoides in an 11-Year-Old Palestinian Boy. 11岁巴勒斯坦男孩的蕈样霉菌病。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/4310796
Duha Rabi, Balqis Shawer, Ahmad Rabee, Mohammad Qudaimat, Mohammad Milhem, Izzeddin Bakri

Cutaneous T-cell lymphoma (CTCL) is a lymphoproliferative disorder of the skin. The most common subtype of CTCL in pediatrics is mycosis fungoides (MF). There are multiple variants of MF. The hypopigmented variant represents more than 50% of MF cases in pediatrics. Misdiagnosis of MF can occur because it may resemble other benign skin pathologies. This is a case of an 11-year-old Palestinian boy presented with generalized nonpruritic hypopigmented maculopapular patches with progressive course for 9-months. Biopsy samples from a hypopigmented patch revealed appearances diagnostic of MF. Immunohistochemical staining was positive for CD3 and CD7 (partial) and a mixture of CD4 and CD8 positive cells. The patient's case was managed with narrowband ultraviolet B (NBUVB) phototherapy. After a few sessions, the hypopigmented lesions improved significantly.

皮肤t细胞淋巴瘤(CTCL)是一种皮肤淋巴细胞增生性疾病。儿科CTCL最常见的亚型是蕈样真菌病(MF)。MF有多种变体。低色素变体占儿科MF病例的50%以上。MF可能会被误诊,因为它可能类似于其他良性皮肤病变。这是一个11岁的巴勒斯坦男孩,表现为全身性非瘙痒性低色素黄斑丘疹,病程进展9个月。低色素斑块的活检样本显示诊断性MF。免疫组化染色CD3和CD7(部分)阳性,CD4和CD8混合阳性细胞。采用窄带紫外线B (NBUVB)光疗治疗。几次治疗后,色素减退病变明显改善。
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引用次数: 0
Granulosis Rubra Nasi: A Case Report and Brief Review of the Literature. 红斑性颗粒病1例报告及文献综述。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/3927244
Girum T Assefa

Granulosis rubra nasi is a rare autosomal dominant disease of the eccrine glands. It is clinically characterized by mid-face hyperhidrosis, most prominent at the tip of the nose, and dark erythematous papules on the nose, cheeks, chin, and upper lip. Although it commonly occurs in childhood, it can also occur in adults. This is a case report of two female granulosis rubra nasi patients. This report, to the best of my knowledge, has not before been described in Ethiopian individuals and is hence being reported due to its rarity.

鼻红色颗粒病是一种罕见的常染色体显性遗传病。临床表现为面部中部多汗症,鼻尖最突出,鼻子、脸颊、下巴和上唇出现黑色红斑丘疹。虽然它通常发生在儿童时期,但也可能发生在成年人身上。本文报告2例女性鼻性肉芽肿患者。据我所知,这一报告以前从未在埃塞俄比亚个人中出现过,因此由于其罕见而予以报道。
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引用次数: 0
LEOPARD Syndrome with a Sporadic PTPN11 Mutation in a Saudi Patient. 豹综合征伴散发性PTPN11突变的沙特患者
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/4161574
Hussein M Alshamrani, Luai M Assaedi, Jumanah A Bahattab, Abdulrahman M Mohammad, Magdy R Abdulghani

LEOPARD syndrome (LS) is a rare autosomal dominant inherited or sporadic genetic disorder caused commonly by missense mutations in the protein-tyrosine phosphatase-nonreceptor type 11 (PTPN11) gene. Due to its rarity and a high chance of misdiagnosis, the epidemiological profile of LS is poorly established. To the best of our knowledge, this is the second report with a documented PTPN11 gene mutation in Saudi Arabia.

豹综合征(LS)是一种罕见的常染色体显性遗传或散发性遗传疾病,通常由蛋白酪氨酸磷酸酶非受体11型(PTPN11)基因的错义突变引起。由于其罕见和误诊的高机会,LS的流行病学概况是不完善的。据我们所知,这是沙特阿拉伯第二份记录PTPN11基因突变的报告。
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引用次数: 0
Treatment of Generalized Granuloma Annulare with Oral Griseofulvin. 口服灰黄霉素治疗广泛性环形肉芽肿。
Q3 Medicine Pub Date : 2022-11-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2523710
Chumsaeng Chumsaengsri, Jongjin Suwanthaweemeesuk

Background: Granuloma annulare (GA) is a benign skin disease that has four clinical variants including localized, generalized, perforating, and subcutaneous GA. The most common type is localized GA, followed by generalized GA. Generalized GA was defined as at least 10 widespread annular plagues and frequently on the trunk, face, neck, and extremities. The diagnosis was made by clinical and histopathology. Generalized GA was difficult to treat. Case Presentation. We presented a Thai woman with nonscaly annular papules and plaques on the trunk and all extremities. A skin biopsy revealed a lesion that was compatible with granuloma annulare. She was partially resolved with 2-month course of oral griseofluvin 500 mg daily. Discussion. The regression of GA response to oral griseofulvin is consistent with the inflammatory nature, which identified IFN-gamma upregulated in GA.

Conclusion: Griseofulvin is safe with few side effects and cost effectiveness. Further studies are needed to better understand the immunology and pathogenesis of GA.

背景:环形肉芽肿(GA)是一种良性皮肤病,临床上有四种变异,包括局部、全身、穿孔和皮下肉芽肿。最常见的是局部遗传算法,其次是广义遗传算法。广泛性GA定义为至少10种广泛分布的环状鼠疫,常发生在躯干、面部、颈部和四肢。经临床及组织病理学诊断。广泛性GA难以治疗。案例演示。我们提出了一个泰国妇女无鳞片环形丘疹和斑块在躯干和四肢。皮肤活检显示病变与环形肉芽肿一致。患者在2个月的疗程中口服griseofluvin,每日500mg,部分缓解。讨论。GA对口服灰黄霉素反应的消退与炎症性质一致,这表明ifn - γ在GA中上调。结论:灰黄霉素安全性好,副作用少,成本效益高。需要进一步研究以更好地了解GA的免疫学和发病机制。
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引用次数: 0
Aggressive Acute Marjolin's Ulcer Arising in a Burn Scar. 烧伤瘢痕引起的侵袭性急性马氏溃疡。
Q3 Medicine Pub Date : 2022-11-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8329050
Adela Alvarez Rio, Josep Oriol Roca Mas, Daniel Navarro Sanchez, Ivan Monge Castresana, Gonzalo Joaquin Soroa Moreno, Jaime Estrada Cuxart

Marjolin's ulcer is one of the clinical variants of squamous-cell carcinoma. It is a highly aggressive disease that develops from chronic wounds. Almost 65% of these lesions have been diagnosed on underlying burn scars. Although the mean latency time between the primary lesion and the apparition of the ulcer is around 25 years, some cases with an early debut have been described. Squamous-cell carcinomas arising in chronic wounds are typically aggressive and are related with a poor prognosis due to their late diagnosis. Therefore, it is important to recognize symptoms that indicate malignant degeneration of chronic wounds, allowing the clinician to make an early diagnosis in order not to delay the surgical treatment that is required to improve the global survival of the patient. The time elapsed between our patient's burn and the appearance of Marjolin's ulcer was only 7 months, drawing attention to its fast and aggressive progression.

马卓林溃疡是鳞状细胞癌的临床变种之一。这是一种由慢性伤口发展而来的高度侵袭性疾病。几乎65%的这些病变被诊断为潜在的烧伤疤痕。虽然原发性病变和溃疡出现之间的平均潜伏期约为25年,但一些早期出现的病例已被描述。慢性伤口中出现的鳞状细胞癌通常具有侵袭性,由于诊断较晚,预后较差。因此,重要的是要识别慢性伤口恶性变性的症状,使临床医生能够做出早期诊断,以避免延迟手术治疗,这是提高患者整体生存率所必需的。从患者的烧伤到出现马卓林溃疡的时间仅为7个月,引起了人们对其快速和侵袭性进展的注意。
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引用次数: 1
Amelanotic Melanoma Treated as Fungal Infection for Years. 无色素黑色素瘤作为真菌感染治疗多年。
Q3 Medicine Pub Date : 2022-11-07 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2598965
Guilherme Kuceki, Dekker C Deacon, Aaron M Secrest

This study describes a case of amelanotic lentigo maligna melanoma in a 69-year-old female that had been growing for approximately 5 years. The asymptomatic lesion had been previously diagnosed and treated as a fungal skin infection, an inflammatory rash, and an actinic keratosis that did not respond to standard treatments. Biopsy revealed confluent and nested atypical melanocytes at the dermal-epidermal junction, consistent with melanoma in situ. Excisional biopsy revealed invasive lentigo maligna melanoma, Breslow depth 0.3 mm, with positive melanoma in situ at margins. She is now 3 years post-Mohs surgery without recurrence. When working up a patient with a hypopigmented or inflammatory lesion not responding to standard therapies, physicians should always consider biopsy to rule out unusual neoplastic etiologies, such as amelanotic melanomas.

本研究描述了一个69岁女性的无色素色素体恶性黑色素瘤,已经生长了大约5年。该无症状病变曾被诊断为真菌性皮肤感染、炎症性皮疹和对标准治疗无效的光化性角化病。活检显示真皮-表皮交界处有融合和巢状的非典型黑色素细胞,与原位黑色素瘤一致。切除活检显示浸润性透镜状恶性黑色素瘤,Breslow深度0.3 mm,边缘原位黑色素瘤阳性。术后3年无复发。当对标准治疗无效的低色素或炎性病变进行检查时,医生应考虑活检以排除不寻常的肿瘤病因,如无色素黑色素瘤。
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引用次数: 1
Giant Dermatofibroma: A Rare Presentation as a Large Scaly Plaque. 巨大皮肤纤维瘤:一种罕见的大鳞状斑块。
Q3 Medicine Pub Date : 2022-10-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2542404
T Iqbal, V Mudaliar

A rare form of dermatofibroma (DF) is described in the literature as giant dermatofibroma. Due to the rarity and distinct presentation that can be confused with more sinister skin tumours, these can cause diagnostic uncertainty and require clinicopathologic correlation. Familiarity with this rare presentation of an otherwise common entity is required to prevent unnecessary clinical doubt and excessive interventions. We report a case of giant dermatofibroma on the leg of a 29-year-old healthy male that presented with a 7 cm, nonulcerated pink, brown plaque, adding to the limited literature of less than 30 known cases.

一种罕见的皮肤纤维瘤(DF)在文献中被描述为巨大的皮肤纤维瘤。由于罕见和独特的表现,可能与更险恶的皮肤肿瘤混淆,这些可能导致诊断不确定性,需要临床病理相关性。熟悉这种罕见的其他常见实体的表现是必要的,以防止不必要的临床怀疑和过度干预。我们报告一例29岁健康男性腿部的巨大皮肤纤维瘤,表现为7厘米,无溃疡的粉红色,棕色斑块,增加了不足30例已知病例的有限文献。
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引用次数: 0
New-Onset Lichen Planus Induced by the Pfizer COVID-19 Vaccine. 新冠肺炎疫苗致新发扁平苔藓的研究
Q3 Medicine Pub Date : 2022-09-17 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2082445
Fadi A Alghamdi, Shahad T Khayyat, Mohammed M Alshareef, Wala'a Felemban

Objective: Coronavirus disease 2019 (COVID-19) vaccine distribution continues to expand; however, increased cutaneous reactions have been reported. Several recent studies suggest a link between COVID-19 vaccination and the development of various cutaneous complications. Lichen planus is a chronic, immune-mediated, inflammatory dermatological illness with an unclear etiology. In this case report, we assessed the relationship between COVID-19 vaccination (Pfizer) and lichen planus diagnosis and evaluated the link between additional doses of the vaccine and disease progression.

Methods: Complete clinical, laboratory, and histopathological assessment of a patient was performed with ethical and privacy considerations. Written informed consent for all clinical data, images, and publication was obtained from the patient.

Results: New-onset lichen planus appeared 48 hours after the first dose of the Pfizer vaccine. The symptoms worsened following the second dose. The patient responded gradually to topical corticosteroids, and lichen planus was controlled within 21 days.

Conclusion: Our case significantly contributes to the literature by highlighting that additional doses of the Pfizer vaccine can contribute to disease progression. Therefore, reporting the patient's condition associated with COVID-19 vaccination should be considered. Future studies should be performed to investigate the combined onset of lichen planus and multisystem COVID-19 vaccine-related complications.

目的:2019冠状病毒病(COVID-19)疫苗分发继续扩大;然而,有报道称皮肤反应增加。最近的几项研究表明,COVID-19疫苗接种与各种皮肤并发症的发生之间存在联系。扁平苔藓是一种慢性、免疫介导的炎症性皮肤病,病因不明。在本病例报告中,我们评估了COVID-19疫苗接种(辉瑞)与扁平苔藓诊断之间的关系,并评估了额外剂量疫苗与疾病进展之间的联系。方法:对患者进行完整的临床、实验室和组织病理学评估,并考虑伦理和隐私。所有临床数据、图像和出版物均获得患者的书面知情同意。结果:首次接种后48小时出现新发扁平苔藓。第二次注射后症状恶化。患者对局部皮质类固醇逐渐有反应,扁平苔藓在21天内得到控制。结论:我们的病例通过强调额外剂量的辉瑞疫苗可以促进疾病进展,对文献做出了重大贡献。因此,应考虑报告与COVID-19疫苗接种相关的患者病情。未来的研究应进一步调查扁平苔藓和多系统COVID-19疫苗相关并发症的合并发病情况。
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引用次数: 2
期刊
Case Reports in Dermatological Medicine
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