Pub Date : 2025-05-24DOI: 10.1016/j.crwh.2025.e00716
Ruth S. Goh , Wee Ming Peh , Christopher Goh Hood Keng
Pyogenic granuloma gravidarum (PGG) is a benign fibrovascular lesion arising during pregnancy. This report concerns a woman in her third trimester of pregnancy with recurrent left epistaxis and a swelling in her left nostril. She was diagnosed with PGG via magnetic resonance imaging (MRI) and nasoendoscopy. The lesion was managed conservatively and the neonate was delivered without complication at 37 weeks of gestation. Evidence shows that MRI is superior to computerised tomography (CT) in the assessment of soft-tissue masses, but there is a paucity of MRI PGG imaging in the literature. This report shows that MRI, together with the clinical context, is adequate to make a diagnosis of PGG. This was a rare case of a nasal lesion that was allowed to involute conservatively, hence avoiding the potential complications of surgery. This appears to be the first published report to include a follow-up to a successful second pregnancy and delivery without the recurrence of PGG.
{"title":"Pyogenic granuloma gravidarum: A case report","authors":"Ruth S. Goh , Wee Ming Peh , Christopher Goh Hood Keng","doi":"10.1016/j.crwh.2025.e00716","DOIUrl":"10.1016/j.crwh.2025.e00716","url":null,"abstract":"<div><div>Pyogenic granuloma gravidarum (PGG) is a benign fibrovascular lesion arising during pregnancy. This report concerns a woman in her third trimester of pregnancy with recurrent left epistaxis and a swelling in her left nostril. She was diagnosed with PGG via magnetic resonance imaging (MRI) and nasoendoscopy. The lesion was managed conservatively and the neonate was delivered without complication at 37 weeks of gestation. Evidence shows that MRI is superior to computerised tomography (CT) in the assessment of soft-tissue masses, but there is a paucity of MRI PGG imaging in the literature. This report shows that MRI, together with the clinical context, is adequate to make a diagnosis of PGG. This was a rare case of a nasal lesion that was allowed to involute conservatively, hence avoiding the potential complications of surgery. This appears to be the first published report to include a follow-up to a successful second pregnancy and delivery without the recurrence of PGG.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00716"},"PeriodicalIF":0.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.crwh.2025.e00715
Stephen Darko , Nnabuike Chibuoke Ngene
Amongst the indications for caesarean delivery (CD) in pregnant women presenting with placental abruption (PA), fetal demise near term, and a previous major uterine surgery are peritonitic abdomen and severe vaginal bleeding. When the presence of these two indications is equivocal, deciding on the mode of delivery becomes challenging, as uterine rupture is a differential diagnosis. This case report develops an algorithm for decision-making on the mode of delivery in this context. A 22-year-old woman (G2P1) with a previous CD presented with antepartum hemorrhage (APH) at 36 weeks of gestation. In the previous pregnancy, she developed pre-eclampsia, PA at 34 weeks of gestation, and had CD and stillbirth. In the index pregnancy, she declined aspirin and had no pre-eclampsia. The APH at index presentation was mild-moderate, making the decision on mode of delivery difficult, but CD was favoured due to the possibility of uterine rupture. Another support for this decision was that access to emergency CD might be limited at the busy hospital the patient attended if an attempt at vaginal delivery were employed and an obvious indication for CD developed later. The decision-delivery time was 95 min. Intra-operatively, Couvelaire uterus, retroplacental clot, and left lateral fundal uterine rupture were found. Lower segment CD was performed, and the uterus repaired in layers. In conclusion, individualized care is recommended for women with PA, fetal demise near term, and a previous major uterine surgery. The clinical condition and context are important considerations that should guide the preferred mode of delivery.
{"title":"Mode of delivery in placental abruption: A case report on difficulty in distinguishing between uterine rupture and placental abruption due to clinical features that overlap","authors":"Stephen Darko , Nnabuike Chibuoke Ngene","doi":"10.1016/j.crwh.2025.e00715","DOIUrl":"10.1016/j.crwh.2025.e00715","url":null,"abstract":"<div><div>Amongst the indications for caesarean delivery (CD) in pregnant women presenting with placental abruption (PA), fetal demise near term, and a previous major uterine surgery are peritonitic abdomen and severe vaginal bleeding. When the presence of these two indications is equivocal, deciding on the mode of delivery becomes challenging, as uterine rupture is a differential diagnosis. This case report develops an algorithm for decision-making on the mode of delivery in this context. A 22-year-old woman (G2P1) with a previous CD presented with antepartum hemorrhage (APH) at 36 weeks of gestation. In the previous pregnancy, she developed pre-eclampsia, PA at 34 weeks of gestation, and had CD and stillbirth. In the index pregnancy, she declined aspirin and had no pre-eclampsia. The APH at index presentation was mild-moderate, making the decision on mode of delivery difficult, but CD was favoured due to the possibility of uterine rupture. Another support for this decision was that access to emergency CD might be limited at the busy hospital the patient attended if an attempt at vaginal delivery were employed and an obvious indication for CD developed later. The decision-delivery time was 95 min. Intra-operatively, Couvelaire uterus, retroplacental clot, and left lateral fundal uterine rupture were found. Lower segment CD was performed, and the uterus repaired in layers. In conclusion, individualized care is recommended for women with PA, fetal demise near term, and a previous major uterine surgery. The clinical condition and context are important considerations that should guide the preferred mode of delivery.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00715"},"PeriodicalIF":0.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-13DOI: 10.1016/j.crwh.2025.e00714
Alyssa Gonzalez , Courtney Fant , Ashten Waks , Thao Le , Jonathan G. Steller
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific condition characterized by pruritus and elevated bile acids. It typically manifests in the third trimester of pregnancy and has been associated with hormonal and genetic factors. Early-onset ICP poses unique diagnostic challenges and may contribute to increased risks of adverse maternal and fetal outcomes. We present a case of severe ICP identified in the early second trimester and later attributed to a rare gene variant.
A 24-year-old patient (G3P0202) was admitted at 17 weeks of gestation with pruritis, abdominal pain, and jaundice. Laboratory studies were notable for elevated total and direct bilirubin as well as elevated bile acids. The patient's medical history included early-onset ICP accompanied by jaundice in all previous pregnancies. A cholestasis gene panel revealed an autosomal recessive variant in the ABCB11 gene, which encodes a bile salt export pump and is associated with benign recurrent intrahepatic cholestasis (BRIC). Throughout the duration of her pregnancy, the patient was co-managed with the hepatobiliary service, and her symptoms were adequately controlled with ursodeoxycholic acid, rifampin, and hydroxyzine. She labored spontaneously at 34 weeks of gestation and delivered a healthy infant.
This case underscores the importance of genetic evaluation in the assessment of atypical ICP, particularly in early-onset, recurrent, or treatment-refractory cases. It also highlights the need for multidisciplinary management of complex cases with obstetricians, hepatologists, and genetic counselors.
{"title":"Early-onset intrahepatic cholestasis of pregnancy resulting from a genetic mutation: A case report","authors":"Alyssa Gonzalez , Courtney Fant , Ashten Waks , Thao Le , Jonathan G. Steller","doi":"10.1016/j.crwh.2025.e00714","DOIUrl":"10.1016/j.crwh.2025.e00714","url":null,"abstract":"<div><div>Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific condition characterized by pruritus and elevated bile acids. It typically manifests in the third trimester of pregnancy and has been associated with hormonal and genetic factors. Early-onset ICP poses unique diagnostic challenges and may contribute to increased risks of adverse maternal and fetal outcomes. We present a case of severe ICP identified in the early second trimester and later attributed to a rare gene variant.</div><div>A 24-year-old patient (G3P0202) was admitted at 17 weeks of gestation with pruritis, abdominal pain, and jaundice. Laboratory studies were notable for elevated total and direct bilirubin as well as elevated bile acids. The patient's medical history included early-onset ICP accompanied by jaundice in all previous pregnancies. A cholestasis gene panel revealed an autosomal recessive variant in the ABCB11 gene, which encodes a bile salt export pump and is associated with benign recurrent intrahepatic cholestasis (BRIC). Throughout the duration of her pregnancy, the patient was co-managed with the hepatobiliary service, and her symptoms were adequately controlled with ursodeoxycholic acid, rifampin, and hydroxyzine. She labored spontaneously at 34 weeks of gestation and delivered a healthy infant.</div><div>This case underscores the importance of genetic evaluation in the assessment of atypical ICP, particularly in early-onset, recurrent, or treatment-refractory cases. It also highlights the need for multidisciplinary management of complex cases with obstetricians, hepatologists, and genetic counselors.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00714"},"PeriodicalIF":0.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-02DOI: 10.1016/j.crwh.2025.e00712
Simon Banh, Susan Keating
{"title":"Corrigendum to “Labial artery pseudoaneurysm following preterm vaginal delivery treated with ultrasound-guided thrombin injection: A case report” [Case Reports in Women's Health Volume 39 (2023)]","authors":"Simon Banh, Susan Keating","doi":"10.1016/j.crwh.2025.e00712","DOIUrl":"10.1016/j.crwh.2025.e00712","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00712"},"PeriodicalIF":0.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-29DOI: 10.1016/j.crwh.2025.e00711
Everett Lwamulungi, Corrine Arara, Jeevan Marasinghe, Jacqueline Van Dam
Spontaneous uterine rupture in the second trimester is an extremely rare but critical obstetric emergency, associated with significant maternal and foetal morbidity and mortality. A 41-year-old multiparous woman presented at 16 weeks of gestation with acute lower abdominal pain and vaginal bleeding. Initial evaluation revealed severe anaemia and haemodynamic instability. Imaging demonstrated massive hemoperitoneum and a possible placental abruption, necessitating emergency surgical intervention. Emergency laparotomy revealed a uterine fundal rupture with active bleeding and a bulging amniotic sac. The foetus was evacuated via a midline vertical uterine incision. A two-layer repair of the uterine defect was performed and the patient was admitted to intensive care for postoperative monitoring. She recovered well and was discharged free of complications. This case emphasizes the importance of early recognition and timely surgical intervention in the management of spontaneous second-trimester uterine rupture to prevent severe adverse outcomes.
{"title":"Spontaneous second-trimester uterine rupture in an unscarred uterus: A case report and review of literature","authors":"Everett Lwamulungi, Corrine Arara, Jeevan Marasinghe, Jacqueline Van Dam","doi":"10.1016/j.crwh.2025.e00711","DOIUrl":"10.1016/j.crwh.2025.e00711","url":null,"abstract":"<div><div>Spontaneous uterine rupture in the second trimester is an extremely rare but critical obstetric emergency, associated with significant maternal and foetal morbidity and mortality. A 41-year-old multiparous woman presented at 16 weeks of gestation with acute lower abdominal pain and vaginal bleeding. Initial evaluation revealed severe anaemia and haemodynamic instability. Imaging demonstrated massive hemoperitoneum and a possible placental abruption, necessitating emergency surgical intervention. Emergency laparotomy revealed a uterine fundal rupture with active bleeding and a bulging amniotic sac. The foetus was evacuated via a midline vertical uterine incision. A two-layer repair of the uterine defect was performed and the patient was admitted to intensive care for postoperative monitoring. She recovered well and was discharged free of complications. This case emphasizes the importance of early recognition and timely surgical intervention in the management of spontaneous second-trimester uterine rupture to prevent severe adverse outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00711"},"PeriodicalIF":0.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-22DOI: 10.1016/j.crwh.2025.e00710
Jennifer Bisland, Paul T.-Y. Ayuk
{"title":"Mpox in pregnancy: Clinical management and preparedness for a clade I outbreak","authors":"Jennifer Bisland, Paul T.-Y. Ayuk","doi":"10.1016/j.crwh.2025.e00710","DOIUrl":"10.1016/j.crwh.2025.e00710","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"47 ","pages":"Article e00710"},"PeriodicalIF":0.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.crwh.2025.e00709
Satyala Satya Priya , Singuang Kamei Gaithaoliu , Kim Johanna Catharina Verschueren , Parishuddharao Koduri
Myiasis refers to an infestation by maggots or fly larvae. Urogenital myiasis, particularly in the uterine cavity, is extremely rare. Previously reported cases involved uterine prolapses, typically managed with hysterectomy. We describe the successful conservative management of myiasis in an episiotomy wound with extension into the uterine cavity. The case involved a woman in her 30s who gave birth to her third child eight days prior and presented with a painful and infected episiotomy site with “worms” emerging from her vagina. Her poverty had led to her malnourishment and poor hygiene; she was being treated for pulmonary tuberculosis. She required 11 days of inpatient care, which included broad-spectrum antibiotics, a three- to five-day course of ivermectin, clindamycin and albendazole, larvae extraction, manual vacuum aspiration, uterine cavity irrigation and the daily application of a menstrual pad soaked in turpentine oil. No further maggots were detected near the end of her hospital stay, nor at follow-up. This case demonstrates that conservative treatment can be effective, though it requires patience. Ensuring proper nutritional status and personal hygiene in the postpartum period is critical to preventing wound infections complicated by myiasis.
{"title":"Successful conservative management of myiasis of an episiotomy wound and the uterine cavity postnatally: A case report","authors":"Satyala Satya Priya , Singuang Kamei Gaithaoliu , Kim Johanna Catharina Verschueren , Parishuddharao Koduri","doi":"10.1016/j.crwh.2025.e00709","DOIUrl":"10.1016/j.crwh.2025.e00709","url":null,"abstract":"<div><div>Myiasis refers to an infestation by maggots or fly larvae. Urogenital myiasis, particularly in the uterine cavity, is extremely rare. Previously reported cases involved uterine prolapses, typically managed with hysterectomy. We describe the successful conservative management of myiasis in an episiotomy wound with extension into the uterine cavity. The case involved a woman in her 30s who gave birth to her third child eight days prior and presented with a painful and infected episiotomy site with “worms” emerging from her vagina. Her poverty had led to her malnourishment and poor hygiene; she was being treated for pulmonary tuberculosis. She required 11 days of inpatient care, which included broad-spectrum antibiotics, a three- to five-day course of ivermectin, clindamycin and albendazole, larvae extraction, manual vacuum aspiration, uterine cavity irrigation and the daily application of a menstrual pad soaked in turpentine oil. No further maggots were detected near the end of her hospital stay, nor at follow-up. This case demonstrates that conservative treatment can be effective, though it requires patience. Ensuring proper nutritional status and personal hygiene in the postpartum period is critical to preventing wound infections complicated by myiasis.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00709"},"PeriodicalIF":0.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-15DOI: 10.1016/j.crwh.2025.e00707
Lalani De Silva , Kaumadi Udeshika , Sinha De Silva , Priyani Amarathunga
Russell bodies have been observed in various inflammatory and neoplastic conditions, although their presence in the female genital tract is rare, with fewer than ten documented cases of Russell body cervicitis. This case report appears to be the first of Russell body cervicitis identified during pregnancy. A 28-year-old woman, at 20 weeks of gestation, underwent a cervical polypectomy after a polyp was detected incidentally during a cervical cerclage procedure. Pathological examination revealed an inflamed endocervical polyp with predominant plasma cell infiltrate. Most of the plasma cells contained intracytoplasmic Russell bodies and there were some Mott cells. Immunohistochemical stains confirmed the polyclonal nature of the plasma cell infiltrate.
This report highlights the diagnostic challenges associated with Russell body cervicitis, given its rarity and histological resemblance to other inflammatory and neoplastic conditions. A review of the literature reveals that the few reported cases presented as a non-neoplastic process during reproductive age, with an uneventful follow-up. This report contributes to the limited knowledge of Russell body cervicitis, particularly in the context of pregnancy.
{"title":"Russell body cervicitis: A case report and literature review highlighting diagnostic pitfalls","authors":"Lalani De Silva , Kaumadi Udeshika , Sinha De Silva , Priyani Amarathunga","doi":"10.1016/j.crwh.2025.e00707","DOIUrl":"10.1016/j.crwh.2025.e00707","url":null,"abstract":"<div><div>Russell bodies have been observed in various inflammatory and neoplastic conditions, although their presence in the female genital tract is rare, with fewer than ten documented cases of Russell body cervicitis. This case report appears to be the first of Russell body cervicitis identified during pregnancy. A 28-year-old woman, at 20 weeks of gestation, underwent a cervical polypectomy after a polyp was detected incidentally during a cervical cerclage procedure. Pathological examination revealed an inflamed endocervical polyp with predominant plasma cell infiltrate. Most of the plasma cells contained intracytoplasmic Russell bodies and there were some Mott cells. Immunohistochemical stains confirmed the polyclonal nature of the plasma cell infiltrate.</div><div>This report highlights the diagnostic challenges associated with Russell body cervicitis, given its rarity and histological resemblance to other inflammatory and neoplastic conditions. A review of the literature reveals that the few reported cases presented as a non-neoplastic process during reproductive age, with an uneventful follow-up. This report contributes to the limited knowledge of Russell body cervicitis, particularly in the context of pregnancy.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00707"},"PeriodicalIF":0.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-05DOI: 10.1016/j.crwh.2025.e00708
Isabella Charlotte Maréchal-Ross , Sashi Siva , Karen Mizia , Jeremy Nicholas Pulvers , Isabella Turton , Ali Moghimi
Umbilical cord hemangiomas are rare benign vascular anomalies with limited documentation in the literature. Given their association with adverse perinatal outcomes, standardised criteria for reporting and monitoring are needed. This case report presents an instance of umbilical cord hemangioma and proposes a structured framework for future documentation.
A comprehensive literature review using OVID Medline and Embase identified cases of umbilical cord hemangiomas, their clinical presentations, and maternal and neonatal outcomes. A case diagnosed in the third trimester is presented, detailing antenatal surveillance, histopathological findings, and perinatal outcomes. Key parameters were analysed in the context of the literature to inform standardised reporting criteria.
A 36-year-old woman (G3P2) was diagnosed with an umbilical cord hemangioma at 29 + 3 weeks gestation following a routine growth scan. Serial ultrasound scans demonstrated lesion stability until 35 + 4 weeks, prompting increased fetal surveillance. Multidisciplinary consensus favoured expectant management, leading to an uncomplicated spontaneous vaginal delivery at 39 weeks. Histopathology confirmed a cord hemangioma composed of dilated, ectatic vascular channels lined by endothelial cells.
This case contributes to the growing body of evidence on umbilical cord hemangiomas by providing detailed clinical, ultrasound, and histopathological findings. Successful expectant management and favourable perinatal outcomes highlight the role of serial ultrasound surveillance. Given the rarity and potential risks of these lesions, standardised reporting is essential to improve understanding and to guide management. By proposing a set of standardised reporting criteria, this case report serves as a step toward enhancing data consistency and informing management strategies.
{"title":"Hemangioma of the umbilical cord: A case report and proposal for standardised reporting criteria","authors":"Isabella Charlotte Maréchal-Ross , Sashi Siva , Karen Mizia , Jeremy Nicholas Pulvers , Isabella Turton , Ali Moghimi","doi":"10.1016/j.crwh.2025.e00708","DOIUrl":"10.1016/j.crwh.2025.e00708","url":null,"abstract":"<div><div>Umbilical cord hemangiomas are rare benign vascular anomalies with limited documentation in the literature. Given their association with adverse perinatal outcomes, standardised criteria for reporting and monitoring are needed. This case report presents an instance of umbilical cord hemangioma and proposes a structured framework for future documentation.</div><div>A comprehensive literature review using OVID Medline and Embase identified cases of umbilical cord hemangiomas, their clinical presentations, and maternal and neonatal outcomes. A case diagnosed in the third trimester is presented, detailing antenatal surveillance, histopathological findings, and perinatal outcomes. Key parameters were analysed in the context of the literature to inform standardised reporting criteria.</div><div>A 36-year-old woman (G3P2) was diagnosed with an umbilical cord hemangioma at 29 + 3 weeks gestation following a routine growth scan. Serial ultrasound scans demonstrated lesion stability until 35 + 4 weeks, prompting increased fetal surveillance. Multidisciplinary consensus favoured expectant management, leading to an uncomplicated spontaneous vaginal delivery at 39 weeks. Histopathology confirmed a cord hemangioma composed of dilated, ectatic vascular channels lined by endothelial cells.</div><div>This case contributes to the growing body of evidence on umbilical cord hemangiomas by providing detailed clinical, ultrasound, and histopathological findings. Successful expectant management and favourable perinatal outcomes highlight the role of serial ultrasound surveillance. Given the rarity and potential risks of these lesions, standardised reporting is essential to improve understanding and to guide management. By proposing a set of standardised reporting criteria, this case report serves as a step toward enhancing data consistency and informing management strategies.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00708"},"PeriodicalIF":0.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder characterized by gastrointestinal polyps and protein-losing enteropathy. While an increasing number of CCS cases have been reported worldwide, no documented cases involving pregnant patients could be found. Consequently, optimal management strategies for CCS during the preconception period and pregnancy remain unclear., The present report concerns the case of a 36-year-old woman with steroid-refractory CCS stabilized with gastrointestinal surgeries and infliximab, an anti-tumor necrosis factor-α (TNF-α) agent, who became pregnant. Infliximab was continued throughout pregnancy and postpartum. Despite persistent hypoalbuminemia, sh delivered a healthy infant weighing 2518 g vaginally at 38 weeks and 2 days without CCS exacerbation. Both the patient and her infant experienced an uneventful postpartum course. This case suggests that maintaining disease control with anti-TNF-α therapy in pregnant patients with CCS may contribute to optimizing maternal and neonatal outcomes.
{"title":"Infliximab treatment for Cronkhite-Canada syndrome in pregnancy: A case report","authors":"Ayano Rosemary Nakamura , Shuji Yamamoto , Yoshitsugu Chigusa , Masaki Mandai , Haruta Mogami","doi":"10.1016/j.crwh.2025.e00706","DOIUrl":"10.1016/j.crwh.2025.e00706","url":null,"abstract":"<div><div>Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder characterized by gastrointestinal polyps and protein-losing enteropathy. While an increasing number of CCS cases have been reported worldwide, no documented cases involving pregnant patients could be found. Consequently, optimal management strategies for CCS during the preconception period and pregnancy remain unclear., The present report concerns the case of a 36-year-old woman with steroid-refractory CCS stabilized with gastrointestinal surgeries and infliximab, an anti-tumor necrosis factor-α (TNF-α) agent, who became pregnant. Infliximab was continued throughout pregnancy and postpartum. Despite persistent hypoalbuminemia, sh delivered a healthy infant weighing 2518 g vaginally at 38 weeks and 2 days without CCS exacerbation. Both the patient and her infant experienced an uneventful postpartum course. This case suggests that maintaining disease control with anti-TNF-α therapy in pregnant patients with CCS may contribute to optimizing maternal and neonatal outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00706"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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