Cerebral cortex最新文献

In their feature article, Lorenzi et al. (2025) compiled extensive biological evidence on the ontogenetic origins of the number sense. Drawing on both behavioral and neurobiological data, they convincingly argue that the "number sense" is fundamentally innate and present from birth in numerically competent animals, including humans. At the same time, the authors acknowledge the role of learning and experience in shaping numerical cognition. This commentary builds on the idea of learning-induced changes to the number sense, extending the concept of an innate number sense to one that is modifiable through learning and experience. It summarizes evidence from single-neuron recordings and proposes neurophysiological mechanisms underlying these learning-induced changes in numerical cognition.

This study explores the diagnostic value of dopamine system imaging characteristics in children with autism spectrum disorder. Functional magnetic resonance data from 551 children in the Autism Brain Imaging Data Exchange database were analyzed, focusing on six dopamine-related brain regions as regions of interest. Functional connectivity between these ROIs and across the whole brain was assessed. Machine learning techniques then evaluated the ability of the dopamine system's imaging features to predict autism spectrum disorder. Functional connectivity was significantly higher in autism spectrum disorder children between the ventral tegmental area and substantia nigra, prefrontal cortex, nucleus accumbens, and between the substantia nigra and hypothalamus compared to typically developing children. Additionally, clustering methods identified two autism spectrum disorder subtypes, achieving over 0.8 accuracy. Subtype 1 showed higher stereotyped behavior scores than subtype 2 in both genders, with subtype-specific functional connectivity differences between male and female autism spectrum disorder groups. These findings suggest that abnormal functional connectivity in the dopamine system serves as a diagnostic biomarker for autism spectrum disorder and can support clinical decision-making and personalized treatment optimization.

Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are both highly prevalent disorders and frequently co-occur. The underlying neurological mechanisms of the co-occurrence of ASD and ADHD (ASD + ADHD) remain unknown. This study focuses on investigating the effective connectivity (EC) alterations within the triple network model in individuals with ASD + ADHD. Resting-state functional magnetic resonance imaging data were obtained from 44 individuals with ASD + ADHD, 60 individuals with ASD without ADHD (ASD-only), 35 individuals with ADHD without ASD (ADHD-only), and 81 healthy controls (HC) from the Autism Brain Imaging Data Exchange II and the ADHD-200 Sample database. Spectral dynamic causal modeling was employed to explore the EC alterations within and between the default mode network, salience network, and central executive network. Our analysis showed that compared to HC, ASD + ADHD, ASD-only, and ADHD-only exhibited both shared and disorder-specific EC alterations within the triple-network model. These results have potential clinical implications for identifying ASD + ADHD, facilitating diagnostic accuracy, guiding targeted treatment approaches, and informing etiological studies.

Embryonic exposure to valproic acid and imidacloprid (a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of valproic acid are mitigated by post-hatch injection of bumetanide, a blocker of the chloride intruder Na-K-2Cl cotransporter 1. Here, we report that these exposures depolarized the reversal potential of local GABAergic transmission in the neurons of the intermediate medial mesopallium, the pallial region critical for imprinting. Furthermore, exposure increased field excitatory post-synaptic potentials in pre-tetanus recordings and impaired long-term potentiation (LTP) by low-frequency tetanic stimulation. Bath-applied bumetanide rescued the impaired LTP in the valproic acid slices, whereas VU0463271, a blocker of the chloride extruder KCC2, suppressed LTP in the control slices, suggesting that hyperpolarizing GABA action is necessary for the potentiation of excitatory synaptic transmission. Whereas a steep increase in the gene expression of KCC2 appeared compared to NKCC1 during the peri-hatch development, significant differences were not found between valproic acid and control post-hatch chicks in these genes. Instead, both valproic acid and imidacloprid downregulated several transcriptional regulators (FOS, NR4A1, and NR4A2) and upregulated the RNA component of signal recognition particles (RN7SL1). Despite different chemical actions, valproic acid and imidacloprid could cause common neuronal effects that lead to impaired imprinting.

The cerebral cortex consists of hierarchically organized areas interconnected by reciprocal axonal projections. However, the coordination of neurogenesis to optimize neuronal production and wiring between distinct cortical areas remains largely unexplored. The somatosensory cortex plays a crucial role in processing tactile information, with inputs from peripheral sensory receptors relayed through the thalamus to the primary and secondary somatosensory areas. To investigate the dynamics of neurogenesis in cortical circuit formation, we employed temporal genetic fate mapping of glutamatergic neuron cohorts across the somatosensory cortices. Our analysis revealed that neuronal production in the secondary somatosensory cortex (S2) precedes that of the primary somatosensory cortex (S1) from the deep-layer neuron production period and terminates earlier. We further revealed a progressive decline in upper-layer neuron output in S2, attributed to the attenuation of the apical ventricular surface, resulting in a reduced number of upper-layer neurons within S2. These findings support the existence of a protomap mechanism governing the area-specific assembly of primary and secondary areas in the developing neocortex.

Neuroinflammation has been identified as an important pathological component of cognitive impairment, and translocator protein imaging has become a valuable tool for assessing its patterns. We aimed to obtain the exact distribution of neuroinflammation in cognitive impairment and its underlying mechanisms with amyloid-beta. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, two investigators searched literature databases for studies that measured translocator protein binding levels. This measurement was performed between healthy controls and subjects with mild cognitive impairment or Alzheimer's disease via voxel-based positron emission tomography image analysis at the whole-brain level. This meta-analysis was performed with the anisotropic effect-size based algorithm. Neuroinflammation in patients with mild cognitive impairment was mainly concentrated in the left middle temporal gyrus and left amygdala. In Alzheimer's disease patients, the brain regions involved were the left inferior temporal gyrus, left calcarine fissure/surrounding cortex, left parahippocampal gyrus, right lingual gyrus, and right middle temporal gyrus. In addition, neuroinflammation in patients with cognitive impairment was highly correlated with amyloid-beta deposition in the cortex. This study deepens our understanding of the patterns of neuroinflammation in patients with cognitive impairment and its interaction with amyloid-beta, providing potential insights for therapeutic approaches targeting neuroinflammation in Alzheimer's disease.

Consumer decision-making varies according to an individual's relationship with the recipient of the gift. This study used a mock purchase task to investigate consumer decision-making and its underlying neurological mechanisms when purchasing gifts of different prices for recipients with varying levels of intimacy. Functional near-infrared spectroscopy was used to record neural activity during the task. Behavioral results found that the lover group had a much higher purchasing rate than the friend group, particularly when acquiring premium products. Analysis of the functional near-infrared spectroscopy data found that neural activity in the dorsolateral prefrontal cortex and orbitofrontal cortex decreased when items were discounted, with lower activation in the dorsolateral prefrontal cortex in lovers during the purchasing of premium products. Furthermore, we identified significant differences in functional connectivity between the dorsolateral prefrontal cortex and orbitofrontal cortex under different conditions. We compared the support vector machine algorithm and logistic regression, finding that logistic regression better predicts purchasing tendencies based on neuroactivation levels. In our view, a stronger emotional connection leads to a more rewarding experience for consumers when buying premium products. This study reveals the impact of intimate relationships on consumer decision-making and provides guidance for businesses in developing marketing strategies targeted at the lover's market.

The question of whether a "sense of number" is innate has been posed in a new article by Lorenzi et al. (2025). The article explores the behavioral and neurobiological evidence from newborn animals to delve into the evolutionary origins of a sense of number. Lorenzi et al.(2025) raises new questions, interpretations, and ideas for future work to understand how number sense has evolved in humans and nonhuman animals. In this commentary, I discuss the arguments for an innate number sense, evaluate the implications for numerical cognition, and suggest how future work could fill the current gaps in our knowledge.

Evidence has evinced the functional complexity, anatomical heterogeneity, connectivity diversity, and clinical relevance of the fusiform gyrus. We aimed to investigate the hierarchical organization of the fusiform gyrus and its underlying molecular basis. Resting-state functional MRI data of 793 healthy subjects were collected from a discovery dataset and two independent cross-scanner, cross-race validation datasets. Functional gradients of the fusiform gyrus were calculated based on the voxel-wise fusiform gyrus-to-cerebrum functional connectivity to reflect its functional organization. Transcription-neuroimaging spatial correlation analysis was performed to determine genes with expression levels tracking the fusiform gyrus functional gradient. The dominant functional gradient that explained the greatest connectivity variance showed an anterior-posterior axis across the fusiform gyrus. More important, there was a strong association between the fusiform gyrus-dominant gradient and gene expression profiles, with two gene sets contributing significantly to this association yet differing in their specific expression and functional annotation. In addition, the fusiform gyrus-dominant gradient was linked closely to intrinsic geometry, slightly to cortical morphology, and gradually to behavioral domains from high-level cognitive processes to low-level sensory functions. Our findings add to the extant knowledge regarding the topographic organization of the fusiform gyrus by informing a novel conceptualization of how functional heterogeneity and multiplicity co-occur within the fusiform gyrus.