Cellular immunology最新文献_第6页

Quercetin alleviates diabetic nephropathy by inhibiting M1 macrophage polarization via targeting NLRC5/NLRP3 pathway 槲皮素通过靶向NLRC5/NLRP3通路抑制M1巨噬细胞极化，缓解糖尿病肾病

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-08-01 Epub Date: 2025-06-17 DOI: 10.1016/j.cellimm.2025.104997

Abudoushalamu Abudoureyimu , Chen Chen , Yan Hu , Dilihumaer Nuermaimaiti , Tao Liu

Background

The activation imbalance of M1/M2 macrophage phenotypes is crucial in diabetic nephropathy (DN). This study aimed to explore the molecular mechanisms underlying quercetin's action against DN.

Methods

In vitro, RAW 264.7 macrophages were incubated with high glucose (HG) with or without quercetin. Overexpression of NLRC5 was investigated to elucidate the mechanism. M1/M2 macrophage differentiation was assessed by flow cytometry using cell surface markers CD86 and CD206. In vivo, a DN mouse model was created using a high-fat diet and streptozotocin (STZ). Quercetin was administered intragastrically to DN mice at 50 mg/kg and 100 mg/kg. After euthanasia, mouse kidneys were analyzed by hematoxylin and eosin (H&E), Masson's trichrome, and immunohistochemistry (IHC) staining. ELISA assay and western blot analysis were performed to determine related molecular levels.

Results

In vitro, quercetin significantly reduced HG-induced expressions of CD86, iNOS, NLRC5, NLRP3, and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), while increasing HG-induced CD206, Arg-1, and IL-10 in RAW 264.7 macrophages. However, these effects of quercetin were abolished when NLRC5 was overexpressed. In DN mice, quercetin administration ameliorated renal histopathological injury and fibrosis. Notably, there was a significant reduction in expressions of NLRC5, NLRP3, Col1a1, and α-SMA, along with decreased expressions of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β).

Conclusion

This study showed that quercetin improves DN by inhibiting M1-type macrophages through targeting the NLRC5/NLRP3 pathway.

M1/M2巨噬细胞表型的激活失衡在糖尿病肾病（DN）中至关重要。本研究旨在探讨槲皮素抗DN的分子机制。方法在体外用槲皮素或不加槲皮素培养高糖（HG）巨噬细胞。研究了NLRC5的过表达以阐明其机制。采用细胞表面标志物CD86和CD206，流式细胞术评估M1/M2巨噬细胞分化情况。在体内，采用高脂肪饮食和链脲佐菌素（STZ）建立DN小鼠模型。槲皮素分别以50 mg/kg和100 mg/kg剂量灌胃DN小鼠。安乐死后，用苏木精和伊红（H&；E）、马松三色和免疫组织化学（IHC）染色对小鼠肾脏进行分析。ELISA法和western blot法检测相关分子水平。结果槲皮素在体外显著降低hg诱导的巨噬细胞CD86、iNOS、NLRC5、NLRP3和促炎细胞因子（TNF-α、IL-6、IL-1β）的表达，升高hg诱导的RAW 264.7巨噬细胞CD206、Arg-1和IL-10的表达。然而，当NLRC5过表达时，槲皮素的这些作用被消除。在DN小鼠中，槲皮素可改善肾组织病理学损伤和纤维化。值得注意的是，NLRC5、NLRP3、Col1a1和α-SMA的表达显著降低，同时促炎细胞因子（TNF-α、IL-6和IL-1β）的表达降低。结论槲皮素通过靶向NLRC5/NLRP3通路抑制m1型巨噬细胞改善DN。

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引用次数: 0

“Mesenchymal stem cell-derived exosomes (MSC-exosomes) in hematology: From mechanisms to clinical breakthroughs” 间充质干细胞衍生外泌体（msc -exosome）在血液学中的应用：从机制到临床突破

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1016/j.cellimm.2025.104986

Irfan Ahmad , Ahmed Hussein , Bhavesh Kanabar , Abhinav Kumar , T. Ramachandran , Aman Shankhyan , A. Karthikeyan , Dhirendra Nath Thatoi , Zafar Aminov , Hamed Soleimani Samarkhazan , Zahra Jafari

Mesenchymal stem cells (MSCs) offer promising therapy because they regulate the immune system and help repair tissues. However, challenges such as low cell survival rates, immune rejection, and ethical concerns related to their clinical use have limited their widespread application. To overcome these limitations, MSC-derived exosomes (MSC-EXOs) have emerged as an innovative and promising cell-free therapeutic strategy. MSC-EXOs are nanosized extracellular vesicles released by MSCs that carry a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids. They share many benefits with MSCs, including immune regulation, anti-inflammatory effects, and tissue repair. MSC-EXOs demonstrate therapeutic potential by modulating the tumor microenvironment, suppressing tumor growth, and enhancing the efficacy of conventional therapies. They can specifically target cells, deliver therapeutic agents, and induce apoptosis in cancer cells. Additionally, MSC-EXOs can modulate the immune response, promote hematopoietic recovery, and alleviate treatment-related side effects. While MSC-EXOs present a promising therapeutic approach, several challenges remain, including the standardization of isolation and characterization methods, understanding their mechanisms of action, and ensuring both safety and efficacy. Despite these challenges, the future of MSC-EXO-based therapies in hematology is promising. Continued research efforts are essential to unravel the intricate biology of exosomes, identify novel biomarkers, and develop innovative therapeutic strategies. By harnessing the power of MSC-EXOs, we can revolutionize the treatment of hematological diseases and improve patient outcomes.

间充质干细胞（MSCs）提供了有希望的治疗方法，因为它们调节免疫系统并帮助修复组织。然而，诸如低细胞存活率、免疫排斥和与临床使用相关的伦理问题等挑战限制了它们的广泛应用。为了克服这些限制，msc衍生外泌体（MSC-EXOs）已成为一种创新且有前途的无细胞治疗策略。msc - exo是由msc释放的纳米级细胞外囊泡，其携带多种生物活性分子，包括蛋白质、脂质和核酸。它们与间充质干细胞有许多共同的好处，包括免疫调节、抗炎作用和组织修复。msc - exo通过调节肿瘤微环境、抑制肿瘤生长和增强常规疗法的疗效，显示出治疗潜力。它们可以特异性靶向细胞，传递治疗药物，诱导癌细胞凋亡。此外，msc - exo可以调节免疫反应，促进造血恢复，减轻治疗相关的副作用。虽然msc - exo是一种很有前景的治疗方法，但仍存在一些挑战，包括分离和表征方法的标准化，了解其作用机制，以及确保安全性和有效性。尽管存在这些挑战，但基于msc - exo的血液学治疗的未来是有希望的。持续的研究工作对于解开外泌体的复杂生物学，识别新的生物标志物和开发创新的治疗策略至关重要。通过利用msc - exo的力量，我们可以彻底改变血液病的治疗方法并改善患者的预后。

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引用次数: 0

Zinc finger protein 217 contributes to natural killer cell dysfunction in murine colorectal cancer 锌指蛋白217与小鼠结直肠癌自然杀伤细胞功能障碍有关

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-10 DOI: 10.1016/j.cellimm.2025.104971

Yibing Yu , Huanbin Yang , Hao Wang , Fei Xiao

Immune cells play active roles in the surveillance and control of colorectal cancer (CRC) progression. Natural killer (NK) cells are powerful anti-tumor effector cells but their regulatory mechanisms in the CRC tissues have not been thoroughly elucidated. In this research using a murine inflammatory colorectal cancer model, we characterized the phenotype and function of NK cells. We found signs of NK cell dysfunction in CRC tissues, including up-regulation of exhaustion markers, down-regulation of activating receptors, deficiencies in degranulation and cytokine expression, and weak cytolytic effect. Interestingly, zinc finger protein 217 (ZNF217), a transcription repressor, was significantly up-regulated in CRC-associated NK cells. In vitro assays revealed that ZNF217 knockdown promoted NK cell cytolytic activity, implying that ZNF217 is an inhibitory factor of NK cell function. Adoptive transfer assays indicated that ZNF217 knockdown also resulted in enhancement of NK cell function in vivo and subsequently suppressed CRC development. Furthermore, hypoxia rather than exhaustion up-regulated ZNF217 expression in NK cells. ZNF217 knockdown promoted NK cell resistance to hypoxia-mediated NK cell dysfunction. Therefore, we discovered a novel regulatory factor of NK cell dysfunction during CRC development.

免疫细胞在监测和控制结直肠癌（CRC）进展中发挥积极作用。自然杀伤细胞（NK）是一种强大的抗肿瘤效应细胞，但其在结直肠癌组织中的调控机制尚未完全阐明。在本研究中，我们利用小鼠炎性结直肠癌模型，表征NK细胞的表型和功能。我们在结直肠癌组织中发现NK细胞功能障碍的迹象，包括衰竭标志物上调，激活受体下调，脱颗粒和细胞因子表达不足，细胞溶解作用弱。有趣的是，锌指蛋白217 (ZNF217)，一种转录抑制因子，在crc相关的NK细胞中显著上调。体外实验显示，ZNF217敲低可促进NK细胞的细胞溶解活性，提示ZNF217是NK细胞功能的抑制因子。过继转移实验表明，ZNF217敲低也导致体内NK细胞功能增强，随后抑制结直肠癌的发展。此外，缺氧而非衰竭上调了NK细胞中ZNF217的表达。ZNF217敲低可促进NK细胞对缺氧介导的NK细胞功能障碍的抵抗。因此，我们发现了在结直肠癌发展过程中NK细胞功能障碍的一个新的调节因子。

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引用次数: 0

METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p METTL3通过m6a依赖的pri-miR-324-5p成熟促进成骨细胞分化和骨再生

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1016/j.cellimm.2025.104974

Jing Xiao , Zhiyuan Xu , Zhiwei Deng , Juntong Xie , Yiyan Qiu

Background

Osteoblast differentiation is essential for fracture healing and bone regeneration. miR-324-5p has been implicated in osteoporosis, but its precise role in osteogenic differentiation remains unclear. We investigated the function and regulatory mechanisms of miR-324-5p in bone marrow mesenchymal stem cells (BMSCs).

Methods

RT-qPCR was used to assess miR-324-5p expression during osteogenic differentiation of BMSCs. ALP, Alizarin Red S (ARS), Oil Red O, and TRAP staining were performed to evaluate osteoblast, adipocyte, and osteoclast differentiation. Rat femoral fracture and calvarial bone defect models were established to assess in vivo bone regeneration. Methylated RNA immunoprecipitation (MeRIP) and luciferase reporter assays were used to investigate METTL3-mediated m6A modification of pri-miR-324-5p and its regulation of ELAVL1.

Results

miR-324-5p expression increased during osteogenic differentiation, and ALP and ARS staining confirmed enhanced osteoblast activity and mineralization following miR-324-5p overexpression. Meanwhile, Oil Red O staining showed reduced adipogenic differentiation, and TRAP staining demonstrated suppressed osteoclast formation. In vivo, miR-324-5p promoted bone healing, bone mass, and bone regeneration. Mechanistically, METTL3-mediated m6A modification facilitated pri-miR-324-5p maturation, positively regulating its expression. Additionally, miR-324-5p directly targeted ELAVL1, and ELAVL1 overexpression reversed the osteogenic effects of miR-324-5p.

Conclusion

The METTL3/miR-324-5p/ELAVL1 axis plays a crucial role in osteogenic differentiation and bone regeneration, providing new insights into m6A modification-driven osteogenesis.

成骨细胞分化对骨折愈合和骨再生至关重要。miR-324-5p与骨质疏松症有关，但其在成骨分化中的确切作用尚不清楚。我们研究了miR-324-5p在骨髓间充质干细胞（BMSCs）中的功能和调控机制。方法采用srt - qpcr检测骨髓间充质干细胞成骨分化过程中miR-324-5p的表达。ALP、茜素红S （ARS）、油红O和TRAP染色来评估成骨细胞、脂肪细胞和破骨细胞的分化。建立大鼠股骨骨折和颅骨骨缺损模型，评估骨再生。使用甲基化RNA免疫沉淀（MeRIP）和荧光素酶报告基因检测来研究mettl3介导的pri-miR-324-5p的m6A修饰及其对ELAVL1的调节。结果miR-324-5p在成骨分化过程中表达增加，ALP和ARS染色证实miR-324-5p过表达后成骨细胞活性和矿化增强。同时，油红O染色显示成脂分化减少，TRAP染色显示破骨细胞形成受到抑制。在体内，miR-324-5p促进骨愈合、骨量和骨再生。在机制上，mettl3介导的m6A修饰促进了pri-miR-324-5p的成熟，积极调节其表达。此外，miR-324-5p直接靶向ELAVL1， ELAVL1过表达逆转了miR-324-5p的成骨作用。结论METTL3/miR-324-5p/ELAVL1轴在成骨分化和骨再生中起着至关重要的作用，为m6A修饰驱动成骨提供了新的见解。

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引用次数: 0

Investigating the effect of neuro-immune communication on immune responses in health and disease: Exploring immunological disorders 研究健康和疾病中神经免疫通讯对免疫反应的影响：探索免疫紊乱

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1016/j.cellimm.2025.104963

Fatemeh Hesampour , Charles N. Bernstein , Jean-Eric Ghia

Recent recognition of the intricate nervous-immune system interplay has prompted research into the specific cellular components involved in these interactions. Emerging evidence suggests that immune and neural cells collaborate within distinct units and act in concert to regulate tissue function and provide protection. These specialized neuro-immune cell units have been identified in diverse body tissues, ranging from lymphoid organs to the bone marrow and mucosal barriers. Their significance has become increasingly apparent as they are recognized as pivotal regulators influencing a broad spectrum of physiological and pathological processes. This recognition extends to critical roles in hematopoiesis, organ function, inflammatory responses, and intricate tissue repair processes. This review explores the bidirectional communication between the nervous and immune systems. The focus is on understanding the profound impact of this communication on immune cells within key anatomical sites, such as the bone marrow, gastrointestinal tract, and lymphoid organs. By examining these interactions, this review aims to shed light on how this intricate network operates under normal and pathological conditions, offering insights into the mechanisms underlying health and disease.

最近对复杂的神经-免疫系统相互作用的认识促使人们对参与这些相互作用的特定细胞成分进行了研究。新出现的证据表明，免疫细胞和神经细胞在不同的单位内协作，共同调节组织功能并提供保护。这些特殊的神经免疫细胞单位已经在不同的身体组织中被发现，从淋巴器官到骨髓和粘膜屏障。它们的重要性已经变得越来越明显，因为它们被认为是影响广泛的生理和病理过程的关键调节因子。这种认识延伸到造血、器官功能、炎症反应和复杂的组织修复过程的关键作用。本文综述了神经系统和免疫系统之间的双向交流。重点是了解这种交流对关键解剖部位（如骨髓、胃肠道和淋巴器官）免疫细胞的深远影响。通过研究这些相互作用，本综述旨在揭示这个复杂的网络在正常和病理条件下是如何运作的，为健康和疾病的潜在机制提供见解。

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引用次数: 0

Progress of exosomes in regulating tumor metastasis by remodeling the pre-metastatic immune microenvironment 外泌体通过重塑转移前免疫微环境调控肿瘤转移的研究进展

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1016/j.cellimm.2025.104960

Jiangning Xiang, Lin Yao, Shan Wang, Lei Zhao, Jing Yu

Exosomes play an important role in the metastatic microenvironment, acting as a transmission belt that facilitates intercellular communication. By delivering proteins, nucleic acids, and other substances in the exosomes, they can change the function of the receptor target cells, change the microenvironment of the metastatic site, and promote the colonization of the tumor cells, thus promoting cancer metastasis. The interaction between tumor cells and the surrounding microenvironment is complex, with exosomes serving as key facilitators of crosstalk between the primary tumor microenvironment and the pre-metastasis microenvironment. Despite many current studies to explore exosomes, we still do not have a detailed understanding of the role and mechanism of exosomes in the pre-metastatic immune microenvironment, and there are many challenges in the clinical application of exosomes. In this paper, we summarize the role of exosomes in regulating the pre-metastatic immune microenvironment and its mechanism, focusing on how exosomes regulate the function of immune cells in the pre-metastatic microenvironment to promote tumor metastasis. In addition, the potential application of exosomes in tumor immunotherapy and strategies for targeting exosomes are discussed. This will contribute to the immunotherapy of cancer metastasis and promote the clinical application of exosomes.

外泌体在转移性微环境中发挥重要作用，作为促进细胞间通讯的传输带。它们通过在外泌体中传递蛋白质、核酸等物质，改变受体靶细胞的功能，改变转移部位的微环境，促进肿瘤细胞的定植，从而促进癌症转移。肿瘤细胞与周围微环境之间的相互作用是复杂的，外泌体是原发肿瘤微环境与转移前微环境之间串扰的关键促进因子。尽管目前有许多研究对外泌体进行了探索，但我们对外泌体在转移前免疫微环境中的作用和机制仍然没有详细的了解，外泌体的临床应用存在许多挑战。本文综述了外泌体调控肿瘤转移前免疫微环境的作用及其机制，重点阐述了外泌体调控肿瘤转移前免疫微环境中免疫细胞的功能，促进肿瘤转移的机制。此外，还讨论了外泌体在肿瘤免疫治疗中的潜在应用以及靶向外泌体的策略。这将有助于肿瘤转移的免疫治疗，促进外泌体的临床应用。

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引用次数: 0

Modular activation of macrophage-like cells by beta-2-microglobulin via mitochondria and the cGAS-STING pathway β -2微球蛋白通过线粒体和cGAS-STING途径模块化激活巨噬细胞样细胞

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1016/j.cellimm.2025.104962

Josefine Kofoed Corneliussen , Helena Borland Madsen , Nadia Thaulov Zelander , Mogens Holst Nissen , Claus Desler

Beta-2-microglobulin (β2m) is a component of the major histocompatibility complex class I. β2m is released into cellular fluids in response to various stimuli, including pro-inflammatory cytokines. Elevated β2m levels have been found associated with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and Crohn's disease, as well as in various hematological cancers and viral infections. Despite an established correlation between immune activation of especially monocytes and macrophages, and circulating β2m levels, the causative relationship remains unclear. Here, we investigate the effects of exogenous β2m and a complement C1s cleaved form, dK58β2m, on two murine macrophage-like cell lines J774 and RAW. We demonstrate that β2m, and to a greater extent dK58β2m, can affect mitochondrial activity. Furthermore, the presence of IFN-γ amplifies the effect, causing altered bioenergetics, and increased production of mitochondrial reactive oxygen species and nitric oxide. In addition, we found activation of the cGAS-STING pathway by β2m and dK58β2m in the presence of IFN-γ. Only dK58β2m in combination with IFN-γ caused apoptosis and cell death. Our findings highlight the modular nature of a β2m-induced macrophage response, potentiated by dK58β2m and IFN-γ, and provide information on the underlying mechanisms responsible for the immune activation properties of β2m.

β -2微球蛋白（β2m）是主要组织相容性复合体i类的一个组成部分。β2m在各种刺激下释放到细胞液中，包括促炎细胞因子。已发现β2m水平升高与自身免疫性疾病，如类风湿关节炎、系统性红斑狼疮和克罗恩病，以及各种血液学癌症和病毒感染有关。尽管免疫激活（尤其是单核细胞和巨噬细胞）与循环β2m水平之间存在明确的相关性，但致病关系尚不清楚。在这里，我们研究了外源性β2m和补体C1s切割形式dK58β2m对两种小鼠巨噬细胞样细胞系J774和RAW的影响。我们证明β2m，以及在更大程度上dK58β2m可以影响线粒体活性。此外，IFN-γ的存在放大了这种效应，导致生物能量学的改变，并增加了线粒体活性氧和一氧化氮的产生。此外，我们发现在IFN-γ存在下，β2m和dK58β2m激活了cGAS-STING通路。仅dK58β2m与IFN-γ联合引起细胞凋亡和死亡。我们的研究结果强调了β2m诱导的巨噬细胞反应的模块化性质，由dK58β2m和IFN-γ增强，并提供了有关β2m免疫激活特性的潜在机制的信息。

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引用次数: 0

Characterization of lysate from NK-92 cells and its potential use as an immunotherapeutic modality NK-92细胞裂解物的特性及其作为免疫治疗方式的潜在用途

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-04-12 DOI: 10.1016/j.cellimm.2025.104951

Himani Chinnapen , Laurent Boissel , Courtney Fleenor , Thomas Bickett , Zhimin Guo , Vidya Godbole , Manju Saxena , Patrick Soon-Shiong , Hans Klingemann

Lysates from human cells represent biofluids that are used in the biotechnology field for a number of reasons such as biomarker identification and antibody detection. Lysate from human blood platelets is widely used in the clinical setting to control bleeding. We hypothesized that the lysate from the cytotoxic natural killer cell line NK-92® should contain perforin and proteolytic enzymes in addition to immunomodulatory cytokines, all of which have biological relevance and could be used for local treatment of cancer lesions. Here lysate from NK-92 (aNK™) cells, and its erIL-2 engineered variant haNK™ was obtained by repeat freeze/thawing. Immunoblot, ELISA and cytokine immunoassay analysis confirmed the presence of perforin and the full spectrum of granzymes, as well as of various chemokines and cytokines known to be expressed in NK-92 cells. Lysate from haNK cells displayed cytotoxic and anti-proliferative activity against human and canine cancer cell lines after only a 15-min exposure in vitro. Importantly, under the same conditions the lysate did not affect primary cells. Intra-tumor injection of haNK lysate into intradermal tumors of immunocompetent C57BL/6 mice provided tumor control in 40 % of treated animals. When re-challenged with the same tumor line several weeks after primary tumor clearance, no growth occurred indicating that intra-tumor administration of haNK lysate can generate a vaccine-like effect.

人类细胞的裂解物是生物流体，在生物技术领域有许多用途，如生物标志物鉴定和抗体检测。人血小板裂解液广泛用于临床控制出血。我们假设细胞毒性自然杀伤细胞系NK-92®的裂解液除了含有免疫调节细胞因子外，还含有穿孔素和蛋白水解酶，所有这些都具有生物学相关性，可用于局部治疗癌症病变。通过重复冷冻/解冻获得NK-92 （aNK™）细胞的裂解液及其erIL-2工程变体haNK™。免疫印迹、ELISA和细胞因子免疫分析证实NK-92细胞中存在穿孔素和全谱颗粒酶，以及各种已知表达的趋化因子和细胞因子。haNK细胞裂解液在体外暴露15分钟后显示出对人和犬癌细胞系的细胞毒性和抗增殖活性。重要的是，在相同的条件下，裂解物不会影响原代细胞。在免疫活性C57BL/6小鼠的肿瘤皮内注射haNK裂解液，对40%的治疗动物有肿瘤控制作用。在原发肿瘤清除几周后，用相同的肿瘤细胞系再次攻击时，没有发生生长，这表明在肿瘤内施用haNK裂解物可以产生类似疫苗的效果。

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引用次数: 0

Retraction notice to "Protective efficacy of a plasmid DNA vaccine against transgene-specific tumors by Th1 cellular immune responses after intradermal injection" [Cell. Immunol. 329 (2018) 17–26] “质粒DNA疫苗皮内注射后Th1细胞免疫反应对转基因特异性肿瘤的保护作用”的撤回通知[Cell]。免疫学报，329(2018):17-26。

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-30 DOI: 10.1016/j.cellimm.2025.104975

Hye-Youn Son , Vasso Apostolopoulos , June-Key Chung , Chul-Woo Kim , Ji-Ung Park

引用次数: 0

Tribute to Mike Cancro – Former editor-in-chief at Cellular Immunology 致敬迈克·坎克罗-前主编在细胞免疫学

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology

Pub Date : 2025-07-01 Epub Date: 2025-05-20 DOI: 10.1016/j.cellimm.2025.104973

Simon Fillatreau , Yi Hao

引用次数: 0