Amphiphilic fullerene derivatives demonstrate promising antineoplastic activity through interactions with tumor-associated proteins and modulation of the tumor microenvironment. However, their target identification remains challenging owing to unique three-dimensional molecular structures and limitations of conventional screening approaches. In this study, we applied competitive activity-based protein profiling (ABPP) to map potential targets of four amphiphilic fullerene derivatives, using the competitive ratio (C-ratio) as a quantitative measure of binding affinity. Leveraging these data, we developed Uni-Full, a tailored AI model based on the Uni-Clip framework, which integrates contrastive learning and a list-wise ranking loss to enhance affinity prediction and generalization. Uni-Full showed a strong correlation with experimental data and accurately identified both established and novel TAEPC targets, including PES1 and PHF19, while effectively minimizing false positives and false negatives. Experimental validation confirmed that TAEPC directly binds PES1, disrupting its nucleolar localization and inhibiting cancer cell proliferation. Our study establishes Uni-Full as a robust, proteome-wide prediction framework that bridges chemoproteomics and AI, accelerating the development of fullerene-based anticancer therapeutics.
{"title":"Uni-Full: An AI Model for Accurate Prediction of Protein Targets of Amphiphilic Fullerene Derivatives","authors":"Libin Yang, Zehu Wang, Zhanfeng Wang, Wenkang Jiang, Yicheng Lu, Bowen Li, Ziyi Zhang, Jiao Li, Feng Yu, Qingqing Guo, Jie Li, Chunru Wang, Chunli Bai","doi":"10.31635/ccschem.025.202506796","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506796","url":null,"abstract":"Amphiphilic fullerene derivatives demonstrate promising antineoplastic activity through interactions with tumor-associated proteins and modulation of the tumor microenvironment. However, their target identification remains challenging owing to unique three-dimensional molecular structures and limitations of conventional screening approaches. In this study, we applied competitive activity-based protein profiling (ABPP) to map potential targets of four amphiphilic fullerene derivatives, using the competitive ratio (C-ratio) as a quantitative measure of binding affinity. Leveraging these data, we developed Uni-Full, a tailored AI model based on the Uni-Clip framework, which integrates contrastive learning and a list-wise ranking loss to enhance affinity prediction and generalization. Uni-Full showed a strong correlation with experimental data and accurately identified both established and novel TAEPC targets, including PES1 and PHF19, while effectively minimizing false positives and false negatives. Experimental validation confirmed that TAEPC directly binds PES1, disrupting its nucleolar localization and inhibiting cancer cell proliferation. Our study establishes Uni-Full as a robust, proteome-wide prediction framework that bridges chemoproteomics and AI, accelerating the development of fullerene-based anticancer therapeutics.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"125 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fullerene-based materials, particularly [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM), are extensively employed as electron transport materials (ETMs) in inverted perovskite solar cells (PSCs) due to their superior electron transport properties. However, their insufficient passivation capability and tendency to aggregates in films can lead to interfacial charge accumulation and charge carrier recombination losses, ultimately compromising both the efficiency and stability of PSCs. To address these challenges, we developed a novel fullerene derivative, PC61BP, by grafting a cyano-phosphate (CNPhP) functional group to fullerene. The phosphate moiety and -CN group in PC61BP can coordinate with under-coordinated Pb2+ ions on the perovskite surface, facilitating defect passivation and suppressing charge non-radiative recombination. Importantly, the incorporation of CNPhP group can modulate intermolecular interactions among PC61BP molecules, preventing aggregation and promoting the formation of a more uniform film. Consequently, the inverted devices using PC61BP as ETM achieve a champion power conversion efficiency (PCE) of 26.01%, markedly outperforming the PC61BM-based control device (PCE = 24.59%), along with improved stability. Moreover, the 1.01 cm2 devices using PC61BP as ETM achieve a high efficiency of 24.48%. This study offers a promising strategy for advancing the performance of inverted PSCs through the rational design of fullerene-based ETMs.
{"title":"Functional Fullerene Electron Transport Material Beyond PC61BM for Efficient Inverted Perovskite Solar Cells","authors":"Zhenyou Guo, Hang Liu, Yuhan Liu, Yihang Yao, Peiyu Hu, Yuping Gao, Xingbang Gao, Weikai Zhao, Yanna Hou, Wenjuan Feng, Yu Chen, Zhiyuan Xu, Ziyang Hu, Guankui Long, Yongsheng Liu","doi":"10.31635/ccschem.025.202507064","DOIUrl":"https://doi.org/10.31635/ccschem.025.202507064","url":null,"abstract":"Fullerene-based materials, particularly [6,6]-phenyl-C<sub>61</sub>-butyric acid methyl ester (PC<sub>61</sub>BM), are extensively employed as electron transport materials (ETMs) in inverted perovskite solar cells (PSCs) due to their superior electron transport properties. However, their insufficient passivation capability and tendency to aggregates in films can lead to interfacial charge accumulation and charge carrier recombination losses, ultimately compromising both the efficiency and stability of PSCs. To address these challenges, we developed a novel fullerene derivative, PC<sub>61</sub>BP, by grafting a cyano-phosphate (CNPhP) functional group to fullerene. The phosphate moiety and -CN group in PC<sub>61</sub>BP can coordinate with under-coordinated Pb<sup>2+</sup> ions on the perovskite surface, facilitating defect passivation and suppressing charge non-radiative recombination. Importantly, the incorporation of CNPhP group can modulate intermolecular interactions among PC<sub>61</sub>BP molecules, preventing aggregation and promoting the formation of a more uniform film. Consequently, the inverted devices using PC<sub>61</sub>BP as ETM achieve a champion power conversion efficiency (PCE) of 26.01%, markedly outperforming the PC<sub>61</sub>BM-based control device (PCE = 24.59%), along with improved stability. Moreover, the 1.01 cm<sup>2</sup> devices using PC<sub>61</sub>BP as ETM achieve a high efficiency of 24.48%. This study offers a promising strategy for advancing the performance of inverted PSCs through the rational design of fullerene-based ETMs.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"35 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.31635/ccschem.025.202506640
Ruobing Bai, Nana Yan, Wenli Bao, Peng Guo, Donghai Mei, Wenfu Yan & Jihong Yu1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 1300122International Center of Future Science, Jilin University, Changchun 1300123National Engineering Research Center of Lower-Carbon Catalysis Technology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 1160234School of Textile Science and Engineering, Tiangong University, Tianjin 3003875University of Chinese Academy of Sciences, Beijing 1000496School of Materials Science and Engineering, Tiangong University, Tianjin 300387
CCS Chemistry, Ahead of Print. Efficient separation of carbon dioxide (CO2) and acetylene (C2H2) is crucial because CO2is a common impurity in C2H2production. Here, we present a strategy for engineering the pore environment ofRHO-type aluminosilicate zeolites by tuning ...
{"title":"Cation-Tuning and Carbon Dioxide Preadsorption in RHO Zeolite Flips Acetylene/Carbon Dioxide Selectivity with Accelerated Adsorption Kinetics","authors":"Ruobing Bai, Nana Yan, Wenli Bao, Peng Guo, Donghai Mei, Wenfu Yan & Jihong Yu1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 1300122International Center of Future Science, Jilin University, Changchun 1300123National Engineering Research Center of Lower-Carbon Catalysis Technology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 1160234School of Textile Science and Engineering, Tiangong University, Tianjin 3003875University of Chinese Academy of Sciences, Beijing 1000496School of Materials Science and Engineering, Tiangong University, Tianjin 300387","doi":"10.31635/ccschem.025.202506640","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506640","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>Efficient separation of carbon dioxide (CO2) and acetylene (C2H2) is crucial because CO2is a common impurity in C2H2production. Here, we present a strategy for engineering the pore environment ofRHO-type aluminosilicate zeolites by tuning ...","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"43 1","pages":"1-12"},"PeriodicalIF":11.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.31635/ccschem.025.202506718
Yue Zhang, Tiangong Liu, Zhen Liu, Zhongqi Peng, Hanliang Zheng, Li Chen, Wei Zhang & Xin Li1State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 3000712West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 6100413Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua 3210044Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192
CCS Chemistry, Ahead of Print. The deracemization of carbonyl compounds represents an attractive strategy for synthesizing enantiomerically pure carbonyl compounds. Herein, we present a novel and general strategy to achieve the direct deracemization of α-aryl ketones through the ...
{"title":"Visible Light-Driven Deracemization of α-Aryl Ketones by Synergistic Aryl Thiol and Chiral Phosphoric Acid Catalysis","authors":"Yue Zhang, Tiangong Liu, Zhen Liu, Zhongqi Peng, Hanliang Zheng, Li Chen, Wei Zhang & Xin Li1State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 3000712West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 6100413Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua 3210044Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192","doi":"10.31635/ccschem.025.202506718","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506718","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>The deracemization of carbonyl compounds represents an attractive strategy for synthesizing enantiomerically pure carbonyl compounds. Herein, we present a novel and general strategy to achieve the direct deracemization of α-aryl ketones through the ...","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"44 1","pages":"1-12"},"PeriodicalIF":11.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aqueous zinc.iodine (Zn-I2) batteries are promising sustainable energy-storage systems due to the high theoretical capacity and the materials abundance. However, their development is hindered by the crucial challenges of polyiodide shuttle, Zn dendrite growth, and sluggish iodine reaction kinetics. Herein, a general strategy for breaking the performance trade-offs in aqueous Zn-I2 batteries is presented, based on a synergistic cation.anion electrolyte additive. This approach uses a redox-active alkylammonium halide where the anion (I−) catalyzes the solid I2 to liquid polyiodides conversion to accelerate reaction kinetics, while the partnering cation instantly precipitates soluble polyiodides into solid complexes, quantitatively suppressing the shuttle effect. Concurrently, the cation forms an electrostatic shield for uniform Zn deposition, and the anion modulates nucleation, synergistically inhibiting dendrite growth. As a proof-of-concept, a symmetric Zn||Zn cell achieves ultra-stable cycling for 5,500 h, and a Zn-I2 full cell exhibited no capacity fading over 50,000 cycles at 5 A g−1 with an ultra-high average Coulombic efficiency (>99.95%). Furthermore, the strategy also enables stable operation of a simplified, dual-electrode-free cell configuration with high Coulombic efficiency. This work establishes a versatile cation.anion synergy paradigm for designing high-power, long-lifespan aqueous Zn batteries based on iodine chemistry.
{"title":"Synergistic Anion-Cation Pair Additive Unites Shuttle-Suppressed and Kinetics-Accelerated I2 Chemistry for Aqueous Zn Batteries","authors":"Zhihao Zhao, Zhiwen Yang, Jian Wang, Longtao Ma, Huihua Li, Huang Zhang","doi":"10.31635/ccschem.025.202506944","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506944","url":null,"abstract":"Aqueous zinc.iodine (Zn-I<sub>2</sub>) batteries are promising sustainable energy-storage systems due to the high theoretical capacity and the materials abundance. However, their development is hindered by the crucial challenges of polyiodide shuttle, Zn dendrite growth, and sluggish iodine reaction kinetics. Herein, a general strategy for breaking the performance trade-offs in aqueous Zn-I<sub>2</sub> batteries is presented, based on a synergistic cation.anion electrolyte additive. This approach uses a redox-active alkylammonium halide where the anion (I<sup>−</sup>) catalyzes the solid I<sub>2</sub> to liquid polyiodides conversion to accelerate reaction kinetics, while the partnering cation instantly precipitates soluble polyiodides into solid complexes, quantitatively suppressing the shuttle effect. Concurrently, the cation forms an electrostatic shield for uniform Zn deposition, and the anion modulates nucleation, synergistically inhibiting dendrite growth. As a proof-of-concept, a symmetric Zn||Zn cell achieves ultra-stable cycling for 5,500 h, and a Zn-I<sub>2</sub> full cell exhibited no capacity fading over 50,000 cycles at 5 A g<sup>−1</sup> with an ultra-high average Coulombic efficiency (>99.95%). Furthermore, the strategy also enables stable operation of a simplified, dual-electrode-free cell configuration with high Coulombic efficiency. This work establishes a versatile cation.anion synergy paradigm for designing high-power, long-lifespan aqueous Zn batteries based on iodine chemistry.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"43 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.31635/ccschem.025.202506736
Jingjing Yu, Hengyi Lin, Zhenhao Long, Mingxin Zhang, Xiaoqiu Wu, Tao Bing, Xiaohong Fang, Weihong Tan
High-throughput sequencing has revolutionized aptamer discovery; however, the process is still limited by the lack of effective methods to extract structural insights from diverse sequences, crucial for aptamer truncation, optimization, and molecular design. Herein, we present a machine learning–based framework that decodes aptamer secondary structures directly from single-round selection data, enabling detailed structural insights without the requirement of iterative enrichment. By employing an unsupervised autoencoder clustering (UAE-Clustering) algorithm, our method identified conserved structural motifs in aptamers targeting a model CD8, a key immune regulatory protein. The resulting optimized aptamer exhibited an order-of-magnitude enhancement in binding affinity. We further validated the generalizability of this approach using fibroblast activation protein (FAP), revealing common sequence–structural binding patterns and successfully generating additional optimized aptamers. This approach enabled the rational truncation and optimization of high-affinity aptamers without relying on conventional multi-round selection protocols or experimental structural determination methods such as nuclear magnetic resonance (NMR) spectroscopy or X-ray crystallography. By predicting functional secondary structures directly from primary sequences, our strategy streamlined aptamer engineering and bypassed the need for traditional structure–function analyses. Overall, this strategy not only markedly accelerates aptamer discovery and optimization, but also provides new paradigms for mechanistic investigations of aptamer–target interactions.
{"title":"Single-Round Aptamer Discovery Empowered by Machine Learning: Revealing Structure–Function Principles of Target Binding","authors":"Jingjing Yu, Hengyi Lin, Zhenhao Long, Mingxin Zhang, Xiaoqiu Wu, Tao Bing, Xiaohong Fang, Weihong Tan","doi":"10.31635/ccschem.025.202506736","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506736","url":null,"abstract":"High-throughput sequencing has revolutionized aptamer discovery; however, the process is still limited by the lack of effective methods to extract structural insights from diverse sequences, crucial for aptamer truncation, optimization, and molecular design. Herein, we present a machine learning–based framework that decodes aptamer secondary structures directly from single-round selection data, enabling detailed structural insights without the requirement of iterative enrichment. By employing an unsupervised autoencoder clustering (UAE-Clustering) algorithm, our method identified conserved structural motifs in aptamers targeting a model CD8, a key immune regulatory protein. The resulting optimized aptamer exhibited an order-of-magnitude enhancement in binding affinity. We further validated the generalizability of this approach using fibroblast activation protein (FAP), revealing common sequence–structural binding patterns and successfully generating additional optimized aptamers. This approach enabled the rational truncation and optimization of high-affinity aptamers without relying on conventional multi-round selection protocols or experimental structural determination methods such as nuclear magnetic resonance (NMR) spectroscopy or X-ray crystallography. By predicting functional secondary structures directly from primary sequences, our strategy streamlined aptamer engineering and bypassed the need for traditional structure–function analyses. Overall, this strategy not only markedly accelerates aptamer discovery and optimization, but also provides new paradigms for mechanistic investigations of aptamer–target interactions.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"29 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.31635/ccschem.025.202506866
Mengdi Wang, Congwei Tan, Hailin Peng
High-dielectric-constant (high-κ) dielectric materials have been instrumental for integrated circuits, where they enable effective gate control and charge storage, underpinning the aggressive miniaturization of silicon metal-oxide-semiconductor technology. Two-dimensional (2D) semiconductors have emerged as a leading platform to replace silicon for fabricating next-generation transistors in sub-1-nm technology nodes. However, achieving precise hetero-integration of 2D semiconductors with ultrathin high-κ dielectrics remains challenging, hindered by a lack of compatible dielectrics and suitable synthesis approaches. Herein, we review the development of high-κ van der Waals (vdW) dielectrics in 2D electronics, from their synthesis to functional integration with 2D semiconductors. We systematically evaluate the material characteristics of state-of-the-art high-κ vdW dielectrics to identify promising dielectric materials for 2D transistors, and comprehensively analyze the growth challenges, synthesis strategies, and recent breakthroughs in wafer-scale high-κ vdW thin film fabrication. We highlight the potential of ultrathin high-κ vdW dielectrics to enable exponential scaling of transistor density, supported by their superior electrostatic gate controllability, effective immunity of short-channel effects, and compatibility with monolithic 3D integration. We also emphasize the advantages of the 2D/2D interface formed by integrating high-κ vdW dielectrics with 2D semiconductors. This atomically sharp and dangling-bond-free interface preserves the intrinsic high carrier mobility of the 2D semiconductor, while avoiding the nonconformal film growth and structural degradation of the underlying material that plague integration with conventional 3D high-κ dielectrics. Finally, from a lab-to-fab perspective, we present the current integration challenges between high-κ vdW dielectrics and 2D semiconductors, and provide promising prospects pertaining to the future investigation of high-κ vdW dielectric materials for next-generation 2D electronics.
{"title":"Synthesis of High-κ van der Waals Dielectric for Two-Dimensional Electronics","authors":"Mengdi Wang, Congwei Tan, Hailin Peng","doi":"10.31635/ccschem.025.202506866","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506866","url":null,"abstract":"High-dielectric-constant (high-κ) dielectric materials have been instrumental for integrated circuits, where they enable effective gate control and charge storage, underpinning the aggressive miniaturization of silicon metal-oxide-semiconductor technology. Two-dimensional (2D) semiconductors have emerged as a leading platform to replace silicon for fabricating next-generation transistors in sub-1-nm technology nodes. However, achieving precise hetero-integration of 2D semiconductors with ultrathin high-κ dielectrics remains challenging, hindered by a lack of compatible dielectrics and suitable synthesis approaches. Herein, we review the development of high-κ van der Waals (vdW) dielectrics in 2D electronics, from their synthesis to functional integration with 2D semiconductors. We systematically evaluate the material characteristics of state-of-the-art high-κ vdW dielectrics to identify promising dielectric materials for 2D transistors, and comprehensively analyze the growth challenges, synthesis strategies, and recent breakthroughs in wafer-scale high-κ vdW thin film fabrication. We highlight the potential of ultrathin high-κ vdW dielectrics to enable exponential scaling of transistor density, supported by their superior electrostatic gate controllability, effective immunity of short-channel effects, and compatibility with monolithic 3D integration. We also emphasize the advantages of the 2D/2D interface formed by integrating high-κ vdW dielectrics with 2D semiconductors. This atomically sharp and dangling-bond-free interface preserves the intrinsic high carrier mobility of the 2D semiconductor, while avoiding the nonconformal film growth and structural degradation of the underlying material that plague integration with conventional 3D high-κ dielectrics. Finally, from a lab-to-fab perspective, we present the current integration challenges between high-κ vdW dielectrics and 2D semiconductors, and provide promising prospects pertaining to the future investigation of high-κ vdW dielectric materials for next-generation 2D electronics.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"4 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stereoselective construction of 1,2-cis β-glycosidic linkages, especially β-manno-/rhamnosidic bonds, is extremely challenging due to their unfavorable stereoelectronic nature and inapplicability of neighboring group participation. Herein, we disclose a convenient and highly stereoselective glycosylation protocol toward β-manno-/rhamnosides employing tetrahydrofuran (THF) as a stereomodulating additive. This method features high yield and good to exclusive β-selectivity, without resorting to the previous devices requiring stereodirecting groups or fixed anomeric configuration of the donors. Mechanistic studies indicate a novel THF participation mechanism in which the THF-derived α-mannosyl oxonium intermediate is rapidly formed and thus favors the following generation of β-glycoside product in a stereoinvertive manner.
{"title":"Stereoselective β-Mannosylation and β-Rhamnosylation Through the Modulation of Tetrahydrofuran","authors":"Fuzhu Yang, Ya-Nan Wang, Haotian Li, Yishan Sun, Xiajing Chen, Peng Xu, Ruopeng Bai, Dapeng Zhu, Biao Yu","doi":"10.31635/ccschem.025.202506750","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506750","url":null,"abstract":"Stereoselective construction of 1,2-cis β-glycosidic linkages, especially β-manno-/rhamnosidic bonds, is extremely challenging due to their unfavorable stereoelectronic nature and inapplicability of neighboring group participation. Herein, we disclose a convenient and highly stereoselective glycosylation protocol toward β-manno-/rhamnosides employing tetrahydrofuran (THF) as a stereomodulating additive. This method features high yield and good to exclusive β-selectivity, without resorting to the previous devices requiring stereodirecting groups or fixed anomeric configuration of the donors. Mechanistic studies indicate a novel THF participation mechanism in which the THF-derived α-mannosyl oxonium intermediate is rapidly formed and thus favors the following generation of β-glycoside product in a stereoinvertive manner.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"82 1","pages":"1-9"},"PeriodicalIF":11.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.31635/ccschem.025.202506840
Zibo Liu, Zheng Wang & Kuiling Ding1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 2000322School of Physical Science and Technology, ShanghaiTech University, Shanghai 2012103Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
CCS Chemistry, Ahead of Print. A palladium/copper dual catalytic system has been developed for the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-2-azaaryl acetates. This system delivers a series of chiral fluorinated compounds featuring an azaaryl ...
{"title":"Pd/Cu Dual Catalysis for Stereodivergent Allylic Alkylation of α-F-Substituted Azaaryl Acetates and Acetamides with Morita–Baylis–Hillman Carbonates","authors":"Zibo Liu, Zheng Wang & Kuiling Ding1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 2000322School of Physical Science and Technology, ShanghaiTech University, Shanghai 2012103Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240","doi":"10.31635/ccschem.025.202506840","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506840","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>A palladium/copper dual catalytic system has been developed for the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-2-azaaryl acetates. This system delivers a series of chiral fluorinated compounds featuring an azaaryl ...","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"82 1","pages":"1-11"},"PeriodicalIF":11.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.31635/ccschem.025.202506940
Mengjie Hao, Ming Lei, Juyao Zhang, Yinghui Xie, He Gu, Zhongshan Chen, Hui Yang, Geoffrey I. N. Waterhouse, Shengqian Ma & Xiangke Wang1College of Environmental Science and Engineering, North China Electric Power University, Beijing 1022062School of Chemical Sciences, The University of Auckland, Auckland 11423Department of Chemistry, University of North Texas, Denton, Texas 76201
CCS Chemistry, Ahead of Print. Covalent organic frameworks (COFs) are increasingly being utilized in photocatalysis due to their programmable band gaps and pore geometries. Flexible COFs are currently of interest for selective sorption, though their use in photocatalysis has received ...
{"title":"Flexible Units in Covalent Organic Frameworks Promote Photocatalytic Uranium Extraction from Wastewater","authors":"Mengjie Hao, Ming Lei, Juyao Zhang, Yinghui Xie, He Gu, Zhongshan Chen, Hui Yang, Geoffrey I. N. Waterhouse, Shengqian Ma & Xiangke Wang1College of Environmental Science and Engineering, North China Electric Power University, Beijing 1022062School of Chemical Sciences, The University of Auckland, Auckland 11423Department of Chemistry, University of North Texas, Denton, Texas 76201","doi":"10.31635/ccschem.025.202506940","DOIUrl":"https://doi.org/10.31635/ccschem.025.202506940","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>Covalent organic frameworks (COFs) are increasingly being utilized in photocatalysis due to their programmable band gaps and pore geometries. Flexible COFs are currently of interest for selective sorption, though their use in photocatalysis has received ...","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"11 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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