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Spatiotemporal flow-induced instability of predator-prey model with Crowley-Martin functional response and prey harvesting. 具有 Crowley-Martin 功能响应和猎物捕获的捕食者-猎物模型的时空流诱导不稳定性。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0222487
Bidhan Bhunia, Tapan Kumar Kar, Santu Ghorai

Ecological systems can generate striking large-scale spatial patterns through local interactions and migration. In the presence of diffusion and advection, this work examines the formation of flow-induced patterns in a predator-prey system with a Crowley-Martin functional response and prey harvesting, where the advection reflects the unidirectional flow of each species migration (or flow). Primarily, the impact of diffusion and advection rates on the stability and the associated Turing and flow-induced patterns are investigated. The theoretical implication of flow-induced instability caused by population migration, mainly the relative migrations between prey and predator, is examined, and it also shows that Turing instability is the particular condition of flow-induced instability. The influence of the relative flow of both species and prey-harvesting effort on the emerging pattern is reported. Advection impacts a wide range of spatiotemporal patterns, including bands, spots, and a mixture of bands and spots in both harvested and unharvested dynamics. We also observe the diagonally bend-type banded patterns and straight-type banded patterns due to positive and negative relative flows, respectively. Here, the increasing relative flow increases the band length. The growing harvesting effort also decreases the band length, producing a thin band and a mixture of spots and bands due to the negative and positive relative flows, respectively. One exciting result observed here is that harvesting effort drives the flow-Turing and flow-Turing-Hopf instability into pure-flow instability.

生态系统可以通过局部相互作用和迁移产生引人注目的大尺度空间模式。在存在扩散和平流的情况下,这项工作研究了具有克劳利-马丁功能响应和猎物捕获的捕食者-猎物系统中流动诱导模式的形成,其中平流反映了每个物种迁移(或流动)的单向流动。主要研究了扩散和平流速率对稳定性的影响以及相关的图灵和流动诱导模式。研究了种群迁徙(主要是猎物和捕食者之间的相对迁徙)引起的流诱导不稳定性的理论含义,并表明图灵不稳定性是流诱导不稳定性的特殊条件。报告了物种和捕食者的相对流动对新出现模式的影响。平流影响了广泛的时空模式,包括捕获和未捕获动态中的带状、点状以及带状和点状的混合。我们还观察到对角弯曲型带状模式和直线型带状模式,它们分别是由正向和负向相对流引起的。在这里,相对流量的增加会增加带状长度。由于负相对流和正相对流的影响,收割力度的增加也会减小带状长度,分别产生薄带状和斑点与带状的混合体。在这里观察到的一个令人兴奋的结果是,采集力将流-图灵不稳定性和流-图灵-霍普夫不稳定性转变为纯流不稳定性。
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引用次数: 0
Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model. 通过数学模型了解 B 细胞在白血病 CAR T 细胞疗法中的作用。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0206341
Sergio Serrano, Roberto Barrio, Álvaro Martínez-Rubio, Juan Belmonte-Beitia, Víctor M Pérez-García

Chimeric antigen receptor T (CAR T) cell therapy has been proven to be successful against a variety of leukemias and lymphomas. This paper undertakes an analytical and numerical study of a mathematical model describing the competition of CAR T, leukemia, tumor, and B cells. Considering its significance in sustaining anti-CD19 CAR T-cell stimulation, a B-cell source term is integrated into the model. Through stability and bifurcation analyses, the potential for tumor eradication, contingent on the continuous influx of B cells, has been revealed, showing a transcritical bifurcation at a critical B-cell input. Additionally, an almost heteroclinic cycle between equilibrium points is identified, providing a theoretical basis for understanding disease relapse. Analyzing the oscillatory behavior of the system, the time-dependent dynamics of CAR T cells and leukemic cells can be approximated, shedding light on the impact of initial tumor burden on therapeutic outcomes. In conclusion, the study provides insights into CAR T-cell therapy dynamics for acute lymphoblastic leukemias, offering a theoretical foundation for clinical observations and suggesting avenues for future immunotherapy modeling research.

嵌合抗原受体 T(CAR T)细胞疗法已被证明能成功治疗多种白血病和淋巴瘤。本文对描述 CAR T、白血病、肿瘤和 B 细胞竞争的数学模型进行了分析和数值研究。考虑到 B 细胞对维持抗 CD19 CAR T 细胞刺激的重要性,模型中加入了 B 细胞源项。通过稳定性和分岔分析,揭示了肿瘤根除的潜力取决于 B 细胞的持续流入,并在关键的 B 细胞输入处出现了跨临界分岔。此外,在平衡点之间还发现了一个几乎异质的循环,为理解疾病复发提供了理论基础。通过分析该系统的振荡行为,可以近似得出 CAR T 细胞和白血病细胞随时间变化的动态,从而揭示初始肿瘤负荷对治疗效果的影响。总之,这项研究为急性淋巴细胞白血病的 CAR T 细胞疗法动力学提供了见解,为临床观察提供了理论基础,并为未来的免疫疗法建模研究提供了途径。
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引用次数: 0
Generalized N-rotor problems, synchronized subsystems, and associated solitons. 广义 N 转子问题、同步子系统和相关孤子。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0216910
M A Lohe

We consider systems of N particles interacting on the unit circle through 2π-periodic potentials. An example is the N-rotor problem that arises as the classical limit of coupled Josephson junctions and for various energies is known to have a wide range of behaviors such as global chaos and ergodicity, together with families of periodic solutions and transitions from order to chaos. We focus here on selected initial values for generalized systems in which the second order Euler-Lagrange equations reduce to first order equations, which we show by example can describe an ensemble of oscillators with associated emergent phenomena such as synchronization. A specific case is that of the Kuramoto model with well-known synchronization properties. We further demonstrate the relation of these models to field theories in 1+1 dimensions that allow static kink solitons satisfying first order Bogomolny equations, well-known in soliton physics, which correspond to the first order equations of the generalized N-rotor models. For the nonlinear pendulum, for example, the first order equations define the separatrix in the phase portrait of the system and correspond to kink solitons in the sine-Gordon equation.

我们考虑在单位圆上通过 2π 周期势相互作用的 N 粒子系统。N 转子问题就是一个例子,它是作为耦合约瑟夫森结的经典极限而产生的,对于各种能量,众所周知它具有广泛的行为,如全局混沌和遍历性,以及周期解系列和从有序到混沌的过渡。在此,我们将重点放在二阶欧拉-拉格朗日方程还原为一阶方程的广义系统的选定初值上,并通过实例说明这可以描述具有同步等相关突发现象的振荡器集合。一个具体的例子是具有著名同步特性的仓本模型。我们进一步证明了这些模型与 1+1 维场理论的关系,这些场理论允许满足一阶博戈莫尔尼方程的静态扭结孤子,这在孤子物理学中是众所周知的,与广义 N 转子模型的一阶方程相对应。例如,对于非线性摆,一阶方程定义了系统相位图中的分离矩阵,并对应于正弦-戈登方程中的扭结孤子。
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引用次数: 0
Channel assisted noise propagation in a two-step cascade. 两步级联中的信道辅助噪声传播。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0208543
Mintu Nandi, Sudip Chattopadhyay, Somshubhro Bandyopadhyay, Suman K Banik

Signal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S→X→Y) regarding intrinsic and extrinsic noise. We identify different channels of noise transmission that regulate the individual and the overall noise properties of each component. Our analysis shows that the intrinsic noise of S alleviates the general noise and information transmission capacity along the cascade. On the other hand, the intrinsic noise of X and Y acts as a bottleneck of information transmission. We also show a hierarchical relationship among the intrinsic noise levels of S, X, and Y, with S exhibiting the highest level of intrinsic noise, followed by X and then Y. This hierarchy is preserved within the two-step cascade, facilitating the highest information transmission from S to Y via X.

生化网络中信号传播的特点是基因表达的内在随机性和环境成分的波动性,通常分别称为内在和外在噪声。我们提出了一个关于内在和外在噪声的通用两步级联(S→X→Y)中噪声传播的理论框架。我们确定了不同的噪声传播渠道,这些渠道可调节每个组件的单个和整体噪声特性。我们的分析表明,S 的固有噪声可减轻级联的总体噪声和信息传输能力。另一方面,X 和 Y 的固有噪声则成为信息传输的瓶颈。我们还显示了 S、X 和 Y 的固有噪声水平之间的等级关系,其中 S 的固有噪声水平最高,其次是 X,然后是 Y。
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引用次数: 0
Wavelet analysis of intermittent dynamics in nocturnal electrocardiography and electroencephalography data. 夜间心电图和脑电图数据间歇动态的小波分析。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0227179
M Zhuravlev, E Egorov, O Moskalenko, Yu Zhuravleva, N Akimova, A Kiselev, O Drapkina, A Runnova

This paper presents the results of a study of the characteristics of phase synchronization between electrocardiography(ECG) and electroencephalography (EEG) signals during night sleep. Polysomnographic recordings of eight generally healthy subjects and eight patients with obstructive sleep apnea syndrome were selected as experimental data. A feature of this study was the introduction of an instantaneous phase for EEG and ECG signals using a continuous wavelet transform at the heart rate frequency using the concept of time scale synchronization, which eliminated the emergence of asynchronous areas of behavior associated with the "leaving" of the fundamental frequency of the cardiovascular system. Instantaneous phase differences were examined for various pairs of EEG and ECG signals during night sleep, and it was shown that in all cases the phase difference exhibited intermittency. Laminar areas of behavior are intervals of phase synchronization, i.e., phase capture. Turbulent intervals are phase jumps of 2π. Statistical studies of the observed intermittent behavior were carried out, namely, distributions of the duration of laminar sections of behavior were estimated. For all pairs of channels, the duration of laminar phases obeyed an exponential law. Based on the analysis of the movement of the phase trajectory on a rotating plane at the moment of detection of the turbulent phase, it was established that in this case the eyelet intermittency was observed. There was no connection between the statistical characteristics of laminar phase distributions for intermittent behavior and the characteristics of night breathing disorders (apnea syndrome). It was found that changes in statistical characteristics in the phase synchronization of EEG and ECG signals were correlated with blood pressure at the time of signal recording in the subjects, which is an interesting effect that requires further research.

本文介绍了夜间睡眠时心电图(ECG)和脑电图(EEG)信号相位同步特征的研究结果。实验数据选取了 8 名一般健康受试者和 8 名阻塞性睡眠呼吸暂停综合征患者的多导睡眠图记录。这项研究的一个特点是利用时标同步的概念,在心率频率上使用连续小波变换,为脑电图和心电图信号引入了瞬时相位,从而消除了与心血管系统基频 "离开 "相关的不同步行为区域的出现。对夜间睡眠时的多对脑电图和心电图信号的瞬时相位差进行了研究,结果表明,在所有情况下,相位差都表现出间歇性。层状行为区域是相位同步的间隔,即相位捕捉。湍流区间为 2π 的相位跳跃。对观察到的间歇行为进行了统计研究,即估算了层流行为区域的持续时间分布。在所有通道对中,层流阶段的持续时间都服从指数规律。根据对检测到湍流相位时相位轨迹在旋转平面上的运动分析,可以确定在这种情况下观察到了孔眼间歇现象。间歇行为层相分布的统计特征与夜间呼吸紊乱(呼吸暂停综合症)的特征之间没有联系。研究发现,脑电图和心电图信号相位同步统计特征的变化与受试者记录信号时的血压有关,这是一个有趣的效应,需要进一步研究。
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引用次数: 0
Realization of logic gates in bi-directionally coupled nonlinear oscillators. 在双向耦合非线性振荡器中实现逻辑门。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0217881
S Deshaka, M Sathish Aravindh, R Arun, A Venkatesan, M Lakshmanan

Implementation of logic gates has been investigated in nonlinear dynamical systems from various perspectives over the years. Specifically, logic gates have been implemented in both single nonlinear systems and coupled nonlinear oscillators. The majority of the works in the literature have been done on the evolution of single oscillators into OR/AND or NOR/NAND logic gates. In the present study, we demonstrate the design of logic gates in bi-directionally coupled double-well Duffing oscillators by applying two logic inputs to the drive system alone along with a fixed bias. The nonlinear system, comprising both bi-directional components, exhibits varied logic behaviors within an optimal range of coupling strength. Both attractive and repulsive couplings yield similar and complementary logic behaviors in the first and second oscillators. These couplings play a major role in exhibiting fundamental and universal logic gates in simple nonlinear systems. Under a positive bias, both the first and second oscillators demonstrate OR logic gate for the attractive coupling, while exhibiting OR and NOR logic gates, respectively, for the repulsive coupling. Conversely, under a negative bias, both the first and second oscillators display AND logic gate for the attractive coupling, and AND and NAND logical outputs for the repulsive coupling. Furthermore, we confirm the robustness of the bi-directional oscillators against moderate noise in maintaining the desired logical outputs.

多年来,人们从不同角度研究了逻辑门在非线性动力学系统中的实现。具体来说,逻辑门既可以在单个非线性系统中实现,也可以在耦合非线性振荡器中实现。文献中的大部分工作都是将单振荡器演化成 OR/AND 或 NOR/NAND 逻辑门。在本研究中,我们展示了在双向耦合双阱达芬振荡器中的逻辑门设计,方法是在驱动系统中单独应用两个逻辑输入和一个固定偏置。由两个双向元件组成的非线性系统在最佳耦合强度范围内表现出不同的逻辑行为。在第一振荡器和第二振荡器中,吸引力耦合和排斥力耦合都会产生相似且互补的逻辑行为。这些耦合在简单非线性系统中展示基本和通用逻辑门方面发挥了重要作用。在正偏压下,第一振荡器和第二振荡器在吸引耦合时都表现出 OR 逻辑门,而在排斥耦合时则分别表现出 OR 逻辑门和 NOR 逻辑门。相反,在负偏压下,第一和第二振荡器在吸引耦合时显示 AND 逻辑门,而在排斥耦合时显示 AND 和 NAND 逻辑输出。此外,我们还证实了双向振荡器在中度噪声下保持所需逻辑输出的鲁棒性。
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引用次数: 0
Model reduction of dynamical systems with a novel data-driven approach: The RC-HAVOK algorithm. 用新颖的数据驱动方法减少动力系统的模型:RC-HAVOK 算法。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0207907
G Yılmaz Bingöl, O A Soysal, E Günay

This paper introduces a novel data-driven approximation method for the Koopman operator, called the RC-HAVOK algorithm. The RC-HAVOK algorithm combines Reservoir Computing (RC) and the Hankel Alternative View of Koopman (HAVOK) to reduce the size of the linear Koopman operator with a lower error rate. The accuracy and feasibility of the RC-HAVOK algorithm are assessed on Lorenz-like systems and dynamical systems with various nonlinearities, including the quadratic and cubic nonlinearities, hyperbolic tangent function, and piece-wise linear function. Implementation results reveal that the proposed model outperforms a range of other data-driven model identification algorithms, particularly when applied to commonly used Lorenz time series data.

本文介绍了一种新颖的数据驱动的库普曼算子近似方法,称为 RC-HAVOK 算法。RC-HAVOK 算法结合了储层计算(RC)和 Koopman 的 Hankel Alternative View(HAVOK),以较低的误差率减小线性 Koopman 算子的大小。RC-HAVOK 算法的准确性和可行性在类洛伦兹系统和具有各种非线性(包括二次和三次非线性、双曲正切函数和片断线性函数)的动力系统上进行了评估。实施结果表明,所提出的模型优于一系列其他数据驱动的模型识别算法,尤其是在应用于常用的洛伦兹时间序列数据时。
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引用次数: 0
Dynamic behaviors of far and near memristive electromagnetic induction in spoon neural network. 勺状神经网络中远近记忆性电磁感应的动态行为。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0216108
Qiang Lai, Yudi Xu

In this paper, a special spoon neural network is proposed, which is composed of four neurons with direct connection and indirect connection. On this basis, the far induction network and the near induction network (NINN) are constructed by using hyperbolic tangent memristors to explore the influence of electromagnetic induction between neurons at different positions on the dynamic behavior of attractors. NINN exhibits more complex attractor structures and wider chaotic parameters, and also displays a heterogeneous coexisting attractor of limit cycles and chaos under network parameter control. By varying the parameters, coexisting chaotic attractors can be synthesized into a double scrolls attractor, and their oscillation amplitude can be controlled without changing the chaotic characteristics. The type of attractors in human brain determines the clarity of memory. These complex dynamic behaviors demonstrate that near induction has a more pronounced effect on the forgetting and disappearance of memory compared to far induction. Finally, a circuit using switches to change the type of electromagnetic induction is constructed and the results are verified.

本文提出了一种特殊的勺状神经网络,它由四个神经元组成,具有直接连接和间接连接两种方式。在此基础上,利用双曲正切忆阻器构建了远感应网络和近感应网络(NINN),探讨了不同位置神经元之间的电磁感应对吸引子动态行为的影响。NINN表现出更复杂的吸引子结构和更宽的混沌参数,并在网络参数控制下表现出极限循环和混沌的异质共存吸引子。通过改变参数,可以将共存的混沌吸引子合成为双卷轴吸引子,并在不改变混沌特性的情况下控制其振荡幅度。人脑中吸引子的类型决定了记忆的清晰度。这些复杂的动态行为表明,与远诱导相比,近诱导对记忆的遗忘和消失有更明显的影响。最后,我们构建了一个利用开关改变电磁感应类型的电路,并对结果进行了验证。
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引用次数: 0
A hyper-distance-based method for hypernetwork comparison. 基于超距离的超网络比较方法。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0221267
Ruonan Feng, Tao Xu, Xiaowen Xie, Zi-Ke Zhang, Chuang Liu, Xiu-Xiu Zhan

Hypernetwork is a useful way to depict multiple connections between nodes, making it an ideal tool for representing complex relationships in network science. In recent years, there has been a marked increase in studies on hypernetworks; however, the comparison of the difference between two hypernetworks has received less attention. This paper proposes a hyper-distance (HD)-based method for comparing hypernetworks. The method is based on higher-order information, i.e, the higher-order distance between nodes and Jensen-Shannon divergence. Experiments carried out on synthetic hypernetworks have shown that HD is capable of distinguishing between hypernetworks generated with different parameters, and it is successful in the classification of hypernetworks. Furthermore, HD outperforms current state-of-the-art baselines to distinguish empirical hypernetworks when hyperedges are randomly perturbed.

超网络(Hypernetwork)是描述节点间多重连接的有效方法,是网络科学中表示复杂关系的理想工具。近年来,有关超网络的研究明显增多,但比较两个超网络之间的差异却较少受到关注。本文提出了一种基于超距离(HD)的超网络比较方法。该方法基于高阶信息,即节点间的高阶距离和詹森-香农分歧。在合成超网络上进行的实验表明,HD 能够区分由不同参数生成的超网络,并能成功地对超网络进行分类。此外,当超边缘受到随机扰动时,HD 在区分经验超网络方面的表现优于目前最先进的基线。
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引用次数: 0
Statistics of punctuation in experimental literature-The remarkable case of Finnegans Wake by James Joyce. 实验文学中的标点符号统计--詹姆斯-乔伊斯的《芬尼根的守灵夜》的非凡案例。
IF 2.7 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-08-01 DOI: 10.1063/5.0203530
Tomasz Stanisz, Stanisław Drożdż, Jarosław Kwapień

As the recent studies indicate, the structure imposed onto written texts by the presence of punctuation develops patterns which reveal certain characteristics of universality. In particular, based on a large collection of classic literary works, it has been evidenced that the distances between consecutive punctuation marks, measured in terms of the number of words, obey the discrete Weibull distribution-a discrete variant of a distribution often used in survival analysis. The present work extends the analysis of punctuation usage patterns to more experimental pieces of world literature. It turns out that the compliance of the the distances between punctuation marks with the discrete Weibull distribution typically applies here as well. However, some of the works by James Joyce are distinct in this regard-in the sense that the tails of the relevant distributions are significantly thicker and, consequently, the corresponding hazard functions are decreasing functions not observed in typical literary texts in prose. Finnegans Wake-the same one to which science owes the word quarks for the most fundamental constituents of matter-is particularly striking in this context. At the same time, in all the studied texts, the sentence lengths-representing the distances between sentence-ending punctuation marks-reveal more freedom and are not constrained by the discrete Weibull distribution. This freedom in some cases translates into long-range nonlinear correlations, which manifest themselves in multifractality. Again, a text particularly spectacular in terms of multifractality is Finnegans Wake.

最近的研究表明,标点符号的存在给书面文本带来的结构模式显示出某些普遍性特征。特别是,基于大量经典文学作品的研究证明,以字数衡量的连续标点符号之间的距离服从离散的韦布尔分布--一种常用于生存分析的分布的离散变体。本研究将标点符号使用模式分析扩展到更多的世界文学实验作品中。事实证明,标点符号之间的距离符合离散韦布尔分布的情况在这里也同样适用。然而,詹姆斯-乔伊斯的一些作品在这方面却与众不同--从这个意义上说,相关分布的尾部明显较厚,因此,相应的危险函数是递减函数,这在典型的散文文学文本中是无法观察到的。芬尼根的守灵夜》(Finnegans Wake)--科学界将物质的最基本成分 "夸克"(quarks)一词归功于这本书--在这方面尤其引人注目。同时,在所有研究的文本中,句子长度(代表句末标点符号之间的距离)显示出更大的自由度,不受离散韦布尔分布的限制。这种自由度在某些情况下转化为长程非线性相关性,表现为多分叉性。同样,《芬尼根的守灵夜》(Finnegans Wake)也是一篇在多重性方面表现尤为突出的文本。
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引用次数: 0
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Chaos
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