Pub Date : 2023-12-09DOI: 10.1016/j.adoms.2023.100471
Simran Kaur Bilkhoo, Valmiki Sharma, Alan Parbhoo
A patient with extensive unilateral synovial chondromatosis (SC) presented with common temporomandibular joint (TMJ) symptoms of pain, cracking noises, locking and limited range of opening. Plain radiographs and computed tomography (CT) imaging revealed numerous dense bodies surrounding the TMJ with one larger multilobular mass medial to the joint. Imaging was diagnostic of SC and the patient underwent synovectomy and removal of the tumours.
{"title":"Extensive synovial osteochondromatosis of the temporomandibular joint: An open approach","authors":"Simran Kaur Bilkhoo, Valmiki Sharma, Alan Parbhoo","doi":"10.1016/j.adoms.2023.100471","DOIUrl":"10.1016/j.adoms.2023.100471","url":null,"abstract":"<div><p>A patient with extensive unilateral synovial chondromatosis (SC) presented with common temporomandibular joint (TMJ) symptoms of pain, cracking noises, locking and limited range of opening. Plain radiographs and computed tomography (CT) imaging revealed numerous dense bodies surrounding the TMJ with one larger multilobular mass medial to the joint. Imaging was diagnostic of SC and the patient underwent synovectomy and removal of the tumours.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100471"},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000833/pdfft?md5=e436559c1a68b25805d539f3342aea58&pid=1-s2.0-S2667147623000833-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1016/j.adoms.2023.100475
Constance Hardwick , Ellie Day , Edward Carlton , Tom Dudding
Background
After the global pandemic of COVID-19 in March 2020, restrictions were implemented on all aspects of routine dental-care with a primary focus to urgent care only.
Aim
To investigate the impact on secondary care medical facilities and Emergency Department (ED) admissions for the management of severe dental infections as a result of restricted access to routine primary dental-care during the period of COVID-19 restrictions.
Design
National level Hospital Episode Statistics was used to describe the number of inpatient admissions for the drainage of a dental abscess and the attendance for dental related to ED. Data was stratified across ethnicity, sex and deprivation.
Results
There was a decrease in admission to secondary care for dental infection and total admissions during the initial period of national lockdown due to COVID-19. Incidence of dental abscess drainage equalled 4.51 per100,000 person years from 2018 to 2021. There was a 209 % increase in admissions in patients with greatest deprivation. This was much more exaggerated compared to that of non-dental comparison conditions and total inpatient admissions. Using subsequent inpatient admission as a marker of severity, 4.2 % dentally related ED attendance required onward admission.
Conclusion
A large proportion of ED attendances with dental related conditions did not require inpatient admission, therefore a large proportion of ED attendances could be managed more appropriately in specific dental services. Dental infections requiring surgical admission disproportionality affects the most deprived communities of the population which is much more exaggerated compared to peri-anal and total inpatient admissions. This highlights the inequalities and links with deprivation that exist in oral and dental health in England, which is much greater than that of general health if total admissions are used as maker for this. This research highlights the need to improve access to primary dental-care services.
{"title":"The consequence of the closure of primary care dental services on secondary care during the COVID-19 pandemic – A national outlook","authors":"Constance Hardwick , Ellie Day , Edward Carlton , Tom Dudding","doi":"10.1016/j.adoms.2023.100475","DOIUrl":"10.1016/j.adoms.2023.100475","url":null,"abstract":"<div><h3>Background</h3><p>After the global pandemic of COVID-19 in March 2020, restrictions were implemented on all aspects of routine dental-care with a primary focus to urgent care only.</p></div><div><h3>Aim</h3><p>To investigate the impact on secondary care medical facilities and Emergency Department (ED) admissions for the management of severe dental infections as a result of restricted access to routine primary dental-care during the period of COVID-19 restrictions.</p></div><div><h3>Design</h3><p>National level Hospital Episode Statistics was used to describe the number of inpatient admissions for the drainage of a dental abscess and the attendance for dental related to ED. Data was stratified across ethnicity, sex and deprivation.</p></div><div><h3>Results</h3><p>There was a decrease in admission to secondary care for dental infection and total admissions during the initial period of national lockdown due to COVID-19. Incidence of dental abscess drainage equalled 4.51 per100,000 person years from 2018 to 2021. There was a 209 % increase in admissions in patients with greatest deprivation. This was much more exaggerated compared to that of non-dental comparison conditions and total inpatient admissions. Using subsequent inpatient admission as a marker of severity, 4.2 % dentally related ED attendance required onward admission.</p></div><div><h3>Conclusion</h3><p>A large proportion of ED attendances with dental related conditions did not require inpatient admission, therefore a large proportion of ED attendances could be managed more appropriately in specific dental services. Dental infections requiring surgical admission disproportionality affects the most deprived communities of the population which is much more exaggerated compared to peri-anal and total inpatient admissions. This highlights the inequalities and links with deprivation that exist in oral and dental health in England, which is much greater than that of general health if total admissions are used as maker for this. This research highlights the need to improve access to primary dental-care services.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100475"},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000870/pdfft?md5=142f1dfedf48c5e3d69e85cebdc67909&pid=1-s2.0-S2667147623000870-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.1016/j.adoms.2023.100467
Hassan Al Ali, Mohammed Albokhamseen, Mohammed Albodbaij
A 34-year-old healthy woman was referred to our department for extraction of the right maxillary third molar. A rare complication happened during the procedure and management options were discussed with the patient; the agreement was to extract the tooth under general anaesthesia. Tooth extraction is a routine procedure performed in oral and maxillofacial surgery. However, complications may occur even with an experienced surgeon. Herein, we present a rare complication of the maxillary third molar displacement into the infratemporal fossa during extraction and its management.
{"title":"Displacement of the maxillary third molar into the infratemporal fossa during extraction: A case report","authors":"Hassan Al Ali, Mohammed Albokhamseen, Mohammed Albodbaij","doi":"10.1016/j.adoms.2023.100467","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100467","url":null,"abstract":"<div><p>A 34-year-old healthy woman was referred to our department for extraction of the right maxillary third molar. A rare complication happened during the procedure and management options were discussed with the patient; the agreement was to extract the tooth under general anaesthesia. Tooth extraction is a routine procedure performed in oral and maxillofacial surgery. However, complications may occur even with an experienced surgeon. Herein, we present a rare complication of the maxillary third molar displacement into the infratemporal fossa during extraction and its management.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100467"},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000791/pdfft?md5=c3d1defef9337c0d680a56d1bdd274ef&pid=1-s2.0-S2667147623000791-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138559021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-07DOI: 10.1016/j.adoms.2023.100473
Í. Aragón Niño, J.L. Del Castillo Pardo de Vera, J.P. Rodríguez Arias, A. Gutiérrez Venturini, J.L. Cebrián Carretero
Physicians are used to having complementary studies that help us in all phases of our work. In the maxillofacial surgery field the most commonly used tests are radiological tests (CT and NMR) and digital clinical photographs.
In recent years, the concept of 3D surgery has been developed and consists of the use of 3D technology applied to surgery. 3D surgery allows us to move from on-site planning of the surgery to pre-surgical planning, with a simulation and preview of the result at the bone and soft tissue level.
Radiological studies are of very limited use in soft tissue planning and digital photography is two-dimensional and dependent on patient positioning. The use of the surface scanner solves these limitations as it computes the spatial coordinates of the patient's anatomical surface in order to create a 3D digital model.
医生们习惯于进行辅助检查,以帮助我们开展各个阶段的工作。在颌面外科领域,最常用的检查是放射学检查(CT 和 NMR)和数字化临床照片。近年来,3D 手术的概念得到了发展,包括将 3D 技术应用于外科手术。三维手术使我们能够从手术现场规划转变为手术前规划,在骨骼和软组织层面模拟和预览手术效果。放射学研究在软组织规划中的作用非常有限,数字摄影是二维的,并且依赖于病人的定位。表面扫描仪可以计算患者解剖表面的空间坐标,从而创建三维数字模型,因此解决了这些局限性。
{"title":"“3D surface scanner in Maxillofacial Surgery: State of the art.”","authors":"Í. Aragón Niño, J.L. Del Castillo Pardo de Vera, J.P. Rodríguez Arias, A. Gutiérrez Venturini, J.L. Cebrián Carretero","doi":"10.1016/j.adoms.2023.100473","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100473","url":null,"abstract":"<div><p>Physicians are used to having complementary studies that help us in all phases of our work. In the maxillofacial surgery field the most commonly used tests are radiological tests (CT and NMR) and digital clinical photographs.</p><p>In recent years, the concept of 3D surgery has been developed and consists of the use of 3D technology applied to surgery. 3D surgery allows us to move from on-site planning of the surgery to pre-surgical planning, with a simulation and preview of the result at the bone and soft tissue level.</p><p>Radiological studies are of very limited use in soft tissue planning and digital photography is two-dimensional and dependent on patient positioning. The use of the surface scanner solves these limitations as it computes the spatial coordinates of the patient's anatomical surface in order to create a 3D digital model.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000857/pdfft?md5=5a7f50603d296904bed22c8924b5fa95&pid=1-s2.0-S2667147623000857-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138557998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The identification of the Facial nerve in parotid surgery stands as a stiff challenge till date. Various different pointers with numerical measurements have been identified. But these landmarks can differ between various race, sex or the presence of a tumour. Tracking the branch to posterior belly of digastric, which is not an expressive branch is the only surgical step where the surgeon can reach the facial nerve trunk without doing any surgical maneuver on facial nerve trunk.
Materials and methods
The study was conducted on 15 patients presenting with disease of the parotid gland. Surgery was done by following appropriate surgical steps and the nerve to posterior belly of digastric was searched for. Signs of Facial nerve palsy post-surgery was looked for and noted.
Results
In all our patients we could find the PDBFN confidently in continuation of the surgery. We observed the PDBFN is a thicker nerve then the marginal mandibular and it's easier to identify if it is intended as it is a constant anatomical landmark. Use of this branch help us to track the nerve which is definitive.
Conclusion
We found the digastric branch of the facial nerve is a reliable, consistent landmark to get the facial nerve trunk. Moreover, it was identified without any manouvere over the facial nerve trunk and as it is a non-expressive branch, it guards the possibility of inducing morbidity.
{"title":"Use of posterior belly digastric branch of the facial nerve to identify facial nerve trunk in doing parotidectomy","authors":"Jyotirmoy Phookan, Bijit Kumar Saikia, Taufeequl Islam, Bibhuti Das, Rakesh Talukdar","doi":"10.1016/j.adoms.2023.100468","DOIUrl":"10.1016/j.adoms.2023.100468","url":null,"abstract":"<div><h3>Introduction</h3><p>The identification of the Facial nerve in parotid surgery stands as a stiff challenge till date. Various different pointers with numerical measurements have been identified. But these landmarks can differ between various race, sex or the presence of a tumour. Tracking the branch to posterior belly of digastric, which is not an expressive branch is the only surgical step where the surgeon can reach the facial nerve trunk without doing any surgical maneuver on facial nerve trunk.</p></div><div><h3>Materials and methods</h3><p>The study was conducted on 15 patients presenting with disease of the parotid gland. Surgery was done by following appropriate surgical steps and the nerve to posterior belly of digastric was searched for. Signs of Facial nerve palsy post-surgery was looked for and noted.</p></div><div><h3>Results</h3><p>In all our patients we could find the PDBFN confidently in continuation of the surgery. We observed the PDBFN is a thicker nerve then the marginal mandibular and it's easier to identify if it is intended as it is a constant anatomical landmark. Use of this branch help us to track the nerve which is definitive.</p></div><div><h3>Conclusion</h3><p>We found the digastric branch of the facial nerve is a reliable, consistent landmark to get the facial nerve trunk. Moreover, it was identified without any manouvere over the facial nerve trunk and as it is a non-expressive branch, it guards the possibility of inducing morbidity.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100468"},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000808/pdfft?md5=18388eddb73bdf614010dfb51b656ad4&pid=1-s2.0-S2667147623000808-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.1016/j.adoms.2023.100474
Sabine S. Linsen , Marcus Teschke , Frederick Far , Louis G. Mercuri
The reconstruction of large mandibular deficits involving the temporomandibular joint (TMJ) can be challenging. Extended alloplastic total temporomandibular joint reconstruction (eTMJR) is one treatment option.
This single center, prospective, long-term observational study evaluates the objective and subjective outcomes of 21 eTMJR subjects followed >5 years postoperatively. The long-term stability of the eTMJR was determined by collecting objective data (mandibular kinematics, contralateral surface electromyography (sEMG), maximum voluntary clenching (MVC)) and subjective oral health related quality of life (oHrQoL).
Except for mandibular deviation on opening, the objective variables markedly improved. A statistically significant decrease was found for ipsilateral condylar hypermobility (P = 0.001), and an increase in bilateral MVC (ipsilateral P = 0.029, contralateral P = 0.015). The subjective outcomes 'diet consistency’ (P = 0.001) and 'physical distress' (P = 0.043) improved significantly.
Based on the stability of the eTMJR devices over the study period, improved objective and subjective variables, eTMJR appears to be a safe and effective predictable management option for patients with large mandibular deficits including the TMJ.
{"title":"Is an extended alloplastic replacement (eTMJR) device an option for the management of mandibular defects involving the temporomandibular joint? - A prospective cohort study","authors":"Sabine S. Linsen , Marcus Teschke , Frederick Far , Louis G. Mercuri","doi":"10.1016/j.adoms.2023.100474","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100474","url":null,"abstract":"<div><p>The reconstruction of large mandibular deficits involving the temporomandibular joint (TMJ) can be challenging. Extended alloplastic total temporomandibular joint reconstruction (eTMJR) is one treatment option.</p><p>This single center, prospective, long-term observational study evaluates the objective and subjective outcomes of 21 eTMJR subjects followed >5 years postoperatively. The long-term stability of the eTMJR was determined by collecting objective data (mandibular kinematics, contralateral surface electromyography (sEMG), maximum voluntary clenching (MVC)) and subjective oral health related quality of life (oHrQoL).</p><p>Except for mandibular deviation on opening, the objective variables markedly improved. A statistically significant decrease was found for ipsilateral condylar hypermobility (P = 0.001), and an increase in bilateral MVC (ipsilateral P = 0.029, contralateral P = 0.015). The subjective outcomes 'diet consistency’ (P = 0.001) and 'physical distress' (P = 0.043) improved significantly.</p><p>Based on the stability of the eTMJR devices over the study period, improved objective and subjective variables, eTMJR appears to be a safe and effective predictable management option for patients with large mandibular deficits including the TMJ.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100474"},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000869/pdfft?md5=244dc8e89db6a59d5da9edada8068483&pid=1-s2.0-S2667147623000869-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138549897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.1016/j.adoms.2023.100470
Michael Boelstoft Holte , Alexandru Diaconu , Else Marie Pinholt
The purpose of the present study was to compare the precision and reliability of voxel- and surface-based registration for computer-assisted assessment of the surgical accuracy and postoperative stability of segmental bimaxillary surgery. Three-dimensional translational and rotational measurements were performed by two observers using voxel- and surface-based registration. The precision and reliability of the measurements were calculated by the mean absolute differences (MAD) and intraclass correlation coefficients (ICC) at 95 % confidence intervals. A paired t-test or the non-parametric equivalent, Wilcoxon signed-rank test, was applied to statistically evaluate whether the precision of voxel- and surface-based registration was statistically significantly different (p < 0.05). Voxel-based registration had high precision (MAD <0.44 mm/0.92°) and excellent reliability, ICC [0.82–1.00]. The precision of surface-based registration was lower (MAD <0.56 mm/1.45°) and the reliability ranged from poor to excellent for the different bone segments, ICC [0.33–1.00]. Both registration techniques had high precision and excellent reliability for the assessment of the surgical accuracy, and the error margin of both techniques was clinical irrelevant. However, the increased precision of voxel-based registration was statistically significant (p < 0.05) for the maxillary segments and the chin, and the stability measurement error (ranging up to 1.58 mm and 4.46°) introduced by surface-based registration may be considered clinical relevant for these bone segments. Within the limitations of the present comparative study, voxel-based registration generally exhibited higher precision and reliability than surface-based registration for the surgical accuracy and postoperative stability assessment of segmental bimaxillary surgery.
本研究的目的是比较体素配准和表面配准在计算机辅助评估节段性双颌手术的手术准确性和术后稳定性方面的精确性和可靠性。由两名观察者使用体素配准和表面配准进行三维平移和旋转测量。测量的精确度和可靠性通过平均绝对差值(MAD)和95%置信区间的类内相关系数(ICC)来计算。采用配对 t 检验或等效的非参数 Wilcoxon 符号秩检验来统计评估体素配准和表面配准的精度是否存在显著的统计学差异(p < 0.05)。基于体素的配准精度高(MAD <0.44毫米/0.92°),可靠性极佳,ICC [0.82-1.00]。基于表面的配准精度较低(MAD<0.56 mm/1.45°),不同骨节的可靠性从较差到优秀不等,ICC [0.33-1.00]。对于手术准确性的评估,两种配准技术都具有很高的精确度和极佳的可靠性,而且两种技术的误差范围与临床无关。然而,基于体素的配准技术对上颌骨节段和下巴的精确度的提高具有统计学意义(p < 0.05),而基于表面的配准技术对这些骨节段带来的稳定性测量误差(范围达 1.58 mm 和 4.46°)可被视为与临床相关。在本对比研究的限制条件下,对于双颌节段手术的手术准确性和术后稳定性评估,基于体素的配准通常比基于表面的配准表现出更高的精确度和可靠性。
{"title":"Computer-assisted assessment of segmental bimaxillary surgery using voxel- and surface-based registration: A comparative study","authors":"Michael Boelstoft Holte , Alexandru Diaconu , Else Marie Pinholt","doi":"10.1016/j.adoms.2023.100470","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100470","url":null,"abstract":"<div><p>The purpose of the present study was to compare the precision and reliability of voxel- and surface-based registration for computer-assisted assessment of the surgical accuracy and postoperative stability of segmental bimaxillary surgery. Three-dimensional translational and rotational measurements were performed by two observers using voxel- and surface-based registration. The precision and reliability of the measurements were calculated by the mean absolute differences (MAD) and intraclass correlation coefficients (ICC) at 95 % confidence intervals. A paired <em>t</em>-test or the non-parametric equivalent, Wilcoxon signed-rank test, was applied to statistically evaluate whether the precision of voxel- and surface-based registration was statistically significantly different (p < 0.05). Voxel-based registration had high precision (MAD <0.44 mm/0.92°) and excellent reliability, ICC [0.82–1.00]. The precision of surface-based registration was lower (MAD <0.56 mm/1.45°) and the reliability ranged from poor to excellent for the different bone segments, ICC [0.33–1.00]. Both registration techniques had high precision and excellent reliability for the assessment of the surgical accuracy, and the error margin of both techniques was clinical irrelevant. However, the increased precision of voxel-based registration was statistically significant (p < 0.05) for the maxillary segments and the chin, and the stability measurement error (ranging up to 1.58 mm and 4.46°) introduced by surface-based registration may be considered clinical relevant for these bone segments. Within the limitations of the present comparative study, voxel-based registration generally exhibited higher precision and reliability than surface-based registration for the surgical accuracy and postoperative stability assessment of segmental bimaxillary surgery.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000821/pdfft?md5=deb20e5302ab0727bd5352beae94a9ad&pid=1-s2.0-S2667147623000821-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138557997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.1016/j.adoms.2023.100464
Fabian Kalt , Martin Hüllner , Moritz C. Wurnig , Gregoire B. Morand , Martina A. Broglie , Paul Stolzmann , Martin Lanzer
Background
Human papilloma virus (HPV) infection is an important risk factor in oropharyngeal cancer. Several studies have analyzed the association of tumoral HPV status and different imaging parameters in FDG-PET/CT and magnetic resonance (MR) diffusion-weighted imaging (DWI), with contradictory findings. In this retrospective study, the influence of HPV-status on different parameters in FDG-imaging and MR DWI is investigated.
Methods
In this retrospective, single-center study we analyzed patients diagnosed with oropharyngeal cancer between January 2018 and December 2020 at a tertiary center in Switzerland. HPV status was assessed via p16 immunohistochemistry and/or PCR. Standardized uptake value (SUV), total lesion glycolysis (TLG) and apparent diffusion coefficient (ADC) were measured in pretreatment imaging (FDG-PET/CT, FDG-PET/MR, DWI MR). Statistical analysis was performed using Mann-Whitney-U tests. All p values reported are two-sided, and p values < 0.05 were considered statistically significant.
Results
142 patients were included. 67% of tumors were HPV-positive. Mean SUVmax in FDG-PET was 15.0+/-5.9 for HPV-positive tumors and 18.6+/-9.7 for HPV-negative tumors (p = 0.15). Mean ADC was 1109 x 106 mm2/s+/-326.8 for HPV-positive tumors and 1045.8 x 106 mm2/s+/-467.0 for HPV-negative tumors (p = 0.76).
Conclusion
and Relevance: We found no correlation between oropharyngeal carcinoma HPV status and any of the analyzed imaging parameters.
背景人乳头瘤病毒(HPV)感染是口咽癌的一个重要危险因素。有几项研究分析了肿瘤 HPV 状态与 FDG-PET/CT 和磁共振(MR)弥散加权成像(DWI)中不同成像参数的关系,但结果相互矛盾。在这项回顾性研究中,我们调查了HPV状态对FDG成像和MR DWI不同参数的影响。方法在这项回顾性单中心研究中,我们分析了2018年1月至2020年12月期间在瑞士一家三级中心确诊的口咽癌患者。HPV状态通过p16免疫组化和/或PCR进行评估。在预处理成像(FDG-PET/CT、FDG-PET/MR、DWI MR)中测量了标准化摄取值(SUV)、病变总糖酵解(TLG)和表观弥散系数(ADC)。统计分析采用 Mann-Whitney-U 检验。所有报告的 p 值均为双侧,p 值为 0.05 时具有统计学意义。67%的肿瘤为HPV阳性。HPV阳性肿瘤的FDG-PET平均SUVmax为15.0+/-5.9,HPV阴性肿瘤为18.6+/-9.7(P = 0.15)。HPV阳性肿瘤的平均ADC为1109 x 106 mm2/s+/-326.8,HPV阴性肿瘤的平均ADC为1045.8 x 106 mm2/s+/-467.0(p = 0.76):我们没有发现口咽癌 HPV 状态与任何分析的成像参数之间存在相关性。
{"title":"Association of oropharyngeal cancer HPV status with diffusion-weighted MR imaging and FDG-PET parameters","authors":"Fabian Kalt , Martin Hüllner , Moritz C. Wurnig , Gregoire B. Morand , Martina A. Broglie , Paul Stolzmann , Martin Lanzer","doi":"10.1016/j.adoms.2023.100464","DOIUrl":"10.1016/j.adoms.2023.100464","url":null,"abstract":"<div><h3>Background</h3><p>Human papilloma virus (HPV) infection is an important risk factor in oropharyngeal cancer. Several studies have analyzed the association of tumoral HPV status and different imaging parameters in FDG-PET/CT and magnetic resonance (MR) diffusion-weighted imaging (DWI), with contradictory findings. In this retrospective study, the influence of HPV-status on different parameters in FDG-imaging and MR DWI is investigated.</p></div><div><h3>Methods</h3><p>In this retrospective, single-center study we analyzed patients diagnosed with oropharyngeal cancer between January 2018 and December 2020 at a tertiary center in Switzerland. HPV status was assessed via p16 immunohistochemistry and/or PCR. Standardized uptake value (SUV), total lesion glycolysis (TLG) and apparent diffusion coefficient (ADC) were measured in pretreatment imaging (FDG-PET/CT, FDG-PET/MR, DWI MR). Statistical analysis was performed using Mann-Whitney-U tests. All p values reported are two-sided, and p values < 0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>142 patients were included. 67% of tumors were HPV-positive. Mean SUV<sub>max</sub> in FDG-PET was 15.0+/-5.9 for HPV-positive tumors and 18.6+/-9.7 for HPV-negative tumors (p = 0.15). Mean ADC was 1109 x 10<sup>6</sup> mm<sup>2</sup>/s+/-326.8 for HPV-positive tumors and 1045.8 x 10<sup>6</sup> mm<sup>2</sup>/s+/-467.0 for HPV-negative tumors (p = 0.76).</p></div><div><h3>Conclusion</h3><p>and Relevance: We found no correlation between oropharyngeal carcinoma HPV status and any of the analyzed imaging parameters.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100464"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000766/pdfft?md5=99ff6db4030f3fe418e355d9e9209f7d&pid=1-s2.0-S2667147623000766-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135664943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An intramuscular (IM) injection into gluteal muscle can lead to iatrogenic trauma to sciatic nerve. The drugs can be injected directly into sciatic or into the tissue adjacent to the nerve. Besides the direct damage to nerve due to needle and drug entrance to nerve tissue, the chemical nature of each drug activates immune system near healthy peripheral nerves in order to remove damaged tissues and start healing process. This immune system response has a great role in creating pathological pain and it makes functional recovery as a major challenge.
Material method
In this study, 25 adults male Fischer- Wistar rats were used. An analgesic drug (diclofenac) was injected in the muscles near sciatic nerve (4 groups) and also in sciatic nerve (1 group, nerve control group). For clinical assessment of sciatic nerves integrity, sciatic functional index test (SFI test) was done before, 1 day and 7 days after surgery. Treatments with meloxicam, dexamethasone and extract of Salvia Officinalis were started for 3 muscle groups and 1 group remained as a control muscle group. After 1 week, all the animals were euthanized under deep anesthesia and the sciatic nerves with surrounding muscles were removed and sent to histopathological examination.
Results
all three treatment groups showed decreased inflammatory process and increased repair regeneration in compare to control group. Although, the amount recovery in the dexamethasone group was significantly higher in compared to the control and other treatment groups.
Conclusion
This study showed That IM injection of analgesic drug (Diclofenac), without direct damage to sciatic nerve, causes activation of the immune system and iatrogenic sciatic neuropathy. This study also showed therapeutic effects of two common drugs (NSAID and corticosteroids) and an extract of Salvia Officinalis. Treatment with all three drugs, decreased inflammatory response at injury site and increased recovery but Long-term usage of corticosteroids and NSAIDs can be challenging. The Salvia extract also have showed acceptable improvement effects with minimal side effects.
{"title":"A comparison between therapeutic effects of Salvia Officinalis. Extract, meloxicam and dexamethasone following acute sciatic nerve injury due to analgesic drug injection in rats","authors":"Mahdieh Katebian , Mirsepehr Pedram , Mohammadmehdi Dehghan , Korosh Mansoori , Mahya Lalehpoor , Farid Kosarifard","doi":"10.1016/j.adoms.2023.100460","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100460","url":null,"abstract":"<div><h3>Background</h3><p>An intramuscular (IM) injection into gluteal muscle can lead to iatrogenic trauma to sciatic nerve. The drugs can be injected directly into sciatic or into the tissue adjacent to the nerve. Besides the direct damage to nerve due to needle and drug entrance to nerve tissue, the chemical nature of each drug activates immune system near healthy peripheral nerves in order to remove damaged tissues and start healing process. This immune system response has a great role in creating pathological pain and it makes functional recovery as a major challenge.</p></div><div><h3>Material method</h3><p>In this study, 25 adults male Fischer- Wistar rats were used. An analgesic drug (diclofenac) was injected in the muscles near sciatic nerve (4 groups) and also in sciatic nerve (1 group, nerve control group). For clinical assessment of sciatic nerves integrity, sciatic functional index test (SFI test) was done before, 1 day and 7 days after surgery. Treatments with meloxicam, dexamethasone and extract of <em>Salvia Officinalis</em> were started for 3 muscle groups and 1 group remained as a control muscle group. After 1 week, all the animals were euthanized under deep anesthesia and the sciatic nerves with surrounding muscles were removed and sent to histopathological examination.</p></div><div><h3>Results</h3><p>all three treatment groups showed decreased inflammatory process and increased repair regeneration in compare to control group. Although, the amount recovery in the dexamethasone group was significantly higher in compared to the control and other treatment groups.</p></div><div><h3>Conclusion</h3><p>This study showed That IM injection of analgesic drug (Diclofenac), without direct damage to sciatic nerve, causes activation of the immune system and iatrogenic sciatic neuropathy. This study also showed therapeutic effects of two common drugs (NSAID and corticosteroids) and an extract of <em>Salvia Officinalis</em>. Treatment with all three drugs, decreased inflammatory response at injury site and increased recovery but Long-term usage of corticosteroids and NSAIDs can be challenging. The Salvia extract also have showed acceptable improvement effects with minimal side effects.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"12 ","pages":"Article 100460"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000729/pdfft?md5=1ffc21c6abcc79ba25db90454de2f5d7&pid=1-s2.0-S2667147623000729-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91959847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.1016/j.adoms.2023.100458
Pablo Crespo , Dennis Sigüenza , Valeria Vázquez
Introduction
The aspiration and ingestion of a molar during its extraction is a rare accident, so there is not enough information about the reported cases. The objective of this study is to carry out a systematic review, analyze the articles on intraoperative dental aspiration and intake, and propose an algorithm for the management of this complication.
Materials and methods
A systematic review was carried out following the PRISMA criteria in the PubMed database in January 2023 with the following limitations: studies conducted in humans; English language; reports of aspiration and swallowing of teeth during dental extraction, age was not limited. Exclusion criteria: studies of aspiration and ingestion of foreign bodies that do not involve teeth.
Results
A total of 5 articles were obtained with 5 reported cases of aspiration. There were no reports associated with the ingestion of a tooth. The most prevalent sex was male, with all cases reported in men, the average age was 24.4 years. The imaging studies of choice were chest radiography and computed tomography. The right bronchus was the most prevalent location site. The first line treatment was bronchoscopy, followed by tracheotomy and thoracotomy.
Conclusion
Tooth extraction is a common surgical procedure, so it is essential to be careful in the event of possible complications such as intraoperative aspiration or tooth ingestion. Tooth aspiration can be a life-threatening complication, so prompt management is important. The proposed algorithm allows adequate management for aspiration and swallowing of teeth.
{"title":"Intraoperative dental aspiration and ingest, systematic review and algorithm proposal","authors":"Pablo Crespo , Dennis Sigüenza , Valeria Vázquez","doi":"10.1016/j.adoms.2023.100458","DOIUrl":"https://doi.org/10.1016/j.adoms.2023.100458","url":null,"abstract":"<div><h3>Introduction</h3><p>The aspiration and ingestion of a molar during its extraction is a rare accident, so there is not enough information about the reported cases. The objective of this study is to carry out a systematic review, analyze the articles on intraoperative dental aspiration and intake, and propose an algorithm for the management of this complication.</p></div><div><h3>Materials and methods</h3><p>A systematic review was carried out following the PRISMA criteria in the PubMed database in January 2023 with the following limitations: studies conducted in humans; English language; reports of aspiration and swallowing of teeth during dental extraction, age was not limited. Exclusion criteria: studies of aspiration and ingestion of foreign bodies that do not involve teeth.</p></div><div><h3>Results</h3><p>A total of 5 articles were obtained with 5 reported cases of aspiration. There were no reports associated with the ingestion of a tooth. The most prevalent sex was male, with all cases reported in men, the average age was 24.4 years. The imaging studies of choice were chest radiography and computed tomography. The right bronchus was the most prevalent location site. The first line treatment was bronchoscopy, followed by tracheotomy and thoracotomy.</p></div><div><h3>Conclusion</h3><p>Tooth extraction is a common surgical procedure, so it is essential to be careful in the event of possible complications such as intraoperative aspiration or tooth ingestion. Tooth aspiration can be a life-threatening complication, so prompt management is important. The proposed algorithm allows adequate management for aspiration and swallowing of teeth.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"12 ","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000705/pdfft?md5=40b0c5425d53c2b7410d450fd90aea97&pid=1-s2.0-S2667147623000705-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92039573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}