Pub Date : 2025-12-01Epub Date: 2025-10-14DOI: 10.1016/j.adoms.2025.100593
Vishal N. Mepani , Bhavin G. Visavadia
{"title":"Erratum to “Atypical case of Lemierre's syndrome secondary to cellulitis of the orofacial region” [Advan Oral Maxillofacial Surg 17 (2025) 100506]","authors":"Vishal N. Mepani , Bhavin G. Visavadia","doi":"10.1016/j.adoms.2025.100593","DOIUrl":"10.1016/j.adoms.2025.100593","url":null,"abstract":"","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-27DOI: 10.1016/j.adoms.2025.100599
Eliandro de Souza Freitas , Tiago Novaes Pinheiro , Carolina Silvano Vilarinho da Silva , Isabelle Dutra de Castro , Bianca Faria de Lima
Proliferating Trichilemmal Cyst (PTC) is a benign follicular tumor. We describe a 32-year-old male with progressive nasal obstruction, recurrent epistaxis, and periorbital swelling. Imaging revealed a soft-tissue mass with orbital extension, initially suggestive of a vascular lesion. Histopathology and immunohistochemistry confirmed PTC with mural vascular malformation. This case represents the first reported case of PTC in the maxillary sinus, underscoring the importance of considering PTC in the differential diagnosis of sinonasal tumors.
{"title":"Giant expansive mass in the maxillary sinus","authors":"Eliandro de Souza Freitas , Tiago Novaes Pinheiro , Carolina Silvano Vilarinho da Silva , Isabelle Dutra de Castro , Bianca Faria de Lima","doi":"10.1016/j.adoms.2025.100599","DOIUrl":"10.1016/j.adoms.2025.100599","url":null,"abstract":"<div><div>Proliferating Trichilemmal Cyst (PTC) is a benign follicular tumor. We describe a 32-year-old male with progressive nasal obstruction, recurrent epistaxis, and periorbital swelling. Imaging revealed a soft-tissue mass with orbital extension, initially suggestive of a vascular lesion. Histopathology and immunohistochemistry confirmed PTC with mural vascular malformation. This case represents the first reported case of PTC in the maxillary sinus, underscoring the importance of considering PTC in the differential diagnosis of sinonasal tumors.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-07-30DOI: 10.1016/j.adoms.2025.100563
Sarfi Dounia , Ben Yahya Ihssane
Introduction
Pregnancy epulis, or pregnancy-associated pyogenic granuloma, is a benign oral tumor linked to hormonal changes and local irritative factors. It typically appears as an exuberant, bleeding, and sometimes painful gingival mass.
Clinical case
We report the case of a 32-year-old woman in her third trimester of pregnancy, presenting with a bilobed tumor evolving over six months, bleeding upon contact. Clinical examination revealed a pedunculated, dark red lesion on the anterior maxillary marginal gingiva. Surgical excision was performed after local debridement. Histology confirmed a pyogenic granuloma. The postoperative course was favorable, with no recurrence until delivery.
Discussion conclusion
This case illustrates the classic features of pregnancy epulis. Proper management allows complete healing without recurrence.
{"title":"Extensive pyogenic granuloma in a pregnant woman","authors":"Sarfi Dounia , Ben Yahya Ihssane","doi":"10.1016/j.adoms.2025.100563","DOIUrl":"10.1016/j.adoms.2025.100563","url":null,"abstract":"<div><h3>Introduction</h3><div>Pregnancy epulis, or pregnancy-associated pyogenic granuloma, is a benign oral tumor linked to hormonal changes and local irritative factors. It typically appears as an exuberant, bleeding, and sometimes painful gingival mass.</div></div><div><h3>Clinical case</h3><div>We report the case of a 32-year-old woman in her third trimester of pregnancy, presenting with a bilobed tumor evolving over six months, bleeding upon contact. Clinical examination revealed a pedunculated, dark red lesion on the anterior maxillary marginal gingiva. Surgical excision was performed after local debridement. Histology confirmed a pyogenic granuloma. The postoperative course was favorable, with no recurrence until delivery.</div></div><div><h3>Discussion conclusion</h3><div>This case illustrates the classic features of pregnancy epulis. Proper management allows complete healing without recurrence.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-23DOI: 10.1016/j.adoms.2025.100585
Dieudonne Banguen , Paul Ndom , Etienne Atenguena Okobaleba
{"title":"Prevalence of oral mucositis induced by cancer chemotherapy at Yaounde General Hospital","authors":"Dieudonne Banguen , Paul Ndom , Etienne Atenguena Okobaleba","doi":"10.1016/j.adoms.2025.100585","DOIUrl":"10.1016/j.adoms.2025.100585","url":null,"abstract":"","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-21DOI: 10.1016/j.adoms.2025.100596
Berete Pornan Issa Jules , Ferri Joel
SATB2-associated syndrome (SAS) is a rare genetic dysmorphic syndrome. The mechanism of haploinsufficiency of the SATB2 gene, located at 2q32-q33, is thought to be responsible for pathogenic variants. This study aims to present the clinical phenotype and maxillofacial management of a patient carrying a de novo mutation of the SATB2 gene.
We present the case of a patient with a de novo heterozygous pathogenic variant of the SATB2 gene, who presented with intellectual disability without radiological brain abnormalities associated with cleft palate, retrognathia and microstomia, dental abnormalities without dactylological abnormalities. High maxillomandibular bone density was observed. It is an exceptional report because of the progressive densification of the bine. This case broadens the phenotypic spectrum of clinical abnormalities associated with the SATB2 gene. It also highlights the importance of genetic analysis in complex craniofacial malformations.
{"title":"Progressive maxillofacial osteo-condensation revealing a de NOVO mutation of the SATB2 gene in a young woman","authors":"Berete Pornan Issa Jules , Ferri Joel","doi":"10.1016/j.adoms.2025.100596","DOIUrl":"10.1016/j.adoms.2025.100596","url":null,"abstract":"<div><div>SATB2-associated syndrome (SAS) is a rare genetic dysmorphic syndrome. The mechanism of haploinsufficiency of the SATB2 gene, located at 2q32-q33, is thought to be responsible for pathogenic variants. This study aims to present the clinical phenotype and maxillofacial management of a patient carrying a de novo mutation of the SATB2 gene.</div><div>We present the case of a patient with a de novo heterozygous pathogenic variant of the SATB2 gene, who presented with intellectual disability without radiological brain abnormalities associated with cleft palate, retrognathia and microstomia, dental abnormalities without dactylological abnormalities. High maxillomandibular bone density was observed. It is an exceptional report because of the progressive densification of the bine. This case broadens the phenotypic spectrum of clinical abnormalities associated with the SATB2 gene. It also highlights the importance of genetic analysis in complex craniofacial malformations.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100596"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood platelet-rich plasma (PRP) contains a variety of biologically active components, including growth factors. The objective of this study was to examine the effects of topical PRP injection on osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) mediator levels in the gingival groove fluid of dogs with orthodontic treatment.
Methods
In this study, six adult male dogs, 10–12 months of age, were included. Every dog was randomly assigned to either an experimental or a control group by injecting thrombin-CaCl2 and PRP into one side (experimental group) and thrombin-CaCl2 and a placebo into the opposite side (control group). During the experiment, a maxillary quadrant on one side was assigned as the experimental group and the opposing side as the control group. Maxillary first premolars were bilaterally extracted, followed by the placement of a titanium nickel spring (200 g) between the second premolar and the canine. A mixture of PRP and CaCl2-thrombin was administered to the experimental group on days 1, 21, and 42, whereas the control group received CaCl2-thrombin mixed with a placebo. Samples of gingival groove fluid were collected regularly during the study (on days 0, 1, 2, 7, 21, 42, and 63). A RANKL and OPG enzyme-linked immunosorbent assay was performed to measure the levels of the mediators.
Results
The experimental group exhibited consistently higher OPG levels (p < 0.001), indicating that the topical injection of PRP had a notable effect on OPG levels and the associated regulatory mechanisms involved in bone remodeling. The RANKL mediator levels in the gingival fluid of orthodontic-treated teeth were increased over time in the experimental group, while the control group did not show any significant changes over time.
Conclusion
The topical injection of PRP demonstrated a significant influence on OPG and RANKL mediator levels, reaffirming its potential as a therapeutic approach for optimizing bone remodeling and enhancing treatment outcomes.
{"title":"Effect of Locally injected PRP on RANKL and OPG in gingival fluid during orthodontic tooth movement: A Canine Model Study","authors":"Aida Jafari , Shirin Zahra Farhad , Nasim Esnaashari , Sepehr Kobravi , Hossein Jafari","doi":"10.1016/j.adoms.2025.100583","DOIUrl":"10.1016/j.adoms.2025.100583","url":null,"abstract":"<div><h3>Aims</h3><div>Blood platelet-rich plasma (PRP) contains a variety of biologically active components, including growth factors. The objective of this study was to examine the effects of topical PRP injection on osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) mediator levels in the gingival groove fluid of dogs with orthodontic treatment.</div></div><div><h3>Methods</h3><div>In this study, six adult male dogs, 10–12 months of age, were included. Every dog was randomly assigned to either an experimental or a control group by injecting thrombin-CaCl2 and PRP into one side (experimental group) and thrombin-CaCl2 and a placebo into the opposite side (control group). During the experiment, a maxillary quadrant on one side was assigned as the experimental group and the opposing side as the control group. Maxillary first premolars were bilaterally extracted, followed by the placement of a titanium nickel spring (200 g) between the second premolar and the canine. A mixture of PRP and CaCl2-thrombin was administered to the experimental group on days 1, 21, and 42, whereas the control group received CaCl2-thrombin mixed with a placebo. Samples of gingival groove fluid were collected regularly during the study (on days 0, 1, 2, 7, 21, 42, and 63). A RANKL and OPG enzyme-linked immunosorbent assay was performed to measure the levels of the mediators.</div></div><div><h3>Results</h3><div>The experimental group exhibited consistently higher OPG levels (p < 0.001), indicating that the topical injection of PRP had a notable effect on OPG levels and the associated regulatory mechanisms involved in bone remodeling. The RANKL mediator levels in the gingival fluid of orthodontic-treated teeth were increased over time in the experimental group, while the control group did not show any significant changes over time.</div></div><div><h3>Conclusion</h3><div>The topical injection of PRP demonstrated a significant influence on OPG and RANKL mediator levels, reaffirming its potential as a therapeutic approach for optimizing bone remodeling and enhancing treatment outcomes.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"20 ","pages":"Article 100583"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-20DOI: 10.1016/j.adoms.2025.100575
Mohammed Inam Ullah Khan , Rabindra Pratap Singh , Jordan Prince , Amanda Vincci Chiu , Hassan El-Awour
Achieving profound local anaesthesia (LA) is a vital skill for oral surgeons, enabling efficient and successful completion of surgical procedures. Recent advances in LA administration aim to enhance patient comfort, improve clinician satisfaction, and increase anaesthetic efficacy.
This review examines the evidence on emerging techniques, including vibrotactile devices, computer-controlled local anaesthetic delivery (CCLAD), single-tooth anaesthesia, intraosseous injections, needleless systems, and buffered LA solutions, comparing them to conventional syringe techniques.
The evidence for these devices and techniques is mixed, with some trials reporting reduced pain or anxiety and increased speed of onset or anaesthesia success in teeth with pulpitis, while other trials report no significant differences compared to conventional syringes. Many of the trials had small sample sizes with high risk of bias, highlighting the need for large scale randomised controlled trials to better establish efficacy of these novel devices. Clinicians should weigh the available evidence alongside their own and patients’ preferences before considering new LA equipment. Emerging techniques hold promise but require further validation to ensure consistent and reliable outcomes in surgical practice.
{"title":"Recent advances in dental local anaesthesia","authors":"Mohammed Inam Ullah Khan , Rabindra Pratap Singh , Jordan Prince , Amanda Vincci Chiu , Hassan El-Awour","doi":"10.1016/j.adoms.2025.100575","DOIUrl":"10.1016/j.adoms.2025.100575","url":null,"abstract":"<div><div>Achieving profound local anaesthesia (LA) is a vital skill for oral surgeons, enabling efficient and successful completion of surgical procedures. Recent advances in LA administration aim to enhance patient comfort, improve clinician satisfaction, and increase anaesthetic efficacy.</div><div>This review examines the evidence on emerging techniques, including vibrotactile devices, computer-controlled local anaesthetic delivery (CCLAD), single-tooth anaesthesia, intraosseous injections, needleless systems, and buffered LA solutions, comparing them to conventional syringe techniques.</div><div>The evidence for these devices and techniques is mixed, with some trials reporting reduced pain or anxiety and increased speed of onset or anaesthesia success in teeth with pulpitis, while other trials report no significant differences compared to conventional syringes. Many of the trials had small sample sizes with high risk of bias, highlighting the need for large scale randomised controlled trials to better establish efficacy of these novel devices. Clinicians should weigh the available evidence alongside their own and patients’ preferences before considering new LA equipment. Emerging techniques hold promise but require further validation to ensure consistent and reliable outcomes in surgical practice.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"19 ","pages":"Article 100575"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-07-26DOI: 10.1016/j.adoms.2025.100566
Bander Y. Alkarri, Mohammed H. Albodbaij, Adam Ahmed M. AlQadhi, Mohammed A. AlQadhi
Actinomycosis is a chronic granulomatous infection caused by anaerobic Gram-positive bacteria, predominantly Actinomyces israelii. The cervicofacial region accounts for more than half of reported cases; however, involvement of the upper lip is extremely rare and often mimics benign tumors or mucoceles. In this case report, we describe a 41-year-old woman who presented with an 8-month history of a painless, slow-growing, mobile mass on the upper left labial mucosa. Diagnosis of an actinomycotic infection of the upper lip was achieved histologically, and the patient was treated with surgical excision and antibiotic therapy. Recovery was uneventful, and no recurrence was observed at 9 months follow-up. Our case highlights the importance of considering actinomycosis in the differential diagnosis of persistent lip nodules.
{"title":"Actinomycosis of upper lip: A rare case report","authors":"Bander Y. Alkarri, Mohammed H. Albodbaij, Adam Ahmed M. AlQadhi, Mohammed A. AlQadhi","doi":"10.1016/j.adoms.2025.100566","DOIUrl":"10.1016/j.adoms.2025.100566","url":null,"abstract":"<div><div>Actinomycosis is a chronic granulomatous infection caused by anaerobic Gram-positive bacteria, predominantly Actinomyces israelii. The cervicofacial region accounts for more than half of reported cases; however, involvement of the upper lip is extremely rare and often mimics benign tumors or mucoceles. In this case report, we describe a 41-year-old woman who presented with an 8-month history of a painless, slow-growing, mobile mass on the upper left labial mucosa. Diagnosis of an actinomycotic infection of the upper lip was achieved histologically, and the patient was treated with surgical excision and antibiotic therapy. Recovery was uneventful, and no recurrence was observed at 9 months follow-up. Our case highlights the importance of considering actinomycosis in the differential diagnosis of persistent lip nodules.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"19 ","pages":"Article 100566"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-20DOI: 10.1016/j.adoms.2025.100571
Faisal Alzahrani , Sally Issa , Akram Alshirah , Noha Seoudi
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative condition that leads to chronic pain and restricted jaw function, significantly reducing quality of life. Minimally invasive treatments such as platelet concentrate (PC) and arthrocentesis have emerged as promising therapeutic options. This systematic review of systematic reviews (SR of SRs) aimed to evaluate the effectiveness of intra-articular injection (IAI) of PC alone or in combination with arthrocentesis, compared to hyaluronic acid (HA), corticosteroids (CS), arthrocentesis alone, or placebo.
A comprehensive search of PubMed, Scopus, the Cochrane Library, and Google Scholar identified 18 systematic reviews and meta-analyses published between 2012 and 2024. Studies evaluating pain reduction and maximum mouth opening (MMO) were included. Methodological quality was assessed using the Critical Appraisal Skills Programme (CASP) and Risk of Bias in Systematic Reviews (ROBIS) tools.
PC, offer superior and sustained pain relief compared to HA, CS, and placebo, especially when combined with arthrocentesis. However, results regarding MMO improvement were inconsistent, likely due to variations in PC preparation, follow-up periods, and patient characteristics. Risk of bias analysis revealed 51 % low risk, 26 % high risk, and 22 % unclear risk, highlighting the need for more standardised high-quality research protocols.
PC show promising potential in managing pain associated with TMJ OA through a minimally invasive approach. Further research is needed to optimise protocols and confirm long-term therapeutic outcomes.
颞下颌关节骨性关节炎（tmjoa）是一种退行性疾病，导致慢性疼痛和颌骨功能受限，显著降低生活质量。微创治疗如血小板浓缩（PC）和关节穿刺已成为有前途的治疗选择。本系统评价的系统评价（SR of SRs）旨在评价与透明质酸（HA）、皮质类固醇（CS）、单独关节穿刺或安慰剂相比，单独关节内注射（IAI） PC或联合关节穿刺的有效性。对PubMed、Scopus、Cochrane图书馆和b谷歌Scholar进行了全面搜索，确定了2012年至2024年间发表的18篇系统综述和荟萃分析。包括评估疼痛减轻和最大张嘴（MMO）的研究。使用关键评估技能计划（CASP）和系统评价偏倚风险（ROBIS）工具评估方法学质量。与HA， CS和安慰剂相比，PC提供了更好的和持续的疼痛缓解，特别是当与关节穿刺联合使用时。然而，关于MMO改善的结果是不一致的，可能是由于PC准备、随访时间和患者特征的差异。偏倚风险分析显示低风险为51%，高风险为26%，不明确风险为22%，强调需要更多标准化的高质量研究方案。PC在通过微创入路治疗TMJ OA相关疼痛方面显示出良好的潜力。需要进一步的研究来优化方案并确认长期治疗结果。
{"title":"Platelet concentrates and arthrocentesis as therapeutic options for temporomandibular joint osteoarthritis: A systematic review of systematic reviews","authors":"Faisal Alzahrani , Sally Issa , Akram Alshirah , Noha Seoudi","doi":"10.1016/j.adoms.2025.100571","DOIUrl":"10.1016/j.adoms.2025.100571","url":null,"abstract":"<div><div>Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative condition that leads to chronic pain and restricted jaw function, significantly reducing quality of life. Minimally invasive treatments such as platelet concentrate (PC) and arthrocentesis have emerged as promising therapeutic options. This systematic review of systematic reviews (SR of SRs) aimed to evaluate the effectiveness of intra-articular injection (IAI) of PC alone or in combination with arthrocentesis, compared to hyaluronic acid (HA), corticosteroids (CS), arthrocentesis alone, or placebo.</div><div>A comprehensive search of PubMed, Scopus, the Cochrane Library, and Google Scholar identified 18 systematic reviews and meta-analyses published between 2012 and 2024. Studies evaluating pain reduction and maximum mouth opening (MMO) were included. Methodological quality was assessed using the Critical Appraisal Skills Programme (CASP) and Risk of Bias in Systematic Reviews (ROBIS) tools.</div><div>PC, offer superior and sustained pain relief compared to HA, CS, and placebo, especially when combined with arthrocentesis. However, results regarding MMO improvement were inconsistent, likely due to variations in PC preparation, follow-up periods, and patient characteristics. Risk of bias analysis revealed 51 % low risk, 26 % high risk, and 22 % unclear risk, highlighting the need for more standardised high-quality research protocols.</div><div>PC show promising potential in managing pain associated with TMJ OA through a minimally invasive approach. Further research is needed to optimise protocols and confirm long-term therapeutic outcomes.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"19 ","pages":"Article 100571"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-03-17DOI: 10.1016/j.adoms.2025.100534
Prawash Sunuwar, Lakshmi Venkatakrishnan, Thomas Aldridge
An abscess is a localized collection of pus within tissue, often due to a bacterial infection. Lip abscesses are particularly rare, especially in immunocompetent individuals, as the lip is typically protected by keratinized mucosa and a good blood supply and lacks common sources of infection. Common causes of lip swelling include allergic reactions, trauma, and specific vascular or lymphatic malformations, such as haemangiomas and lymphangiomas. This article presents a rare case of a spontaneous lower lip abscess in an immunocompetent individual, discussing the clinical approach, surgical management, and a review of literature for insights into diagnostic and treatment challenges.
{"title":"Spontaneous lower lip abscess in an immunocompetent individual","authors":"Prawash Sunuwar, Lakshmi Venkatakrishnan, Thomas Aldridge","doi":"10.1016/j.adoms.2025.100534","DOIUrl":"10.1016/j.adoms.2025.100534","url":null,"abstract":"<div><div>An abscess is a localized collection of pus within tissue, often due to a bacterial infection. Lip abscesses are particularly rare, especially in immunocompetent individuals, as the lip is typically protected by keratinized mucosa and a good blood supply and lacks common sources of infection. Common causes of lip swelling include allergic reactions, trauma, and specific vascular or lymphatic malformations, such as haemangiomas and lymphangiomas. This article presents a rare case of a spontaneous lower lip abscess in an immunocompetent individual, discussing the clinical approach, surgical management, and a review of literature for insights into diagnostic and treatment challenges.</div></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"19 ","pages":"Article 100534"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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