中华消化杂志最新文献

{"title":"Expression and its significance of long non-coding transcription factor 7 in gastric cancer","authors":"Hui Zhang, Jia Xu, Jiangnan Wan, Shan-shan Wang, Yong-Jian Lin, Haifeng Ren, Yeqian Zhang","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.005","url":null,"abstract":"Objective \u0000To explore the expression and clinical pathological significance of long non-coding transcription factor 7 (lncTCF7) in gastric cancer tissues and to investigate the role of lncTCF7 in the invasion and metastasis of gastric cancer by in vitro experimental study. \u0000 \u0000 \u0000Methods \u0000From January to June 2011, one hundred patients with gastric cancer who underwent radical gastrectomy were selected from Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The expression of lncTCF7 at mRNA level was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The patients were divided into high expression group (50 cases) and low expression group (50 cases) according to the lncTCF7 mRNA expression level. The stable interferenced lncTCF7 cell line (stable interference group) and blank control lncTCF7 cell line (blank control group) were established. Then the relationship between lncTCF7 expression level and clinical pathological characteristics and prognosis was analyzed. The interferenced lncTCF7 cell line was constructed and utilized, and the role of lncTCF7 in the invasion and metastasis of gastric cancer was detected by wound healing, Transwell and Western blotting method. The Chi square test and t test were performed for statistical analysis. The Kaplan-Meier curve was used for survival analysis. Univariate and multivariate analyses were used for screening the independent factors affecting prognosis. \u0000 \u0000 \u0000Results \u0000The results of qRT-PCR showed that the expression levels of lncTCF7 mRNA in high expression group and low expression group were 0.019±0.003 and 0.002±0.001, respectively. The survival rate of high expression group was lower than that of low expression group (46%, 23/50 vs. 72%, 36/50), and the difference was statistically significant (P=0.002 5). The expression level of lncTCF7 was correlated with intravascular tumor thrombus formation, nerve invasion, depth of invasion and lymph node metastasis (χ2=7.862, 7.162, 11.903 and 8.280, all P<0.05). The results of univariate and multivariate analyses showed that the expression level of lncTCF7 was significantly correlated with the depth of invasion (hazard ratio (HR)=4.205, P=0.002; HR=3.125, P=0.018). The results of wound healing assay indicated that lncTCF7 interference could significantly inhibit wound healing ((92.90±1.51)% vs. (12.33±0.67)%, t=48.72, P<0.01). The results of Transwell assay demonstrated that after 24 hours of culture the number of cells passed through the membrane of the chamber of blank control group was higher than that of stable interference group (83.6±12.5 vs. 26.6±4.3), and the difference was statistically significant (t=9.65, P<0.01). The results of Western blotting showed that the expression of E-cadherin, a marker of epithelial origin, of stable interference group was significantly increased compared with that of blank control group (0.32±0.01 vs. 0.76±0.01), however the expression levels of vimentin and N-cadherin, marke","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"49 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81374503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function observation and clinical features of 100 cases of elderly patients with non-alcoholic fatty liver disease","authors":"Jing Xu, Li Yang, Xuan Shi, Dan Wang","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.008","url":null,"abstract":"Objective \u0000To observe the changes of cognitive function, clinical characteristics and hippocampal structure in elderly patients with non-alcoholic fatty liver disease (NAFLD). \u0000 \u0000 \u0000Methods \u0000From December 2014 to June 2016, at Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 169 elderly hospitalized patients who underwent health checkups were enrolled and divided into NAFLD group and non-NAFLD group. The clinical data of two groups were collected, and the Montreal cognitive assessment scale (MoCA) was used for cognitive function assessment. The serum level of soluble transferrin receptor (sTfR) was detected, the liver-spleen ratio was measured and hippocampal proton magnetic resonance spectroscopy (1H-MRS) was performed. T test and linear regression analysis were used for statistical analysis. \u0000 \u0000 \u0000Results \u0000Among the 169 elderly patients, 100 were NAFLD and 69 were non-NAFLD. The body mass index(BMI) and waist-to-hip ratio(WHR)of patients in NAFLD group were (25.9±3.4) kg/m2 and 1.03±0.13, respectively, which were higher than those in non-NAFLD group ((24.2±3.7) kg/m2 and 0.95±0.06), and the differences were statistically significant (t=-2.714 and -3.605, both P<0.01). MoCA score of the patients in NAFLD group was 20.1±5.8, which was lower than that in non-NAFLD group (22.1±4.4), and the difference was statistically significant(t=2.154, P=0.033). The serum sTfR level and liver-spleen computed tomography(CT) ratio of NAFLD group were (8.78±4.31) mg/L and 0.97±0.12, respectively, which were lower than those of non-NAFLD group ((12.66±3.93) mg/L and 1.19±0.15), and the differences were statistically significant(t=3.765 and 6.142, both P<0.01). The CT ratio of liver to spleen (β=7.597, 95% confidence interval(CI): 2.938 to 12.935) and sTfR (β= 0.552, 95%CI: 0.304 to 0.787) were positively correlated with cognitive function in elderly patients (both P<0.01). The height of right hippocampus of NAFLD group was (0.410±0.074) mm, which was lower than that of non-NAFLD group ((0.453±0.086) mm), and the difference was statistically significant (t=2.078, P=0.042). \u0000 \u0000 \u0000Conclusion \u0000Cognitive impairment in elderly NAFLD patients is closely related to iron load and liver fat. \u0000 \u0000 \u0000Key words: \u0000Cognition; Non-alcoholic fatty liver disease; Soluble transferrin receptor; Proton magnetic resonance spectroscopy","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"1 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76310341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of 326 cases of erosive esophagitis in healthy population undergoing health checkup in Eastern Zhejiang Province","authors":"H. Ren, Dawei Chen, N. Dai","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.002","url":null,"abstract":"Objective \u0000To explore the incidence of asymptomatic erosive esophagitis (AEE) and clinical characteristics of symptoms of erosive esophagitis in healthy population undergoing health check-up. \u0000 \u0000 \u0000Methods \u0000From January 2012 to December 2015, at Ningbo Medical Treatment Center Lihuili Eastern Hospital, a total of 3 052 healthy people receiving routine health checkup and underwent gastroendoscopy were retrospectively analyzed. The demographic characteristics, endoscopic findings, reflux-related symptoms, metabolic syndrome and biochemical parameters were analyzed in AEE and symptomatic erosive esophagitis (SEE) patients. T test and Chi square test were performed for univariate analysis, and multivariate logistic regression analysis was used to compare differences between AEE and SEE patients. \u0000 \u0000 \u0000Results \u0000There were 326 cases of erosive esophagitis, and the incidence rate was 10.7% (326/3 052). Among them, the incidence rate of AEE was 4.9% (151/3 052), which accounted for 46.3% (151/326) of erosive esophagitis; and the incidence rate of SEE was 5.7% (175/3 052), and accounted for 53.7% (175/326) of erosive esophagitis. About 98.2%(320/326) of the patients were diagnosed with mild esophagitis (Los Angeles grade A or B). The results of univariate analysis indicated that, compared with AEE group, there were more smokers (31.8%, 48/151 vs. 45.7%, 80/175) and more drinkers (27.8%, 42/151 vs. 41.7%, 73/175), and higher body mass index (BMI) ((23.95±2.32) kg/m2 vs. (24.53±2.19) kg/m2) were in SEE group, and the differences were statistically significant (χ2=6.592 and 6.859, t=-2.351; all P 0.05). The results of multivariate logistic regression analysis indicated that smoking (odds ratio (OR)=1.67, 95% confidence interval (CI) 1.05 to 2.65, P=0.030), alcohol drinking (OR=1.69, 95%CI 1.05 to 2.72, P=0.030) and high BMI (OR=1.11, 95%CI 1.00 to 1.23, P=0.044) were the independent risk factors of gastroesophageal reflux symptoms in patients with erosive esophagitis. \u0000 \u0000 \u0000Conclusions \u0000AEE is common in Chinese population, and the incidence is similar to SEE. Smoking, alcohol drinking and high BMI are the risk factors of reflux symptom in patients with erosive esophagitis. \u0000 \u0000 \u0000Key words: \u0000Endoscopy; Risk factors; Asymptomatic erosive esophagitis; Gastroesophageal reflux disease symptoms","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"19 1","pages":"2-6"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87459530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory bowel disease with thrombosis: a single center retrospective study","authors":"L. Jin, Wei Juan, Chen Chunyan, Z. Li, Chen Zhijian, Wu Lin, Wu Xingjiang, Wang Fang-yu, Liu Jiong","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.007","url":null,"abstract":"Objective \u0000To analyze the clinical features and clinical significance of patients with inflammatory bowel disease (IBD) complicated by thrombosis. \u0000 \u0000 \u0000Methods \u0000From March 14th, 2001 to February sixth 2017, at Nanjing General Hospital of Nanjing Military Command, 27 IBD patients with thrombosis diagnosed by clinical symptoms, endoscopy, imaging and pathology were enrolled. During the same period, 81 gender and age matched IBD patients without thrombosis were included in the control group. The basic data, information of IBD diagnosis and treatment and thrombotic events of patients were collected and analyzed. T-test and Chi-square test were performed for statistical analysis. Binary logistics regression was used for risk factors analysis. \u0000 \u0000 \u0000Results \u0000The mean age of diagnosis of IBD patients with thrombosis was (44.8±15.8) years, which was higher than that of the IBD patients of control group ((36.0±14.4) years), and the difference was statistically significant (t=2.69, P=0.008). Among 27 IBD patients with thrombosis, arterial thrombosis was 51.9%(14/27), deep venous thrombosis of the lower extremity veins was 29.6%(8/27), portal venous system involved was 11.1% (3/27), pulmonary embolism was 3.7%(1/27) and disseminated intravascular coagulation accounted for 7.4%(2/27). Nine patients (33.3%, 9/27) underwent surgery six months before the diagnosis of thrombosis. The results of binary logistic regression indicated that the age of diagnosis and vascular catheterization were independent risk factors for thrombosis in IBD patients (odds ratio (OR)=1.04, 95%confidence interval (CI)1.01 to 1.07, P=0.01; OR=5.64, 95%CI 1.39 to 22.96, P=0.02). After medicine treatment or surgery, 81.5%(22/27) of the patients improved, 9.1%(2/22) were worse and 13.6%(3/22) died. \u0000 \u0000 \u0000Conclusion \u0000Screening and prevention of thrombosis should be paid attention in IBD patients with a history of vascular catheterization, at active phase and older age when diagnosed. \u0000 \u0000 \u0000Key words: \u0000Inflammatory bowel diseases; Venous thrombosis; Risk factors","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"145 12 1","pages":"31-34"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84863980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and esophageal motility characteristics of patients with esophagogastric junction outflow obstruction","authors":"Xia Liu, Hong Wang, Ling-ting Wang, Qianshu Liu","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.003","url":null,"abstract":"Objective \u0000To analyze the clinical features and esophageal motility characteristics of patients with esophagogastric junction outflow obstruction (EGJOO). \u0000 \u0000 \u0000Methods \u0000From January 2015 to January 2018, at Affiliated Hospital of Zunyi Medical College, the clinical data of 663 outpatients with various gastrointestinal symptoms were collected. Gastroscopy and esophageal high resolution manometry (HRM) were performed to exclude gastrointestinal organic lesions. The 120 patients were divided into EGJOO group (71 cases) and non-EGJOO group (49 cases). Furthermore, according to integrated relaxation pressure (IRP) the 71 EGJOO patients were divided into mild group (41 cases), moderate group (20 cases) and severe group (10 cases). Independent sample t test and one-way analysis of variance were performed for statistical analysis. \u0000 \u0000 \u0000Results \u0000Among 71 EGJOO patients, 43.7% (31/71) showed post sternal heartburn or acid regurgitation, 32.4% (23/71) showed obstruction or dysphagia, 21.1% (15/71) showed chest pain, 21.1% (15/71) showed other atypical symptoms such as hiccups and bloating, and 5.6% (4/71) showed upper abdominal pain. The IRP, lower esophageal sphincter (LES) length, LES resting pressure and intrabolus pressure (IBP) of the EGJOO group were higher than those of the non-EGJOO group ((18.24±3.07) mmHg (1 mmHg=0.133 kPa) vs. (10.92±2.37) mmHg, (3.47±0.85) cm vs. (3.11±0.80) cm, (32.33±9.11) mmHg vs. (21.31±6.55) mmHg, (6.22±3.74) mmHg vs. (4.69±2.68) mmHg), and the differences were statistically significant (t=-13.947, -2.303, -7.706 and -2.626; all P<0.05). The LES relaxation rate and distal contractile integral (DCI) of the EGJOO group were lower than those of the non-EGJOO group ((44.03±9.86)% vs. (53.86±11.33)%, (1 410.13±794.23) mmHg·s·cm vs. (1 741.86±894.16) mmHg·s·cm), and the differences were statistically significant (t=5.046 and 2.136, both P<0.05). The LES resting pressure of the mild group was higher than that of the moderate group ((30.76±9.23) mmHg vs. (29.69±5.87) mmHg); the LES resting pressure of the moderate group was lower than that of the severe group ((29.69±5.87) mmHg vs. (42.02±9.23) mmHg); and the differences were statistically significant (both Tamhane test, P=0.012 and 0.011). The IBP of the mild group was lower than that of the moderate group and the severe group ((5.16±3.41) mmHg vs. (8.02±2.58) mmHg and (7.46±3.48) mmHg), and the differences were statistically significant (both least-significant difference test, both P<0.05). The DCI of the mild group was lower than that of the moderate group ((1 241.41±606.12) mmHg·s·cm vs. (1 438.55±644.74) mmHg·s·cm), and the difference was statistically significant (Tamhane test, P=0.011). \u0000 \u0000 \u0000Conclusions \u0000Heartburn, acid reflux and dysphagia are common clinical symptoms in EGJOO patients. The weaker the peristalsis of the esophageal body of EGJOO patients, the more obvious of dysphagia. Increased IBP is an indirect manifestation of esophagogastric junction relaxation disorder","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"101 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85461641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of decoy receptors and osteoprotegerin gene polymorphisms with susceptibility and clinical phenotypes of Crohn′s disease","authors":"X. Shao, D. Lin, Liang Sun, Q. Lin, Shijie Ying, Baoping Yu","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.006","url":null,"abstract":"Objective \u0000To investigate the correlation between decoy receptor (DcR)1, DcR2, osteoprotegerin (OPG) gene polymorphisms and susceptibility of Crohn′s disease (CD) in Han population in Zhejiang province. \u0000 \u0000 \u0000Methods \u0000From April 2008 to July 2017, at the Department of Gastroenterology of The Second Affiliated Hospital of Wenzhou Medical University, The First Affiliated Hospital of Wenzhou Medical University, Central Hospital of Wenzhou and Renmin Hospital of Wenzhou, 285 patients diagnosed as having CD were enrolled, and during the same period 572 healthy individuals who received health checkup at the Second Affiliated Hospital of Wenzhou Medical University were collected as healthy control. The single nucleotide polymorphism (SNP) of DcR1 (rs12549481), DcR2 (rs1133782) and OPG (rs3102735) were examined by SNaPshot technique. An unconditional logistic regression analysis was performed to analyze the differences in each SNP mutation alleles and genotype frequencies between CD group and control group. Furthermore, their correlation with clinicopathological features of CD and the efficacy of corticosteroid and infliximab was also evaluated. \u0000 \u0000 \u0000Results \u0000The frequencies of mutant allele A and genotype GA+ AA of DcR2 (rs1133782) of CD group were 11.93% (68/570) and 22.81% (65/285), respectively, which were higher than those of healthy control group (8.22%, 94/1 144; and 15.91%, 91/572; odds ratio (OR)=1.513, 95% confidence interval (CI) 1.088 to 2.104, P=0.013; OR=1.562, 95%CI 1.094 to 2.230, P=0.014). However there was no statistically significant difference in the mutant allele and genotype frequencies of DcR1 (rs12549481) and OPG (rs3102735) between two groups (all P>0.05). The frequencies of mutant allele C and genotype TC+ CC of DcR1 (rs12549481) in patients with stricturing CD were 13.89% (25/180) and 27.78% (25/90), respectively, which were lower than those of patients with non-stricturing, non-penetrating CD (27.68%, 62/224 and 48.21%, 54/112), and the differences were statistically significant (OR=0.421, 95%CI 0.252 to 0.705, P=0.001; OR=0.413, 95%CI 0.229 to 0.747, P=0.003). Besides, the frequencies of mutant allele A and genotypes GA+ AA of DcR2 in patients with penetrating CD were 7.23% (12/166) and 13.25% (11/83), which were lower than those of patients with non-stricturing, non-penetrating CD (15.62%, 35/224 and 30.36%, 34/112), and the differences were statistically significant (OR=0.407, 95%CI 0.205 to 0.809, P=0.009; OR=0.350, 95%CI 0.165 to 0.743, P=0.005). In addition, there was no statistically significant difference in the frequencies of mutant allele and genotypes of OPG (rs3102735) among subtypes of CD with different features (all P>0.012 5). Moreover, the DcR1 (rs12549481), DcR2 (rs1133782) and OPG (rs3102735) polymorphisms were not correlated with the efficacy of corticosteroid and infliximab (all P>0.05). \u0000 \u0000 \u0000Conclusions \u0000DcR1 (rs12549481) mutation may be correlated with stricturing CD. DcR2 (rs1133782) mutation may be corre","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"42 1","pages":"24-30"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86589859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of different treatment options for cholecysto-choledocholithiasis","authors":"Ping Chen, Bingzhong Su, Chunli Cong, Hongxia Wang, Tong-ling Zhang, Jianjun Ren, Qi Wang, Xudong Liu","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.009","url":null,"abstract":"Objective \u0000To evaluate the efficacy of different treatment options for cholecysto-choledocholithiasis (CCL), and try to find the ideal treatment. \u0000 \u0000 \u0000Methods \u0000From January 2006 to January 2016, a total of 3 107 patients with CCL from the Affiliated Hospital of Inner Mongolia Medical University were enrolled. Among them, 1 283 patients were in open cholecystectomy (OC) and open common bile duct exploration (OCBDE) group, 964 patients were in laparoscopic cholecystectomy (LC) and laparoscopic common bile duct exploration (LCBDE) group, and 860 patients were in endoscopic retrograde cholangiopancreatography (ERCP)+ LC group. The clinical data of the three groups were analysed. One-way analysis of variance and chi-square test were performed for statistical analysis. \u0000 \u0000 \u0000Results \u0000From 2006 to 2010, the percentage of patients treated with OC+ OCBDE, LC+ LCBDE, and ERCP+ LC were 56.05%(829/1 479), 25.15%(372/1 479) and 18.80%(278/1 479), respectively; from 2011 to 2016, the percentage of patients received the above three treatments were 27.89%(454/1 628), 36.36%(592/1 628) and 35.75%(582/1 628), respectively. The difference in the proportion of the same treatment at different times was statistically significant (χ2=4.775, 4.168 and 0.669, all P 0.05). The hospital stay of the OC+ OCBDE group, the LC+ LCBDE group and the ERCP+ LC group were (6.7±1.3) days, (5.6±1.2) days and (10.9±1.6) days, respectively, and the differences were statistically significant (F=90.010, P<0.01). The hospitalization expenses of OC+ OCBDE group, LC+ LCBDE group and ERCP+ LC group were (13 720±1 910) yuan, (18 150±1 490) yuan and (25 830±2 430) yuan, respectively, and the differences were statistically significant (F=302.991, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000The first choice of patients with CCL is endoscopic minimally invasive treatment and open surgery can be used as a remedial method for endoscopic treatment. \u0000 \u0000 \u0000Key words: \u0000Cholecysto-choledocholithiasis; Endoscopic minimally invasive treatment; Open surgery","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"79 1","pages":"40-44"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75155157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum metabonomics study in 66 patients with gastric cancer by liquid chromatography-mass spectrometry","authors":"Ge Li, Xiaomi Li, Huiming Lu","doi":"10.3760/CMA.J.ISSN.0254-1432.2019.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2019.01.004","url":null,"abstract":"Objective \u0000To detect whether patients with gastric cancer had unique serum metabolomic characteristics by liquid chromatography-mass spectrometry (LC-MS) metabolomic analysis, and to screen potential markers for early gastric cancer and to preliminarily explore the related metabolic pathways. \u0000 \u0000 \u0000Methods \u0000At the First Affiliated Hospital of Soochow University, 66 patients with gastric cancer and 44 patients with benign gastric disease from July, 2017 to January, 2018 were enrolled, and 50 healthy subjects served as controls. Twenty-five patients with gastric cancer at stage Ⅰ and Ⅱ and 25 patients with gastric cancer at stage Ⅲ and Ⅳ were selected from the 66 patients with gastric cancer, and 25 subjects were also selected from 50 healthy controls. The plasma small molecule metabolites of patients with gastric cancer and benign gastric disease and healthy controls were detected by LC-MS method. Multivariate logistic regression analysis was used to establish and validate the principal component analysis (PCA) model and partial least squares-discriminant analysis (PLS-DA) model and screen the differential metabolites. The receiver operating characteristic curve analysis was used to evaluated the clinical efficacy of differential metabolites. \u0000 \u0000 \u0000Results \u0000PCA and PLS-DA models showed that gastric cancer had a obviously specific metabolites profile, the profile of benign gastric disease overlapped with that of gastric cancer and healthy controls. The results of multivariate logistic regression analysis confirmed that four metabolites including isoleucine, benzophenone, sphingosine-1-phosphate and galactopyranose set could be used to establish an optimal diagnostic model. The area under the curve (AUC) (95% confidence interval (CI)) was 0.963 (0.930 to 0.997), and the best cut off value, sensitivity and specificity were 0.871, 93.1% and 94.0%, respectively. Meanwhile, patients with gastric cancer at stage Ⅰ+ Ⅱ and stage Ⅲ+ Ⅳ had a distinct clustering trend compared with the control group. In the serum of patients with gastric cancer at stage Ⅰ+ Ⅱ and stage Ⅲ+ Ⅳ, a total of 24 differential metabolites were identified, the concentration of five of which including lysine, carnitine, benzenesulfonamide, arginine and docosahexaenoic acid ethyl ester, increased along with the progression of gastric cancer. Pipecolic acid and kynurenine might served as biomarkers for early and mid gastric cancer (stage Ⅰ+ Ⅱ) screening. \u0000 \u0000 \u0000Conclusions \u0000LC-MS metabolomic effectively confirm the unique changes of serum metabolites in patients with gastric cancer. The screened differential metabolites have potential clinical application value for predicting the risk of gastric cancer. \u0000 \u0000 \u0000Key words: \u0000Stomach neoplasms; Metabolism; Biological markers; Liquid chromatography-mass spectrometer","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"32 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86036912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the clinicopathological features between synchronous multiple early gastric cancer and single early gastric cancer","authors":"Guangxia Chen, Chuannan Wu, Haihan Zhang, Li-yong Gao, Jin Ding, Liu Shiyu","doi":"10.3760/CMA.J.ISSN.0254-1432.2018.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2018.12.004","url":null,"abstract":"Objective \u0000To investigate the clinicopathological features and correlation between synchronous multiple early gastric cancer(SMEGC)and single early gastric cancer (EGC). \u0000 \u0000 \u0000Methods \u0000From January 2008 to December 2016, the clinical data of 994 patients with EGC who underwent open or laparoscopic gastrectomy surgery were collected from the electronic medical data base of the First Affiliated Hospital of Nanjing Medical University and Xuzhou No.1 People′s Hospital. The data of patients including gender, age, tumor morphologys, tumor location, tumor size, histological type, depth of invasion, lymph nodes metastasis, lymphovascular metastasis, peripheral nerve invasion, and blood types were analyzed. T test and Chi square test were used for statistical analysis. \u0000 \u0000 \u0000Results \u0000Among 994 EGC patients, 27 cases (2.7%) were SMEGC, and 967 cases (97.3%) were single EGC. The percentage of male and female of single EGC were 71.4% (690/967) and 28.6% (277/967), respectively; the percentage of male and female of SMEGC were 88.9% (24/27) and 11.1%(3/27), respectively, and there was statistically significant difference in the gender composition ratio between single EGC and SMEGC (χ2=3.975, P=0.046). The incidence of ulcer in single EGC and SMEGC were 50.6% (489/967) and 29.6% (8/27), respectively, and the difference in the incidence of ulcers between single EGC and SMEGC was statistically significant (χ2=4.653, P=0.031). There were no statistically significant differences between single EGC and SMEGC in gross morphology, depth of invasion, lymph nodes metastasis, lymphovascular metastasis, peripheral nerve invasion, tumor location, pathological type and blood types (all P>0.05). In the SMEGC patients, the incidence of main lesions invading the mucosa was 48.1% (13/27) and submucosa invasion was 51.9% (14/27); and for minor lesions, the corresponding incidences were 77.8% (21/27) and 22.2% (6/27), respectively, and the difference was statistically significant (χ2=5.063, P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The main risk factors of SMEGC are male and no ulcerative lesions. The clinicopathological features are similar between main lesions and minor lesions in SMEGC. \u0000 \u0000 \u0000Key words: \u0000Synchronous multiple early gastric cancer; Main lesions; Minor lesions; Clinicopathological features","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"135 44","pages":"806-810"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72558932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective cohort study on triglycerides levels and risk of acute pancreatitis","authors":"G. Zhu, Bing Zhang, R. Ji, Q. Sun, Yanmin Zhang, Haitao Wang, Shan Wang, B. Tong, Hailing Zhang, Qian Wang, Jiejing Zhang, Xiaozhong Jiang, Shuohua Chen, Xi Men","doi":"10.3760/CMA.J.ISSN.0254-1432.2018.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1432.2018.12.008","url":null,"abstract":"Objective \u0000To investigate the effects of fasting serum triglycerides (TG) levels at different baseline on the risk of new-onset acute pancreatitis (AP) in in-service and retired employees of Kailuan Group. \u0000 \u0000 \u0000Methods \u0000A total of 125 178 in-service and retired employees of Kailuan Group who received health check-ups from 2006 to 2009 and had no AP history but had complete TG data were prospectively enrolled. According to quantile level, the baseline serum fasting TG level of study subjects were divided into 1.64 mmol/L group (n=41 339). The incidence of new-onset AP of these three groups was analyzed. The survival curve was plotted by Kaplan-Meier method. The cumulative incidence rate was calculated and tested by log-rank method. And multivariate Cox proportional hazards regression model was performed to calculate hazard ratios (HR) of baseline fasting serum TG level for AP. \u0000 \u0000 \u0000Results \u0000After followed up for (7.36±1.23) years, a total of 193 cases of AP occurred. The incidences of AP in 1.64 mmol/L group were 1.43 events/10 000 person-years, 2.37 events/10 000 person-years and 2.49 events/10 000 person-years, respectively. The cumulative incidence rates of AP in 1.64 mmol/L group were 0.10% (44/42 128), 0.18% (73/41 711) and 0.18% (76/41 339), respectively, and the difference was statistically significant (χ2=9.998, P=0.007). The results of multivariate Cox proportional hazards regression model analysis indicated that the risk of AP increased in 1.01 to 1.64 mmol/L group and >1.64 mmol/L group compared with that of 1.64 mmol/L group were 1.70 (1.11 to 2.58) and 1.69 (1.10 to 2.60), respectively. \u0000 \u0000 \u0000Conclusion \u0000Baseline fasting serum TG levels over 1.01 mmol/L may increase the risk of AP. \u0000 \u0000 \u0000Key words: \u0000Triglycerides; Cohort studies; Acute pancreatitis","PeriodicalId":10009,"journal":{"name":"中华消化杂志","volume":"122 1","pages":"829-834"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77939010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}