We report on the noise and Josephson mixing properties of high-Tc superconductor (HTS) Josephson junctions. Direct radiation measurements and heterodyne mixing experiments in the frequency range 45–141 GHz have been performed by using YBa2Cu3O7−x (YBCO) step-edge junctions (SEJ) on LaAlO3 and MgO and bicrystal junctions (BCJ) on MgO substrates. Junctions with current voltage characteristics (CVC) close to predictions of the resistivity shunted junction (RSJ) model were mounted into a high sensitive radiometer system. From linewidth measurements we calculated an effective noise temperature of our junctions. In heterodyne mixing experiments we obtained conversion efficiencies around −14 dB in the 11 GHz intermediate frequency (IF) band under the radiation of two monochromatic signals. In the fundamental mixing regime we observed response at IF at working temperatures up to 72 K. The measured receiver and mixer noise temperature of the Josephson mixer at 94 GHz local oscillator (LO) frequency, an IF of 1.4 GHz and at a working temperature of 10 K was 4700 and 3400 K, respectively.