Clínica e Investigación en Arteriosclerosis (English Edition)最新文献_第2页

Environmental pollution and cardiovascular health. Challenges and new perspectives 环境污染与心血管健康。挑战和新视角

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-05-01 Epub Date: 2026-03-13 DOI: 10.1016/j.artere.2026.500802

Francisco Gomez-Delgado , Manuel Raya-Cruz , Juan L. Romero-Cabrera , Pablo Perez-Martinez

Environmental pollution is a key factor in cardiovascular disease (CVD) development. Several evidences support its impact at the pathophysiology of arteriosclerosis, highlighting the role of the ``exposome'', a concept that encompasses all environmental factors such as air pollution, water pollution, climate change and noise and light pollution. These factors are associated with an increased risk of ischemic heart disease (IHD), stroke, high blood pressure (HBP), heart failure (HF) and atrial fibrillation (AF). Currently, air pollution is the main environmental factor related to CVD. Components such as particulates matter (PM_0.1, PM_2.5, PM₁₀), sulfur dioxide (SO₂), nitrogen oxide and dioxide (NO_x), carbon monoxide (CO) and ozone (O₃) have a high capacity to penetrate the body and trigger both local and systemic inflammatory processes. These effects promote a proinflammatory, procoagulant state and an increase in oxidative stress. Similarly, aquatic pollution exposes the body to pollutants such as heavy metals, pesticides and microplastics, both through direct contact and via the food chain, thus contributing to the phenomena mentioned above. On the other hand, factors such as noise and light pollution, together with effects caused from climate change (extreme temperatures, wildfires, desertification, among others), have been closely linked to pathophysiological processes that favour the development and progression of atherosclerosis. These mechanisms include sympathetic nervous system (SNS) activation, stress hormones release such as cortisol and catecholamines, as well as chronodisruption. This review analyses the role of factors related to the exposome (air pollution, water pollution, noise and light pollution and phenomena associated with climate change) in atherosclerosis progression, as well as their involvement in the incidence, prevalence and prognosis of CVD. Physicians should promote awareness of environmental pollution impact on cardiovascular health, integrating the assessment of environmental factors into their clinical practice, advocating for sustainable policies to prevent diseases and protect present and future health.

环境污染是心血管疾病（CVD）发展的关键因素。一些证据支持其对动脉硬化病理生理的影响，强调了“暴露”的作用，这一概念涵盖了所有环境因素，如空气污染、水污染、气候变化、噪音和光污染。这些因素与缺血性心脏病（IHD）、中风、高血压（HBP）、心力衰竭（HF）和心房颤动（AF）的风险增加有关。目前，大气污染是与心血管疾病相关的主要环境因素。颗粒物（PM0.1、PM2.5、PM10）、二氧化硫（SO2）、氮氧化物和二氧化氮（NOx）、一氧化碳（CO）和臭氧（O3）等成分具有很高的穿透身体并引发局部和全身炎症过程的能力。这些作用促进了促炎、促凝状态和氧化应激的增加。同样，水生污染通过直接接触和通过食物链使人体暴露于重金属、农药和微塑料等污染物中，从而导致上述现象。另一方面，噪音和光污染等因素，以及气候变化（极端温度、野火、荒漠化等）造成的影响，与有利于动脉粥样硬化发展和进展的病理生理过程密切相关。这些机制包括交感神经系统（SNS）的激活，皮质醇和儿茶酚胺等应激激素的释放，以及时间紊乱。本文就空气污染、水污染、噪声、光污染、气候变化等环境暴露相关因素在动脉粥样硬化发展中的作用及其与心血管疾病发病率、患病率和预后的关系进行综述。医生应提高对环境污染对心血管健康影响的认识，将环境因素的评估纳入其临床实践，倡导可持续的政策，以预防疾病，保护现在和未来的健康。

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引用次数: 0

Lipid profile and atherogenic risk in metabolically healthy and unhealthy obese individuals: A cohort analysis by sex and sociodemographic factors 代谢健康和不健康肥胖个体的脂质特征和动脉粥样硬化风险：性别和社会人口因素的队列分析

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-05-01 Epub Date: 2025-12-03 DOI: 10.1016/j.artere.2025.500840

Miguel García Samuelsson , Pedro Juan Tárraga López , Ángel Arturo López González , Carla Busquets-Cortés , Joan Obrador de Hevia , José Ignacio Ramírez Manent

Objective

To analyze lipid profiles and sociodemographic factors associated with atherogenic risk in obese workers classified as metabolically healthy (MHO) or unhealthy (MNHO).

Methods

Cross-sectional study of 68,884 obese workers. Atherogenic lipid indices (total cholesterol/HDL-c, LDL-c/HDL-c, triglycerides/HDL-c) and prevalence of atherogenic dyslipidemia were assessed. Multinomial logistic regression identified factors linked to lipid risk.

Results

MNHO individuals exhibited significantly higher atherogenic indices across sexes and diagnostic criteria. Atherogenic dyslipidemia and lipid triad were more prevalent in MNHO. Male sex, older age, lower educational level, lower social class, physical inactivity, low adherence to the Mediterranean diet, and smoking were associated with higher lipid risk.

Conclusion

Although MHO individuals show a more favorable lipid profile than MNHO, this advantage weakens with less stringent definitions. Sociodemographic and lifestyle factors strongly modulate atherogenic risk.

目的分析代谢健康（MHO）和代谢不健康（MNHO）肥胖工人的脂质特征和与动脉粥样硬化风险相关的社会人口学因素。方法对68884名肥胖工人进行横断面调查。评估致动脉粥样硬化脂质指数（总胆固醇/HDL-c、LDL-c/HDL-c、甘油三酯/HDL-c）和致动脉粥样硬化性血脂异常的患病率。多项逻辑回归确定了与血脂风险相关的因素。结果smnho个体在不同性别和诊断标准下均表现出较高的动脉粥样硬化指数。动脉粥样硬化性血脂异常和脂质三联症在MNHO中更为普遍。男性、年龄较大、受教育程度较低、社会地位较低、缺乏体育锻炼、不坚持地中海饮食和吸烟与血脂风险升高有关。结论尽管MHO个体比MNHO个体表现出更有利的脂质特征，但这种优势随着定义的放宽而减弱。社会人口和生活方式因素强烈调节动脉粥样硬化风险。

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引用次数: 0

Don Carlos A. Villaverde Grote and his scientific legacy 唐·卡洛斯·a·维拉韦德·格罗特和他的科学遗产

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-05-01 Epub Date: 2026-03-21 DOI: 10.1016/j.artere.2026.500909

Lina Badimon , Juan J. Badimon , Ginés Escolar , Lluís Masana , José López-Miranda

引用次数: 0

Association between neutrophil percentage-to-albumin ratio (NPAR) and long-term mortality in community-dwelling adults with chest pain: Evidence from US NHANES 2001–2018 社区居住胸痛成人中性粒细胞百分比与白蛋白比率（NPAR）与长期死亡率之间的关系：来自美国NHANES 2001-2018的证据

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-05-01 Epub Date: 2026-05-03 DOI: 10.1016/j.artere.2026.500843

Qiyun Long , Zejiang Liu , Qin Guo , Xuhui Song , Yongcan Guo

Objective

The neutrophil percentage-to-albumin ratio (NPAR) is a readily available biomarker with prognostic significance across various disease conditions. However, its role in predicting mortality among community patients with chest pain remains underexplored. This study examined NPAR's association with long-term mortality in adults with chest pain using NHANES 2001–2018 data.

Methods

We analyzed data from 6846 community-dwelling adults reporting chest pain. Cox proportional hazards regression models, restricted cubic spline (RCS) analysis, and Kaplan–Meier survival curves were employed to evaluate the relationship between NPAR and the risk of all-cause and cardiovascular mortality. Models were adjusted for demographic, clinical, and laboratory covariates.

Results

Participants were categorized into tertiles based on NPAR values: T1 (<13.0), T2 (13.0–15.0), and T3 (>15.0). Multivariable analysis revealed that the T3 cohort demonstrated significantly increased risks of all-cause mortality (HR 1.56, 95% CI 1.32–1.84, P < 0.001) and cardiovascular mortality (HR 1.86, 95% CI 1.37–2.51, P < 0.001) relative to T1. RCS analysis identified a J-shaped relationship between NPAR and mortality risk, with a significant inflection point at NPAR >13.5 (P for non-linearity <0.001). Incremental analysis showed that each unit increase in NPAR was associated with an 11% higher risk of all-cause mortality (HR 1.11, 95% CI 1.07–1.14, P < 0.001) and a 14% increased risk of cardiovascular mortality (HR 1.14, 95% CI 1.08–1.20, P < 0.001).

Conclusions

Elevated NPAR levels are independently associated with increased long-term mortality in adults with chest pain. These findings position NPAR as a promising prognostic biomarker in this patient population.

目的中性粒细胞百分比-白蛋白比率（NPAR）是一种易于获得的生物标志物，在各种疾病条件下具有预后意义。然而，它在预测社区胸痛患者死亡率方面的作用仍未得到充分探讨。本研究使用NHANES 2001-2018年的数据研究了NPAR与胸痛成人长期死亡率的关系。方法：我们分析了6846名报告胸痛的社区居住成年人的数据。采用Cox比例风险回归模型、限制性三次样条（RCS）分析和Kaplan-Meier生存曲线来评估NPAR与全因死亡率和心血管死亡率之间的关系。根据人口统计学、临床和实验室协变量对模型进行了调整。结果根据NPAR值将参与者分为T1 （<13.0）、T2（13.0 - 15.0）和T3 （>15.0）三组。多变量分析显示，与T1相比，T3队列的全因死亡率（HR 1.56, 95% CI 1.32-1.84, P < 0.001）和心血管死亡率（HR 1.86, 95% CI 1.37-2.51, P < 0.001）显著增加。RCS分析发现NPAR与死亡风险之间呈j型关系，在NPAR >；13.5处出现显著拐点（P为非线性<；0.001）。增量分析显示，NPAR每增加一个单位，全因死亡风险增加11% (HR 1.11, 95% CI 1.07-1.14, P < 0.001)，心血管死亡风险增加14% （HR 1.14, 95% CI 1.08-1.20, P < 0.001）。结论NPAR水平升高与胸痛患者长期死亡率升高独立相关。这些发现使NPAR成为该患者群体中有希望的预后生物标志物。

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引用次数: 0

Differential regulation of the HIF-1α/apoptosis axis by miR-126-5p in cardiac cells during ischemia/reperfusion injury 缺血/再灌注损伤心肌细胞中miR-126-5p对HIF-1α/凋亡轴的差异调控

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-05-01 Epub Date: 2026-05-03 DOI: 10.1016/j.artere.2026.500842

Lisaidy Ramos-Regalado , Leonie Schoch , Sebastià Alcover , Marta Magaldi , Ignacio Barriuso , Teresa Padró , María Borrell , Lina Badimon , Carlos Zaragoza , Gemma Vilahur

Background

MicroRNAs (miRs) regulate gene expression post-transcriptionally and are transported by high-density lipoproteins (HDL). Hypercholesterolemic HDL particles are enriched with miR-126-3p/5p, which can be delivered to endothelial cells, leading to the downregulation of hypoxia-inducible-factor-1α (HIF-1α), a key transcription factor involved in metabolic responses to hypoxia and cell survival during myocardial ischemia/reperfusion (I/R).

Objective

To investigate the effects of miR-126 mimic and inhibitor transfection on the HIF-1α/apoptosis axis in cardiac cell constituents under experimental I/R.

Methods

Firstly, specific durations of I/R were established for cardiac cells (cardiomyocytes, fibroblasts, endothelial cells, and macrophages) based on their susceptibility to metabolic changes and cell death. Then, we assessed the impact of transfecting these cells with mimic-miR-126-5p and anti-miR-126-5p to the selected timings of I/R on the HIF-1α/apoptosis axis.

Results

Endothelial cells were resistant to I/R and fibroblasts were sensitive to ischemia whereas cardiomyocytes displayed high metabolic flexibility. Endogenous miR-126 expression was exclusively found in endothelial cells. Transfection with anti-miR-126 increased HIF-1α transcription in endothelial cells and cardiomyocytes, while reducing HIF-1α levels in fibroblasts, resulted in decreased transcript levels of apoptotic markers. HIF-1α transcript levels remained unchanged in macrophages and transfection with mimic-miR-126 exerted no changes in the HIF-1α/apoptosis axis in all tested cells.

Conclusions

miR-126 differentially regulates HIF-1α/apoptosis expression in cardiac cells exposed to experimental I/R and may serve as a potential therapeutic target for enhancing myocardial resilience in the setting of myocardial infarction.

micrornas （miRs）通过转录后调控基因表达，并通过高密度脂蛋白（HDL）进行转运。高胆固醇血症的HDL颗粒富含miR-126-3p/5p， miR-126-3p/5p可传递到内皮细胞，导致缺氧诱导因子-1α (HIF-1α)下调，HIF-1α是心肌缺血/再灌注（I/R）期间缺氧代谢反应和细胞存活的关键转录因子。目的探讨转染miR-126模拟物和抑制物对实验性I/R下心肌细胞成分HIF-1α/凋亡轴的影响。方法首先，根据心肌细胞、成纤维细胞、内皮细胞和巨噬细胞对代谢变化和细胞死亡的易感性，建立心肌细胞（心肌细胞、成纤维细胞、内皮细胞和巨噬细胞）的特定I/R持续时间。然后，我们评估了用mimic-miR-126-5p和anti-miR-126-5p转染这些细胞对HIF-1α/凋亡轴上I/R选择时间的影响。结果内皮细胞对缺血有抵抗性，成纤维细胞对缺血有敏感性，而心肌细胞则表现出较高的代谢灵活性。内源性miR-126仅在内皮细胞中表达。转染anti-miR-126增加内皮细胞和心肌细胞中HIF-1α的转录，同时降低成纤维细胞中HIF-1α的水平，导致凋亡标志物的转录水平降低。巨噬细胞中HIF-1α转录水平保持不变，转染mimic-miR-126对所有测试细胞的HIF-1α/凋亡轴没有影响。结论smir -126对实验性I/R心肌细胞HIF-1α/凋亡表达有差异调控作用，可能是增强心肌梗死心肌恢复力的潜在治疗靶点。

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引用次数: 0

Evaluation of video content quality on PCSK9 inhibitors in social media 社交媒体中PCSK9抑制剂对视频内容质量的影响

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-03-01 Epub Date: 2026-03-17 DOI: 10.1016/j.artere.2026.500829

David Gabriel David-Pardo , Julián E. Barahona-Correa , Nancy M. Herrera-Leaño , Lauren S. Calvo Betancourt , Óscar Mauricio Muñoz Velandia , Daniel G. Fernández-Ávila , Ángel Alberto García Peña

Background and aims

The internet is a major source of health information, with platforms like YouTube® and Facebook® widely used by patients to learn about diseases and treatments. However, the reliability of content on PCSK9 inhibitors (PCSK9i), a therapy for dyslipidemia, remains unknown. This study aims to evaluate the general characteristics, user engagement metrics, reliability, comprehensiveness, and quality of English- and Spanish-language PCSK9i videos on YouTube® and Facebook®.

Materials and methods

Analytical observational study. Paired evaluations were conducted using validated tools: the modified DISCERN (mDISCERN) for reliability, a modified content score for comprehensiveness, and the Global Quality Score (GQS) for quality. Comparisons were made based on platform, source, and language.

Results

A total of 203 videos were analyzed. YouTube® videos had significantly higher median views, longer duration, and greater engagement than Facebook® videos, while Facebook® contained a higher proportion of non-valuable content (19.6% vs. 3.2%, p < 0.001). Most videos targeted patients and healthcare professionals, with professional organizations and independent users as the primary contributors. YouTube® videos were more frequently rated as “good or better” based on mDISCERN, content score, and GQS. Notably, for-profit organizations achieved the highest content scores and GQS values. Inter-rater reliability was excellent across all scoring tools, with kappa coefficients exceeding 0.89.

Conclusions

YouTube® videos on PCSK9i had higher engagement and reliability than those on Facebook®. For-profit organizations produced the most reliable and exhaustive videos. However, overall quality remains suboptimal, underscoring the need for greater oversight and effective strategies to ensure the dissemination of accurate, high-quality information.

背景和目的互联网是健康信息的主要来源，患者广泛使用YouTube®和Facebook®等平台了解疾病和治疗方法。然而，PCSK9抑制剂（PCSK9i）含量的可靠性仍然未知，PCSK9i是一种治疗血脂异常的药物。本研究旨在评估YouTube®和Facebook®上的英语和西班牙语PCSK9i视频的一般特征、用户参与度指标、可靠性、全面性和质量。材料与方法：分析性观察研究。使用经过验证的工具进行配对评估：改进的DISCERN （mDISCERN）用于可靠性，修改的内容评分用于全面性，以及全球质量评分（GQS）用于质量。基于平台、来源和语言进行比较。结果共分析了203个视频。与Facebook视频相比，YouTube视频具有更高的中位数浏览量、更长的持续时间和更高的参与度，而Facebook包含更高比例的无价值内容（19.6% vs. 3.2%, p < 0.001）。大多数视频针对的是患者和医疗保健专业人员，专业组织和独立用户是主要贡献者。基于mDISCERN、内容评分和GQS， YouTube®视频更经常被评为“好或更好”。值得注意的是，营利性组织获得了最高的内容分数和GQS值。所有评分工具间的信度都很好，kappa系数超过0.89。结论youtube视频在PCSK9i平台上的参与度和可靠性高于Facebook平台。营利性组织制作了最可靠、最详尽的视频。但是，总体质量仍然不够理想，强调需要加强监督和有效战略，以确保传播准确、高质量的信息。

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引用次数: 0

Association between sociodemographic variables, lifestyle factors, and stress with lipoprotein ratio values 社会人口学变量、生活方式因素和压力与脂蛋白比值值之间的关系

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1016/j.artere.2025.500803

Ángel Arturo López-González , José Ignacio Ramírez-Manent , Emilio Martínez-Almoyna Rifá , Hernán Paublini Oliveira , Cristina Martorell Sánchez , Pedro Juan Tárraga López

Introduction

Atherosclerosis is a multifactorial process underlying major cardiovascular diseases (CVDs). Among the associated risk factors, lipoprotein ratios have been identified as key indicators of atherogenic risk. However, the influence of sociodemographic variables, lifestyle factors, and stress levels on lipoprotein ratios remains underexplored.

Objective

To analyze the relationship between sociodemographic variables, healthy lifestyle habits, and stress levels with lipoprotein ratios and atherogenic risk in a large cohort of Spanish workers.

Materials and methods

A cross-sectional study was conducted in 24,244 Spanish workers. The association between age, gender, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress levels with atherogenic risk scales, including atherogenic dyslipidemia (AD) and atherogenic indices, was evaluated.

Results

A significant association was found between all analyzed variables and lipoprotein ratios. The strongest associations were observed with age and gender, followed by occupational status, tobacco and alcohol consumption, physical activity, diet, and stress levels. Men exhibited a higher atherogenic risk compared to women (OR 2.36; 95% CI 2.18−2.55). The risk increased significantly with age, peaking in the 50−69 age group (OR 5.00; 95% CI 3.70−6.31). Manual workers had a higher prevalence of atherogenic dyslipidemia compared to non-manual workers (OR 1.35; 95% CI 1.27−1.41). Furthermore, smoking (OR 1.84; 95% CI 1.71−1.97) and alcohol consumption (OR 1.45; 95% CI 1.36−1.55), physical inactivity (OR 1.90; 95% CI 1.76−2.05), and low adherence to the Mediterranean diet (OR 1.72; 95% CI 1.60−1.84) were associated with higher atherogenic index values.

Conclusions

The presence of an adverse lipoprotein profile is strongly influenced by sociodemographic factors, lifestyle habits, and stress. Identifying these determinants may enable the implementation of preventive strategies aimed at reducing atherogenic risk and improving cardiovascular health in working populations.

动脉粥样硬化是主要心血管疾病（cvd）的多因素发病过程。在相关的危险因素中，脂蛋白比率已被确定为动脉粥样硬化风险的关键指标。然而，社会人口变量、生活方式因素和压力水平对脂蛋白比率的影响仍未得到充分探讨。目的分析西班牙工人脂蛋白比率和动脉粥样硬化风险与社会人口学变量、健康生活习惯和压力水平的关系。材料与方法对24,244名西班牙工人进行了一项横断面研究。评估了年龄、性别、社会经济地位、烟酒消费、体育活动、地中海饮食依从性和压力水平与动脉粥样硬化风险量表（包括动脉粥样硬化性血脂异常（AD）和动脉粥样硬化指数）之间的关系。结果所有分析变量均与脂蛋白比值有显著相关性。年龄和性别的相关性最强，其次是职业状况、烟酒消费、体育活动、饮食和压力水平。与女性相比，男性表现出更高的动脉粥样硬化风险（OR 2.36; 95% CI 2.18−2.55）。随着年龄的增长，风险显著增加，在50 ~ 69岁年龄组达到高峰（OR 5.00; 95% CI 3.70 ~ 6.31）。体力劳动者患动脉粥样硬化性血脂异常的比例高于非体力劳动者（OR 1.35; 95% CI 1.27−1.41）。此外，吸烟（OR 1.84, 95% CI 1.71 - 1.97）和饮酒（OR 1.45, 95% CI 1.36 - 1.55）、缺乏体育活动（OR 1.90, 95% CI 1.76 - 2.05）和低地中海饮食依从性（OR 1.72, 95% CI 1.60 - 1.84）与较高的动脉粥样硬化指数值相关。结论不良脂蛋白谱的存在受社会人口因素、生活习惯和压力的强烈影响。确定这些决定因素可能有助于实施旨在减少动脉粥样硬化风险和改善工作人群心血管健康的预防战略。

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引用次数: 0

Dietary guidelines for Americans (DGA): 2025–2030: similarities and contrasts with the recommendations document of the Spanish society of atherosclerosis (SEA) (2024 update) 美国人膳食指南（DGA）： 2025-2030：与西班牙动脉粥样硬化学会（SEA）推荐文件（2024年更新）的异同

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-03-01 Epub Date: 2026-02-19 DOI: 10.1016/j.artere.2026.500896

Pablo Perez-Martinez , José M. Ordovás

引用次数: 0

Spanish Society of Arteriosclerosis Standards 2026: A compass for vascular risk management 西班牙动脉硬化协会标准2026：血管风险管理指南

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-03-01 Epub Date: 2026-02-25 DOI: 10.1016/j.artere.2026.500897

Jose María Mostaza

引用次数: 0

Relationship between apolipoprotein(a) isoforms and lipoprotein(a) levels in patients with acute coronary syndrome 急性冠状动脉综合征患者载脂蛋白(a)亚型与脂蛋白(a)水平的关系

Clínica e Investigación en Arteriosclerosis (English Edition)

Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.artere.2026.500870

Rosa Fernández-Olmo , Jesús Lara Mariscal , Ana García Ruano , Alberto Cordero , Juan Manuel Castillo Casas , Diego Franco

Lp(a) is a cardiovascular risk factor influenced by the LPA gene and apo(a) isoforms. Their relationship is not always linear and there are discordant phenotypes, for this reason in our work we evaluated the association between apo(a) isoforms and Lp(a) levels in patients with acute coronary syndrome (ACS). To this end, 43 patients with ACS and Lp(a) > 50 mg/dL were studied. The isoforms were characterized in 12 bands by Western blotting. The association between bands and Lp(a) concentrations was evaluated by statistical analysis. It was observed that the intermediate molecular weight bands (b5–b8) were the most frequent, with band 8 predominating. No significant association was found between isoform size and Lp(a) levels (p > 0.05). We conclude that in this cohort no correlation was observed between apo(a) and Lp(a) isoforms. Other genetic or regulatory mechanisms could explain the observed variability, supporting the need for larger studies.

Lp(a)是受LPA基因和载脂蛋白(a)亚型影响的心血管危险因素。它们的关系并不总是线性的，并且存在不一致的表型，因此在我们的工作中，我们评估了急性冠脉综合征（ACS）患者载脂蛋白(a)亚型和脂蛋白(a)水平之间的关系。为此，我们对43例ACS患者Lp(a) >； 50 mg/dL进行了研究。Western blotting将其分为12个条带。通过统计分析评估波段与Lp(a)浓度之间的关系。结果表明，中间分子量带（b5 ~ b8）最为常见，以8带居多。异构体大小与Lp(a)水平无显著相关性（p > 0.05）。我们得出结论，在这个队列中，载脂蛋白(a)和脂蛋白(a)亚型之间没有相关性。其他遗传或调节机制可以解释观察到的差异，支持需要进行更大规模的研究。

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引用次数: 0